Hydroxypropyl methylcellulose (HPMC) waa polymer si caadi ah loo isticmaalo oo biyaha ku milma, oo si weyn loogu isticmaalo daawooyinka, qurxinta, cuntada iyo beeraha warshadaha, gaar ahaan diyaarinta jel. Sifooyinka jireed iyo dhaqanka kala diriddu waxay saameyn weyn ku leeyihiin waxtarka codsiyada kala duwan. Heerkulka jelitaanka ee jel HPMC waa mid ka mid ah sifooyinka muhiimka ah ee jireed, kaas oo si toos ah u saameeya waxqabadkiisa diyaargarowyada kala duwan, sida sii deynta la xakameeyey, sameynta filimka, xasilloonida, iwm.
1. Qaab-dhismeedka iyo sifooyinka HPMC
HPMC waa polymer-ka biyaha ku milma ee laga helo qalfoofka molecular-ka ee cellulose-ka iyadoo la gelinayo laba beddelka, hydroxypropyl iyo methyl. Qaab-dhismeedkiisa molecular-ka wuxuu ka kooban yahay laba nooc oo beddel ah: hydroxypropyl (-CH2CHOHCH3) iyo methyl (-CH3). Arrimaha sida hydroxypropyl-ka kala duwan, heerka methylation-ka, iyo heerka polymerization-ka ayaa saameyn muhiim ah ku yeelan doona milmida, dhaqanka jelling-ka, iyo sifooyinka farsamada ee HPMC.
Xalalka biyaha, AnxinCel®HPMC waxay samaysaa xalal kolloid ah oo deggan iyadoo sameysa isku xidhka haydarojiin iyo molecules-ka biyaha iyo la falgalka qalfoofkeeda ku salaysan cellulose. Marka deegaanka dibadda (sida heerkulka, xoogga ionic, iwm.) uu isbeddelo, isdhexgalka u dhexeeya molecules-ka HPMC wuu isbeddeli doonaa, taasoo keenta jelitaanka.
2. Qeexidda iyo arrimaha saameeya heerkulka jelitaanka
Heerkulka Jelaynta (Heerkulka Jelaynta, T_gel) waxaa loola jeedaa heerkulka uu xalka HPMC ka bilaabo inuu ka gudbo dareeraha una gudbo adag marka heerkulka xalka uu gaaro heer gaar ah. Heerkulkan, dhaqdhaqaaqa silsiladaha molecular-ka ee HPMC waa la xaddidi doonaa, taasoo samaynaysa qaab-dhismeed shabakad saddex-geesood ah, taasoo keenta walax u eg jel.
Heerkulka jelitaanka ee HPMC waxaa saameeya arrimo badan, mid ka mid ah arrimaha ugu muhiimsan waa hydroxypropyl. Marka laga soo tago hydroxypropyl, arrimo kale oo saameeya heerkulka jel waxaa ka mid ah miisaanka molecular, fiirsashada xalka, qiimaha pH, nooca dareeraha, xoogga ionic, iwm.
3. Saamaynta maadada hydroxypropyl ee heerkulka jelka HPMC
3.1 Kordhinta maadada hydroxypropyl waxay keentaa kororka heerkulka jelka
Heerkulka jelitaanka ee HPMC wuxuu si dhow ula xiriiraa heerka beddelka hydroxypropyl ee molecule-kiisa. Marka heerka hydroxypropyl uu sii kordho, tirada walxaha hydrophilic-ga ah ee ku jira silsiladda molecule-ka ee HPMC ayaa kordha, taasoo keenta is-dhexgalka sii kordhaya ee u dhexeeya molecule-ka iyo biyaha. Is-dhexgalkani wuxuu sababaa in silsiladaha molecule-ku ay sii fidaan, taasoo yareynaysa xoogga isdhexgalka silsiladaha molecule-ka. Iyada oo ku jirta xaddi gaar ah oo fiirsasho ah, kordhinta heerka hydroxypropyl-ka waxay gacan ka geysataa kor u qaadista heerka fuuq-baxa waxayna kor u qaaddaa isku-dubaridka labada dhinac ee silsiladaha molecule-ka, si qaab-dhismeedka shabakadu u samaysmo heerkul sare. Sidaa darteed, heerkulka jelitaanka badanaa wuu kordhaa marka hydroxypropyl-ku kordho iyadoo la kordhinayo nuxurka.
