Hydroxypropyl methylcellulose (HPMC)ke ether e tsoakiloeng ea cellulose e sa ionic, e qhibilihang ka metsing. Ponahalo e tšoeu ho isa ho e mosehla hanyane kapa thepa e nang le granular, ha e na tatso, ha e na monko, ha e na chefo, e tsitsitse ka lik'hemik'hale, 'me e qhibiliha ka metsing ho etsa tharollo e boreleli, e bonaletsang le e nang le viscous. E 'ngoe ea litšobotsi tsa bohlokoa ka ho fetisisa tsa hydroxypropyl methylcellulose ha e sebelisoa ke hore e eketsa viscosity ea mokelikeli. Phello ea ho teteana e itšetlehile ka tekanyo ea polymerization (DP) ea sehlahisoa, mahloriso a ether ea cellulose ka har'a tharollo ea metsi, sekhahla sa ho kuta, le mocheso oa tharollo. Le lintlha tse ling.
01
Mofuta oa mokelikeli oa tharollo ea metsi ea HPMC
Ka kakaretso, kgatello ya mokelikeli phallong ya ho kgaola e ka hlahiswa e le mosebetsi wa sekgahla sa ho kgaola feela ƒ(γ), ha feela e sa itshetlehe ka nako. Ho itshetlehile ka sebopeho sa ƒ(γ), maro a ka arolwa ka mefuta e fapaneng, e leng: maro a Newtonian, maro a atolohang, maro a pseudoplastic le maro a polasetiki a Bingham.
Li-ether tsa cellulose li arotsoe ka mekhahlelo e 'meli: e 'ngoe ke ether ea cellulose e seng ea ionic 'me e 'ngoe ke ether ea cellulose e ionic. Bakeng sa rheology ea mefuta ena e 'meli ea li-ether tsa cellulose. SC Naik le ba bang ba entse phuputso e bapisitsoeng ka botlalo le e hlophisitsoeng mabapi le litharollo tsa hydroxyethyl cellulose le sodium carboxymethyl cellulose. Liphetho li bontšitse hore litharollo tsa ether tsa cellulose e seng ea ionic le litharollo tsa ether tsa cellulose e seng tsa ionic e ne e le tsa pseudoplastic. Phallo, ke hore, phallo e seng ea Newtonian, e atamela li-liquids tsa Newtonian feela ka maemo a tlase haholo. Pseudoplasticity ea tharollo ea hydroxypropyl methylcellulose e bapala karolo ea bohlokoa ts'ebelisong. Mohlala, ha e sebelisoa ho li-coat, ka lebaka la litšobotsi tsa ho fokotsa ho kuta ha litharollo tsa metsi, viscosity ea tharollo e fokotseha ka keketseho ea sekhahla sa ho kuta, e leng se thusang ho hasana ho tšoanang ha likaroloana tsa pigment, 'me hape se eketsa phallo ea ho kuta. Phello e kholo haholo; ha e ntse e phomotse, viscosity ea tharollo e kholo haholo, e thibelang ka katleho ho beoa ha likaroloana tsa pigment ka har'a coat.
02
Mokhoa oa Teko ea Viscosity ea HPMC
Sesupo sa bohlokoa sa ho lekanya phello ea ho teteana ha hydroxypropyl methylcellulose ke ho teteana ho bonahalang ha tharollo ea metsi. Mekhoa ea ho lekanya ho teteana ho bonahalang hangata e kenyelletsa mokhoa oa ho teteana ha capillary, mokhoa oa ho rotational viscosity le mokhoa oa ho teteana ha bolo e oelang.
moo: ke viscosity e bonahalang, mPa s; K ke viscometer constant; d ke bongata ba sampole ea tharollo ho 20/20°C; t ke nako ea hore tharollo e fete karolong e ka holimo ea viscometer ho ea letšoao le ka tlase, s; Nako eo oli e tloaelehileng e phallang ka har'a viscometer e lekanngoa.
Leha ho le jwalo, mokhoa wa ho lekanya ka capillary viscometer o na le mathata le ho feta.li-ether tsa seluloseHo thata ho sekaseka ho sebelisoa capillary viscometer hobane litharollo tsena li na le palo e nyenyane ea lintho tse sa qhibiliheng tse bonoang feela ha capillary viscometer e koetsoe. Ka hona, bahlahisi ba bangata ba sebelisa li-viscometer tse potolohang ho laola boleng ba hydroxypropyl methylcellulose. Li-viscometer tsa Brookfield li sebelisoa hangata linaheng tse ling, 'me li-viscometer tsa NDJ li sebelisoa Chaena.
03
Mabaka a susumetsang ho viscous ea HPMC
3.1 Kamano le tekanyo ea ho bokellana
Ha diparamente tse ding di sa fetohe, viscosity ya tharollo ya hydroxypropyl methylcellulose e lekana le tekanyo ya polymerization (DP) kapa boima ba dimolek'hule kapa bolelele ba ketane ya dimolek'hule, mme e eketseha ka keketseho ya tekanyo ya polymerization. Phello ena e bonahala haholo tabeng ya tekanyo e tlase ya polymerization ho feta tabeng ya tekanyo e phahameng ya polymerization.
