Hydroxypropyl methyl cellulose HPMC wani nau'in ether ne mai gauraye wanda ba ionic ba ne a cikin nau'ikan da kuma ionic methyl carboxymethyl cellulose gauraye ether, ba ya amsawa da ƙarfe masu nauyi. Wani nau'in oxygen ne saboda yawan sinadarin hydroxypropyl methyl cellulose da kuma bambancin rabon abun ciki da danko, ya zama nau'ikan daban-daban akan aikin, misali, yawan sinadarin methoxyl da ƙarancin abun ciki na nau'ikan hydroxypropyl, aikin sa yana kusa da methyl cellulose kuma ƙarancin abun ciki na methoxyl da babban abun ciki na nau'ikan hydroxypropyl, kuma aikin sa yana kusa da hydroxypropyl methyl cellulose ana samar da shi. Amma a cikin kowane nau'in, kodayake yana ɗauke da ƙaramin adadin hydroxypropyl ko ƙaramin adadin methoxy, narkewar sinadarai a cikin sinadarai masu narkewa ko zafin jiki na flocculation a cikin ruwan ruwa, akwai babban bambanci.
1, narkewar cellulose hydroxypropyl methyl
Hydroxypropyl methyl cellulose a cikin ruwa yana narkewar hydroxypropyl methyl cellulose a zahiri wani nau'in propylene oxide (methyl oxypropyl zobe) wanda aka gyara methyl cellulose, don haka har yanzu yana da irin wannan tare da methyl cellulose mai narkewar ruwan sanyi da kuma ruwan zafi mara narkewa. Duk da haka, zafin gelation na hydroxypropyl da aka gyara ya fi na methyl cellulose a cikin ruwan zafi. Misali, danko na hydroxypropyl methylcellulose mai ruwa tare da kashi 2% na methoxy DS=0.73 da hydroxypropyl abun ciki MS=0.46 shine 500 mpa a 20℃. Zafin gel na samfurin S yana kusa da 100℃, yayin da na methyl cellulose na zafin iri ɗaya yake kusan 55℃ kawai. Dangane da yadda yake narkewa a cikin ruwa, an kuma inganta shi sosai, misali, bayan murƙushe hydroxypropyl methylcellulose (siffar hatsi 0.2 ~ 0.5mm a 20℃ 4% na danko na ruwa na 2pA? S ana iya narkar da samfuran cikin sauƙi a cikin ruwa ba tare da sanyaya a zafin ɗaki ba.
(2) Hydroxypropyl methyl cellulose a cikin sinadaran sinadarai na halitta, narkewar hydroxypropyl methyl cellulose a cikin sinadaran sinadarai na halitta, kuma ya fi methyl cellulose kyau, buƙatar methyl cellulose a cikin matakin maye gurbin methoxy na samfuran 2.1 ko fiye, kuma ya ƙunshi hydroxypropyl MS=1.5~1.8 da methoxy DS=0.2~1.0, Babban danko hydroxypropyl methyl cellulose tare da cikakken matakin maye gurbin sama da 1.8 yana narkewa a cikin methanol da ethanol na anhydrous, kuma yana da thermoplastic da ruwa mai narkewa. Hakanan yana narkewa a cikin hydrocarbons masu chlorine kamar dichloromethane da trichloromethane, da kuma sinadaran sinadarai na halitta kamar acetone, isopropyl alcohol, da diacetone alcohol. Narkewarsa a cikin sinadaran sinadarai na halitta ya fi narkewar ruwa kyau.
2, dankowar hydroxypropyl methyl cellulose na abubuwan da ke tasiri
Abubuwan da ke haifar da danko na Hydroxypropyl methylcellulose sune tantance danko na hydroxypropyl methylcellulose, da sauran cellulose ether iri ɗaya ne, suna a 20℃ tare da maganin ruwa na 2% kamar yadda aka ƙayyade. Danko na samfurin iri ɗaya, tare da ƙaruwar maida hankali da ƙaruwa, yawan samfuran nauyin kwayoyin halitta daban-daban, nauyin kwayoyin halitta na samfurin shine babban danko. Alaƙarsa da zafin jiki yayi kama da na methyl cellulose. Lokacin da zafin jiki ya tashi, danko ya fara raguwa, amma lokacin da ya kai wani zafin jiki, danko ya tashi kwatsam kuma yana faruwa. Zafin gel na samfuran tare da ƙarancin danko ya fi na samfuran tare da babban danko. Matsayin wurin gel ɗinsa, ban da babban danko na ether, amma kuma tare da rabon ether methoxy da hydroxypropyl group combination da jimlar matakin maye gurbin suna da alaƙa. Dole ne a lura cewa hydroxypropyl methylcellulose shima pseudoplastic ne; maganinsa yana da karko lokacin da aka adana a zafin ɗaki kuma baya nuna wani lalacewar danko sai dai yiwuwar lalacewar enzymatic.
