Hydroxypropyl methylcellulose (HPMC)waa cellulose aan-ionic ahayn, biyo-milmi kara oo isku qasan. Muuqashadu waa caddaan ilaa wax yar oo huruud ah budo ama walxo granular ah, aan dhadhamin, ur lahayn, aan sun ahayn, kiimiko ahaan deggan, oo ku milma biyaha si ay u sameeyaan xal siman, hufan iyo viscous. Mid ka mid ah sifooyinka ugu muhiimsan ee hydroxypropyl methylcellulose ee codsiga waa in ay kordhiso viscosity ee dareeraha. Saamaynta dhumucdu waxay kuxirantahay heerka polymerization (DP) ee alaabta, fiirsashada etherka cellulose ee xalka aqueous, heerka dhogorta, iyo heerkulka xalka. Iyo qodobo kale.
01
Nooca dareeraha ee xalka aqueous HPMC
Guud ahaan, walbahaarka dareeraha qulqulka xiiridda waxaa lagu muujin karaa shaqeyn ahaan kaliya heerka xiirta ƒ(γ), waa haddii aysan waqti ku xirneyn. Iyadoo ku xiran qaabka ƒ(γ), dareerayaasha waxaa loo qaybin karaa noocyo kala duwan, kuwaas oo kala ah: Dheecaannada Newtonian, dareeraha dilatant, dareeraha pseudoplastic iyo dareeraha caaga ah ee Bingham.
Ether-yada Cellulose waxa loo qaybiyaa laba qaybood: mid waa ether-ka cellulose-ka aan-ionic ahayn iyo kan kale ether-ka ionic cellulose. Waayo, rheology ee labadan nooc ee ethers cellulose. SC Naik iyo al. waxay sameeyeen daraasad is barbar dhig ah oo dhamaystiran oo habaysan oo ku saabsan hydroxyethyl cellulose iyo sodium carboxymethyl cellulose xalalka. Natiijooyinku waxay muujiyeen in labadaba xalalka cellulose ether-ka aan-ionic-ka ahayn iyo xalalka ether-ka ionic cellulose ay ahaayeen pseudoplastic. Socodka, ie socodka aan Newtoniyaanka ahayn, waxay ku dhawaadaan dareerayaasha Newtoniya iyagoo aad u yar. Pseudoplasticity ee xalka hydroxypropyl methylcellulose ayaa door muhiim ah ka ciyaara codsiga. Tusaale ahaan, marka lagu dhejiyo dahaarka, sababtoo ah sifooyinka khafiifinta dhogorta ee xalalka aqueous, viscosity ee xalka ayaa hoos u dhacaya kororka heerka xiiridda, taas oo u sahlaysa kala firdhinta lebiska ee qaybaha midabka, iyo sidoo kale waxay kordhisaa dareeraha dahaarka. Saameyntu waa mid aad u weyn; inta lagu jiro nasashada, viscosity ee xalku waa mid aad u weyn, kaas oo si wax ku ool ah uga hortagaya dhigista qaybaha midabka ee daahan.
02
Habka Imtixaanka Viscosity HPMC
Tilmaame muhiim ah oo lagu cabbiro saamaynta dhumucda hydroxypropyl methylcellulose waa mawjadaha muuqda ee xalka aqueous. Hababka cabbiraadda ee muujinta viscosity-ka sida caadiga ah waxaa ka mid ah habka viscosity capillary, habka viscosity rotational iyo habka viscosity kubada.
halka: waa viscosity muuqda, mPa s; K waa viscometer joogto ah; d waa cufnaanta muunadda xalka 20/20 ° C; t waa waqtigii uu xalku u mari lahaa qaybta sare ee viscometerka ilaa calaamadda hoose, s; Waqtiga uu saliidda caadiga ah ku dhex qulqulayo viscometerka ayaa la cabbiraa.
Si kastaba ha ahaatee, habka lagu cabbiro viscometer-ka capillary ayaa ka sii dhib badan. viscosities badanethers celluloseWay adag tahay in la falanqeeyo iyada oo la isticmaalayo viscometer-ka xididada sababtoo ah xalalkani waxay ka kooban yihiin cadad cadad ah oo aan milmi karin kuwaas oo la ogaado kaliya marka viskometerka xididada la xiro. Sidaa darteed, soosaarayaasha intooda badani waxay isticmaalaan viscometers wareeg ah si ay u xakameeyaan tayada hydroxypropyl methylcellulose. Viscometers Brookfield waxaa caadi ahaan looga isticmaalaa wadamada shisheeye, NDJ viscometers ayaa lagu isticmaalaa Shiinaha.
03
Waxyaabaha saamaynta leh ee viscosity HPMC
3.1 Xiriirka heerka isku-darka
Marka qiyaasaha kale aysan isbeddelin, viscosity of hydroxypropyl methylcellulose solution waxay u dhigantaa heerka polymerization (DP) ama miisaanka kelli ama dhererka silsiladda kelli, waxayna kordhisaa korodhka heerka polymerization. Saamayntani waxay si aad ah ugu caddahay kiiska heerka hoose ee polymerization marka loo eego heerka heerka sare ee polymerization.
