Ko te Hydroxypropyl methyl cellulose HPMC he cellulose kore-ionic i konatunatua ki te ether i roto i te momo me te ionic methyl carboxymethyl cellulose ionic i konatunatua ki te ether, kāore e tauhohe ki ngā konganuku taumaha. Nā te nui o te hydroxypropyl methyl cellulose me te rerekētanga o te nui me te matotoru o te hydroxypropyl, ka rerekē te mahi a ngā momo, hei tauira, he nui te nui o te methoxyl me te iti o te hydroxypropyl, he tata te mahi ki te methyl cellulose me te iti o te methoxyl me te nui o te hydroxypropyl, ā, he tata te mahi ki te hydroxypropyl methyl cellulose e puta ana. Engari i roto i ia momo, ahakoa he iti noa te hydroxypropyl, he iti noa rānei te methoxy, he nui te rerekētanga o te wairewa i roto i ngā whakarewa waro, i te pāmahana flocculation rānei i roto i te wairewa wai.
1, te wairewatanga o te hydroxypropyl methyl cellulose
Ko te wairewatanga o te hydroxypropyl methyl cellulose i roto i te wai he momo propylene oxide (methyl oxypropyl ring) kua whakarerekētia te methyl cellulose, nō reira he rite tonu ōna āhuatanga ki te methyl cellulose wai matao me te wai wera kore-wairewa. Heoi, he nui ake te pāmahana whakakī o te hydroxypropyl kua whakarerekētia i te methyl cellulose i roto i te wai wera. Hei tauira, ko te matotoru o te wairewa hydroxypropyl methylcellulose me te 2% ihirangi methoxy DS=0.73 me te ihirangi hydroxypropyl MS=0.46 he 500 mpa i te 20℃. Ko te pāmahana whakakī o te hua S e tata ana ki te 100℃, ko te pāmahana o te methyl cellulose o taua pāmahana he tata ki te 55℃ noa iho. Mō tōna wairewatanga ki te wai, i tino pai ake hoki, hei tauira, i muri i te kuru o te hydroxypropyl methylcellulose (te āhua o te witi 0.2 ~ 0.5mm i te 20℃ 4% te matotoru wai o te 2pA? Ka taea te wairewa ngāwari i ngā hua S ki te wai me te kore e whakamatao i te pāmahana rūma.
(2) Ko te wairewatanga o te hydroxypropyl methyl cellulose i roto i ngā whakarewa waro Ko te wairewatanga o te hydroxypropyl methyl cellulose i roto i ngā whakarewa waro, he pai ake i te methyl cellulose, me 2.1 neke atu rānei ngā hua e hiahiatia ana e te methyl cellulose, ā, kei roto ko te hydroxypropyl MS=1.5~1.8 me te methoxy DS=0.2~1.0. Ko te hydroxypropyl methyl cellulose matotoru teitei me te taumata whakakapinga katoa i runga ake i te 1.8 ka wairewa i roto i ngā otinga methanol me te ethanol kore wai, ā, he wairewatanga thermoplastic me te wai. Ka wairewahia hoki i roto i ngā hauwaiwai chlorinated pērā i te dichloromethane me te trichloromethane, me ngā whakarewa waro pērā i te acetone, te waipiro isopropyl, me te waipiro diacetone. Ko tōna wairewatanga i roto i ngā whakarewa waro he pai ake i te wairewatanga wai.
2, te matotoru o te hydroxypropyl methyl cellulose o ngā āhuatanga awe
Ko ngā āhuatanga matotoru o te hydroxypropyl methylcellulose, ko te hydroxypropyl methylcellulose te whakatau i te matotoru paerewa, me ētahi atu cellulose ether he rite tonu, kei te 20℃ me te 2% wairewa hei whakatau paerewa. Ko te matotoru o te hua kotahi, me te pikinga ake o te kukū me te pikinga, ko te kukū ōrite o ngā hua taumaha ngota rerekē, he matotoru teitei te taumaha ngota o te hua. Ko tōna whanaungatanga ki te pāmahana he rite ki te methyl cellulose. Ina piki te pāmahana, ka tīmata te heke o te matotoru, engari ina tae ki tētahi pāmahana, ka piki ohorere te matotoru ka puta te wairewa. Ko te pāmahana wairewa o ngā hua he iti te matotoru he teitei ake i te pāmahana o ngā hua he nui te matotoru. Ko te taumata o tōna ira wairewa, hei tāpiri atu ki te matotoru teitei me te iti o te ether, engari he hononga anō hoki ki te ōwehenga hanganga o te ether methoxy me te hydroxypropyl group me te taumata katoa o te whakakapinga. Me mōhio he pseudoplastic anō hoki te hydroxypropyl methylcellulose; he pumau tōna otinga ina rongoatia ki te pāmahana rūma, ā, kāore e whakaatu i tetahi hekenga o te matotoru engari ko te āheinga o te pirau whākōkī.
