Hydroxypropyl methyl cellulose HPMC ni eteri ivanze ya cellulose itari ionic mu bwoko butandukanye kandi ivanze na methyl carboxymethyl cellulose, ntabwo ihura n'ibyuma bikomeye. Imwe mu ngirabuzimafatizo za ogisijeni bitewe n'ingano ya hydroxypropyl methyl cellulose n'ingano itandukanye y'ingano ya hydroxypropyl n'ubushyuhe, yabaye ubwoko butandukanye bitewe n'imikorere, urugero, ingano nyinshi ya methoxyl n'ingano nke ya hydroxypropyl, imikorere yayo iri hafi ya methyl cellulose n'ingano nke ya methoxyl n'ingano nyinshi ya hydroxypropyl, kandi imikorere yayo iri hafi ya hydroxypropyl methyl cellulose ikorwa. Ariko muri buri bwoko, nubwo burimo ingano nto ya hydroxypropyl cyangwa ingano nto ya methoxy, gushonga mu binyabutabire cyangwa ubushyuhe bwa flocculation mu gisubizo cy'amazi, hari itandukaniro rikomeye.
1, gushonga kwa hydroxypropyl methyl cellulose
Hydroxypropyl methyl cellulose mu mazi, gushonga kwa hydroxypropyl methyl cellulose mu by’ukuri ni ubwoko bwa propylene oxide (methyl oxypropyl ring) methyl cellulose yahinduwe, bityo ikaba igifite imiterere isa na methyl cellulose ikonje ishobora gushonga n’amazi ashyushye. Ariko, ubushyuhe bwa gelation bwa hydroxy propyl yahinduwe buri hejuru cyane ugereranyije n’ubwa methyl cellulose mu mazi ashyushye. Urugero, ubushyuhe bwa hydroxypropyl methylcellulose amazi afite 2% methoxy content DS = 0.73 n’ubushyuhe bwa hydroxypropyl content MS = 0.46 ni 500 mpa kuri 20°C. Ubushyuhe bwa gel bwa S's product buri hafi ya 100°C, mu gihe ubwa methyl cellulose ifite ubushyuhe bumwe buri hafi 55°C gusa. Ku bijyanye no gushonga kwayo mu mazi, nabyo byarushijeho kuba byiza cyane, urugero, nyuma yo gushwanyaguza hydroxypropyl methylcellulose (ishusho y'ibinyampeke 0.2 ~ 0.5mm kuri 20℃ 4% y'amazi ya 2pA? Ibicuruzwa bya S bishobora gushonga byoroshye mu mazi bitabaye ngombwa gukonjesha ku bushyuhe bw'icyumba.
(2) Hydroxypropyl methyl cellulose mu bintu biyungurura ibinyabuzima, gushonga kwa hydroxypropyl methyl cellulose mu bintu biyungurura ibinyabuzima, ni byiza kurusha methyl cellulose, methyl cellulose ikenewe mu gipimo cyo gusimbuza methoxy cya 2.1 cyangwa birenga, kandi irimo hydroxypropyl MS = 1.5 ~ 1.8 na methoxy DS = 0.2 ~ 1.0, Hydroxypropyl methyl cellulose ifite ubukana bwinshi bw’ubusumbane buri hejuru ya 1.8 irashonga mu bisubizo bya methanoli na ethanoli, kandi ifite gushonga kwa thermoplastic n’amazi. Irashonga kandi mu bintu biyungurura chlorine nka dichloromethane na trichloromethane, hamwe n’ibintu biyungurura ibinyabuzima nka asetone, isopropyl alcohol, na diacetone alcohol. Gushonga kwayo mu bintu biyungurura ibinyabuzima biruta gushonga mu mazi.
2, hydroxypropyl methyl cellulose viscosity y'ibintu bigira ingaruka
Ibipimo bya Hydroxypropyl methylcellulose, hydroxypropyl methylcellulose, na ether ya cellulose ni bimwe, biri kuri 20°C hamwe n'umuti w'amazi wa 2% nk'uko bigenwa. Ubushobozi bw'umuti umwe, hamwe n'ubwiyongere bw'ubwinshi n'ubwiyongere, uburemere bumwe bw'ibicuruzwa bitandukanye bifite uburemere bwa molekile, uburemere bwa molekile bw'umuti buba buri hejuru. Isano yabyo n'ubushyuhe busa n'ubwa methyl cellulose. Iyo ubushyuhe buzamutse, ubudahangarwa butangira kugabanuka, ariko iyo bugeze ku bushyuhe runaka, ubudahangarwa buhita bwiyongera maze hakavuka ubwiyongere. Ubushyuhe bwa gelation bw'ibicuruzwa bifite ubudahangarwa buke buri hejuru y'ubw'ibicuruzwa bifite ubudahangarwa bwinshi. Urwego rw'ingingo ya gel, uretse ubudahangarwa bwinshi n'ubuke bwa ether, ariko nanone hamwe n'ikigereranyo cya ether methoxy na hydroxypropyl group composition hamwe n'urwego rwose rwo gusimbuza birafitanye isano. Ni ngombwa kumenya ko hydroxypropyl methylcellulose nayo ari pseudoplastic; umuti wayo uhoraho iyo ubitswe ku bushyuhe bw'icyumba kandi ntugaragaza kwangirika kwa viscosity keretse ko hashobora kwangirika kwa enzymatic.
