I-Hydroxypropyl methyl cellulose HPMC iyi-non-ionic cellulose mixed ether ehlukahlukene futhi i-ionic methyl carboxymethyl cellulose mixed ether, ayisabelani nezinsimbi ezisindayo. I-oxygen radicals eyodwa ngenxa yokuqukethwe kwe-hydroxypropyl methyl cellulose kanye nesilinganiso esihlukile sokuqukethwe kwe-hydroxypropyl kanye ne-viscosity, yaba izinhlobo ezihlukile ekusebenzeni, isibonelo, okuqukethwe okuphezulu kwe-methoxyl kanye nokuqukethwe okuphansi kwezinhlobo ze-hydroxypropyl, ukusebenza kwayo kuseduze ne-methyl cellulose kanye nokuqukethwe okuphansi kwe-methoxyl kanye nokuqukethwe okuphezulu kwezinhlobo ze-hydroxypropyl, futhi ukusebenza kwayo kuseduze ne-hydroxypropyl methyl cellulose ekhiqizwayo. Kodwa kuhlobo ngalunye, yize kuqukethe inani elincane le-hydroxypropyl noma inani elincane le-methoxy, ukuncibilika kwezithako eziphilayo noma izinga lokushisa le-flocculation kusisombululo samanzi, kunomehluko omkhulu.
1, ukuncibilika kwe-hydroxypropyl methyl cellulose
I-Hydroxypropyl methyl cellulose ekuncibilikeni kwamanzi kwe-hydroxypropyl methyl cellulose empeleni uhlobo lwe-propylene oxide (indandatho ye-methyl oxypropyl) i-modified methyl cellulose, ngakho-ke isenezici ezifanayo ne-methyl cellulose ebandayo encibilikayo kanye nezingancibiliki emanzini ashisayo. Kodwa-ke, izinga lokushisa le-gelation le-modified hydroxy propyl liphakeme kakhulu kunele-methyl cellulose emanzini ashisayo. Isibonelo, i-viscosity yesisombululo samanzi se-hydroxypropyl methylcellulose esinokuqukethwe okungu-2% kwe-methoxy DS=0.73 kanye nokuqukethwe kwe-hydroxypropyl MS=0.46 kungu-500 mpa ku-20℃. Izinga lokushisa le-gel lomkhiqizo we-S liseduze no-100℃, kanti elo le-methyl cellulose lokushisa elifanayo licishe libe ngu-55℃ kuphela. Ngokuphathelene nokuncibilika kwayo emanzini, kuthuthuke kakhulu, isibonelo, ngemva kokuchotshozwa kwe-hydroxypropyl methylcellulose (okusanhlamvu okuma 0.2 ~ 0.5mm ku-20℃ 4% aqueous viscosity yemikhiqizo ye-2pA? S ingancibilika kalula emanzini ngaphandle kokupholisa ekushiseni kwegumbi.
(2) I-Hydroxypropyl methyl cellulose ezinyibilikisini eziphilayo ukuncibilika kwe-hydroxypropyl methyl cellulose ezinyibilikisini eziphilayo ukuncibilika, futhi kungcono kune-methyl cellulose, izidingo ze-methyl cellulose ezingeni lokushintshana kwe-methoxy elingu-2.1 noma ngaphezulu kwemikhiqizo, futhi iqukethe i-hydroxypropyl MS=1.5~1.8 kanye ne-methoxy DS=0.2~1.0, I-hydroxypropyl methyl cellulose ene-viscosity ephezulu enezinga lokushintshana eliphelele elingaphezu kuka-1.8 incibilika ezixazululweni ze-anhydrous methanol kanye ne-ethanol, futhi inokuncibilika kwe-thermoplastic kanye namanzi. Iphinde incibilike kuma-hydrocarbon ane-chlorine njenge-dichloromethane kanye ne-trichloromethane, kanye nezinyibilikisi eziphilayo njenge-acetone, i-isopropyl alcohol, kanye ne-diacetone alcohol. Ukuncibilika kwayo ezinyibilikisini eziphilayo kungcono kunokuncibilika kwamanzi.
2, i-hydroxypropyl methyl cellulose viscosity yezinto ezithonya
Izinto ezibonisa i-Hydroxypropyl methylcellulose viscosity factors, i-hydroxypropyl methylcellulose standard viscosity determination, kanye nezinye i-cellulose ether ziyafana, ziku-20℃ ngesisombululo samanzi esingu-2% njengesibikezelo esijwayelekile. I-viscosity yomkhiqizo ofanayo, ngokwanda kokuhlushwa nokwanda, ukuhlushwa okufanayo kwemikhiqizo ehlukene yesisindo sama-molecule, isisindo sama-molecule somkhiqizo si-viscosity ephezulu. Ubuhlobo bayo nokushisa bufana nobe-methyl cellulose. Lapho izinga lokushisa likhuphuka, i-viscosity iqala ukwehla, kodwa uma ifika ezingeni lokushisa elithile, i-viscosity ikhuphuka ngokuzumayo futhi kwenzeka i-gelation. Izinga lokushisa le-gelation lemikhiqizo ene-viscosity ephansi liphakeme kunelemikhiqizo ene-viscosity ephezulu. Izinga lephuzu layo le-gel, ngaphezu kwe-viscosity ephezulu nephansi ye-ether, kodwa futhi ne-ether methoxy kanye ne-hydroxypropyl group composition ratio kanye nezinga eliphelele lokushintshaniswa kuhlobene. Kumele kuqashelwe ukuthi i-hydroxypropyl methylcellulose nayo iyi-pseudoplastic; isixazululo sayo sizinzile uma sigcinwa ekushiseni kwegumbi futhi asibonisi noma yikuphi ukuwohloka kwe-viscosity ngaphandle kokuthi kungenzeka ukuthi i-enzymatic degeneration.
