Nā waiwai o ka hydroxypropyl methylcellulose

ʻO ka Hydroxypropyl methylcellulose HPMC kahi ʻano o ka hui ʻana o ka cellulose non-ionic ether. ʻAʻole like me ka ionic methyl carboxymethyl cellulose i hui ʻia me ka ether, ʻaʻole ia e pane me nā metala kaumaha. Ma muli o nā lakio like ʻole o ka ʻike methoxyl a me ka ʻike hydroxypropyl i loko o ka hydroxypropyl methylcellulose a me nā viscosities like ʻole, nui nā ʻano like ʻole me nā waiwai like ʻole, no ka laʻana, kiʻekiʻe ka ʻike methoxyl a haʻahaʻa ka ʻike hydroxypropyl. Ua kokoke kāna hana i ka methyl cellulose, ʻoiai ʻo ka haʻahaʻa o ka ʻike methoxyl a me ke kiʻekiʻe o ka ʻike hydroxypropyl ua kokoke i ka hydroxypropyl methyl cellulose. Eia nō naʻe, i kēlā me kēia ʻano, ʻoiai he liʻiliʻi wale nō ka nui o ka hui hydroxypropyl a i ʻole kahi liʻiliʻi o ka hui methoxyl i loko, aia nā ʻokoʻa nui i ka solubility i nā mea hoʻoheheʻe organik a i ʻole ka mahana flocculation i nā hopena wai.

(1) Nā waiwai hoʻoheheʻe ʻia o ka hydroxypropyl methylcellulose

①ʻO ka hoʻoheheʻe ʻana o ka hydroxypropyl methylcellulose i ka wai ʻO ka Hydroxypropyl methylcellulose he ʻano methylcellulose i hoʻololi ʻia e ka propylene oxide (methoxypropylene), no laila he mau waiwai like nō ia me ka methyl cellulose. Loaʻa i ka Cellulose nā ʻano like o ka hoʻoheheʻe ʻana i ka wai anuanu a me ka insolubility i ka wai wela. Eia nō naʻe, ma muli o ka hui hydroxypropyl i hoʻololi ʻia, ʻoi aku ka kiʻekiʻe o kona mahana gelation i ka wai wela ma mua o ka methyl cellulose. No ka laʻana, ʻo ka viscosity o ka hydroxypropyl methylcellulose aqueous solution me 2% methoxy content substitution degree DS=0.73 a me ka hydroxypropyl content MS=0.46 he 500 mpa·s ma 20°C, a ʻo kona mahana gel hiki ke hōʻea i kahi kokoke i 100°C, ʻoiai ʻo ka methyl cellulose ma ka mahana like he 55°C wale nō. No kona hoʻoheheʻe ʻana i ka wai, ua hoʻomaikaʻi nui ʻia. No ka laʻana, hiki ke kūʻai ʻia ka hydroxypropyl methylcellulose i hoʻoheheʻe ʻia (ʻano granular 0.2 ~ 0.5mm ma 20°C me ka 4% aqueous solution viscosity o 2pa•s ma Ma ka mahana o ka lumi, hiki ke hoʻoheheʻe maʻalahi ʻia i ka wai me ka ʻole o ka hoʻomaʻalili ʻana.

②Ka hoʻoheheʻe ʻia ʻana o ka hydroxypropyl methylcellulose i loko o nā mea hoʻoheheʻe organik ʻOi aku ka maikaʻi o ka hoʻoheheʻe ʻia ʻana o ka hydroxypropyl methylcellulose i loko o nā mea hoʻoheheʻe organik ma mua o ka methylcellulose. No nā huahana ma luna o 2.1, ʻo ka hydroxypropyl methylcellulose viscosity kiʻekiʻe e loaʻa ana ka hydroxypropyl MS=1.5~1.8 a me ka methoxy DS=0.2~1.0, me ka huina o ka pani ʻana ma luna o 1.8, hiki ke hoʻoheheʻe ʻia i loko o ka methanol anhydrous a me nā hopena ethanol Medium, a me ka thermoplastic a me ka wai-hoʻoheheʻe ʻia. Hiki ke hoʻoheheʻe ʻia hoʻi i loko o nā hydrocarbons chlorinated e like me ka methylene chloride a me ka chloroform, a me nā mea hoʻoheheʻe organik e like me ka acetone, isopropanol a me ka diacetone alcohol. ʻOi aku ka maikaʻi o kona hoʻoheheʻe ʻia ʻana i loko o nā mea hoʻoheheʻe organik ma mua o ka hoʻoheheʻe ʻia ʻana o ka wai.