3.2 Kamano pakeng tsa ho teteana le ho tsepamisa maikutlo
Ho teteana ha hydroxypropyl methylcellulose hoa eketseha ha ho eketseha ha mahloriso a sehlahisoa ka har'a tharollo ea metsi. Esita le phetoho e nyane ea mahloriso e tla baka phetoho e kholo ho teteana. Ka ho teteana ho tloaelehileng ha hydroxypropyl methylcellulose Phello ea phetoho ea mahloriso a tharollo holim'a ho teteana ha tharollo e bonahala haholoanyane.
3.3 Kamano pakeng tsa ho teteana le sekhahla sa ho beola
Tharollo ea metsi ea Hydroxypropyl methylcellulose e na le thepa ea ho fokotsa ho shear. Hydroxypropyl methylcellulose ea viscosity e fapaneng ea nominal e lokisetsoa tharollong ea metsi ea 2%, 'me viscosity ea eona ka sekhahla se fapaneng sa ho shear e lekanngoa ka ho latellana. Liphetho ke tse latelang Joalokaha ho bontšitsoe setšoantšong. Ka sekhahla se tlase sa ho shear, viscosity ea tharollo ea hydroxypropyl methylcellulose ha ea ka ea fetoha haholo. Ka keketseho ea sekhahla sa ho shear, viscosity ea tharollo ea hydroxypropyl methylcellulose e nang le viscosity e phahameng ea nominal e ile ea fokotseha ka ho hlaka haholoanyane, ha tharollo e nang le viscosity e tlase e sa ka ea fokotseha ka ho hlaka.
3.4 Kamano pakeng tsa ho teteana le mocheso
Ho teteana ha tharollo ea hydroxypropyl methylcellulose ho angoa haholo ke mocheso. Ha mocheso o ntse o eketseha, ho teteana ha tharollo hoa fokotseha. Joalokaha ho bontšitsoe setšoantšong, e lokisoa hore e be tharollo e metsi e nang le mahloriso a 2%, 'me phetoho ea ho teteana ha mocheso e lekanngoa.
3.5 Mabaka a mang a susumetsang
Ho teteana ha tharollo ea metsi ea hydroxypropyl methylcellulose le hona ho angoa ke lintho tse ekelitsoeng ka har'a tharollo, boleng ba pH ba tharollo, le ho senyeha ha likokoana-hloko. Hangata, e le ho fumana ts'ebetso e ntle ea ho teteana kapa ho fokotsa litšenyehelo tsa ts'ebeliso, ho hlokahala ho eketsa li-modifiers tsa rheology, tse kang letsopa, letsopa le fetotsoeng, phofo ea polymer, starch ether le aliphatic copolymer, tharollong ea metsi ea hydroxypropyl methylcellulose. , 'me li-electrolyte tse kang chloride, bromide, phosphate, nitrate, jj. le tsona li ka eketsoa tharollong ea metsi. Lintho tsena tse ekelitsoeng li ke ke tsa ama feela litšobotsi tsa ho teteana ha tharollo ea metsi, empa hape li tla ama litšobotsi tse ling tsa ts'ebeliso ea hydroxypropyl methylcellulose joalo ka ho boloka metsi. , ho hanyetsa ho sag, jj.
Ho teteana ha tharollo ea metsi ea hydroxypropyl methylcellulose ha ho amehe haholo ke asiti le alkali, 'me ka kakaretso e tsitsitse ho tloha ho 3 ho isa ho 11. E ka mamella bongata bo itseng ba li-acid tse fokolang, joalo ka formic acid, acetic acid, phosphoric acid, boric acid, citric acid, jj. Leha ho le joalo, asiti e kopaneng e tla fokotsa ho teteana. Empa caustic soda, potassium hydroxide, metsi a lime, jj. ha e na phello e kholo ho eona. Ha e bapisoa le li-ether tse ling tsa cellulose,hydroxypropyl methylcelluloseTharollo ea metsi e na le botsitso bo botle ba likokoana-hloko, lebaka le ka sehloohong ke hore hydroxypropyl methylcellulose e na le lihlopha tse sa rateng metsi tse nang le tekanyo e phahameng ea ho nkeloa sebaka le tšitiso ea steric ea lihlopha Leha ho le joalo, kaha karabelo ea ho nkeloa sebaka hangata ha e tšoane, yuniti ea anhydroglucose e sa nkeloang sebaka e senyeha habonolo ke likokoana-hloko, e leng se fellang ka ho senyeha ha limolek'hule tsa ether tsa cellulose le ho arohana ha ketane. Tshebetso ke hore viscosity e bonahalang ea tharollo ea metsi ea fokotseha. Haeba ho hlokahala ho boloka tharollo ea metsi ea hydroxypropyl methylcellulose nako e telele, ho khothalletsoa ho eketsa palo e nyane ea moemeli oa antifungal e le hore viscosity e se ke ea fetoha haholo. Ha u khetha metsoako e loantšang fungal, li-preservative kapa li-fungicides, u lokela ho ela hloko polokeho, 'me u khethe lihlahisoa tse seng chefo 'meleng oa motho, tse nang le thepa e tsitsitseng le tse se nang monko, tse kang li-fungicides tsa DOW Chem's AMICAL, li-preservative tsa CANGUARD64, metsoako ea libaktheria tsa FUELSAVER le lihlahisoa tse ling. li ka bapala karolo e tsamaellanang.
Nako ea poso: Mmesa-28-2024