IHydroxypropyl methylcellulose (HPMC)yi-non-ionic, i-cellulose enyibilikayo emanzini exutywe i-ether. Imbonakalo imhlophe ukuya kumgubo omthubi kancinane okanye imathiriyeli yegranular, ayinancasa, ayinavumba, ayinatyhefu, izinzile ngokwekhemikhali, kwaye inyibilika emanzini ukwenza isisombululo esigudileyo, esiselubala kunye nesibonakalayo. Enye yezona zinto zibalulekileyo ze-hydroxypropyl methylcellulose ekusetyenzisweni kukuba inyusa i-viscosity yolwelo. Isiphumo sokuqina sixhomekeke kwiqondo lepolymerization (DP) yemveliso, ukuxinwa kwe-cellulose ether kwisisombululo esinamanzi, izinga lokucheba, kunye nobushushu besisombululo. Kunye nezinye izinto.
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Uhlobo lolwelo lwesisombululo se-aqueous HPMC
Ngokubanzi, uxinzelelo lolwelo lokucheba lunokubonakaliswa njengomsebenzi wesantya sokucheba kuphela ƒ(γ), okoko nje kungaxhomekekanga kwixesha. Ngokuxhomekeke kuhlobo ƒ(γ), ulwelo lunokwahlulwa lube ziindidi ezahlukeneyo, ezizezi: ulwelo oluseNewtonian, ulwelo oludityanisiweyo, ulwelo oluyipseudoplastic kunye nolwelo lweplastiki yaseBingham.
I-cellulose ethers yahlulwe yangamacandelo amabini: enye yi-non-ionic cellulose ether kwaye enye yi-ionic cellulose ether. Kwi-rheology yezi ntlobo zimbini ze-cellulose ethers. SC Naik et al. yenze uphononongo olubanzi nolucwangcisiweyo oluthelekisayo kwi-hydroxyethyl cellulose kunye nezisombululo ze-sodium carboxymethyl cellulose. Iziphumo zibonise ukuba zombini izisombululo ze-cellulose ze-ether ze-non-ionic kunye nezisombululo ze-ionic cellulose ether zaziyi-pseudoplastic. Ukuqukuqela, oko kukuthi, imiqukuqelo engeyiyo eyeNewtonian, isondela kulwelo lweNewtonian kuphela kwindawo ephantsi kakhulu. I-pseudoplasticity yesisombululo se-hydroxypropyl methylcellulose idlala indima ebalulekileyo kwisicelo. Ngokomzekelo, xa isetyenziswe kwiingubo, ngenxa yeempawu zokunciphisa i-shear yezisombululo ezinamanzi, i-viscosity yesisombululo iyancipha ngokunyuka kwesantya sokucheba, esilungele ukusasazeka okufanayo kwamasuntswana e-pigment, kwaye kwandisa ukumanzi kwengubo. Isiphumo sikhulu kakhulu; ngelixa uphumle, i-viscosity yesisombululo inkulu kakhulu, ekhusela ngokufanelekileyo ukufakwa kwee-pigment particles kwi-coating.
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Indlela yoVavanyo lwe-HPMC yeViscosity
Isalathisi esibalulekileyo sokulinganisa umphumo wokuqina kwe-hydroxypropyl methylcellulose yi-viscosity ebonakalayo yesisombululo samanzi. Iindlela zokulinganisa i-viscosity ebonakalayo idla ngokubandakanya indlela ye-capillary viscosity, indlela ye-rotational viscosity kunye nendlela ye-viscosity yebhola ewayo.
apho: yi-viscosity ebonakalayo, mPa s; I-K yi-viscometer engatshintshiyo; d ubuninzi besampulu yesisombululo kwi-20/20 ° C; t lixesha lokuba isisombululo sidlule kwindawo ephezulu ye-viscometer ukuya kumanqaku aphantsi, s; Ixesha apho ioli eqhelekileyo ihamba nge-viscometer ilinganiswa.
Nangona kunjalo, indlela yokulinganisa i-capillary viscometer inzima kakhulu. I-viscosities yabaninzii-cellulose ethersKunzima ukuhlalutya usebenzisa i-capillary viscometer kuba ezi zisombululo ziqulethe umkhondo wezinto ezinganyibilikiyo ezichongwa kuphela xa i-capillary viscometer ivaliwe. Ngoko ke, abaninzi abavelisi basebenzisa i-viscometers ejikelezayo ukulawula umgangatho we-hydroxypropyl methylcellulose. I-Brookfield viscometers isetyenziswa ngokuqhelekileyo kumazwe angaphandle, kwaye i-NDJ viscometers isetyenziswa eChina.
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Imiba enempembelelo ye-HPMC viscosity
3.1 Ubudlelwane kunye neqondo lokuhlanganisa
Xa ezinye iiparitha zihlala zingatshintshi, i-viscosity ye-hydroxypropyl methylcellulose isisombululo ihambelana neqondo le-polymerization (DP) okanye ubunzima bemolekyuli okanye ubude be-molecular chain, kwaye inyuka ngokunyuka kwezinga le-polymerization. Esi siphumo sibonakala ngakumbi kwimeko yeqondo eliphantsi le-polymerization kunokuba kwimeko yezinga eliphezulu le-polymerization.
