Umphumela wokuqukethwe kwe-hydroxypropyl ekushiseni kwejeli ye-HPMC

I-Hydroxypropyl methylcellulose (HPMC) iyi-polymer evame ukusetshenziswa emanzini, esetshenziswa kakhulu kwezokwelapha, izimonyo, ukudla kanye nezimboni, ikakhulukazi ekulungiseleleni ama-gel. Izakhiwo zayo zomzimba kanye nokuziphatha kokuncibilika kunomthelela omkhulu ekusebenzeni kahle kwezicelo ezahlukene. Izinga lokushisa le-gelation le-gel ye-HPMC lingenye yezakhiwo zayo ezibalulekile zomzimba, ezithinta ngqo ukusebenza kwayo kumalungiselelo ahlukahlukene, njengokukhululwa okulawulwayo, ukwakheka kwefilimu, ukuzinza, njll.

1. Isakhiwo kanye nezakhiwo ze-HPMC

I-HPMC iyi-polymer encibilika emanzini etholakala ngokungenisa izinto ezimbili ezithatha indawo, i-hydroxypropyl kanye ne-methyl, ku-skeleton yama-molecule e-cellulose. Isakhiwo sayo sama-molecule siqukethe izinhlobo ezimbili zezinto ezithatha indawo: i-hydroxypropyl (-CH2CHOHCH3) kanye ne-methyl (-CH3). Izici ezifana nokuqukethwe okuhlukile kwe-hydroxypropyl, izinga le-methylation, kanye nezinga le-polymerization kuzoba nomthelela obalulekile ekuncibilikeni, ekuziphatheni kwe-gelling, kanye nezakhiwo ze-mechanical ze-HPMC.

Ezixazululweni zamanzi, i-AnxinCel®HPMC yakha izixazululo eziqinile ze-colloidal ngokwakha izibopho ze-hydrogen nama-molecule amanzi kanye nokusebenzisana nohlaka lwayo olusekelwe ku-cellulose. Lapho indawo yangaphandle (njengokushisa, amandla e-ionic, njll.) ishintsha, ukusebenzisana phakathi kwama-molecule e-HPMC kuzoshintsha, okuholela ekukhuleni kwe-gelation.

2. Incazelo kanye nezici ezithonya izinga lokushisa le-gelation

Izinga lokushisa le-Gelation (Izinga lokushisa le-Gelation, T_gel) libhekisela ezingeni lokushisa lapho isixazululo se-HPMC siqala khona ukushintsha kusuka koketshezi siye kokuqinile lapho izinga lokushisa lesisombululo likhuphuka liye ezingeni elithile. Kuleli zinga lokushisa, ukunyakaza kwamaketanga ama-molecule e-HPMC kuzovinjelwa, kwakha isakhiwo senethiwekhi esinezinhlangothi ezintathu, okuholela entweni efana nejeli.

Izinga lokushisa le-gelation le-HPMC lithintwa yizici eziningi, esinye sezici ezibaluleke kakhulu okuqukethwe yi-hydroxypropyl. Ngaphezu kokuqukethwe yi-hydroxypropyl, ezinye izici ezithinta izinga lokushisa le-gel zifaka phakathi isisindo sama-molecule, ukuhlushwa kwesisombululo, inani le-pH, uhlobo lwe-solvent, amandla e-ionic, njll.

3. Umphumela wokuqukethwe kwe-hydroxypropyl ekushiseni kwejeli ye-HPMC

3.1 Ukwanda kokuqukethwe kwe-hydroxypropyl kuholela ekwandeni kokushisa kwejeli

Izinga lokushisa le-gelation le-HPMC lihlobene kakhulu nezinga lokufakwa esikhundleni kwe-hydroxypropyl ku-molecule yayo. Njengoba okuqukethwe kwe-hydroxypropyl kukhuphuka, inani lezinto ezithatha indawo ye-hydrophilic ku-HPMC molecular chain liyakhula, okuholela ekuxhumaneni okuthuthukisiwe phakathi kwe-molecule namanzi. Lokhu kuxhumana kubangela ukuthi izintambo zama-molecule zeluleke kakhulu, ngaleyo ndlela kunciphisa amandla okuxhumana phakathi kwezintambo zama-molecule. Ngaphakathi kobubanzi obuthile bokuhlushwa, ukwandisa okuqukethwe kwe-hydroxypropyl kusiza ukuthuthukisa izinga lokuswakama futhi kukhuthaza ukuhlelwa okuhlangene kwama-molecule chain, ukuze isakhiwo senethiwekhi sakhiwe ekushiseni okuphezulu. Ngakho-ke, izinga lokushisa le-gelation livame ukwanda lapho i-hydroxypropyl ikhuphuka ngokuqukethwe okwandayo.