3, hydroxypropyl methyl cellulose acid da juriyar alkaline
Hydroxypropyl methylcellulose acid alkali hydroxypropyl methylcellulose acid da alkali, gabaɗaya suna da ƙarfi, a cikin kewayon PH PH2 ~ 12 ba ya shafar, yana iya jure wa wani adadin acid mai sauƙi, kamar formic acid, acetic acid, citric acid, succinic acid, phosphoric acid, boric acid, da sauransu. Amma acid mai ƙarfi yana da tasirin rage danko. Alkali kamar caustic soda, caustic potassium da ruwan lemun tsami ba su da wani tasiri a kansa, amma tasirin ƙara danko na maganin zai ragu a hankali a nan gaba.
4, ana iya haɗa hydroxypropyl methyl cellulose
Ana iya haɗa maganin Hydroxypropyl methyl cellulose da mahaɗan polymer masu narkewa cikin ruwa, kuma su zama mafita mai haske iri ɗaya tare da ɗanko mai yawa. Waɗannan mahaɗan kwayoyin halitta masu yawa sune polyethylene glycol, polyvinyl acetate, polysilicone, polymethyl vinyl siloxane da hydroxyethyl cellulose da methyl cellulose, da sauransu. Haɗaɗɗun polymer na halitta kamar gum Arabic, locust bean gum, thorn tree gum da sauransu suma suna da kyakkyawan cakuda tare da maganin. Hakanan ana iya haɗa Hydroxypropyl methyl cellulose da stearic acid ko palmitic acid mannitol ester ko sorbitol ester, amma kuma tare da glycerol, sorbitol da mannitol, waɗannan mahaɗan ana iya amfani da su azaman hydroxypropyl methyl cellulose plasticizer.
5, hydroxypropyl methyl cellulose mai narkewa cikin ruwa mara narkewa
Hydroxypropyl methyl cellulose cellulose wanda ba ya narkewa a cikin ruwa, yana iya zama haɗin saman tare da aldehydes, kuma yana sa waɗannan ether mai narkewa a cikin ruwa su zama ba ya narkewa a cikin ruwa. Kuma yin hydroxypropyl methylcellulose wanda ba ya narkewa a cikin aldehyde, formaldehyde, glyoxal, succinaldehyde, dialdehyde, da sauransu, amfani da formaldehyde ya kamata ya kula da ƙimar PH na maganin, wanda a cikinsa glyoxal ya amsa da sauri, don haka a cikin masana'antu ana amfani da glyoxal azaman wakilin haɗin giciye. Yawan wannan nau'in wakilin haɗin giciye a cikin maganin shine 0.2% ~ 10% na nauyin ether, mafi kyawun shine 7% ~ 10%, kamar amfani da glyoxal tare da 3.3% ~ 6% shine mafi dacewa. Zafin magani gabaɗaya shine 0 ~ 30℃, lokacin shine 1 ~ 120min. Ana buƙatar aiwatar da amsawar haɗin giciye a ƙarƙashin yanayin acidic. Gabaɗaya, ana ƙara acid mai ƙarfi na inorganic ko kuma carbonoxylic acid na organic a cikin maganin don daidaita PH na maganin zuwa kimanin 2-6, zai fi dacewa tsakanin 4-6, sannan a ƙara aldehydes don haɗa haɗin gwiwa. Abubuwan da ake amfani da su sune hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxy acetic acid, succinic acid ko citric acid, daga cikinsu akwai formic acid ko acetic acid mafi kyau, yayin da formic acid shine mafi kyau. Hakanan ana iya ƙara acid da aldehydes a lokaci guda don ba da damar haɗin gwiwa na maganin a cikin kewayon PH da ake so. Sau da yawa ana amfani da wannan amsawar a cikin tsarin ƙarshe na tsarin shirya cellulose ether, don kada cellulose ether ya narke, yana da sauƙin amfani da ruwa 20-25℃ don wankewa da tsarkakewa. Lokacin da aka yi amfani da samfurin, ana iya ƙara abubuwan alkaline zuwa maganin samfurin don daidaita PH na maganin ya zama alkaline, kuma samfurin yana narkewa da sauri a cikin maganin. Ana iya amfani da wannan hanyar idan aka yi amfani da maganin cellulose ether don yin fim sannan aka yi wa fim ɗin magani don yin fim ɗin da ba ya narkewa.