3, i-hydroxypropyl methyl cellulose acid kanye nokumelana ne-alkaline
I-Hydroxypropyl methylcellulose acid, i-alkali hydroxypropyl methylcellulose acid kanye ne-alkali, ngokuvamile izinzile, ku-PH PH2 ~ 12 range ayithinteki, ingamelana nenani elithile le-asidi elula, njenge-formic acid, i-acetic acid, i-citric acid, i-succinic acid, i-phosphoric acid, i-boric acid, njll. Kodwa i-acid egxilile inomphumela wokunciphisa i-viscosity. I-Alkali efana ne-caustic soda, i-caustic potassium kanye namanzi e-lime ayinawo umphumela kuyo, kodwa umphumela wokwandisa kancane i-viscosity yesisombululo uzoncipha kancane esikhathini esizayo.
4, i-hydroxypropyl methyl cellulose ingaxutshwa
Isixazululo se-hydroxypropyl methyl cellulose singaxutshwa nama-polymer compounds ancibilikayo emanzini, futhi sibe yisisombululo esifanayo esibonakalayo esine-viscosity ephezulu. Lawa ma-molecule compounds aphezulu yi-polyethylene glycol, i-polyvinyl acetate, i-polysilicone, i-polymethyl vinyl siloxane kanye ne-hydroxyethyl cellulose kanye ne-methyl cellulose, njll. Ama-polymer compounds emvelo njenge-gum Arabic, i-locust bean gum, i-thorn tree gum nokunye nawo anengxube enhle nesixazululo sawo. I-Hydroxypropyl methyl cellulose ingaxutshwa ne-stearic acid noma i-palmitic acid i-mannitol ester noma i-sorbitol ester, kodwa futhi ne-glycerol, i-sorbitol kanye ne-mannitol, lawa ma-comounds angasetshenziswa njenge-hydroxypropyl methyl cellulose plasticizer.
5, i-hydroxypropyl methyl cellulose enganyibiliki emanzini
I-hydroxypropyl methyl cellulose ether engancibiliki emanzini, ingaba ukuxhumanisa kwamanzi ne-aldehydes, futhi yenze lezi ether ezincibiliki emanzini zifakwe esixazululweni, zingancibiliki emanzini. Futhi zenze i-hydroxypropyl methylcellulose i-aldehyde engancibiliki, i-formaldehyde, i-glyoxal, i-succinaldehyde, i-dialdehyde, njll., ukusetshenziswa kwe-formaldehyde kufanele kunake kakhulu inani le-PH lesisombululo, lapho ukusabela kwe-glyoxal kushesha khona, ngakho-ke ekukhiqizweni kwezimboni kuvame ukusetshenziswa i-glyoxal njenge-ejenti yokuxhumanisa. Umthamo walolu hlobo lwe-ejenti yokuxhumanisa esixazululweni ungu-0.2% ~ 10% wesisindo se-ether, okungcono kakhulu kungu-7% ~ 10%, njengokusetshenziswa kwe-glyoxal ene-3.3% ~ 6% okufanele kakhulu. Izinga lokushisa lokwelashwa elijwayelekile lingu-0 ~ 30℃, isikhathi singu-1 ~ 120min. Ukusabela kokuxhumanisa kudingeka kwenziwe ngaphansi kwezimo ze-acidic. Ngokuvamile, i-asidi enamandla engaphili noma i-organic carboxylic acid ingezwa esixazululweni ukuze kulungiswe i-PH yesisombululo ibe cishe yi-2 ~ 6, okungcono phakathi kwe-4 ~ 6, bese kufakwa ama-aldehydes ukuze kuhlangatshezwane nokusabela okuxhumene. Ama-asidi asetshenziswayo yi-hydrochloric acid, i-sulfuric acid, i-phosphoric acid, i-formic acid, i-acetic acid, i-hydroxy acetic acid, i-succinic acid noma i-citric acid, phakathi kwawo i-formic acid noma i-acetic acid engcono kakhulu, kuyilapho i-formic acid iyona engcono kakhulu. Ama-asidi nama-aldehydes angangezwa ngesikhathi esifanayo ukuze kuvunyelwe isixazululo ukuthi sihlanganiswe kububanzi be-PH obufunwayo. Lokhu kusabela kuvame ukusetshenziswa enqubweni yokugcina yenqubo yokulungiselela i-cellulose ether, ukuze i-cellulose ether ingancibiliki, kulula ukuyisebenzisa emanzini angu-20 ~ 25℃ ukuwasha nokuwahlanza. Lapho kusetshenziswa umkhiqizo, izinto ze-alkaline zingangezwa esixazululweni somkhiqizo ukuze kulungiswe i-PH yesisombululo ibe yi-alkaline, futhi umkhiqizo uncibilikiswe ngokushesha esixazululweni. Le ndlela ingasetshenziswa futhi lapho kusetshenziswa isixazululo se-cellulose ether ukwenza ifilimu bese ifilimu iphathwa ukuze yenze ifilimu engancibiliki.