I-HPMC enokuqukethwe okuphezulu kwe-hydroxypropyl (njenge-HPMC K15M) ivame ukubonisa izinga lokushisa eliphakeme le-gelation ngesilinganiso esifanayo kune-AnxinCel®HPMC enokuqukethwe okuphansi kwe-hydroxypropyl (njenge-HPMC K4M). Lokhu kungenxa yokuthi okuqukethwe okuphezulu kwe-hydroxypropyl kwenza kube nzima ngama-molecule ukusebenzisana nokwakha amanethiwekhi emazingeni okushisa aphansi, okudinga amazinga okushisa aphezulu ukunqoba lokhu kufakwa kwamanzi nokukhuthaza ukusebenzisana kwama-molecular ukuze kwakheke isakhiwo senethiwekhi esinezinhlangothi ezintathu.

3.2 Ubudlelwano phakathi kokuqukethwe kwe-hydroxypropyl kanye nokuhlushwa kwesisombululo

Ukuhlushwa kwesisombululo nakho kuyisici esibalulekile esithinta izinga lokushisa le-gelation le-HPMC. Ezixazululweni ze-HPMC ezihlushwa kakhulu, ukusebenzisana kwama-molecule kunamandla, ngakho izinga lokushisa le-gelation lingaba phezulu noma ngabe okuqukethwe yi-hydroxypropyl kuphansi. Uma kuhlushwa okuphansi, ukusebenzisana phakathi kwama-molecule e-HPMC kubuthakathaka, futhi isixazululo cishe singaba yi-gel emazingeni okushisa aphansi.

Uma okuqukethwe yi-hydroxypropyl kukhuphuka, yize i-hydrophilicity ikhuphuka, izinga lokushisa eliphakeme lisadingeka ukuze kwakhiwe ijeli. Ikakhulukazi ngaphansi kwezimo zokuhlushwa okuphansi, izinga lokushisa le-gelation likhuphuka kakhulu. Lokhu kungenxa yokuthi i-HPMC enokuqukethwe okuphezulu kwe-hydroxypropyl kunzima kakhulu ukubangela ukusebenzisana phakathi kwamaketanga ama-molecule ngokushintsha kwezinga lokushisa, futhi inqubo ye-gelation idinga amandla okushisa engeziwe ukuze kunqotshwe umphumela we-hydration.

3.3 Umphumela wokuqukethwe kwe-hydroxypropyl enqubweni yokugaya

Ngaphakathi kobubanzi obuthile bokuqukethwe kwe-hydroxypropyl, inqubo yokugaya ilawulwa ukusebenzisana phakathi kokufaka amanzi kanye namaketanga ama-molecule. Lapho okuqukethwe kwe-hydroxypropyl ku-molecule ye-HPMC kuphansi, ukugaya amanzi kuba buthakathaka, ukusebenzisana phakathi kwama-molecule kuba namandla, futhi izinga lokushisa eliphansi lingakhuthaza ukwakheka kwejeli. Lapho okuqukethwe kwe-hydroxypropyl kuphakeme, ukugaya amanzi kuba ngcono kakhulu, ukusebenzisana phakathi kwamaketanga ama-molecule kuba buthakathaka, futhi izinga lokushisa lokugaya amanzi liyakhuphuka.

Okuqukethwe okuphezulu kwe-hydroxypropyl kungaholela ekwandeni kwe-viscosity yesisombululo se-HPMC, ushintsho oluvame ukwandisa izinga lokushisa lokuqala kwe-gelation.

Okuqukethwe kwe-hydroxypropyl kunomthelela omkhulu ekushiseni kwe-gelation kweI-HPMCNjengoba okuqukethwe yi-hydroxypropyl kukhuphuka, i-hydrophilicity ye-HPMC iyanda futhi ukusebenzisana phakathi kwamaketanga ama-molecule kuyawohloka, ngakho-ke izinga lokushisa layo le-gelation livame ukukhuphuka. Lesi simo singachazwa ngendlela yokusebenzisana phakathi kwe-hydration kanye namaketanga ama-molecule. Ngokulungisa okuqukethwe yi-hydroxypropyl ye-HPMC, ukulawulwa okunembile kwezinga lokushisa le-gelation kungafinyelelwa, ngaleyo ndlela kuthuthukiswe ukusebenza kwe-HPMC kwezemithi, ukudla kanye nezinye izinhlelo zokusebenza zezimboni.