3.2 Ubudlelwane phakathi kwe-viscosity kunye nokugxila
I-viscosity ye-hydroxypropyl methylcellulose iyanda ngokunyuka koxinzelelo lwemveliso kwisisombululo samanzi. Nokuba utshintsho oluncinci loxinzelelo luya kubangela utshintsho olukhulu kwi-viscosity. Nge-viscosity ebizwa ngokuba yi-hydroxypropyl methylcellulose Umphumo wenguqu yoxinzelelo lwesisombululo kwi-viscosity yesisombululo kubonakala ngakumbi.
3.3 Ubudlelwane phakathi kwe-viscosity kunye nereyithi yokucheba
I-Hydroxypropyl methylcellulose isisombululo samanzi sinepropathi yokucheba. I-Hydroxypropyl methylcellulose ye-viscosity eyahlukileyo ye-nominal ilungiswa kwi-2% yesisombululo samanzi, kunye ne-viscosity yayo kumazinga ahlukeneyo okucheba alinganiswa ngokulandelelana. Iziphumo zezi zilandelayo Njengoko kubonisiwe kumzobo. Kwinqanaba eliphantsi le-shear, i-viscosity ye-hydroxypropyl methylcellulose isisombululo ayizange itshintshe kakhulu. Ngokunyuka kwezinga lokucheba, i-viscosity ye-hydroxypropyl methylcellulose isisombululo esine-viscosity ephezulu ye-nominal yehle ngokucacileyo, ngelixa isisombululo esine-viscosity ephantsi asizange sehle ngokucacileyo.
3.4 Ubudlelwane phakathi kwe-viscosity kunye nobushushu
I-viscosity yesisombululo se-hydroxypropyl methylcellulose ichaphazeleka kakhulu ngubushushu. Njengoko iqondo lokushisa linyuka, i-viscosity yesisombululo iyancipha. Njengoko kuboniswe kumzobo, kulungiselelwe kwisisombululo samanzi kunye ne-concentration ye-2%, kwaye ukuguqulwa kwe-viscosity kunye nokunyuka kweqondo lokushisa kulinganiswa.
3.5 Ezinye izinto ezinefuthe
I-viscosity yesisombululo se-aqueous ye-hydroxypropyl methylcellulose iphinda ichaphazeleke izongezo kwisisombululo, ixabiso le-pH lesisombululo, kunye nokuthotywa kwe-microbial. Ngokuqhelekileyo, ukuze ufumane ukusebenza kakuhle kwe-viscosity okanye ukunciphisa iindleko zokusetyenziswa, kuyimfuneko yokongeza i-rheology modifiers, njengodongwe, udongwe olulungisiweyo, i-polymer powder, i-starch ether kunye ne-aliphatic copolymer, kwisisombululo samanzi se-hydroxypropyl methylcellulose. , kunye ne-electrolytes ezifana ne-chloride, i-bromide, i-phosphate, i-nitrate, njl. Ezi zongezo aziyi kuchaphazela kuphela iimpawu ze-viscosity zesisombululo samanzi, kodwa zichaphazela nezinye iimpawu zesicelo se-hydroxypropyl methylcellulose ezifana nokugcinwa kwamanzi. , ukuxhathisa kwe-sag, njl.
I-viscosity yesisombululo se-aqueous ye-hydroxypropyl methylcellulose phantse ayichaphazeleki nge-asidi kunye ne-alkali, kwaye ngokuqhelekileyo izinzile kuluhlu lwe-3 ukuya kwe-11. Iyakwazi ukumelana nomlinganiselo othile we-acids ebuthakathaka, njenge-fomic acid, i-acetic acid, i-phosphoric acid, i-boric acid, i-citric acid, njl. Kodwa i-caustic soda, i-potassium hydroxide, i-lime yamanzi, njl. Xa kuthelekiswa nezinye ii-cellulose ethers,ihydroxypropyl methylcelluloseisisombululo samanzi sinozinzo oluhle lwe-antimicrobial, isizathu esona sizathu kukuba i-hydroxypropyl methylcellulose inamaqela e-hydrophobic anezinga eliphezulu lokutshintshwa kunye nokuphazamiseka kwe-steric yamaqela Nangona kunjalo, ekubeni impendulo yokutshintshwa ngokuqhelekileyo ayifani, iyunithi ye-anhydroglucose engatshintshiyo ichithwa ngokulula yi-microorganisms, okubangelwa ukuchithwa kwe-molecule ye-cellulose kunye ne-cellulose. Ukusebenza kukuba i-viscosity ebonakalayo yesisombululo samanzi iyancipha. Ukuba kuyimfuneko ukugcina isisombululo samanzi se-hydroxypropyl methylcellulose ixesha elide, kucetyiswa ukuba ungeze umlinganiselo we-antifungal agent ukwenzela ukuba i-viscosity ingatshintshi kakhulu. Xa ukhetha i-anti-fungal agents, i-preservatives okanye i-fungicides, kufuneka ubeke ingqalelo ekukhuseleni, kwaye ukhethe iimveliso ezingenayo ityhefu emzimbeni womntu, zinezakhiwo ezizinzileyo kwaye azinavumba, njenge-DOW Chem's AMICAL fungicides, i-CANGUARD64 preservatives, i-FUELSAVER bacteria agents kunye nezinye iimveliso. inokudlala indima ehambelanayo.
Ixesha lokuposa: Apr-28-2024