Hydroxypropyl methyl cellulose HPMC ke ether e tsoakiloeng ea cellulose e seng ionic ka har'a mefuta e fapaneng 'me ether e tsoakiloeng ea ionic methyl carboxymethyl cellulose, ha e arabele ka litšepe tse boima. E 'ngoe ea li-radical tsa oksijene ka lebaka la hydroxypropyl methyl cellulose le karolo e fapaneng ea hydroxypropyl le viscosity, e fetohile mefuta e fapaneng ka lebaka la ts'ebetso, mohlala, methoxyl e ngata le dikahare tse tlase tsa mefuta ea hydroxypropyl, ts'ebetso ea eona e haufi le methyl cellulose le dikahare tse tlase tsa methoxyl le dikahare tse phahameng tsa mefuta ea hydroxypropyl, 'me ts'ebetso ea eona e haufi le hydroxypropyl methyl cellulose e hlahisoa. Empa mofuteng o mong le o mong, leha ho na le karolo e nyane feela ea hydroxypropyl kapa methoxy e nyane, ho qhibiliha ha li-solvents tsa manyolo kapa mocheso oa flocculation tharollong ea metsi, ho na le phapang e kholo.
1, ho qhibiliha ha hydroxypropyl methyl cellulose
Hydroxypropyl methyl cellulose ka ho qhibiliha ha metsi ha hydroxypropyl methyl cellulose ha e le hantle ke mofuta oa propylene oxide (methyl oxypropyl ring) methyl cellulose e fetotsoeng, kahoo e ntse e na le litšobotsi tse tšoanang le tsa methyl cellulose tse batang tse qhibilihang le tse sa qhibiliheng ka metsi a chesang. Leha ho le joalo, mocheso oa gelation oa hydroxy propyl e fetotsoeng o phahame haholo ho feta oa methyl cellulose ka metsing a chesang. Mohlala, viscosity ea tharollo ea metsi ea hydroxypropyl methylcellulose e nang le 2% methoxy content DS=0.73 le hydroxypropyl content MS=0.46 ke 500 mpa ho 20℃. Mocheso oa gel oa sehlahisoa sa S o haufi le 100℃, ha oa methyl cellulose oa mocheso o tšoanang e le hoo e ka bang 55℃ feela. Ha e le ho qhibiliha ha eona metsing, le hona ho ntlafetse haholo, mohlala, kamora ho sila ha hydroxypropyl methylcellulose (sebopeho sa koro 0.2 ~ 0.5mm ho 20℃ 4% aqueous viscosity ea 2pA? Lihlahisoa tsa S li ka qhibiliha habonolo metsing ntle le ho pholisa mochesong oa kamore.
(2) Hydroxypropyl methyl cellulose ka har'a metsoako ea tlhaho ea hydroxypropyl methyl cellulose ka har'a metsoako ea tlhaho ea organic solvents, e boetse e betere ho feta methyl cellulose, litlhoko tsa methyl cellulose ka tekanyo ea phetisetso ea methoxy ea lihlahisoa tse 2.1 kapa ho feta, 'me e na le hydroxypropyl MS=1.5~1.8 le methoxy DS=0.2~1.0, Hydroxypropyl methyl cellulose e nang le viscosity e phahameng e nang le tekanyo ea phetisetso e felletseng e kaholimo ho 1.8 e qhibiliha ka har'a litharollo tsa methanol le ethanol tse sa keneleng metsi, 'me e na le ho qhibiliha ha thermoplastic le metsi. E boetse e qhibiliha ka har'a li-hydrocarbon tse nang le chlorine tse kang dichloromethane le trichloromethane, le metsoako ea tlhaho e kang acetone, isopropyl alcohol, le diacetone alcohol. Ho qhibiliha ha eona ka har'a metsoako ea tlhaho ho feta ho qhibiliha ha metsi.
2, hydroxypropyl methyl cellulose viscosity ea lintho tse susumetsang
Dintlha tsa viscosity tsa Hydroxypropyl methylcellulose, hydroxypropyl methylcellulose, ho fumana viscosity e tloaelehileng, le ether e 'ngoe ea cellulose, li ho 20℃ ka tharollo ea metsi ea 2% joalo ka qeto e tloaelehileng. Viscosity ea sehlahisoa se le seng, ka keketseho ea mahloriso le keketseho, mahloriso a tšoanang a lihlahisoa tse fapaneng tsa boima ba limolek'hule, boima ba limolek'hule ba sehlahisoa ke viscosity e phahameng. Kamano ea eona le mocheso e tšoana le ea methyl cellulose. Ha mocheso o phahama, viscosity e qala ho fokotseha, empa ha e fihla mochesong o itseng, viscosity e phahama ka tšohanyetso 'me gelation ea etsahala. Mocheso oa gelation oa lihlahisoa tse nang le viscosity e tlase o phahame ho feta oa lihlahisoa tse nang le viscosity e phahameng. Boemo ba ntlha ea eona ea gel, ho phaella ho viscosity e phahameng le e tlase ea ether, empa hape le karolelano ea ether methoxy le hydroxypropyl group composition le tekanyo eohle ea phetolo lia amana. Ho lokela ho hlokomeloa hore hydroxypropyl methylcellulose le eona ke pseudoplastic; tharollo ea eona e tsitsitse ha e bolokoa mochesong oa kamore 'me ha e bontše ho senyeha ha viscosity ntle le monyetla oa ho senyeha ha enzymatic.
