Hydroxypropyl methyl cellulose HPMC imhando ye non-ionic cellulose mixed ether ine mhando dzakasiyana uye ionic methyl carboxymethyl cellulose mixed ether, haibatanidzi nesimbi dzinorema. Imwe oxygen radicals nekuda kwehydroxypropyl methyl cellulose content uye huwandu hwakasiyana hwehydroxypropyl content uye viscosity, yakava mhando dzakasiyana pakushanda, semuenzaniso, methoxyl content yakawanda uye yakaderera yehydroxypropyl varieties, kushanda kwayo kuri pedyo nemethyl cellulose uye yakaderera methoxyl content uye yakakwirira yehydroxypropyl varieties, uye kushanda kwayo kuri pedyo nehydroxypropyl methyl cellulose inogadzirwa. Asi mumhando yega yega, kunyangwe iine huwandu hushoma hwehydroxypropyl kana huwandu hushoma hwemethoxy, kunyungudika mu organic solvents kana flocculation tembiricha mumushonga wemvura, pane musiyano mukuru.
1, kunyungudika kwehydroxypropyl methyl cellulose
Hydroxypropyl methyl cellulose mukunyungudika kwemvura kwehydroxypropyl methyl cellulose chaizvoizvo rudzi rwepropylene oxide (methyl oxypropyl ring) modified methyl cellulose, saka ichiri nechimiro chakafanana nemethyl cellulose cold water soluble uye hot water insoluble. Zvisinei, gelation tembiricha ye modified hydroxy propyl yakakwira zvikuru kupfuura yemethyl cellulose mumvura inopisa. Semuenzaniso, viscosity yehydroxypropyl methylcellulose aqueous solution ine 2% methoxy content DS=0.73 uye hydroxypropyl content MS=0.46 i500 mpa pa20℃. Gel tembiricha yeS's product iri pedyo ne100℃, nepo methyl cellulose yetembiricha imwechete iri 55℃ chete. Kana iri yekunyungudika kwayo mumvura, semuenzaniso, yakagadziridzwa zvikuru mushure mekupwanywa kwehydroxypropyl methylcellulose (chimiro chezviyo 0.2 ~ 0.5mm pa20℃ 4% viscosity yemvura ye2pA? Zvigadzirwa zveS zvinogona kunyungudutswa nyore nyore mumvura pasina kutonhora patembiricha yemumba.
(2) Hydroxypropyl methyl cellulose mu organic solvents kunyungudika kwehydroxypropyl methyl cellulose mu organic solvents kunyungudika, iri naniwo kupfuura methyl cellulose, methyl cellulose inoda mu methoxy substitution degree ye2.1 kana kupfuura zvigadzirwa, uye ine hydroxypropyl MS=1.5~1.8 uye methoxy DS=0.2~1.0, High viscosity hydroxypropyl methyl cellulose ine total substitution degree iri pamusoro pe1.8 inonyungudika mu anhydrous methanol uye ethanol solutions, uye ine thermoplastic uye water solubility. Inonyungudikawo mu chlorinated hydrocarbons dzakadai se dichloromethane ne trichloromethane, uye organic solvents dzakadai se acetone, isopropyl alcohol, uye diacetone alcohol. Kunyungudika kwayo mu organic solvents kuri nani pane mvura solubility.
2, hydroxypropyl methyl cellulose viscosity yezvinhu zvinopesvedzera
Hydroxypropyl methylcellulose viscosity factors hydroxypropyl methylcellulose standard viscosity determination, uye mamwe ether cellulose zvakafanana, zviri pa20℃ ne 2% aqueous solution se standard determination. Viscosity yechigadzirwa chimwe chete, nekuwedzera kwe concentration nekuwedzera, concentration yakafanana yezvigadzirwa zvakasiyana zvemamorekuru, molecular weight yechigadzirwa ine viscosity yakakwira. Hukama hwayo netembiricha hwakafanana nehwe methyl cellulose. Kana tembiricha yakwira, viscosity inotanga kudzikira, asi kana yasvika pane imwe tembiricha, viscosity inomuka kamwe kamwe uye gelation inoitika. Gelation tembiricha yezvigadzirwa zvine viscosity yakaderera yakakwira kupfuura yezvigadzirwa zvine viscosity yakakwira. Level ye gel point yayo, pamusoro pe high and low viscosity ye ether, asiwo ne ether methoxy uye hydroxypropyl group composition ratio uye total degree of substitution zvine chekuita. Zvinofanira kucherechedzwa kuti hydroxypropyl methylcellulose ipseudoplastic zvakare; mhinduro yayo yakagadzikana kana yakachengetwa patembiricha yemumba uye hairatidze chero kuora kwe viscosity kunze kwekunge paine mukana we enzyme degradation.