HPMC oo leh hydroxypropyl sare (sida HPMC K15M) waxay u egtahay inay muujiso heerkul ka sarreeya isku-darka marka loo eego AnxinCel®HPMC oo leh hydroxypropyl hooseeya (sida HPMC K4M). Tani waa sababta oo ah hydroxypropyl sare waxay ka dhigaysaa molecules inay isdhexgalaan oo ay sameeyaan shabakado heerkul hoose, taasoo u baahan heerkul sare si ay uga gudbaan fuuq-baxan una horumariyaan isdhexgalka molecular-ka si loo sameeyo qaab-dhismeed shabakad saddex-geesood ah.
3.2 Xiriirka ka dhexeeya maadada hydroxypropyl iyo fiirsashada xalka
Fiirsashada xalka sidoo kale waa arrin muhiim ah oo saameysa heerkulka jelitaanka ee HPMC. Xalalka HPMC ee xoogga badan, isdhexgalka molecular-ka ayaa xoog badan, sidaa darteed heerkulka jelitaanka ayaa laga yaabaa inuu sarreeyo xitaa haddii maadada hydroxypropyl ay hooseyso. Fiirsashada hoose, isdhexgalka molecules-ka HPMC waa mid daciif ah, xalkana wuxuu u badan yahay inuu jeleeyo heerkulka hoose.
Marka heerka hydroxypropyl uu kordho, inkastoo heerka hydrophilicity uu kordho, heerkul sare ayaa weli loo baahan yahay si loo sameeyo jel. Gaar ahaan xaaladaha hoose ee fiirsashada, heerkulka gelation-ku si weyn ayuu u kordhaa. Tani waa sababta oo ah HPMC oo leh heerka hydroxypropyl sare ayaa aad u adag in la kiciyo isdhexgalka silsiladaha molecular-ka iyada oo loo marayo isbeddellada heerkulka, habka gelation-kuna wuxuu u baahan yahay tamar kuleyl oo dheeraad ah si looga gudbo saameynta fuuq-baxa.
3.3 Saamaynta maadada hydroxypropyl ay ku leedahay habka jelitaanka
Noocyo gaar ah oo ka kooban hydroxypropyl, habka jelitaanka waxaa xukuma isdhexgalka u dhexeeya fuuq-celinta iyo silsiladaha molecular-ka. Marka maaddada hydroxypropyl ee ku jirta molecule-ka HPMC ay yar tahay, fuuq-celinta way daciiftaa, isdhexgalka u dhexeeya molecules-ku waa xooggan yahay, heerkul hoosena wuxuu kor u qaadi karaa sameynta jel. Marka maaddada hydroxypropyl ay sareeyso, fuuq-celinta si weyn ayaa loo kordhiyaa, isdhexgalka u dhexeeya silsiladaha molecular-ka ayaa daciifa, heerkulka jelitaankana wuu kordhaa.
Heerka sare ee hydroxypropyl ayaa sidoo kale horseedi kara kororka daxalka xalka HPMC, isbeddel mararka qaarkood kordhiya heerkulka bilawga ee jelitaanka.
Maaddada Hydroxypropyl waxay saameyn weyn ku leedahay heerkulka jelitaanka eeHPMCMarka heerka hydroxypropyl uu kordho, heerka hydrophilicity-ka ee HPMC wuu kordhaa, isdhexgalka silsiladaha molecular-kana wuu daciifaa, sidaas darteed heerkulka jelitaanka badanaa wuu kordhaa. Dhacdadan waxaa lagu sharxi karaa habka isdhexgalka ee u dhexeeya fuuq-baxa iyo silsiladaha molecular-ka. Iyadoo la hagaajinayo heerka hydroxypropyl ee HPMC, waxaa la gaari karaa xakameyn sax ah oo heerkulka jelitaanka ah, taasoo wanaajisa waxqabadka HPMC ee dawooyinka, cuntada iyo codsiyada kale ee warshadaha.
Waqtiga boostada: Jan-04-2025