3, hydroxypropyl methyl cellulose acid le khanyetso ea alkaline
Hydroxypropyl methylcellulose acid alkali hydroxypropyl methylcellulose acid le alkali, ka kakaretso e tsitsitse, maemong a ph PH2 ~ 12 ha e amehe, e ka mamella tekanyo e itseng ea asiti e bobebe, joalo ka formic acid, acetic acid, citric acid, succinic acid, phosphoric acid, boric acid, jj. Empa asiti e kopaneng e na le phello ea ho fokotsa viscosity. Alkali tse kang caustic soda, caustic potassium le metsi a lime ha li na phello ho eona, empa phello ea ho eketsa viscosity hanyane ea tharollo e tla fokotseha butle nakong e tlang.
4, hydroxypropyl methyl cellulose e ka tsoakoa
Tharollo ea hydroxypropyl methyl cellulose e ka kopanngoa le metsoako ea polymer e qhibilihang ka metsing, 'me ea fetoha tharollo e bonaletsang e tšoanang e nang le viscosity e phahameng. Metsoako ena e phahameng ea limolek'hule ke polyethylene glycol, polyvinyl acetate, polysilicone, polymethyl vinyl siloxane le hydroxyethyl cellulose le methyl cellulose, jj. Metsoako ea tlhaho ea polymer e kang gum Arabic, locust bean gum, thorn tree gum le tse ling le tsona li na le motsoako o motle le tharollo ea eona. Hydroxypropyl methyl cellulose e ka boela ea kopanngoa le stearic acid kapa palmitic acid mannitol ester kapa sorbitol ester, empa hape le glycerol, sorbitol le mannitol, metsoako ena e ka sebelisoa e le hydroxypropyl methyl cellulose plasticizer.
5, hydroxypropyl methyl cellulose e sa qhibiliheng metsing
Hydroxypropyl methyl cellulose ether e sa qhibiliheng metsing e qhibilihang ka har'a metsi e ka ba holim'a metsi a crosslinking le aldehydes, 'me ea etsa hore ether ena e qhibilihang ka metsing e be e sa qhibiliheng ka har'a tharollo, e se ke ea qhibiliha ka har'a metsi. 'Me e etse hore hydroxypropyl methylcellulose e sa qhibiliheng aldehyde, formaldehyde, glyoxal, succinaldehyde, dialdehyde, jj., tšebeliso ea formaldehyde e lokela ho ela hloko ka ho khetheha boleng ba PH ba tharollo, eo ho eona glyoxal e arabelang ka potlako, kahoo tlhahisong ea indasteri e atisa ho sebelisoa glyoxal e le moemeli oa ho kopanya. Tekanyo ea mofuta ona oa moemeli oa ho kopanya ka har'a tharollo ke 0.2% ~ 10% ea boima ba ether, e ntle ka ho fetisisa ke 7% ~ 10%, joalo ka ha ho sebelisoa glyoxal e nang le 3.3% ~ 6% e loketse ka ho fetisisa. Mocheso o akaretsang oa kalafo ke 0 ~ 30℃, nako ke 1 ~ 120min. Karabelo ea ho kopanya ka 'ngoe e hloka ho etsoa tlas'a maemo a asiti. Ka kakaretso, asiti e matla e sa pheleng kapa asiti ea carboxylic ea tlhaho e eketsoa tharollong ho fetola PH ea tharollo ho isa ho hoo e ka bang 2 ~ 6, haholo-holo pakeng tsa 4 ~ 6, ebe li-aldehydes lia eketsoa bakeng sa karabelo ea ho kopanya. Li-acid tse sebelisoang ke hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxy acetic acid, succinic acid kapa citric acid, tseo har'a tsona formic acid kapa acetic acid e leng eona e ntle ka ho fetisisa, ha formic acid e le eona e ntle ka ho fetisisa. Li-acid le aldehydes le tsona li ka eketsoa ka nako e le 'ngoe ho lumella tharollo ho hokahanngoa ka har'a mefuta ea PH e lakatsehang. Karabelo ena hangata e sebelisoa ts'ebetsong ea ho qetela ea ts'ebetso ea ho lokisa ether ea cellulose, e le hore ether ea cellulose e se ke ea qhibiliha, ho bonolo ho e sebelisa metsi a 20 ~ 25℃ ho hlatsoa le ho hloekisa. Ha sehlahisoa se sebelisoa, lintho tse nang le alkaline li ka eketsoa tharollong ea sehlahisoa ho fetola PH ea tharollo hore e be alkaline, 'me sehlahisoa se qhibiliha kapele tharollong. Mokhoa ona o ka boela oa sebelisoa ha tharollo ea ether ea cellulose e sebelisoa ho etsa filimi ebe filimi e phekoloa ho etsa filimi e sa qhibiliheng.
