Hydroxypropyl methylcellulose (HPMC) bụ polima a na-ejikarị eme ihe na mmiri, nke a na-ejikarị eme ihe n'ọgwụ, ihe ịchọ mma, nri na ngalaba ụlọ ọrụ mmepụta ihe, ọkachasị n'ịkwadebe gels. Àgwà anụ ahụ ya na omume ịgbaze ya nwere mmetụta dị ukwuu na irè ya n'ọrụ dị iche iche. Okpomọkụ gelation nke HPMC gel bụ otu n'ime ihe ndị bụ isi ya, nke na-emetụta arụmọrụ ya ozugbo na nkwadebe dị iche iche, dịka mwepụta a na-achịkwa, nhazi ihe nkiri, nkwụsi ike, wdg.
1. Nhazi na ihe onwunwe nke HPMC
HPMC bụ polima mmiri na-agbaze site n'itinye ihe abụọ dị ka hydroxypropyl na methyl n'ime ọkpụkpụ molekul cellulose. Ọdịdị molekul ya nwere ụdị ihe abụọ dị iche iche: hydroxypropyl (-CH2CHOHCH3) na methyl (-CH3). Ihe ndị dị ka ọdịnaya hydroxypropyl dị iche iche, ogo methylation, na ogo polymerization ga-enwe mmetụta dị mkpa na mgbaze, omume gelling, na njirimara igwe nke HPMC.
N'ime mmiri mmiri, AnxinCel®HPMC na-emepụta mmiri colloidal kwụsiri ike site n'ịmepụta njikọ hydrogen na molekul mmiri ma na-akpakọrịta na ọkpụkpụ ya nke sitere na cellulose. Mgbe gburugburu ebe obibi (dịka okpomọkụ, ike ionic, wdg) gbanwere, mmekọrịta dị n'etiti molekul HPMC ga-agbanwe, na-ebute jelation.
2. Nkọwa na ihe ndị na-emetụta okpomọkụ gelation
Okpomọkụ Gelation (Okpomọkụ Gelation, T_gel) na-ezo aka na okpomọkụ ebe ngwọta HPMC na-amalite ịgbanwe site na mmiri mmiri gaa na ihe siri ike mgbe okpomọkụ ngwọta ahụ rịgoro ruo n'ọkwa ụfọdụ. N'ọnọdụ okpomọkụ a, mmegharị nke agbụ molekul HPMC ga-ebelata, na-emepụta nhazi netwọk atọ, na-eme ka ihe dị ka gel.
Ọtụtụ ihe na-emetụta okpomọkụ gelation nke HPMC, otu n'ime ihe ndị kacha mkpa bụ ọdịnaya hydroxypropyl. Na mgbakwunye na ọdịnaya hydroxypropyl, ihe ndị ọzọ na-emetụta okpomọkụ gel gụnyere ibu molekul, ntinye nke ngwọta, uru pH, ụdị ihe mgbaze, ike ionic, wdg.
3. Mmetụta nke ọdịnaya hydroxypropyl na okpomọkụ jel HPMC
3.1 Mmụba nke ọdịnaya hydroxypropyl na-eduga na mmụba nke okpomọkụ jel
Okpomọkụ njikọta nke HPMC nwere njikọ chiri anya na oke mgbanwe hydroxypropyl na molekul ya. Ka ọdịnaya hydroxypropyl na-abawanye, ọnụọgụ nke ihe ndị na-anọchi hydrophilic na yinye molekul HPMC na-abawanye, na-eme ka mmekọrịta dị n'etiti molekul na mmiri dịkwuo mma. Mmekọrịta a na-eme ka agbụ molekul gbasaa karịa, si otú a na-ebelata ike nke mmekọrịta dị n'etiti agbụ molekul. N'ime oke ntinye ụfọdụ, ịbawanye ọdịnaya hydroxypropyl na-enyere aka ime ka ogo mmiri dịkwuo elu ma na-akwalite nhazi nke agbụ molekul, ka e wee nwee ike ịmepụta nhazi netwọk na okpomọkụ dị elu. Ya mere, okpomọkụ njikọta na-abawanyekarị ka hydroxypropyl na-ebili ka ọdịnaya na-abawanye.
