I-Hydroxypropyl methylcellulose (HPMC) yipolymer esetyenziswa kakhulu emanzini, esetyenziswa kakhulu kumayeza, kwizinto zokuthambisa, ekutyeni nakwiindawo zoshishino, ingakumbi ekulungiseleleni iijeli. Iimpawu zayo zomzimba kunye nendlela ezisebenza ngayo ekunyibilikeni zinempembelelo enkulu ekusebenzeni kakuhle kwizicelo ezahlukeneyo. Ubushushu be-gelation yejeli ye-HPMC yenye yezona mpawu zayo ziphambili zomzimba, ezichaphazela ngokuthe ngqo ukusebenza kwayo kumalungiselelo ahlukeneyo, njengokukhululwa okulawulwayo, ukwakheka kwefilimu, ukuzinza, njl.
1. Ulwakhiwo kunye neempawu ze-HPMC
I-HPMC yipolymer enyibilikayo emanzini efunyenwe ngokungenisa izinto ezimbini ezithatha indawo, i-hydroxypropyl kunye ne-methyl, kwi-skeleton ye-molecular cellulose. Ulwakhiwo lwayo lwe-molecular luneentlobo ezimbini zezinto ezithatha indawo: i-hydroxypropyl (-CH2CHOHCH3) kunye ne-methyl (-CH3). Izinto ezifana nomxholo owahlukileyo we-hydroxypropyl, inqanaba le-methylation, kunye nenqanaba le-polymerization ziya kuba nefuthe elibalulekileyo ekunyibilikeni, ukuziphatha kwe-gelling, kunye neempawu ze-mechanical ze-HPMC.
Kwizisombululo zamanzi, i-AnxinCel®HPMC yenza izisombululo ze-colloidal ezizinzileyo ngokwenza iibhondi ze-hydrogen kunye neemolekyuli zamanzi kunye nokusebenzisana ne-skeleton yayo esekelwe kwi-cellulose. Xa imeko-bume yangaphandle (njengobushushu, amandla e-ionic, njl.njl.) itshintsha, ukusebenzisana phakathi kweemolekyuli ze-HPMC kuya kutshintsha, nto leyo ephumela kwi-gelation.
2. Inkcazo kunye nezinto ezichaphazela ubushushu be-gelation
Ubushushu beGelation (Ubushushu beGelation, T_gel) bubhekisa kubushushu apho isisombululo se-HPMC siqala khona ukutshintsha ukusuka kulwelo ukuya kuqinileyo xa ubushushu besisombululo bunyuka busiya kwinqanaba elithile. Kolu bushushu, intshukumo yeetsheyini zeemolekyuli ze-HPMC iya kuthintelwa, yenze isakhiwo senethiwekhi esinemilinganiselo emithathu, nto leyo ephumela kwinto efana nejeli.
Ubushushu be-gelation ye-HPMC buchaphazeleka zizinto ezininzi, enye yezona zinto zibalulekileyo ngumxholo we-hydroxypropyl. Ukongeza kumxholo we-hydroxypropyl, ezinye izinto ezichaphazela ubushushu be-gel ziquka ubunzima be-molecular, uxinzelelo lwesisombululo, ixabiso le-pH, uhlobo lwe-solvent, amandla e-ionic, njl.
3. Impembelelo yomxholo we-hydroxypropyl kubushushu bejeli ye-HPMC
3.1 Ukwanda komxholo we-hydroxypropyl kukhokelela ekwandeni kobushushu bejeli
Ubushushu be-gelation ye-HPMC bunxulumene kakhulu nomlinganiselo wokutshintshwa kwe-hydroxypropyl kwi-molecule yayo. Njengoko umxholo we-hydroxypropyl usanda, inani lezinto ezithatha indawo ye-hydrophilic kwi-molecular chain ye-HPMC liyanda, nto leyo ebangela ukuba kubekho unxibelelwano oluphuculweyo phakathi kwe-molecule namanzi. Olu nxibelelwano lubangela ukuba ii-molecular chain zoluleke ngakumbi, ngaloo ndlela kunciphisa amandla onxibelelwano phakathi kwee-molecular chain. Ngaphakathi koluhlu oluthile loxinzelelo, ukwandisa umxholo we-hydroxypropyl kunceda ukuphucula umgangatho wokufuma kunye nokukhuthaza ulungelelwaniso oludibeneyo lwee-molecular chain, ukuze isakhiwo senethiwekhi sinokwenziwa kubushushu obuphezulu. Ke ngoko, ubushushu be-gelation buhlala bunyuka xa i-hydroxypropyl inyuka ngomxholo okhulayo.
