I-Hydroxypropyl methylcellulose, eyaziwa kakhulu ngokuthi i-HPMC, iyisithako esisetshenziswa kabanzi kwezokwelapha kanye nesithako sokudla. Ngenxa yokuncibilika kwayo okuhle kakhulu, ikhono lokubopha kanye nezakhiwo zokwakha ifilimu, isetshenziswe kabanzi embonini yezokwelapha. I-HPMC isetshenziswa kakhulu embonini yokudla njengesithako esiqinisayo, esihlanganisayo kanye nesiqinisi. Ubumsulwa be-HPMC bubaluleke kakhulu embonini yezokwelapha kanye neyokudla njengoba kuthinta ukusebenza kahle kanye nokuphepha komkhiqizo. Lesi sihloko sizoxoxa ngokunqunywa kobumsulwa be-HPMC kanye nezindlela zayo.
Ayini ama-HPMC?
I-Hydroxypropylmethylcellulose (HPMC) iyi-cellulose ether etholakala ku-methylcellulose. Isisindo sayo sama-molecule singama-Dalton ayi-10,000 kuya ku-1,000,000, futhi iyimpuphu emhlophe noma engemhlophe, ayinaphunga futhi ayinambitheki. I-HPMC incibilika kalula emanzini, futhi incibilika kwezinye izinyibilikisi eziphilayo ezifana ne-ethanol, i-butanol, ne-chloroform. Inezakhiwo ezithile ezihlukile njengokugcinwa kwamanzi, ukuqina kanye nekhono lokubopha, okwenza ifaneleke kakhulu embonini yezemithi kanye neyokudla.
Ukunqunywa kobumsulwa be-HPMC
Ubumsulwa be-HPMC buncike ezintweni eziningana ezifana nezinga lokushintshana (DS), okuqukethwe komswakama kanye nokuqukethwe komlotha. I-DS imelela inani lamaqembu e-hydroxyl athathelwe indawo amaqembu e-hydroxypropyl ku-molecule ye-cellulose. Izinga eliphezulu lokushintshana landisa ukuncibilika kwe-HPMC futhi lithuthukisa ikhono lokwenza ifilimu. Ngokuphambene nalokho, izinga eliphansi lokushintshana lingabangela ukuncipha kokuncibilika kanye nezakhiwo ezimbi zokwakha ifilimu.
Indlela Yokunquma Ubumsulwa be-HPMC
Kunezindlela eziningana zokunquma ubumsulwa be-HPMC, okuhlanganisa i-acid-base titration, ukuhlaziywa kwezinto eziyisisekelo, i-high-performance liquid chromatography (HPLC), kanye ne-infrared spectroscopy (IR). Nansi imininingwane yendlela ngayinye:
i-titration yesisekelo se-asidi
Le ndlela isekelwe ekusabeleni kokungaguquguquki phakathi kwamaqembu ane-acidic kanye namaqembu ayisisekelo ku-HPMC. Okokuqala, i-HPMC incibilikiswa ku-solvent bese kufakwa umthamo owaziwayo wesisombululo se-acid noma sesisekelo sokuhlushwa okwaziwayo. I-Titration yenziwa kuze kube yilapho i-pH ifinyelela iphuzu elingathathi hlangothi. Kusukela enanini le-acid noma isisekelo esisetshenzisiwe, izinga lokushintshana lingabalwa.
Ukuhlaziywa kwezinto eziyisisekelo
Ukuhlaziywa kwezinto eziyisisekelo kulinganisa iphesenti lento ngayinye ekhona kusampula, okuhlanganisa ikhabhoni, i-hydrogen, kanye nomoya-mpilo. Izinga lokushintshana lingabalwa kusukela enanini lento ngayinye ekhona kusampula ye-HPMC.
I-Chromatography Yoketshezi Esebenza Kakhulu (i-HPLC)
I-HPLC iyindlela yokuhlaziya esetshenziswa kabanzi ehlukanisa izingxenye zengxube ngokusekelwe ekusebenzisaneni kwazo nezigaba ezimile nezihambayo. Ku-HPMC, izinga lokushintshana lingabalwa ngokulinganisa isilinganiso se-hydroxypropyl kumaqembu e-methyl kusampula.
I-Infrared Spectroscopy (IR)
I-infrared spectroscopy iyindlela yokuhlaziya elinganisa ukumuncwa noma ukudluliselwa kwemisebe ye-infrared ngesampula. I-HPMC ineziqongo ezahlukene zokumuncwa kwe-hydroxyl, i-methyl kanye ne-hydroxypropyl, ezingasetshenziswa ukunquma izinga lokufakwa esikhundleni.
Ubumsulwa be-HPMC bubalulekile embonini yezemithi kanye nokudla, futhi ukuzimisela kwayo kubalulekile ukuqinisekisa ukuphepha nokusebenza kahle komkhiqizo wokugcina. Kunezindlela eziningana ezitholakalayo zokunquma ubumsulwa be-HPMC, okuhlanganisa i-acid-base titration, ukuhlaziywa kwezinto eziyisisekelo, i-HPLC, kanye ne-IR. Indlela ngayinye inezinzuzo nezinkinga zayo futhi ingakhethwa ngokwezidingo ezithile zokusetshenziswa. Ukuze kugcinwe ubumsulwa be-HPMC, kumele igcinwe endaweni eyomile, epholile kude nokukhanya kwelanga nezinye izinto ezingcolisayo.
Isikhathi sokuthunyelwe: Agasti-25-2023