Cia peb tham txog hydroxypropyl methyl celluloseHPMCthiab yuav ntsuas nws cov viscosity li cas. Qhov viscosity ntawm no yog hais txog qhov viscosity pom tseeb, uas yog qhov tseem ceeb rau hydroxypropyl methyl cellulose.
Tus qauv. Cov txheej txheem ntsuas ib txwm yog kev ntsuas viscosity rotational, kev ntsuas capillary viscosity thiab kev ntsuas viscosity poob. Txoj kev txiav txim siab ntawm hydroxypropyl methyl cellulose yog capillary adhesion.
Txoj kev txiav txim siab qib, siv Uchs viscometer. Feem ntau qhov kev txiav txim siab ntawm cov tshuaj yog 2% aqueous kua, cov mis yog: V = Kdt. V yog viscosity hauv mpa. s thiab K yog viscometer tas mus li.
D yog qhov ceev ntawm qhov kub tas li thiab T yog lub sijhawm los ntawm sab saud mus rau hauv qab los ntawm lub viscometer hauv vib nas this. Txoj kev ua haujlwm no nyuaj dua, yog tias muaj cov khoom tsis yaj.
Cov lus yooj yim ua rau muaj qhov yuam kev, nws nyuaj rau txheeb xyuas qhov zoo ntawm hydroxypropyl methyl cellulose. Tam sim no nws feem ntau siv los ntsuas qhov viscosity ntawm lub rotary viscometer, kev siv dav dav hauv Suav teb.
Cov mis ntawm NDJ-1 viscometer yog η = Kα. η yog viscosity, kuj nyob rau hauv mpa. s, K yog tus coefficient ntawm viscometer, thiab α yog qhov nyeem ntawm tus pointer viscometer.
Hydroxypropyl methyl cellulose 2% viscosity xeem txoj kev:
1, txoj kev no yog qhov tsim nyog rau kev txiav txim siab ntawm cov kua dej tsis-Newtonian (cov kua polymer, kev ncua, kua emulsion dispersion lossis cov kua surfactant, thiab lwm yam).
2. Cov Cuab Yeej thiab cov khoom siv
2.1 Lub tshuab ntsuas viscometer (NdJ-1 thiab NDJ-4 yog qhov yuav tsum tau ua los ntawm Suav Pharmacopoeia)
2.2 Qhov kub thiab txias tas li ntawm qhov dej da dej tas li qhov tseeb ntawm 0.10C
2.3 Qhov ntsuas kub yog 0.20C, uas tau txheeb xyuas tas li.
2.4 Lub ntsuas zaus Viscometers siv cov kev ntsuas kev ruaj khov zaus (xws li NDJ-1 thiab NDJ-4) yuav tsum tau tseg cia. Qhov tseeb ntawm 1%. A
8. Cov qauv 0g raug ntsuas kom raug thiab muab tso rau hauv lub khob qhuav, toned 400mL siab. Ntxiv li 100mL ntawm 80-90 degree dej kub thiab do rau 10 feeb kom sib cais.
Sib tov kom sib npaug, do thiab ntxiv dej txias rau hauv 400mL tag nrho. Lub sijhawm no, do tas li rau 30 feeb kom ua tau 2% (W/W), thiab muab tso rau hauv lub tub yees kom txias kom txog thaum nws ua dej khov nyias nyias rau ntawm qhov chaw.
Tshem tawm thiab muab tso rau hauv lub tank kub tas li kom qhov kub hauv nruab nrab mus rau 20 ℃ 0.1 ℃.
3.1 Kev teeb tsa thiab kev ua haujlwm ntawm lub cuab yeej yuav tsum tau ua raws li cov lus qhia ua haujlwm ntawm lub cuab yeej, thiab lub rotor thiab rotor tsim nyog yuav tsum tau xaiv raws li qhov ntau ntawm viscosity ntawm cov khoom kuaj thiab cov kev cai ntawm pharmacopoeia nyob rau hauv cov ntawv nyeem ntawm cov khoom.
Kev sib hloov ceev.
3.2 Kho qhov kub ntawm dej kom ruaj khov raws li qhov kev txiav txim siab hauv qab txhua yam tshuaj.
3.3 Cov khoom kuaj tau muab tso rau hauv lub thawv uas tau teev tseg los ntawm lub cuab yeej, thiab lub kaum sab xis (a) tau ntsuas raws li txoj cai tom qab 30 feeb ntawm qhov kub tas li. Tua lub cev muaj zog thiab rov pib dua rau kev txiav txim siab ib zaug ntxiv
Qhov sib txawv ntawm cov nqi nruab nrab yuav tsum tsis pub tshaj 3%, txwv tsis pub yuav tsum ntsuas qhov thib peb.
3.4 Xam tus nqi nruab nrab ntawm ob qhov kev sim raws li cov mis kom tau txais qhov dynamic viscosity ntawm cov khoom sim.
4. Sau thiab xam
4.1 Sau cov qauv rotary viscometer, tus lej rotor thiab qhov ceev siv, viscometer constant (K 'tus nqi), qhov kub ntsuas, thiab txhua qhov ntsuas. Tus nqi.
Cov qauv xam ntawm 4.2
Dynamic viscosity (MPa”s)=Ka qhov twg K yog viscometer tas li ntsuas nrog cov kua dej txheem ntawm cov viscosity paub thiab A yog lub kaum sab xis deflection
Lub sijhawm tshaj tawm: Plaub Hlis-25-2024