6, hydroxypropyl methyl cellulose anti-enzyme
A ka'ida, juriyar enzyme na hydroxypropyl methyl cellulose na abubuwan da suka samo asali daga cellulose, kamar kowace ƙungiyar anhydroglucose kamar akwai haɗin gwiwa mai ƙarfi na maye gurbin ƙungiyoyi, yashewar ƙwayoyin cuta ba shi da sauƙin kamuwa da cuta, amma a zahiri samfurin da aka gama don maye gurbin ƙimar fiye da 1, haka nan ta hanyar lalacewar enzyme, wannan shine bayanin kowace ƙungiya a cikin matakin maye gurbin sarkar cellulose ba iri ɗaya bane, Ƙananan halittu na iya lalacewa kusa da ƙungiyoyin glucose da aka bushe ba tare da maye gurbinsu ba don samar da sukari, wanda ƙwayoyin cuta za su iya sha ta abinci. Saboda haka, idan matakin maye gurbin etherification na cellulose ya ƙaru, juriyar cellulose ether zuwa yashewar enzymatic zai ƙaru. An ruwaito cewa a ƙarƙashin yanayi mai sarrafawa, ragowar danko na hydroxypropyl methyl cellulose (DS=1.9), methyl cellulose (DS=1.83), methyl cellulose (DS=1.66), da hydroxyethyl cellulose (1.7%) ya kasance 13.2%, 7.3%, 3.8%, da 1.7%, bi da bi. Hydroxypropyl methyl cellulose yana da ƙarfin hana enzyme. Don haka hydroxypropyl methylcellulose kyakkyawan maganin hana enzyme ne, tare da kyakkyawan watsawa, kauri da samuwar fim, wanda aka shafa a cikin murfin emulsion, da sauransu, gabaɗaya ba sa buƙatar ƙara abubuwan kiyayewa. Duk da haka, don hana adana maganin na dogon lokaci ko yiwuwar gurɓatawa daga duniyar waje, ana iya ƙara abubuwan kiyayewa, waɗanda za a iya tantance zaɓin su bisa ga buƙatun ƙarshe na maganin. Phenylmercuric acetate da manganese fluosilicate suna da tasiri wajen kiyayewa, amma suna da guba kuma dole ne a yi aiki da kyau. Gabaɗaya, ana iya ƙara phenylmercuric acetate 1 ~ 5mg a kowace lita na maganin.
7, aikin membrane na hydroxypropyl methyl cellulose
Aikin fim ɗin Hydroxypropyl methyl cellulose na hydroxypropyl methyl cellulose yana da kyakkyawan fim, ruwansa na ruwa ko ruwan da ke narkewa a cikin ruwa, wanda aka lulluɓe shi da farantin gilashi, bayan bushewa ya zama ba shi da launi, bayyananne kuma mai tauri. Yana da kyakkyawan juriya ga danshi kuma yana da ƙarfi a yanayin zafi mai yawa. Kamar ƙara plasticizer na hygroscopic, zai iya haɓaka tsayinsa da sassaucinsa, don inganta lanƙwasa, glycerol da sorbitol da sauran plasticizer shine mafi dacewa. Yawan maganin gabaɗaya shine 2% ~ 3%, yawan plasticizer shine 10% ~ 20% na cellulose ether. Idan abun cikin plasticizer ya kasance mai yawa, raguwar yanayin bushewar colloid na iya faruwa a cikin zafi mai yawa. Ƙarfin juriya na plasticizer da aka ƙara fim ɗin ya fi girma fiye da wanda ba a ƙara ba, kuma yana ƙaruwa tare da ƙaruwar adadin da aka ƙara, kamar yadda hygroscopicity na fim ɗin kuma yana ƙaruwa tare da ƙaruwar adadin plasticizer.
Lokacin Saƙo: Satumba-08-2022