HPMC nwere nnukwu hydroxypropyl (dịka HPMC K15M) na-egosipụtakarị okpomọkụ gelation dị elu na otu mkpokọta ahụ karịa AnxinCel®HPMC yana obere ọdịnaya hydroxypropyl (dịka HPMC K4M). Nke a bụ n'ihi na nnukwu ọdịnaya hydroxypropyl na-eme ka ọ siere molekul ike ịkpakọrịta ma mepụta netwọk na obere okpomọkụ, na-achọ okpomọkụ dị elu iji merie mmiri a ma kwalite mmekọrịta intermolecular iji mepụta nhazi netwọk atọ.
3.2 Mmekọrịta dị n'etiti ọdịnaya hydroxypropyl na mkpokọta ihe ngwọta
Njupụta nke ngwọta bụkwa ihe dị mkpa na-emetụta okpomọkụ gelation nke HPMC. Na ngwọta HPMC nke nwere nnukwu njupụta, mmekọrịta intermolecular na-esikwu ike, yabụ okpomọkụ gelation nwere ike ịdị elu ọbụlagodi na ọdịnaya hydroxypropyl dị ala. Na obere njupụta, mmekọrịta dị n'etiti molekul HPMC adịghị ike, ngwọta ahụ nwekwara ike ịgbaze na obere okpomọkụ.
Mgbe ọdịnaya hydroxypropyl mụbara, ọ bụ ezie na ịdị elu nke hydrophilicity na-abawanye, a ka chọrọ okpomọkụ dị elu iji mepụta gel. Karịsịa n'ọnọdụ dị ala nke itinye uche, okpomọkụ gelation na-abawanye nke ukwuu. Nke a bụ n'ihi na HPMC nwere nnukwu ọdịnaya hydroxypropyl na-esiri ike ịkpalite mmekọrịta n'etiti agbụ molekul site na mgbanwe okpomọkụ, usoro gelation na-achọkwa ike okpomọkụ ọzọ iji merie mmetụta mmiri.
3.3 Mmetụta nke ọdịnaya hydroxypropyl na usoro gelation
N'ime oke hydroxypropyl dị iche iche, usoro gelation na-achịkwa site na mmekọrịta dị n'etiti hydration na molekul chains. Mgbe ọdịnaya hydroxypropyl dị na molekul HPMC dị ala, hydration adịghị ike, mmekọrịta dị n'etiti molekul na-esi ike, okpomọkụ dị ala nwere ike ịkwalite mmepụta nke gel. Mgbe ọdịnaya hydroxypropyl dị elu, hydration na-eme ka nke ukwuu dịkwuo mma, mmekọrịta dị n'etiti molekul na-adị ike, okpomọkụ gelation na-abawanye.
Oke hydroxypropyl nwere ike ibute mmụba na viscosity nke ngwọta HPMC, mgbanwe nke na-eme ka okpomọkụ mmalite nke gelation dịkwuo elu mgbe ụfọdụ.
Ọdịnaya hydroxypropyl nwere mmetụta dị ukwuu na okpomọkụ gelation nkeHPMCKa ọdịnaya hydroxypropyl na-abawanye, ike hydrophilicity nke HPMC na-abawanye, mmekọrịta dị n'etiti agbụ molekul na-ebelatakwa, ya mere okpomọkụ gelation ya na-abawanyekarị. Enwere ike ịkọwa ihe a site na usoro mmekọrịta dị n'etiti hydration na agbụ molekul. Site na ịgbanwe ọdịnaya hydroxypropyl nke HPMC, enwere ike nweta njikwa ziri ezi nke okpomọkụ gelation, si otú a na-eme ka arụmọrụ nke HPMC ka mma na ngwa ọgwụ, nri na ụlọ ọrụ mmepụta ihe ndị ọzọ.
Oge ozi: Jenụwarị-04-2025