3, hydroxypropyl methyl cellulose acid uye alkaline resistance
Hydroxypropyl methylcellulose acid, alkali hydroxypropyl methylcellulose acid uye alkali, kazhinji yakagadzikana, muhuwandu hwePH2 ~ 12 haina kukanganiswa, inogona kutsungirira huwandu hwakati hweasidhi yakareruka, senge formic acid, acetic acid, citric acid, succinic acid, phosphoric acid, boric acid, nezvimwewo. Asi acid yakaomeswa ine simba rekuderedza viscosity. Alkali dzakadai se caustic soda, caustic potassium uye lime water hazvina simba pairi, asi simba rekuwedzera viscosity yemushonga richadzikira zvishoma nezvishoma mune ramangwana.
4, hydroxypropyl methyl cellulose inogona kusanganiswa
Mushonga weHydroxypropyl methyl cellulose unogona kusanganiswa nemakemikari epolymer anonyungudika mumvura, uye wova mhinduro yakafanana yakajeka ine viscosity yakakura. Makemikoro aya ane mamorekuru akawanda ndee polyethylene glycol, polyvinyl acetate, polysilicone, polymethyl vinyl siloxane uye hydroxyethyl cellulose uye methyl cellulose, nezvimwewo. Makemikoro epolymer echisikigo akadai segum Arabic, locustbean gum, thorn tree gum nezvimwewo ane musanganiswa wakanaka nemhinduro yawo. Hydroxypropyl methyl cellulose inogonawo kusanganiswa ne stearic acid kana palmitic acid mannitol ester kana sorbitol ester, asiwo ne glycerol, sorbitol ne mannitol, makemikoro aya anogona kushandiswa se hydroxypropyl methyl cellulose plasticizer.
5, hydroxypropyl methyl cellulose isinganyungudike mumvura
Hydroxypropyl methyl cellulose isinganyungudike mumvura-inonyungudika cellulose ether, inogona kusanganiswa ne aldehydes pamusoro, uye inoita kuti ether iyi inonyungudika mumvura iite seyakagadziriswa, isinganyungudike mumvura. Uye inoita kuti hydroxypropyl methylcellulose isanyungudike aldehyde, formaldehyde, glyoxal, succinaldehyde, dialdehyde, nezvimwewo, kushandiswa kwe formaldehyde kunofanira kunyatsotarisa kukosha kwe PH kwemhinduro, umo glyoxal reaction inokurumidza, saka mukugadzirwa kwemaindasitiri inowanzoshandiswa glyoxal se cross-linking agent. Chiyero chemhando iyi ye crosslinking agent mumhinduro i0.2% ~ 10% ye ether mass, yakanakisa i7% ~ 10%, senge kushandiswa kwe glyoxal ne 3.3% ~ 6% ndiyo yakakodzera. Kupisa kwekurapa kwakajairika i0 ~ 30℃, nguva i1 ~ 120min. Kugadziriswa kwe crosslinking kunofanirwa kuitwa mumamiriro ezvinhu ane acidic. Kazhinji, inorganic strong acid kana organic carboxylic acid inowedzerwa mumushonga kuti igadzirise PH yemushonga kuti ive inenge 2~6, zviri nani pakati pe4~6, uye maaldehydes anowedzerwa kuti pave ne cross-linking reaction. Maacid anoshandiswa ihydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxy acetic acid, succinic acid kana citric acid, pakati pawo iformic acid kana acetic acid ndiyo yakanakisa, nepo formic acid iriyo yakanakisa. Maacid nealdehydes zvinogonawo kuwedzerwa panguva imwe chete kuti mhinduro isanganiswe muPH range inodiwa. Iyi reaction inowanzo shandiswa mukupedzisira kwegadziriro ye cellulose ether, kuitira kuti cellulose ether isanyungudike, zviri nyore kushandisa 20~25℃ mvura yekugeza nekuchenesa. Kana chigadzirwa chikashandiswa, zvinhu zvealkaline zvinogona kuwedzerwa mumushonga wemushonga kuti ugadzirise PH yemushonga kuti ive alkaline, uye chigadzirwa chinokurumidza kunyungudika mumushonga. Nzira iyi inogona kushandiswawo kana mushonga we cellulose ether uchishandiswa kugadzira firimu uye firimu racho rozorapwa kuti rigadzire firimu risinganyungudike.
