He aha ka Hydroxypropyl methyl cellulose HPMC?

ʻO ka Hydroxypropyl methyl cellulose HPMC kahi ʻano cellulose non-ionic i hui ʻia me ka ether i loko o nā ʻano like ʻole a me ka ionic methyl carboxymethyl cellulose i hui pū ʻia me ka ether, ʻaʻole ia e pane me nā metala kaumaha. Ma muli o ka nui o ka hydroxypropyl methyl cellulose a me ka ʻokoʻa o ka nui o ka hydroxypropyl a me ka viscosity, ua lilo nā ʻano like ʻole i ʻokoʻa ma ka hana, no ka laʻana, kiʻekiʻe ka nui o ka methoxyl a me ka haʻahaʻa o nā ʻano hydroxypropyl, kokoke kāna hana i ka methyl cellulose a me ka haʻahaʻa o ka methoxyl a me ka nui o nā ʻano hydroxypropyl, a kokoke kāna hana i ka hydroxypropyl methyl cellulose i hana ʻia. Akā i kēlā me kēia ʻano, ʻoiai he liʻiliʻi wale nō ka hydroxypropyl a i ʻole kahi liʻiliʻi o ka methoxy, ʻo ka solubility i nā mea hoʻoheheʻe organik a i ʻole ka mahana flocculation i loko o ka hopena wai, aia kahi ʻokoʻa nui.
 
1, ka hiki ke hoʻoheheʻe ʻia ka hydroxypropyl methyl cellulose
ʻO ka hydroxypropyl methyl cellulose i ka wai e hoʻoheheʻe ʻia ai ka hydroxypropyl methyl cellulose he ʻano ia o ka propylene oxide (methyl oxypropyl ring) i hoʻololi ʻia i ka methyl cellulose, no laila he like nō ia me nā ʻano methyl cellulose i hiki ke hoʻoheheʻe ʻia i ka wai anuanu a me ka wai wela. Eia nō naʻe, ʻoi aku ka kiʻekiʻe o ka mahana gelation o ka hydroxy propyl i hoʻololi ʻia ma mua o ka methyl cellulose i ka wai wela. No ka laʻana, ʻo ka viscosity o ka hydroxypropyl methylcellulose aqueous solution me 2% methoxy content DS=0.73 a me ka hydroxypropyl content MS=0.46 he 500 mpa ma 20℃. ʻO ka mahana gel o ka huahana S kokoke i 100℃, ʻoiai ʻo ka methyl cellulose o ka mahana like he 55℃ wale nō. No kona solubility i ka wai, ua hoʻomaikaʻi nui ʻia hoʻi, no ka laʻana, ma hope o ka kuʻi ʻana o ka hydroxypropyl methylcellulose (ʻano palaoa 0.2 ~ 0.5mm ma 20℃ 4% aqueous viscosity o 2pA? Hiki ke hoʻoheheʻe maʻalahi ʻia nā huahana S i ka wai me ka ʻole o ka hoʻomaʻalili ʻana i ka mahana o ka lumi.
 
(2) ʻO ka solubility o ka hydroxypropyl methyl cellulose i loko o nā mea hoʻoheheʻe organik, ʻoi aku ka maikaʻi ma mua o ka methyl cellulose, pono ka methyl cellulose i ke kekelē pani methoxy o 2.1 a ʻoi aku paha nā huahana, a loaʻa iā ia ka hydroxypropyl MS = 1.5 ~ 1.8 a me ka methoxy DS = 0.2 ~ 1.0, ʻO ka hydroxypropyl methyl cellulose kiʻekiʻe me ke kekelē pani holoʻokoʻa ma luna o 1.8 e hiki ke hoʻoheheʻe ʻia i loko o nā hopena methanol anhydrous a me ethanol, a he thermoplastic a me ka wai solubility. Hiki ke hoʻoheheʻe ʻia i loko o nā hydrocarbons chlorinated e like me dichloromethane a me trichloromethane, a me nā mea hoʻoheheʻe organik e like me acetone, isopropyl alcohol, a me ka diacetone alcohol. ʻOi aku ka maikaʻi o kona solubility i loko o nā mea hoʻoheheʻe organik ma mua o ka wai solubility.
 
