I-Hydroxypropyl methyl cellulose HPMC yi-non-ionic cellulose mixed ether kwi-variety kwaye i-ionic methyl carboxymethyl cellulose mixed ether, ayisebenzi kwiintsimbi ezinzima. I-oxygen radicals enye ngenxa yomxholo we-hydroxypropyl methyl cellulose kunye nomlinganiselo owahlukileyo womxholo we-hydroxypropyl kunye ne-viscosity, yaba ziintlobo ezahlukeneyo ekusebenzeni, umzekelo, umxholo ophezulu we-methoxyl kunye nomxholo ophantsi weentlobo ze-hydroxypropyl, ukusebenza kwayo kusondele kwi-methyl cellulose kunye nomxholo ophantsi we-methoxyl kunye nomxholo ophezulu weentlobo ze-hydroxypropyl, kwaye ukusebenza kwayo kusondele kwi-hydroxypropyl methyl cellulose eveliswayo. Kodwa kuhlobo ngalunye, nangona luqulathe kuphela inani elincinci le-hydroxypropyl okanye inani elincinci le-methoxy, ukunyibilika kwi-organic solvents okanye ubushushu be-flocculation kwisisombululo samanzi, kukho umahluko omkhulu.
1, ukunyibilika kwe-hydroxypropyl methyl cellulose
I-hydroxypropyl methyl cellulose ekunyibilikeni kwamanzi kwe-hydroxypropyl methyl cellulose ngokwenene luhlobo lwe-propylene oxide (methyl oxypropyl ring) modified methyl cellulose, ngoko ke iseneempawu ezifanayo ne-methyl cellulose cold water soluble kunye ne-hot water inselling. Nangona kunjalo, i-gelation ye-gelation ye-modified hydroxy propyl iphezulu kakhulu kune-methyl cellulose emanzini ashushu. Umzekelo, i-viscosity yesisombululo samanzi se-hydroxypropyl methylcellulose esinomxholo we-2% we-methoxy DS=0.73 kunye nomxholo we-hydroxypropyl MS=0.46 yi-500 mpa kwi-20℃. Iqondo lobushushu be-gel yemveliso ye-S lisondele kwi-100℃, ngelixa elo le-methyl cellulose lobushushu obufanayo limalunga ne-55℃ kuphela. Ngokuphathelele ukunyibilika kwayo emanzini, kuphucuke kakhulu, umzekelo, emva kokutyunyuzwa kwe-hydroxypropyl methylcellulose (ubume bengqolowa obuyi-0.2 ~ 0.5mm kwi-20℃ 4% ye-viscosity yamanzi ye-2pA? Iimveliso ze-S zinokunyibilika lula emanzini ngaphandle kokupholisa kubushushu begumbi.
(2) I-hydroxypropyl methyl cellulose kwi-organic solvents ukunyibilika kwe-hydroxypropyl methyl cellulose kwi-organic solvents ukunyibilika, ikwangcono kune-methyl cellulose, i-methyl cellulose ifuna kwi-methoxy substitution degree ye-2.1 okanye ngaphezulu kweemveliso, kwaye iqulethe i-hydroxypropyl MS=1.5~1.8 kunye ne-methoxy DS=0.2~1.0, I-hydroxypropyl methyl cellulose ene-total substitution degree engaphezulu kwe-1.8 iyanyibilika kwi-anhydrous methanol kunye ne-ethanol solutions, kwaye ine-thermoplastic kunye ne-water solubility. Ikwanyibilika kwi-chlorined hydrocarbons ezifana ne-dichloromethane kunye ne-trichloromethane, kunye ne-organic solvents ezifana ne-acetone, i-isopropyl alcohol, kunye ne-diacetone alcohol. Ukunyibilika kwayo kwi-organic solvents kungcono kunokunyibilika kwamanzi.
2, i-hydroxypropyl methyl cellulose viscosity yezinto ezichaphazelayo
Izinto ezibangela ukuxinana kwe-hydroxypropyl methylcellulose, ukumisela i-viscosity standard hydroxypropyl methylcellulose, kunye nezinye i-cellulose ether ziyafana, zikwi-20℃ kunye nesisombululo samanzi esiyi-2% njengokumisela okuqhelekileyo. Ukuqina kwemveliso efanayo, ngokwanda koxinzelelo kunye nokwanda, uxinzelelo olufanayo lweemveliso ezahlukeneyo zobunzima beemolekyuli, ubunzima beemolekyuli zemveliso bubunzima obuphezulu. Ubudlelwane bayo nobushushu bufana nobe-methyl cellulose. Xa ubushushu bunyuka, ukuqina buqala ukwehla, kodwa xa bufikelela kubushushu obuthile, ukuqina bunyuka ngequbuliso kwaye kwenzeka i-gelation. Ubushushu be-gelation yeemveliso ezine-viscosity ephantsi buphezulu kunobo beemveliso ezine-viscosity ephezulu. Inqanaba le-gel point yayo, ukongeza kwi-viscosity ephezulu nephantsi ye-ether, kodwa kunye ne-ether methoxy kunye ne-hydroxypropyl group composition ratio kunye ne-total degree of substitution zinxulumene. Kufuneka kuqatshelwe ukuba i-hydroxypropyl methylcellulose nayo yi-pseudoplastic; isisombululo sayo sizinzile xa sigcinwe kubushushu begumbi kwaye asibonisi naluphi na ukonakala kwe-viscosity ngaphandle kokuba kunokwenzeka ukuwohloka kwe-enzyme.
