I-Hydroxypropyl methylcellulose (HPMC)iyi-ether exubile ye-cellulose engeyona i-ionic, encibilikayo emanzini. Ukubukeka kumhlophe kuya kophuzi kancane impuphu noma izinto ezi-granular, akunambitheki, akunaphunga, akunabuthi, kuzinzile ngamakhemikhali, futhi kuyancibilika emanzini ukuze kwakheke isixazululo esibushelelezi, esibonakalayo nesiqinile. Esinye sezimpawu ezibaluleke kakhulu ze-hydroxypropyl methylcellulose ekusetshenzisweni ukuthi yandisa i-viscosity yoketshezi. Umphumela wokujiya uncike ezingeni le-polymerization (DP) yomkhiqizo, ukuhlushwa kwe-cellulose ether esixazululweni samanzi, izinga lokugunda, kanye nokushisa kwesisombululo. Nezinye izici.
01
Uhlobo oluketshezi lwesisombululo samanzi se-HPMC
Ngokuvamile, ukucindezeleka koketshezi ekugelezeni kwe-shear kungavezwa njengomsebenzi wesilinganiso sokushefa kuphela ƒ(γ), inqobo nje uma kungaxhomekile esikhathini. Kuye ngesimo se-ƒ(γ), uketshezi lungahlukaniswa ngezinhlobo ezahlukene, okungukuthi: uketshezi lwe-Newtonian, uketshezi olunwebekayo, uketshezi lwe-pseudoplastic kanye noketshezi lwepulasitiki lwe-Bingham.
Ama-ether e-cellulose ahlukaniswe ngezigaba ezimbili: enye i-non-ionic cellulose ether kanti enye i-ionic cellulose ether. Ngokwe-rheology yalezi zinhlobo ezimbili zama-ether e-cellulose. U-SC Naik nabanye benze ucwaningo oluphelele noluhlelekile lokuqhathanisa ngezixazululo ze-hydroxyethyl cellulose kanye ne-sodium carboxymethyl cellulose. Imiphumela ibonise ukuthi zombili izixazululo ze-non-ionic cellulose ether kanye nezixazululo ze-ionic cellulose ether kwakuyi-pseudoplastic. Ukugeleza, okungukuthi ukugeleza okungewona ama-Newtonian, kusondela kuketshezi lwe-Newtonian kuphela ngamanani aphansi kakhulu. I-pseudoplasticity yesisombululo se-hydroxypropyl methylcellulose idlala indima ebalulekile ekusetshenzisweni. Isibonelo, uma isetshenziswa ezimbozweni, ngenxa yezici zokunciphisa ukugunda kwezixazululo zamanzi, i-viscosity yesisombululo iyancipha ngokwanda kwesilinganiso sokugunda, okusiza ekusabalaleni okufanayo kwezinhlayiya ze-pigment, futhi kwandisa nokugeleza kokugqoka. Umphumela mkhulu kakhulu; ngenkathi uphumule, i-viscosity yesisombululo inkulu kakhulu, okuvimbela ngempumelelo ukufakwa kwezinhlayiya ze-pigment embozweni.
02
Indlela Yokuhlola Ukuthambekela kwe-HPMC
Isibonakaliso esibalulekile sokulinganisa umphumela wokujiya kwe-hydroxypropyl methylcellulose ukujiya okubonakalayo kwesisombululo samanzi. Izindlela zokulinganisa ukujiya okubonakalayo zivame ukufaka indlela ye-capillary viscosity, indlela ye-rotational viscosity kanye nendlela ye-falling ball viscosity.
lapho: kungukubonakala kwe-viscosity, i-mPa s; u-K ungu-viscometer constant; u-d uwubuningi besampula yesisombululo ku-20/20°C; u-t yisikhathi sokuba isixazululo sidlule engxenyeni engenhla ye-viscometer siye ephawulweni elingezansi, s; Isikhathi lapho uwoyela ojwayelekile ugeleza khona nge-viscometer siyalinganiswa.
Kodwa-ke, indlela yokulinganisa nge-capillary viscometer iyinkinga kakhulu. Ukuqina kwabaningiama-ether e-celluloseKunzima ukuhlaziya kusetshenziswa i-capillary viscometer ngoba lezi zixazululo ziqukethe inani elincane lezinto ezinganyibiliki ezitholakala kuphela lapho i-capillary viscometer ivaliwe. Ngakho-ke, abakhiqizi abaningi basebenzisa ama-viscometer ajikelezayo ukulawula ikhwalithi ye-hydroxypropyl methylcellulose. Ama-Brookfield viscometer avame ukusetshenziswa emazweni angaphandle, kanti ama-NDJ viscometer asetshenziswa eShayina.
03
Izici ezithonya ukuthambekela kwe-HPMC
3.1 Ubudlelwano nezinga lokuhlanganiswa
Uma ezinye izilinganiso zingashintshi, i-viscosity yesisombululo se-hydroxypropyl methylcellulose ilingana nezinga le-polymerization (DP) noma isisindo sama-molecule noma ubude be-molecular chain, futhi iyanda ngokukhuphuka kwezinga le-polymerization. Lo mphumela ubonakala kakhulu esimweni sezinga eliphansi le-polymerization kunasesimweni sezinga eliphezulu le-polymerization.