3, te ātete ki te waikawa hydroxypropyl methyl cellulose me te kawakore
Ko te waikawa hydroxypropyl methylcellulose me te waikawa alkali, he pumau te nuinga, kāore e pāngia i roto i te awhe pH PH2 ~ 12, ka taea te tu atu i tētahi nui o ngā waikawa māmā, pērā i te waikawa formic, te waikawa acetic, te waikawa citric, te waikawa succinic, te waikawa phosphoric, te waikawa boric, me ētahi atu. Engari ko te waikawa kukū he pānga ki te whakaiti i te matotoru. Ko ngā kawakore pērā i te houra kaustic, te pāhare pākawa kaustic me te wai raima kāore he pānga ki a ia, engari ko te pānga o te whakanui ake i te matotoru o te otinga ka heke haere i te heke mai.
4, ka taea te whakaranu i te hydroxypropyl methyl cellulose
Ka taea te whakaranu i te otinga hydroxypropyl methyl cellulose ki ngā pūhui polymer wairewa-wai, ka huri hei otinga mārama ōrite me te matotoru teitei ake. Ko ēnei pūhui ngota teitei ko te polyethylene glycol, te polyvinyl acetate, te polysilicone, te polymethyl vinyl siloxane me te hydroxyethyl cellulose me te methyl cellulose, me ētahi atu. Ko ngā pūhui polymer tūturu pērā i te gum Arabic, te locust bean gum, te thorn tree gum me ētahi atu he pai te ranunga ki tana otinga. Ka taea hoki te whakaranu i te hydroxypropyl methyl cellulose ki te stearic acid, te palmitic acid mannitol ester, te sorbitol ester rānei, engari me te glycerol, te sorbitol me te mannitol hoki, ka taea te whakamahi i ēnei pūhui hei hydroxypropyl methyl cellulose plasticizer.
5, hydroxypropyl methyl cellulose wairewa korekore
Ko te hydroxypropyl methyl cellulose cellulose ether wai-wairewa korekore, ka taea te hono-mata ki ngā aldehydes, ka meinga ēnei ether wai-wairewa korekore kia rewa i roto i te wairewa, kia kore e rewa i roto i te wai. Ā, ka meinga te hydroxypropyl methylcellulose aldehyde, formaldehyde, glyoxal, succinaldehyde, dialdehyde, me ētahi atu kia rewa korekore, me aro nui ki te uara PH o te wairewa te whakamahinga o te formaldehyde, ka tere ake te tauhohenga glyoxal, nō reira i roto i te hanga ahumahi e whakamahia whānuitia ana te glyoxal hei kaihoko hono-whakawhiti. Ko te horopeta o tēnei momo kaihoko hono-whakawhiti i roto i te wairewa ko te 0.2% ~ 10% o te papatipu ether, ko te mea pai ko te 7% ~ 10%, pērā i te whakamahinga o te glyoxal me te 3.3% ~ 6% te mea tino tika. Ko te pāmahana maimoatanga whānui ko te 0 ~ 30 ℃, ko te wā ko te 1 ~ 120 meneti. Me mahi te tauhohenga hono-whakawhiti i raro i ngā āhuatanga waikawa. I te nuinga o te wā, ka tāpirihia he waikawa kaha kore-waro, he waikawa carboxylic waro rānei ki te otinga hei whakatika i te PH o te otinga ki te 2~6 pea, ko te pai ake i waenga i te 4~6, kātahi ka tāpirihia he aldehydes hei tauhohenga hononga-whiti. Ko ngā waikawa e whakamahia ana ko te waikawa hauwaiora, te waikawa whanariki, te waikawa phosphoric, te waikawa formic, te waikawa acetic, te waikawa hydroxy acetic, te waikawa succinic, te waikawa citric rānei, ā, ko te waikawa formic, te waikawa acetic rānei te mea pai rawa atu, ko te waikawa formic te mea pai rawa atu. Ka taea hoki te tāpiri i ngā waikawa me ngā aldehydes i te wā kotahi kia taea ai te hononga-whiti o te otinga ki te awhe PH e hiahiatia ana. He maha ngā wā ka whakamahia tēnei tauhohenga i roto i te tukanga whakamutunga o te tukanga whakarite cellulose ether, kia kore ai e memeha te cellulose ether, he ngāwari ki te whakamahi i te wai 20~25℃ hei horoi me te pure. Ina whakamahia te hua, ka taea te tāpiri i ngā matū kawakore ki te otinga o te hua hei whakatika i te PH o te otinga kia kawakore, ā, ka tere te memeha o te hua i roto i te otinga. Ka taea hoki te whakamahi i tēnei tikanga ina whakamahia te otinga cellulose ether hei hanga i tētahi kiriata, kātahi ka tukatukahia te kiriata kia puta ai he kiriata kore e rewa.