3, i-hydroxypropyl methyl cellulose acid kunye nokumelana ne-alkaline
I-Hydroxypropyl methylcellulose acid, i-alkali hydroxypropyl methylcellulose acid kunye ne-alkali, ngokubanzi izinzile, kuluhlu lwe-PH2 ~ 12 ayichaphazeleki, inokumelana nomlinganiselo othile we-asidi ekhanyayo, njenge-formic acid, i-acetic acid, i-citric acid, i-succinic acid, i-phosphoric acid, i-boric acid, njl. Kodwa i-acid egxininisiweyo inefuthe lokunciphisa i-viscosity. I-alkali efana ne-caustic soda, i-caustic potassium kunye namanzi ekalika ayinafuthe kuyo, kodwa isiphumo sokwandisa kancinci i-viscosity yesisombululo siya kuncipha kancinci kwixesha elizayo.
4, i-hydroxypropyl methyl cellulose ingaxutywa
Isisombululo se-hydroxypropyl methyl cellulose sinokuxutywa neekhompawundi ze-polymer ezinyibilikayo emanzini, size sibe sisisombululo esibonakalayo esifanayo esine-viscosity ephezulu. Ezi khompawundi ziphezulu ze-molecular yi-polyethylene glycol, i-polyvinyl acetate, i-polysilicone, i-polymethyl vinyl siloxane kunye ne-hydroxyethyl cellulose kunye ne-methyl cellulose, njl. Iikhompawundi ze-polymer zendalo ezifana ne-gum Arabic, i-locust bean gum, i-thorn tree gum njalo njalo nazo zinomxube olungileyo kunye nesisombululo sazo. I-Hydroxypropyl methyl cellulose ingaxutywa ne-stearic acid okanye i-palmitic acid i-mannitol ester okanye i-sorbitol ester, kodwa kunye ne-glycerol, i-sorbitol kunye ne-mannitol, ezi khompawundi zingasetyenziswa njenge-hydroxypropyl methyl cellulose plasticizer.
5, i-hydroxypropyl methyl cellulose enganyibilikiyo emanzini
I-hydroxypropyl methyl cellulose ether enganyibilikiyo emanzini, inokuba ngumphezulu odibanisa i-aldehydes, kwaye yenze ezi ether zinganyibilikiyo emanzini zifakwe kwisisombululo, zinganyibilikiyo emanzini. Kwaye zenze i-hydroxypropyl methylcellulose i-aldehyde enganyibilikiyo, i-formaldehyde, i-glyoxal, i-succinaldehyde, i-dialdehyde, njl., ukusetyenziswa kwe-formaldehyde kufuneka kunikelwe ingqalelo ekhethekileyo kwixabiso le-PH yesisombululo, apho i-glyoxal isabela ngokukhawuleza, ngoko kwimveliso yemizi-mveliso isetyenziswa kakhulu njenge-arhente yokudibanisa i-cross-linking. Idosi yolu hlobo lwe-arhente yokudibanisa i-crosslinking kwisisombululo yi-0.2% ~ 10% yobunzima be-ether, eyona ilungileyo yi-7% ~ 10%, njengokusetyenziswa kwe-glyoxal ene-3.3% ~ 6% yeyona ifanelekileyo. Ubushushu bonyango ngokubanzi yi-0 ~ 30℃, ixesha liyi-1 ~ 120min. I-crosslinking reaction kufuneka yenziwe phantsi kweemeko ze-asidi. Ngokubanzi, i-asidi enamandla e-inorganic okanye i-organic carboxylic acid yongezwa kwisisombululo ukuze kulungiswe i-PH yesisombululo ibe malunga ne-2 ~ 6, kungcono phakathi kwe-4 ~ 6, emva koko kongezwa ii-aldehydes kwi-cross-linking reaction. Ii-asidi ezisetyenziswayo yi-hydrochloric acid, i-sulfuric acid, i-phosphoric acid, i-formic acid, i-acetic acid, i-hydroxy acetic acid, i-succinic acid okanye i-citric acid, phakathi kwazo i-formic acid okanye i-acetic acid yeyona ilungileyo, ngelixa i-formic acid yeyona ilungileyo. Ii-asidi kunye nee-aldehydes zingongezwa ngaxeshanye ukuvumela isisombululo ukuba sidityaniswe kuluhlu lwe-PH olufunekayo. Olu tshintsho ludla ngokusetyenziswa kwinkqubo yokugqibela yokulungiselela i-cellulose ether, ukuze i-cellulose ether inganyibiliki, kulula ukuyisebenzisa emanzini angama-20 ~ 25 ℃ ukuhlamba nokucoca. Xa kusetyenziswa imveliso, izinto ze-alkaline zingongezwa kwisisombululo semveliso ukuze kulungiswe i-PH yesisombululo ukuba ibe yi-alkaline, kwaye imveliso inyibilika ngokukhawuleza kwisisombululo. Le ndlela ingasetyenziswa xa isisombululo se-cellulose ether sisetyenziselwa ukwenza ifilimu kwaye emva koko ifilimu inyangwa ukuze yenze ifilimu enganyibilikiyo.