3.2 Ubudlelwano phakathi kokujiya kanye nokuhlushwa
I-viscosity ye-hydroxypropyl methylcellulose iyanda ngokwanda kokuhlushwa komkhiqizo esixazululweni samanzi. Ngisho noshintsho lokuhlushwa okuncane luzobangela ushintsho olukhulu ekuhlushweni. Nge-viscosity ejwayelekile ye-hydroxypropyl methylcellulose Umphumela woshintsho lokuhlushwa kwesisombululo ekuhlushweni kwesisombululo usobala kakhulu.
3.3 Ubudlelwano phakathi kwe-viscosity kanye ne-shear rate
Isixazululo samanzi se-hydroxypropyl methylcellulose sinempahla yokunciphisa ukucheba. I-hydroxypropyl methylcellulose ye-viscosity ehlukile eqondile ilungiswa ibe yisisombululo samanzi esingu-2%, futhi i-viscosity yayo ngamanani ahlukene okucheba ilinganiswa ngokulandelana. Imiphumela imi kanje Njengoba kuboniswe esithombeni. Ngesilinganiso esiphansi sokucheba, i-viscosity yesisombululo se-hydroxypropyl methylcellulose ayizange ishintshe kakhulu. Ngokukhuphuka kwesilinganiso sokucheba, i-viscosity yesisombululo se-hydroxypropyl methylcellulose ene-viscosity ephezulu eqondile yehle ngokusobala, kuyilapho isixazululo esine-viscosity ephansi singazange sehle ngokusobala.
3.4 Ubudlelwano phakathi kwe-viscosity kanye nokushisa
Ukuqina kwesisombululo se-hydroxypropyl methylcellulose kuthinteka kakhulu yizinga lokushisa. Njengoba izinga lokushisa likhuphuka, ukuqina kwesisombululo kuyancipha. Njengoba kuboniswe esithombeni, silungiswa sibe yisisombululo samanzi esinokugxila okungu-2%, futhi ushintsho lwe-viscosity ngokukhuphuka kwezinga lokushisa luyalinganiswa.
3.5 Ezinye izinto ezithonyayo
I-viscosity yesisombululo samanzi se-hydroxypropyl methylcellulose nayo ithintwa yizithasiselo ezikusisombululo, inani le-pH yesisombululo, kanye nokuwohloka kwamagciwane. Ngokuvamile, ukuze kutholakale ukusebenza okungcono kwe-viscosity noma kuncishiswe izindleko zokusebenzisa, kuyadingeka ukwengeza ama-rheology modifier, njengobumba, ubumba oluguquliwe, i-polymer powder, i-starch ether kanye ne-aliphatic copolymer, kusisombululo samanzi se-hydroxypropyl methylcellulose. , kanye nama-electrolyte afana ne-chloride, i-bromide, i-phosphate, i-nitrate, njll. angangezwa futhi kusixazululo samanzi. Lezi zithasiselo ngeke zithinte kuphela izakhiwo ze-viscosity zesisombululo samanzi, kodwa futhi zizothinta nezinye izakhiwo zokusetshenziswa ze-hydroxypropyl methylcellulose njengokugcinwa kwamanzi. , ukumelana nokuwa, njll.
I-viscosity yesisombululo samanzi se-hydroxypropyl methylcellulose cishe ayithinteki yi-asidi ne-alkali, futhi ngokuvamile izinzile ebangeni eli-3 kuya ku-11. Ingamelana nenani elithile lama-acid abuthakathaka, njenge-formic acid, i-acetic acid, i-phosphoric acid, i-boric acid, i-citric acid, njll. Kodwa-ke, i-concentrated acid izonciphisa i-viscosity. Kodwa i-caustic soda, i-potassium hydroxide, amanzi e-lime, njll. ayinawo umthelela omkhulu kuyo. Uma kuqhathaniswa namanye ama-cellulose ethers,i-hydroxypropyl methylcelluloseIsixazululo samanzi sinokuzinza okuhle kokulwa namagciwane, isizathu esiyinhloko ukuthi i-hydroxypropyl methylcellulose inamaqembu angenawo umoya anezinga eliphezulu lokushintsha kanye nokuvimbela amaqembu aqinile. Kodwa-ke, njengoba ukusabela kokushintsha ngokuvamile kungalingani, iyunithi ye-anhydroglucose engashintshiwe iguguleka kalula yizinto ezincane, okuholela ekuwohlokeni kwama-molecule e-cellulose ether kanye nokuqhekeka kweketanga. Ukusebenza ukuthi i-viscosity ebonakalayo yesisombululo samanzi iyancipha. Uma kudingeka ukugcina isixazululo samanzi se-hydroxypropyl methylcellulose isikhathi eside, kunconywa ukuthi wengeze inani elincane le-antifungal agent ukuze i-viscosity ingashintshi kakhulu. Lapho ukhetha ama-anti-fungal agents, ama-preservatives noma ama-fungicides, kufanele unake ukuphepha, futhi ukhethe imikhiqizo engeyona ubuthi emzimbeni womuntu, enezakhiwo ezizinzile futhi engenaphunga, njenge-DOW Chem's AMICAL fungicides, ama-preservatives e-CANGUARD64, ama-FUELSAVER bacteria agents kanye neminye imikhiqizo.
Isikhathi sokuthunyelwe: Ephreli-28-2024