6, hydroxypropyl methyl cellulose anti-enzyme
Ko te ātete o te whākōkī hydroxypropyl methyl cellulose ki ngā hua cellulose i roto i te ariā, pērā i ia rōpū anhydroglucose pērā i te mea he huinga totoka o ngā rōpū whakakapi, he iti ake te ngawari o te mimiti o ngā moroiti ki te mate, engari ko te mea pono ko te hua kua oti te whakakapi i te uara neke atu i te 1, nā te pirau o te whākōkī hoki, koinei te whakaahuatanga o ia rōpū i roto i te mekameka whakakapinga cellulose kāore i te ōrite, Ka taea e ngā moroiti te mimiti tata ki ngā rōpū huka maroke kāore i whakakapia hei hanga huka, ka taea te mimiti e ngā moroiti hei kai. Nō reira, ki te piki ake te tohu whakakapinga etherification o te cellulose, ka whakanuia te ātete o te cellulose ether ki te mimiti whākōkī. E ai ki ngā pūrongo i raro i ngā āhuatanga whakahaere, ko te matotoru toenga o te hydroxypropyl methyl cellulose (DS=1.9), methyl cellulose (DS=1.83), methyl cellulose (DS=1.66), me te hydroxyethyl cellulose (1.7%) he 13.2%, 7.3%, 3.8%, me te 1.7%, ia. He kaha te kaha ārai-whākōkī o te Hydroxypropyl methyl cellulose. Nō reira, he pai rawa te hydroxypropyl methylcellulose hei ārai i te whākōkī, me tōna horapa pai, te whakamātotoru me te hanganga kiriata, e whakamahia ana i roto i ngā paninga emulsion, me ētahi atu, kāore e hiahiatia he tāpiri i ngā mea tiaki. Heoi, hei ārai i te rokiroki roa o te otinga, i te poke pea rānei mai i te ao o waho, ka taea te tāpiri i ngā mea tiaki, ā, ka taea te whakatau i te kōwhiringa i runga i ngā whakaritenga whakamutunga o te otinga. He mea tiaki whai hua te phenylmercuric acetate me te manganese fluosilicate, engari he paitini, me tino whakahaere. I te nuinga o te wā, ka taea te tāpiri i te 1~5mg phenylmercuric acetate ki ia rita o te otinga.
7, te mahi a te kiriuhi hydroxypropyl methyl cellulose
He tino pai te mahi a te kiriata hydroxypropyl methyl cellulose, ko tōna wairewa wai, ko tōna wairewa whakarewa waro rānei, ka pania ki te pereti karāhe, ā, i muri i te whakamaroke ka huri hei kiriata mārama, pakari hoki. He pai te ātete ki te makuku, ā, ka noho totoka tonu i ngā pāmahana tiketike. Pērā i te tāpiri o te plasticizer hygroscopic, ka taea te whakanui ake i tōna roa me te ngāwari, hei whakapai ake i te piko, ko te glycerol me te sorbitol me ētahi atu plasticizer te mea tino tika. Ko te kukū otinga whānui ko te 2%~3%, ko te horopeta plasticizer ko te 10%~20% o te cellulose ether. Mena he nui te ihirangi o te plasticizer, ka puta te āhuatanga whakaheke o te maroke colloid i te makuku teitei. Ko te kaha kume o te kiriata i tāpirihia he nui ake i te mea kāore i tāpirihia, ā, ka piki ake me te nui o te tāpiri, mō te hygroscopicity o te kiriata ka piki ake hoki me te nui o te plasticizer.
Wā tuku: Hepetema-08-2022