3.2 Xiriirka ka dhexeeya viscosity iyo fiirsashada
Viscosity of hydroxypropyl methylcellulose waxay kordhisaa kororka xoogga alaabta ee xalka aqueous. Xitaa isbeddelka xoogga yar wuxuu keeni doonaa isbeddel weyn oo ku yimaadda viscosity. Iyada oo la adeegsanayo viscosity magaceed ee hydroxypropyl methylcellulose Saamaynta isbeddelka diiradda saarista xalka ee viscosity ee xalka ayaa aad iyo aad u muuqda.
3.3 Xiriirka ka dhexeeya viscosity iyo heerka xiirid
Hydroxypropyl methylcellulose xal aqueous ah ayaa leh hantida khafiifinta xiirta. Hydroxypropyl methylcellulose ee viscosity magaceed oo kala duwan ayaa loo diyaariyey 2% xal aqueous ah, iyo viscositykeeda heerar kala duwan oo dhogorta ayaa loo cabbiraa siday u kala horreeyaan. Natiijadu waa sida soo socota Sida sawirka ka muuqata. Heerarka dhogorta hoose, viscosity ee xalka hydroxypropyl methylcellulose si weyn isuma beddelin. Kor u kaca heerka dhogorta, viscosity of hydroxypropyl methylcellulose xalka oo leh mawqif magaciisu sareeyo ayaa hoos u dhacay si cad, halka xalka maangalku hooseeyo uusan hoos u dhicin si cad.
3.4 Xiriirka ka dhexeeya viscosity iyo heerkulka
Viscosity ee xalka hydroxypropyl methylcellulose ayaa si weyn u saameeya heerkulka. Marka heerkulku kordho, viscosity ee xalka ayaa hoos u dhacaya. Sida ku cad shaxanka, waxaa loo diyaariyaa xal aqueous ah oo leh fiirsashada 2%, iyo isbeddelka viscosity ee korodhka heerkulka ayaa la qiyaasaa.
3.5 Qodobbada kale ee saamaynta leh
Viscosity ee xalka aqueous ee hydroxypropyl methylcellulose ayaa sidoo kale saameeya wax lagu daro ee xalka, qiimaha pH ee xalka, iyo hoos u dhaca microbial. Caadi ahaan, si loo helo waxqabadka viscosity ka wanaagsan ama loo yareeyo kharashka isticmaalka, waxaa lagama maarmaan ah in lagu daro wax ka beddelka rheology, sida dhoobada, dhoobada wax laga beddelay, budada polymer, istaarijka ether iyo aliphatic copolymer, xalka aqueous ee hydroxypropyl methylcellulose. , iyo electrolytes sida chloride, bromide, phosphate, nitrate, iwm ayaa sidoo kale lagu dari karaa xal aqueous. Waxyaalahan lagu daro kaliya ma saameyn doonaan sifooyinka viscosity ee xalka aqueous, laakiin sidoo kale waxay saameeyaan sifooyinka kale ee codsiga ee hydroxypropyl methylcellulose sida xajinta biyaha. , caabbinta sag, iwm.
Viscosity ee xalka aqueous ee hydroxypropyl methylcellulose ku dhawaad ma saameeyaa acid iyo alkali, iyo guud ahaan waa xasilloon ee kala duwan ee 3 ilaa 11. Waxay u adkeysan kartaa qadar gaar ah oo acids daciif ah, sida formic acid, acetic acid, fosfooraska acid, boric acid, citric acid, iwm. Laakiin soodhaha caustic, potassium hydroxide, biyaha lime, iwm ayaa saameyn yar ku leh. Marka la barbardhigo ether-yada kale ee cellulose,hydroxypropyl methylcelluloseXalka aqueous wuxuu leeyahay xasillooni antimicrobial wanaagsan, sababta ugu weyn waa in hydroxypropyl methylcellulose uu leeyahay kooxaha hydrophobic leh heerka sare ee beddelka iyo caqabad ku steric ee kooxaha Si kastaba ha ahaatee, tan iyo falcelinta beddelka sida caadiga ah ma aha labis, unugga anhydroglucose aan la bedelin ayaa si fudud u baabi'in by microorganisms, taasoo keentay in hoos u dhaca silsiladda molecules iyo eyda cellulose. Waxqabadku waa in muuqaalka muuqda ee xalka aqueous uu hoos u dhaco. Haddii ay lagama maarmaan tahay in la kaydiyo xalka aqueous ee hydroxypropyl methylcellulose muddo dheer, waxaa lagu talinayaa in lagu daro qadar raad ah wakiilka antifungal si viscosity uusan si weyn u beddelin. Markaad dooranayso wakiilada fangas-ka-hortagga ah, kuwa ilaaliya ama fungicides, waa inaad fiiro gaar ah u yeelataa badbaadada, oo aad doorataa alaabta aan sunta ahayn ee jidhka bini'aadamka, waxay leeyihiin sifooyin xasilan oo aan ur lahayn, sida DOW Chem's AMICAL fungicides, CANGUARD64 preservatives, FUELSAVER bakteeriyada iyo alaabooyin kale. door u dhigma ayaa ciyaari kara.
Waqtiga boostada: Abriil-28-2024