I-HPMC enomxholo ophezulu we-hydroxypropyl (njenge-HPMC K15M) idla ngokubonisa ubushushu obuphezulu be-gelation kuxinzelelo olufanayo kune-AnxinCel®HPMC enomxholo ophantsi we-hydroxypropyl (njenge-HPMC K4M). Oku kungenxa yokuba umxholo ophezulu we-hydroxypropyl wenza kube nzima ngakumbi kwiimolekyuli ukusebenzisana nokwenza iinethiwekhi kubushushu obuphantsi, nto leyo efuna ubushushu obuphezulu ukuze yoyise olu manzi kwaye ikhuthaze ukusebenzisana phakathi kweemolekyuli ukwenza isakhiwo senethiwekhi esinemilinganiselo emithathu.
3.2 Ubudlelwane phakathi komxholo we-hydroxypropyl kunye noxinzelelo lwesisombululo
Uxinzelelo lwesisombululo lukwayinto ebalulekileyo echaphazela ubushushu be-gelation ye-HPMC. Kwizisombululo ze-HPMC ezinoxinzelelo oluphezulu, ukusebenzisana phakathi kweemolekyuli kunamandla, ngoko ke ubushushu be-gelation bunokuba phezulu nokuba umxholo we-hydroxypropyl uphantsi. Xa uxinano oluphantsi, ukusebenzisana phakathi kweemolekyuli ze-HPMC kubuthathaka, kwaye isisombululo sinokuthi sijike kubushushu obuphantsi.
Xa umxholo we-hydroxypropyl usanda, nangona i-hydrophilicity iyanda, kusafuneka ubushushu obuphezulu ukuze kwenziwe ijeli. Ingakumbi phantsi kweemeko eziphantsi zoxinzelelo, ubushushu be-gelation buyanda kakhulu. Oku kungenxa yokuba i-HPMC enomxholo ophezulu we-hydroxypropyl kunzima ngakumbi ukukhuthaza ukusebenzisana phakathi kwee-molecular chains ngokutshintsha kobushushu, kwaye inkqubo ye-gelation ifuna amandla obushushu ongezelelweyo ukuze yoyise isiphumo se-hydration.
3.3 Impembelelo yomxholo we-hydroxypropyl kwinkqubo yokugaya
Ngaphakathi koluhlu oluthile lomxholo we-hydroxypropyl, inkqubo yokugaya ilawulwa kukunxibelelana phakathi kokufaka amanzi kunye neetsheyini zemolekyuli. Xa umxholo we-hydroxypropyl kwimolekyuli ye-HPMC uphantsi, ukufakelwa kwamanzi kuba buthathaka, ukusebenzisana phakathi kweemolekyuli kuba namandla, kwaye ubushushu obuphantsi bunokukhuthaza ukwakheka kwejeli. Xa umxholo we-hydroxypropyl uphezulu, ukufakelwa kwamanzi kuba bhetele kakhulu, ukusebenzisana phakathi kweetsheyini zemolekyuli kuba buthathaka, kwaye ubushushu bokugaya buyanda.
Umthamo ophezulu we-hydroxypropyl unokukhokelela ekwandeni kwe-viscosity yesisombululo se-HPMC, utshintsho oluthi ngamanye amaxesha lunyuse ubushushu bokuqala kwe-gelation.
Umxholo we-hydroxypropyl unempembelelo enkulu kubushushu be-gelationI-HPMCNjengoko umxholo we-hydroxypropyl usanda, i-hydrophilicity ye-HPMC iyanda kwaye ukusebenzisana phakathi kwee-molecular chains kuyawohloka, ngoko ke ubushushu bayo be-gelation buhlala busanda. Le nto ingachazwa yindlela yokusebenzisana phakathi kwe-hydration kunye nee-molecular chains. Ngokulungisa umxholo we-hydroxypropyl we-HPMC, ulawulo oluchanekileyo lobushushu be-gelation lunokufezekiswa, ngaloo ndlela kuphuculwe ukusebenza kwe-HPMC kumayeza, ukutya kunye nezinye izicelo zoshishino.
Ixesha leposi: Jan-04-2025