6, hydroxypropyl methyl cellulose anti-enzyme
Hydroxypropyl methyl cellulose enzyme resistance of cellulose derivatives in theory, semamwe mapoka ega ega anhydroglucose akadai sekuti kune musanganiswa wakasimba wekutsiva mapoka, kukanganiswa kwetupukanana hakunyanyi kubatwa nehutachiona, asi kutaura chokwadi chigadzirwa chakapedzwa chekutsiva kukosha kupfuura 1, zvakare nekuora kwe enzyme, iyi ndiyo tsananguro yeboka rega rega muchikamu chekutsiva cellulose chain haisi yakafanana, Tupukanana tunogona kutsakatika pedyo nemapoka eglucose asina kutsiva akapera mvura kuti tigadzire shuga, iyo inogona kutorwa netupukanana sechikafu. Naizvozvo, kana chiyero chekutsiva etherification che cellulose chikawedzera, kupesana kwe cellulose ether kune enzyme erosion kuchawedzerwa. Zvinonzi pasi pemamiriro ezvinhu akadzorwa, viscosity yakasara yehydroxypropyl methyl cellulose (DS=1.9), methyl cellulose (DS=1.83), methyl cellulose (DS=1.66), uye hydroxyethyl cellulose (1.7%) yaive 13.2%, 7.3%, 3.8%, uye 1.7%, zvichiteerana. Hydroxypropyl methyl cellulose ine simba guru rekudzivirira maenzyme. Saka hydroxypropyl methylcellulose inodzivirira maenzyme zvakanaka, pamwe chete nekupararira kwayo kwakanaka, kukora uye kugadzirwa kwefirimu, inoshandiswa mu emulsion coatings, nezvimwewo, kazhinji haidi kuwedzera zvinochengetedza. Zvisinei, kuitira kudzivirira kuchengetwa kwenguva refu kwemushonga kana kusvibiswa kunogona kubva kunze, zvinochengetedza zvinogona kuwedzerwa, izvo zvinosarudzwa zvinogona kusarudzwa zvichienderana nezvinodiwa zvekupedzisira zvemushonga. Phenylmercuric acetate uye manganese fluosilicate zvinochengetedza zvinoshanda, asi zvine chepfu uye zvinofanirwa kushandiswa nokungwarira. Kazhinji, 1~5mg phenylmercuric acetate inogona kuwedzerwa kune rimwe nerimwe litre remushonga.
7, mashandiro e hydroxypropyl methyl cellulose membrane
Hydroxypropyl methyl cellulose firimu inoshanda zvakanaka. Hydroxypropyl methyl cellulose firimu ine firimu rakanaka kwazvo, mhinduro yayo yemvura kana organic solvent solution, yakaputirwa pagirazi, mushure mekuomeswa inova isina ruvara, yakajeka uye yakasimba firimu. Ine hunyoro hwakanaka uye inoramba yakasimba pakupisa kwakanyanya. Sekuwedzera hygroscopic plasticizer, inogona kuwedzera kureba kwayo uye kuchinjika kwayo, kuti ivandudze flexure, glycerol nesorbitol nezvimwe plasticizer ndizvo zvakakodzera. Kuwanda kwemhinduro kwakajairika i2% ~ 3%, plasticizer dosage i10% ~ 20% ye cellulose ether. Kana zviri mukati me plasticizer zvichidikanwa, shrinkage effect ye colloid dehydration inogona kuitika muhunyoro hwakawanda. Simba rekusimba re plasticizer yakawedzerwa mufirimu rakakura kupfuura risina kuwedzerwa, uye rinowedzera nekuwedzera kwehuwandu hwekuwedzera, sezvo hygroscopicity yefirimu inowedzerawo nekuwedzera kwehuwandu hwe plasticizer.
Nguva yekutumira: Gunyana-08-2022