2, ka hydroxypropyl methyl cellulose viscosity o nā mea e hoʻohuli ai i nā kumu
ʻO nā kumu viscosity Hydroxypropyl methylcellulose hydroxypropyl methylcellulose ka hoʻoholo ʻana i ka viscosity maʻamau, a me nā cellulose ether ʻē aʻe he like, aia ma 20 ℃ me ka 2% wai hoʻonā e like me ka hoʻoholo maʻamau. ʻO ka viscosity o ka huahana like, me ka hoʻonui ʻana o ka noʻonoʻo a me ka hoʻonui ʻana, ʻo ka noʻonoʻo like o nā huahana kaumaha molekala like ʻole, ʻo ke kaumaha molekala o ka huahana he viscosity kiʻekiʻe. ʻO kona pilina me ka mahana ua like ia me ko ka methyl cellulose. Ke piʻi ka mahana, hoʻomaka ka viscosity e emi, akā i ka wā e hiki ai i kahi mahana, piʻi koke ka viscosity a hana ʻia ka gelation. ʻOi aku ka kiʻekiʻe o ka mahana gelation o nā huahana me ka viscosity haʻahaʻa ma mua o nā huahana me ka viscosity kiʻekiʻe. ʻO ke kiʻekiʻe o kona kiko gel, me ka viscosity kiʻekiʻe a me ka haʻahaʻa o ka ether, akā pili pū kekahi me ka ether methoxy a me ka hydroxypropyl group composition ratio a me ke kēkelē holoʻokoʻa o ka pani ʻana. Pono e hoʻomaopopo ʻia he pseudoplastic nō hoʻi ka hydroxypropyl methylcellulose; paʻa kona hopena i ka wā e mālama ʻia ai i ka mahana o ka lumi a ʻaʻole hōʻike i kekahi hōʻino o ka viscosity koe wale nō ka hiki ke hōʻino ʻia ka enzymatic.
 
3, hydroxypropyl methyl cellulose acid a me ke kūpaʻa alkaline
ʻO ka waikawa Hydroxypropyl methylcellulose alkali hydroxypropyl methylcellulose a me ka alkali, ma ke ʻano laulā he paʻa, ʻaʻole i hoʻopilikia ʻia i ka pae pH PH2 ~ 12, hiki iā ia ke kū i kahi nui o ka waikawa māmā, e like me ka waikawa formic, acetic acid, citric acid, succinic acid, phosphoric acid, boric acid, a pēlā aku. Akā ʻo ka waikawa i hoʻopaʻa ʻia he hopena o ka hōʻemi ʻana i ka viscosity. ʻO nā alkali e like me ka caustic soda, caustic potassium a me ka wai lime ʻaʻohe hopena ma luna, akā ʻo ka hopena o ka hoʻonui iki ʻana i ka viscosity o ka hopena e emi mālie i ka wā e hiki mai ana.
 
4, hiki ke hui pū ʻia ka hydroxypropyl methyl cellulose
Hiki ke hoʻohuihui ʻia ka hopena hydroxypropyl methyl cellulose me nā hui polymer wai-hoʻoheheʻe ʻia, a lilo i hopena moakaka like me ka viscosity kiʻekiʻe. ʻO kēia mau hui molekala kiʻekiʻe he polyethylene glycol, polyvinyl acetate, polysilicone, polymethyl vinyl siloxane a me hydroxyethyl cellulose a me methyl cellulose, a pēlā aku. ʻO nā hui polymer kūlohelohe e like me ka gum Arabic, locust bean gum, thorn tree gum a pēlā aku, he hui maikaʻi ko lākou me kāna hopena. Hiki ke hoʻohuihui ʻia ka hydroxypropyl methyl cellulose me ka stearic acid a i ʻole ka palmitic acid mannitol ester a i ʻole sorbitol ester, akā me ka glycerol, sorbitol a me mannitol, hiki ke hoʻohana ʻia kēia mau hui e like me ka hydroxypropyl methyl cellulose plasticizer.
 