6, i-hydroxypropyl methyl cellulose anti-enzyme
Ukuxhathisa i-enzyme ye-hydroxypropyl methyl cellulose ye-cellulose derivatives kwithiyori, njengamaqela e-anhydroglucose nganye, njengoko kukho indibaniselwano eqinileyo yamaqela atshintshayo, ukukhukuliseka kwee-microorganisms akuchaphazeleki lula kusulelo, kodwa eneneni imveliso egqityiweyo yokutshintsha ixabiso elingaphezulu kwe-1, nayo ngokudilizwa kwe-enzyme, le yinkcazo yeqela ngalinye kwi-degree ye-cellulose chain substitution ayifani, ii-Microorganisms zinokudilika kufutshane namaqela e-glucose angenamanzi atshintshiweyo ukuze zenze iiswekile, ezinokufunxwa zii-microorganisms njengokutya. Ke ngoko, ukuba i-degree ye-etherification substitution ye-cellulose iyanda, ukuxhathisa kwe-cellulose ether kwi-enzymatic erosion kuya kuphucuka. Kuxelwe ukuba phantsi kweemeko ezilawulwayo, i-viscosity eseleyo ye-hydroxypropyl methyl cellulose (DS=1.9), i-methyl cellulose (DS=1.83), i-methyl cellulose (DS=1.66), kunye ne-hydroxyethyl cellulose (1.7%) yayiyi-13.2%, 7.3%, 3.8%, kunye ne-1.7%, ngokulandelelana. I-Hydroxypropyl methyl cellulose inamandla okulwa ne-enzyme. Ngoko ke i-hydroxypropyl methylcellulose i-anti-enzyme egqwesileyo, idibene nokusasazeka kwayo okuhle, ukuqina kunye nokwakheka kwefilimu, esetyenziswa kwiingubo ze-emulsion, njl.njl., ngokubanzi akufuneki kongezwe izigcini. Nangona kunjalo, ukuze kuthintelwe ukugcinwa kwexesha elide kwesisombululo okanye ungcoliseko olunokwenzeka oluvela kwihlabathi langaphandle, izigcini zingongezwa, ukhetho lwazo lunokugqitywa ngokweemfuno zokugqibela zesisombululo. I-Phenylmercuric acetate kunye ne-manganese fluosilicate zizivigcini zisebenzayo, kodwa zinobuthi kwaye kufuneka zisetyenziswe ngononophelo. Ngokubanzi, i-1~5mg ye-phenylmercuric acetate ingongezwa kwilitha nganye yesisombululo.
7, ukusebenza kwe-hydroxypropyl methyl cellulose membrane
Ukusebenza kwefilimu ye-hydroxypropyl methyl cellulose ye-hydroxypropyl methyl cellulose inefilimu egqwesileyo, isisombululo sayo samanzi okanye isisombululo se-organic solvent, esigqunywe kwipleyiti yeglasi, emva kokuba yomile iba yifilimu engenambala, ecacileyo neqinileyo. Inokumelana nokufuma okuhle kwaye ihlala iqinile kumaqondo obushushu aphezulu. Njengokongeza i-hygroscopic plasticizer, inokuphucula ubude bayo kunye nokuguquguquka, ukuphucula i-flexure, i-glycerol kunye ne-sorbitol kunye nezinye i-plasticizer zezona zifanelekileyo. Uxinzelelo lwesisombululo ngokubanzi yi-2% ~ 3%, umthamo we-plasticizer yi-10% ~ 20% ye-cellulose ether. Ukuba umxholo we-plasticizer uyimfuneko, isenzeko sokuncitshiswa kokuphelelwa ngamanzi emzimbeni kwe-colloid sinokwenzeka kumswakama ophezulu. Amandla okuxinana kwe-plasticizer eyongeziweyo yefilimu makhulu kakhulu kunaleyo ingongezwanga, kwaye iyanda ngokunyuka kobuninzi be-added, njengoko i-hygroscopicity yefilimu nayo iyanda ngokunyuka kobuninzi be-plasticizer.
Ixesha lokuthumela: Sep-08-2022