3, aside ya hydroxypropyl methyl cellulose hamwe no kurwanya alkaline
Aside ya Hydroxypropyl methylcellulose alkali hydroxypropyl methylcellulose aside na alkali, muri rusange irahamye, mu rugero rwa PH2 ~ 12 ntabwo irahinduka, ishobora kwihanganira ingano runaka ya aside yoroshye, nka aside formic, aside acetic, aside citric, aside succinic, aside fosforic, aside boric, nibindi. Ariko aside yibumbiyemo ifite ingaruka zo kugabanya ubukana. Alkali nka soda caustic, potasiyumu caustic n'amazi y'indimu nta ngaruka igira kuri yo, ariko ingaruka zo kongera ubukana gato bw'umuti zizagabanuka buhoro buhoro mu gihe kizaza.
4, hydroxypropyl methyl cellulose ishobora kuvangwa
Umuti wa Hydroxypropyl methyl cellulose ushobora kuvangwa n'ibinyabutabire bya polymer bishonga mu mazi, kandi ukaba igisubizo kimwe gisobanutse neza gifite ubukana bwinshi. Ibi binyabutabire byinshi ni polyethylene glycol, polyvinyl acetate, polysilicone, polymethyl vinyl siloxane na hydroxyethyl cellulose na methyl cellulose, nibindi. Ibinyabutabire karemano bya polymer nka gum Arabic, locustbean gum, thorn tree gum nibindi nabyo bifite uruvange rwiza hamwe n'umuti wabyo. Hydroxypropyl methyl cellulose ishobora kandi kuvangwa na aside stearic cyangwa aside palmitic mannitol ester cyangwa sorbitol ester, ariko kandi hamwe na glycerol, sorbitol na mannitol, ibi binyabutabire bishobora gukoreshwa nk'imashini ikora pulasitiki ya hydroxypropyl methyl cellulose.
5, hydroxypropyl methyl cellulose idashonga mu mazi ishongesha
Hydroxypropyl methyl cellulose idashobora gushonga mu mazi, ishobora guhuza ubuso na aldehydes, kandi bigatuma iyi ether ishonga mu mazi ishyirwa mu gisubizo, idashobora gushonga mu mazi. Kandi bigatuma hydroxypropyl methylcellulose idashobora gushonga aldehyde, formaldehyde, glyoxal, succinaldehyde, dialdehyde, nibindi, ikoreshwa rya formaldehyde rigomba kwitabwaho cyane n'agaciro ka PH k'igisubizo, aho glyoxal ikora vuba, bityo mu nganda ikoreshwa cyane glyoxal nk'igikoresho gihuza. Igipimo cy'ubu bwoko bw'igikoresho gihuza mu gisubizo ni 0.2% ~ 10% by'uburemere bwa ether, icyiza ni 7% ~ 10%, nko gukoresha glyoxal ifite 3.3% ~ 6% ni cyo gikwiye cyane. Ubushyuhe rusange bwo kuvura ni 0 ~ 30℃, igihe ni iminota 1 ~ 120. Igikorwa gihuza kigomba gukorwa mu bihe bya aside. Muri rusange, aside ikomeye idakora cyangwa aside karubokisilike y’umwimerere yongerwa mu gisubizo kugira ngo PH y’igisubizo ihinduke hafi 2 ~ 6, byaba byiza hagati ya 4 ~ 6, hanyuma aldehyde zongerwamo kugira ngo zihuze. Aside zikoreshwa ni aside hidrokloriki, aside sulfuriki, aside fosforiki, aside formike, aside asetiki, aside hydroxy acetic, aside succinic cyangwa aside citric, muri zo aside formike cyangwa aside asetiki ni byo byiza cyane, mu gihe aside formike ari byo byiza cyane. Aside na aldehyde zishobora no kongerwamo icyarimwe kugira ngo umuti uhuzwe mu rugero rwa PH wifuza. Iyi reaction ikunze gukoreshwa mu gikorwa cya nyuma cyo gutegura eteri ya cellulose, kugira ngo eteri ya cellulose idashonga, byoroshye gukoresha amazi ya 20 ~ 25 ℃ kugira ngo yozwe kandi yozwe neza. Iyo ibicuruzwa bikoreshejwe, ibintu bya alkaline bishobora kongerwa mu gisubizo cy’igisubizo kugira ngo PH y’igisubizo ibe alkaline, kandi umusaruro uhita ushonga mu gisubizo. Ubu buryo bushobora kandi gukoreshwa iyo umuti wa eteri ya cellulose ukoreshejwe mu gukora firime hanyuma firime igatunganywa kugira ngo ikore firime idashonga.