5, hydroxypropyl methyl cellulose insoluble wai hoʻoheheʻe ʻole
ʻO ka hydroxypropyl methyl cellulose insoluble water-soluble cellulose ether, hiki ke hoʻopili ʻia ma luna me nā aldehydes, a hoʻoheheʻe ʻia kēia mau ether wai-soluble i loko o ka hopena, a lilo i mea hoʻoheheʻe ʻole i ka wai. A hana i ka hydroxypropyl methylcellulose insoluble aldehyde, formaldehyde, glyoxal, succinaldehyde, dialdehyde, etc., pono e hoʻohana ʻia ka formaldehyde i ka waiwai PH o ka hopena, kahi e wikiwiki ai ka hopena glyoxal, no laila i ka hana ʻoihana e hoʻohana pinepine ʻia ai ka glyoxal ma ke ʻano he mea hoʻopili. ʻO ka nui o kēia ʻano mea hoʻopili i loko o ka hopena he 0.2% ~ 10% o ka nui o ka ether, ʻo ka maikaʻi loa he 7% ~ 10%, e like me ka hoʻohana ʻana o ka glyoxal me 3.3% ~ 6% ka mea kūpono loa. ʻO ka mahana lapaʻau maʻamau he 0 ~ 30 ℃, ʻo ka manawa he 1 ~ 120min. Pono e hana ʻia ka hopena hoʻopili ma lalo o nā kūlana acidic. Ma keʻano laulā, hoʻohui ʻia ka waikawa ikaika inorganic a i ʻole ka waikawa carboxylic organik i ka hopena e hoʻoponopono i ka PH o ka hopena i kahi o 2 ~ 6, ʻoi aku ka maikaʻi ma waena o 4 ~ 6, a laila hoʻohui ʻia nā aldehydes no ka hopena cross-linking. ʻO nā waikawa i hoʻohana ʻia he hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxy acetic acid, succinic acid a i ʻole citric acid, ma waena o ia mea ʻoi aku ka maikaʻi o ka formic acid a i ʻole acetic acid, ʻoiai ʻo ka formic acid ka mea maikaʻi loa. Hiki ke hoʻohui ʻia nā waikawa a me nā aldehydes i ka manawa like e ʻae i ka hopena e cross-linked i ka pae PH i makemake ʻia. Hoʻohana pinepine ʻia kēia hopena i ke kaʻina hana hope loa o ke kaʻina hana hoʻomākaukau cellulose ether, i ʻole e hoʻoheheʻe ʻia ka cellulose ether, maʻalahi e hoʻohana i ka wai 20 ~ 25 ℃ e holoi a hoʻomaʻemaʻe. Ke hoʻohana ʻia ka huahana, hiki ke hoʻohui ʻia nā mea alkaline i ka hopena o ka huahana e hoʻoponopono i ka PH o ka hopena i alkaline, a hoʻoheheʻe koke ʻia ka huahana i loko o ka hopena. Hiki ke hoʻohana ʻia kēia ʻano hana ke hoʻohana ʻia ka hopena cellulose ether e hana i kahi kiʻiʻoniʻoni a laila mālama ʻia ke kiʻiʻoniʻoni e hana i kahi kiʻiʻoniʻoni hiki ʻole ke hoʻoheheʻe ʻia.
 