6, anti-enzyme ea hydroxypropyl methyl cellulose
Hydroxypropyl methyl cellulose e hanyetsa enzyme ea derivatives ea cellulose ka khopolo-taba, joalo ka ha lihlopha ka 'ngoe tsa anhydroglucose joalo ka ha ho na le motsoako o tiileng oa lihlopha tse nkeloang sebaka, ho senyeha ha likokoana-hloko ho ka ba bonolo ho tšoaetsoa, empa ha e le hantle sehlahisoa se felileng se nkang sebaka sa boleng bo fetang 1, hape ka ho senyeha ha enzyme, ena ke tlhaloso ea sehlopha ka seng tekanyong ea phetolo ea ketane ea cellulose ha e tšoane, Likokoana-hloko li ka senyeha haufi le lihlopha tsa glucose tse se nang metsi tse sa nkeloang sebaka ho etsa tsoekere, e ka monngoang ke likokoana-hloko e le lijo. Ka hona, haeba tekanyo ea phetolo ea etherification ea cellulose e eketseha, ho hanyetsa ha ether ea cellulose ho khoholeho ea enzymatic ho tla ntlafala. Ho tlalehoa hore tlas'a maemo a laoloang, viscosity e setseng ea hydroxypropyl methyl cellulose (DS=1.9), methyl cellulose (DS=1.83), methyl cellulose (DS=1.66), le hydroxyethyl cellulose (1.7%) e ne e le 13.2%, 7.3%, 3.8%, le 1.7%, ka ho latellana. Hydroxypropyl methyl cellulose e na le bokgoni bo matla ba ho thibela dienzyme. Kahoo hydroxypropyl methylcellulose ke antienzyme e ntle haholo, e kopantsweng le ho hasana ha yona hantle, ho teteana le ho thehwa ha filimi, e sebediswang ka hara dikobo tsa emulsion, jj., hangata ha ho hlokahale hore ho eketswe di-preservative. Leha ho le jwalo, e le ho thibela polokelo ya nako e telele ya tharollo kapa tshilafatso e ka bang teng lefatsheng le kantle, di-preservative di ka eketswa, tseo kgetho ya tsona e ka kgethwang ho ya ka ditlhoko tsa ho qetela tsa tharollo. Phenylmercuric acetate le manganese fluosilicate ke di-preservative tse sebetsang, empa di na le chefo mme di lokela ho sebediswa ka hloko. Ka kakaretso, 1~5mg phenylmercuric acetate e ka eketswa ho litara e nngwe le e nngwe ya tharollo.
7, ts'ebetso ea lera la hydroxypropyl methyl cellulose
Tšebetso ea filimi ea hydroxypropyl methyl cellulose ea hydroxypropyl methyl cellulose e na le filimi e ntle haholo, tharollo ea eona ea metsi kapa tharollo ea organic solvent, e koahetsoeng poleiting ea khalase, kamora ho oma e fetoha filimi e se nang 'mala, e bonaletsang le e thata. E na le khanyetso e ntle ea mongobo 'me e lula e tiile mochesong o phahameng. Joalo ka ho eketsa plasticizer ea hygroscopic, ho ka ntlafatsa bolelele ba eona le ho tenyetseha, ho ntlafatsa ho tenyetseha, glycerol le sorbitol le plasticizer e 'ngoe ke eona e loketseng ka ho fetisisa. Khakanyo ea tharollo e akaretsang ke 2% ~ 3%, tekanyo ea plasticizer ke 10% ~ 20% ea ether ea cellulose. Haeba litaba tsa plasticizer li hlokahala, ketsahalo ea ho fokotseha ha metsi a colloid e ka etsahala mongobong o phahameng. Matla a ho tsikinyeha a plasticizer e ekelitsoeng filiming a maholo haholo ho feta a sa eketsoang, 'me a eketseha ka keketseho ea bongata ba e ekelitsoeng, ha e le hygroscopicity ea filimi le eona e eketseha ka keketseho ea bongata ba plasticizer.
Nako ea poso: Loetse-08-2022