6, i-hydroxypropyl methyl cellulose anti-enzyme
Ukumelana kwe-enzyme ye-hydroxypropyl methyl cellulose ye-cellulose derivatives ngokombono, njengamaqembu e-anhydroglucose ngalinye njengoba kukhona inhlanganisela eqinile yamaqembu angena esikhundleni, ukuguguleka kwamagciwane akulula ukutheleleka, kodwa empeleni umkhiqizo oqediwe ukufaka esikhundleni senani elingaphezu kuka-1, futhi ngokuwohloka kwe-enzyme, lokhu kuyincazelo yeqembu ngalinye ezingeni lokushintshana kwe-cellulose chain akuyona into efanayo, Amagciwane angaguguleka eduze kwamaqembu e-glucose angenamanzi angashintshiwe ukuze akhe ushukela, ongamuncwa yizinto ezincane njengokudla. Ngakho-ke, uma izinga lokushintshana kwe-etherification ye-cellulose landa, ukumelana kwe-cellulose ether ekugugulekeni kwe-enzymatic kuzothuthukiswa. Kubikwa ukuthi ngaphansi kwezimo ezilawulwayo, i-viscosity esele ye-hydroxypropyl methyl cellulose (DS=1.9), i-methyl cellulose (DS=1.83), i-methyl cellulose (DS=1.66), kanye ne-hydroxyethyl cellulose (1.7%) kwakungu-13.2%, 7.3%, 3.8%, kanye no-1.7%, ngokulandelana. I-Hydroxypropyl methyl cellulose inekhono eliqinile lokulwa nama-enzyme. Ngakho-ke i-hydroxypropyl methylcellulose iyi-anti-enzyme enhle kakhulu, ehlanganiswe nokusabalala kwayo okuhle, ukuqina kanye nokwakheka kwefilimu, esetshenziswa ezimbozweni ze-emulsion, njll., ngokuvamile ayidingi ukwengeza izithasiselo. Kodwa-ke, ukuze kuvinjelwe ukugcinwa kwesikhathi eside kwesisombululo noma ukungcola okungenzeka okuvela ezweni langaphandle, izithasiselo zingangezwa, okukhethwa kwazo kunganqunywa ngokwezidingo zokugcina zesisombululo. I-Phenylmercuric acetate kanye ne-manganese fluosilicate ziyizithasiselo ezisebenzayo, kodwa zinobuthi futhi kumele zisetshenziswe ngokucophelela. Ngokuvamile, i-1~5mg ye-phenylmercuric acetate ingangezwa kwilitha ngayinye yesisombululo.
7, ukusebenza kwe-membrane ye-hydroxypropyl methyl cellulose
Ukusebenza kwefilimu ye-hydroxypropyl methyl cellulose ye-hydroxypropyl methyl cellulose kunefilimu enhle kakhulu, isixazululo sayo samanzi noma isixazululo se-organic solvent, esimbozwe epuletini lengilazi, ngemva kokomiswa iba ifilimu engenambala, esobala futhi eqinile. Inokumelana okuhle komswakama futhi ihlala iqinile emazingeni okushisa aphezulu. Njengokungezwa kwe-plasticizer ye-hygroscopic, kungathuthukisa ukunwebeka kwayo nokuguquguquka, ukuze kuthuthukiswe ukuguquguquka, i-glycerol ne-sorbitol kanye nezinye i-plasticizer yiyona efaneleka kakhulu. Ukuhlushwa kwesisombululo okujwayelekile kungu-2% ~ 3%, umthamo we-plasticizer ungu-10% ~ 20% we-cellulose ether. Uma okuqukethwe kwe-plasticizer kuyadingeka, isimo sokuncishiswa kokuphelelwa amanzi emzimbeni kwe-colloid kungenzeka emswakama ophezulu. Amandla okuqina kwe-plasticizer engeziwe efilimu makhulu kakhulu kunalawo angangeziwe, futhi ayanda ngokwanda kwenani le-added, njengoba i-hygroscopicity yefilimu nayo iyanda ngokwanda kwenani le-plasticizer.
Isikhathi sokuthunyelwe: Septhemba-08-2022