Hydroxypropyl methylcellulose, nke a na-akpọkarị HPMC, bụ ihe na-enye ọgwụ na ihe mgbakwunye nri nke a na-ejikarị eme ihe. N'ihi ike ya dị mma, ikike ijikọ ya na ihe ndị na-emepụta ihe nkiri, ejirila ya mee ihe n'ọtụtụ ebe n'ụlọ ọrụ ọgwụ. A na-ejikarị HPMC eme ihe n'ụlọ ọrụ nri dị ka ihe na-eme ka ihe sie ike, ihe na-eme ka ihe sie ike, na ihe na-eme ka ihe sie ike. Ịdị ọcha nke HPMC dị oke mkpa n'ụlọ ọrụ ọgwụ na nri n'ihi na ọ na-emetụta arụmọrụ na nchekwa nke ngwaahịa ahụ. Isiokwu a ga-atụle mkpebi nke ịdị ọcha nke HPMC na ụzọ ya.
Kedu ihe bụ HPMCs?
Hydroxypropylmethylcellulose (HPMC) bụ cellulose ether nke sitere na methylcellulose. Ibu ya dị n'ime molekul bụ Daltons 10,000 ruo 1,000,000, ọ bụkwa ntụ ọcha ma ọ bụ nke na-acha ọcha, ọ naghị esi isi ma na-enweghị ụtọ. HPMC na-agbaze ngwa ngwa na mmiri, ọ na-agbazekwa na ụfọdụ ihe mgbaze organic dịka ethanol, butanol, na chloroform. O nwere ihe pụrụ iche dịka idobe mmiri, ike ịkewa na ijikọ ya, nke na-eme ka ọ dị mma maka ụlọ ọrụ ọgwụ na nri.
Mkpebi nke ịdị ọcha nke HPMC
Ịdị ọcha nke HPMC dabere n'ọtụtụ ihe dịka ogo nnọchi (DS), ọdịnaya mmiri na ọdịnaya ntụ. DS na-anọchite anya ọnụọgụ nke otu hydroxyl nke otu hydroxypropyl nọchiri na molekul cellulose. Oke ogo nnọchi na-eme ka HPMC dịkwuo mma ma na-eme ka ikike ịmepụta fim ka mma. N'aka nke ọzọ, obere ogo nnọchi ga-eme ka ọ ghara ịgbaze ma ghara inwe àgwà nhazi fim na-adịghị mma.
Usoro Nchọpụta Ọcha nke HPMC
E nwere ọtụtụ ụzọ esi achọpụta ịdị ọcha nke HPMC, gụnyere titration acid-base, nyocha elemental, high-performance liquid chromatography (HPLC), na infrared spectroscopy (IR). Lee nkọwa maka usoro ọ bụla:
ntinye nke isi acid
Usoro a dabere na mmeghachi omume nkewa dị n'etiti otu acidic na nke bụ isi na HPMC. Nke mbụ, a na-agbaze HPMC na ihe mgbaze ma tinye olu a maara nke acid ma ọ bụ ihe ngwọta ntọala nke a maara nke ọma. A na-eme titration ruo mgbe pH ruru ebe na-anọpụ iche. Site na ọnụọgụ acid ma ọ bụ ntọala e riri, enwere ike ịgbakọ ogo nnọchi.
Nyocha nke ihe
Nnyocha elemental na-atụle pasentị nke ihe ọ bụla dị na ihe nlele ahụ, gụnyere carbon, hydrogen, na oxygen. Enwere ike ịgbakọ ọkwa nnọchi site na ọnụọgụ nke ihe ọ bụla dị na ihe nlele HPMC.
Chromatography mmiri arụmọrụ dị elu (HPLC)
HPLC bụ usoro nyocha a na-ejikarị eme ihe nke na-ekewa ihe ndị dị na ngwakọta dabere na mmekọrịta ha na usoro ndị na-anaghị agagharị agagharị na ndị na-anaghị agagharị. Na HPMC, enwere ike ịgbakọ ọkwa nke nnọchi site na ịtụ oke nke hydroxypropyl na otu methyl na sample.
Igwe nyocha infrared (IR)
Usoro nyocha nke infrared bụ usoro nyocha nke na-atụle nnabata ma ọ bụ nnyefe nke radieshon infrared site na ihe nlele. HPMC nwere oke mmịpụta dị iche iche maka hydroxyl, methyl na hydroxypropyl, nke enwere ike iji chọpụta oke nnọchi.
Ịdị ọcha nke HPMC dị oke mkpa n'ụlọ ọrụ ọgwụ na nri, mkpebi ya dịkwa oke mkpa iji hụ na nchekwa na irè nke ngwaahịa ikpeazụ. E nwere ọtụtụ ụzọ iji chọpụta ịdị ọcha nke HPMC, gụnyere titration acid-base, nyocha elemental, HPLC, na IR. Usoro ọ bụla nwere uru na ọghọm nke ya ma enwere ike ịhọrọ ya dịka ihe achọrọ kpọmkwem maka ojiji ahụ si dị. Iji nọgide na-adị ọcha nke HPMC, a ga-echekwa ya n'ebe kpọrọ nkụ, dị jụụ, pụọ na anwụ na ihe ndị ọzọ na-emerụ ahụ.
Oge ozi: Ọgọst-25-2023