6, hydroxypropyl methyl cellulose anti-enzyme
ʻO ke kūpaʻa ʻana o ka enzyme Hydroxypropyl methyl cellulose i nā derivatives cellulose ma ke kumumanaʻo, e like me kēlā me kēia hui anhydroglucose e like me ka hui pū ʻana o nā hui pani, ʻoi aku ka liʻiliʻi o ka maʻalahi o ka erosion o nā microorganisms i ka maʻi, akā ʻo ka ʻoiaʻiʻo, ʻoi aku ka waiwai o ka huahana i hoʻopau ʻia ma mua o 1, e ka hoʻohaʻahaʻa ʻana o ka enzyme, ʻo kēia ka wehewehe ʻana o kēlā me kēia hui i ke kēkelē pani kaulahao cellulose ʻaʻole like, hiki i nā Microorganisms ke erode kokoke i nā hui glucose dehydrated i hoʻololi ʻole ʻia e hana i nā kō, hiki ke omo ʻia e nā microorganisms e like me ka meaʻai. No laila, inā piʻi ka kekelē pani etherification o ka cellulose, e hoʻonui ʻia ke kūpaʻa o ka cellulose ether i ka erosion enzymatic. Ua hōʻike ʻia ma lalo o nā kūlana i kāohi ʻia, ʻo ke koena o ka viscosity o ka hydroxypropyl methyl cellulose (DS=1.9), methyl cellulose (DS=1.83), methyl cellulose (DS=1.66), a me ka hydroxyethyl cellulose (1.7%) he 13.2%, 7.3%, 3.8%, a me 1.7%, kēlā me kēia. Loaʻa i ka Hydroxypropyl methyl cellulose ka hiki ke anti-enzyme. No laila, ʻo ka hydroxypropyl methylcellulose he anti-enzyme maikaʻi loa, i hui pū ʻia me kona hoʻopuehu maikaʻi ʻana, ka mānoanoa a me ka hoʻokumu ʻana i ka ʻili, i hoʻopili ʻia i loko o nā uhi emulsion, a me nā mea ʻē aʻe, ʻaʻole pono e hoʻohui i nā mea mālama. Eia nō naʻe, i mea e pale ai i ka mālama lōʻihi ʻana o ka hopena a i ʻole ka haumia mai waho o ka honua, hiki ke hoʻohui ʻia nā mea mālama, hiki ke hoʻoholo ʻia kā lākou koho e like me nā koi hope o ka hopena. ʻO ka Phenylmercuric acetate a me ka manganese fluosilicate he mau mea mālama maikaʻi, akā he mea ʻawahia lākou a pono e hana pono ʻia. Ma ke ʻano laulā, hiki ke hoʻohui ʻia he 1 ~ 5mg phenylmercuric acetate i kēlā me kēia lita o ka hopena.
 
7, hana o ka membrane hydroxypropyl methyl cellulose
ʻO ka hana o ka kiʻiʻoniʻoni Hydroxypropyl methyl cellulose o ka hydroxypropyl methyl cellulose he kiʻiʻoniʻoni maikaʻi loa, ʻo kona hopena wai a i ʻole ka hopena solvent organik, i uhi ʻia ma ka papa aniani, ma hope o ka maloʻo ʻana e lilo i kiʻiʻoniʻoni kala ʻole, moakaka a paʻakikī. Loaʻa iā ia ke kūpaʻa maikaʻi i ka makū a noho paʻa i nā mahana kiʻekiʻe. E like me ka hoʻohui ʻana o ka plasticizer hygroscopic, hiki ke hoʻonui i kona elongation a me ka maʻalahi, no ka hoʻomaikaʻi ʻana i ka flexure, glycerol a me sorbitol a me nā plasticizer ʻē aʻe ka mea kūpono loa. ʻO ka nui o ka hopena maʻamau he 2% ~ 3%, ʻo ka dosage plasticizer he 10% ~ 20% o ka cellulose ether. Inā koi ʻia ka nui o ka plasticizer, hiki ke hana i ka hanana shrinkage o ka dehydration colloid i ka haʻahaʻa kiʻekiʻe. ʻOi aku ka ikaika tensile o ka kiʻiʻoniʻoni i hoʻohui ʻia ka plasticizer ma mua o ka mea i hoʻohui ʻole ʻia, a hoʻonui me ka hoʻonui ʻana o ka nui o ka mea i hoʻohui ʻia, e like me ka hygroscopicity o ke kiʻiʻoniʻoni e hoʻonui pū ʻia me ka hoʻonui ʻana o ka nui o ka plasticizer.