6, hydroxypropyl methyl cellulose irwanya enzyme
Ubudahangarwa bwa enzyme ya Hydroxypropyl methyl cellulose y’ibintu bikomoka kuri selulosi mu buryo bw’imitekerereze, nk’uko buri tsinda rya anhydroglucose rishobora kuba rifite uruvange rukomeye rw’amatsinda asimbuza, kwangirika kwa mikorobe ntibikunze kwandura, ariko mu by’ukuri umusaruro urangiye wo gusimbuza agaciro karenze 1, nanone binyuze mu kwangirika kwa enzyme, iyi niyo mvugo ya buri tsinda mu cyiciro cyo gusimbuza uruhererekane rwa selulosi ntabwo ari imwe, Udukoko dushobora kwangirika hafi y’amatsinda ya glucose yangiritse idasimbuwe kugira ngo habe isukari, ishobora kwinjizwa na mikorobe nk’ibiryo. Kubwibyo, niba urugero rwo gusimbuza ether rwa selulosi rwiyongera, ubudahangarwa bwa ether ya selulosi ku kwangirika kwa enzyme buzarushaho kwiyongera. Byatangajwe ko mu bihe bigenzurwa, ubukana busigaye bwa hydroxypropyl methyl cellulose (DS = 1.9), methyl cellulose (DS = 1.83), methyl cellulose (DS = 1.66), na hydroxyethyl cellulose (1.7%) bwari 13.2%, 7.3%, 3.8%, na 1.7%, uko bikurikirana. Hydroxypropyl methyl cellulose ifite ubushobozi bukomeye bwo kurwanya enzyme. Bityo, hydroxypropyl methylcellulose irwanya enzyme nziza cyane, hamwe n'uburyo ikwirakwira neza, ikagira ubunini n'imiterere myiza ya firime, ikoreshwa mu gutwikira emulsion, nibindi, muri rusange ntabwo bisaba kongeramo ibintu bibungabunga. Ariko, kugira ngo hirindwe ko umuti ubikwa igihe kirekire cyangwa ngo habeho kwanduzwa n'isi yo hanze, ibintu bibungabunga bishobora kongerwamo, ibyo bihitamo bishobora kugenwa hakurikijwe ibisabwa bya nyuma by'umuti. Phenylmercuric acetate na manganese fluosilicate ni ibintu bibungabunga neza, ariko ni uburozi kandi bigomba gukoreshwa neza. Muri rusange, 1 ~ 5mg ya phenylmercuric acetate ishobora kongerwa kuri buri litiro y'umuti.
7, imikorere y'urukiramende rwa hydroxypropyl methyl cellulose
Imikorere ya filime ya Hydroxypropyl methyl cellulose ya hydroxypropyl methyl cellulose ifite filime nziza cyane, umuti wayo w’amazi cyangwa umuti wa organic solvent, upfutse ku kirahure, nyuma yo kuma uba udafite ibara, ubonerana kandi ukomeye. Ifite ubushobozi bwo kwihanganira ubushuhe kandi ikomeza gukomera ku bushyuhe bwinshi. Nk’iyongerwamo plasticizer ya hygroscopic, ishobora kongera uburebure bwayo n’ubushobozi bwayo bwo koroha, kugira ngo yongere flexure, glycerol na sorbitol n’indi plasticizer ni byo bikwiye cyane. Igipimo rusange cy’umuti ni 2% ~ 3%, ingano ya plasticizer ni 10% ~ 20% ya ether ya cellulose. Niba ingano ya plasticizer ikenewe, ikibazo cyo kugabanuka kwa colloid dehydration gishobora kubaho mu bushuhe bwinshi. Ingufu zo gukurura za plasticizer yongewemo filime ni nini cyane kuruta izitari zongewemo, kandi ziyongera uko umubare w’izongewemo wiyongera, nkuko hygroscopicity ya filime nayo yiyongera uko ingano ya plasticizer yiyongera.
Igihe cyo kohereza ubutumwa: Nzeri-08-2022