(2) Nā mea e pili ana i ka viscosity o ka hydroxypropyl methylcellulose ʻO ka hoʻoholo ʻana o ka viscosity maʻamau o ka hydroxypropyl methylcellulose ua like ia me nā ethers cellulose ʻē aʻe, a ua ana ʻia ma 20°C me kahi hopena wai 2% e like me ke kūlana. Hoʻonui ka viscosity o ka huahana like me ka hoʻonui ʻia ʻana o ka nui. No nā huahana me nā kaumaha molekala like ʻole ma ka nui like, ʻoi aku ka kiʻekiʻe o ka viscosity o ka huahana me ke kaumaha molekala nui aʻe. Ua like kona pilina me ka mahana me ko ka methyl cellulose. Ke piʻi ka mahana, hoʻomaka ka viscosity e emi, akā i ka wā e hiki ai i kahi mahana,

Piʻi koke ka viscosity a loaʻa ka gelation. ʻOi aku ke kiʻekiʻe o ka mahana gel o nā huahana viscosity haʻahaʻa. kiʻekiʻe. ʻAʻole pili wale kona kiko gel i ka viscosity o ka ether, akā pili pū kekahi i ka ratio o ka hui ʻana o ka hui methoxyl a me ka hui hydroxypropyl i ka ether a me ka nui o ke kekelē pani holoʻokoʻa. Pono e hoʻomaopopo ʻia he pseudoplastic nō hoʻi ka hydroxypropyl methylcellulose, a paʻa kona hopena i ka mahana o ka lumi me ka ʻole o ka hōʻino ʻana i ka viscosity koe wale nō ka hiki ke hōʻino ʻia e ka enzymatic.

(3) Ka hoʻomanawanui paʻakai o ka hydroxypropyl methylcellulose ʻOiai he ether non-ionic ka hydroxypropyl methylcellulose, ʻaʻole ia e ionize i loko o ka wai, ʻaʻole like me nā ethers cellulose ionic ʻē aʻe, No ka laʻana, hana ka carboxymethyl cellulose me nā ion metala kaumaha a hoʻoheheʻe ʻia i loko o ka hopena. ʻAʻole e hoʻoheheʻe ʻia nā paʻakai maʻamau e like me ka chloride, bromide, phosphate, nitrate, a me nā mea ʻē aʻe i ka wā e hoʻohui ʻia ai i kāna hopena wai. Eia nō naʻe, ʻo ka hoʻohui ʻana o ka paʻakai he mana koʻikoʻi ia i ka mahana flocculation o kāna hopena wai. Ke piʻi ka nui o ka paʻakai, emi ka mahana gel. Ke emi ka nui o ka paʻakai ma lalo o ka wahi flocculation, e piʻi ka viscosity o ka hopena. No laila, ua hoʻohui ʻia kahi nui o ka paʻakai. , i ka hoʻohana ʻana, hiki iā ia ke hoʻokō i ka hopena mānoanoa me ka ʻoi aku ka waiwai. No laila, i kekahi mau noi, ʻoi aku ka maikaʻi o ka hoʻohana ʻana i ka hui ʻana o ka cellulose ether a me ka paʻakai ma mua o ka nui o ka hopena ether e hoʻokō ai i ka hopena mānoanoa.

(4) Ke kūpaʻa ʻana o ka waikawa Hydroxypropyl methylcellulose a me ka alkali. Kūpaʻa ka Hydroxypropyl methylcellulose i nā waikawa a me nā alkalis, a ʻaʻole i hoʻopilikia ʻia i ka pae pH 2 ~ 12. Hiki iā ia ke kū i kahi nui o nā waikawa Māmā, e like me ka waikawa formic, ka waikawa acetic, ka waikawa citric, ka waikawa succinic, ka waikawa phosphoric, ka waikawa boric, a pēlā aku. Akā, ʻo ka waikawa i hoʻopaʻa ʻia he hopena ia o ka hōʻemi ʻana i ka viscosity. ʻAʻohe hopena o nā alkalis e like me ka caustic soda, ka caustic potash a me ka wai lime, akā hiki iā lākou ke hoʻonui iki i ka viscosity o ka hopena, a laila e hoʻemi mālie.

(5) ʻO ka hoʻohuihui ʻana o ka hydroxypropyl methylcellulose Hiki ke hoʻohuihui ʻia ka hopena Hydroxypropyl methylcellulose me nā hui polymer wai-soluble e lilo i hopena like a moakaka me ka viscosity kiʻekiʻe. ʻO kēia mau hui polymer e komo pū me ka polyethylene glycol, polyvinyl acetate, polysilicone, polymethylvinylsiloxane, hydroxyethyl cellulose, a me ka methyl cellulose. ʻO nā hui molekala kiʻekiʻe kūlohelohe e like me ka gum arabic, locust bean gum, karaya gum, a me nā mea ʻē aʻe he kūpono maikaʻi hoʻi me kāna hopena. Hiki ke hoʻohuihui ʻia ka Hydroxypropyl methylcellulose me ka mannitol ester a i ʻole sorbitol ester o ka stearic acid a i ʻole palmitic acid, a hiki ke hoʻohuihui ʻia me ka glycerin, sorbitol a me ka mannitol, a hiki ke hoʻohana ʻia kēia mau hui e like me ka hydroxypropyl methylcellulose Plasticizer no ka cellulose.

(6) Hiki ke hoʻopili ʻia nā ethers cellulose wai-hoʻoheheʻe ʻole o ka hydroxypropyl methylcellulose me nā aldehydes ma luna o ka ʻili, i mea e hoʻoheheʻe ʻia ai kēia mau ethers wai-hoʻoheheʻe ʻia i loko o ka hopena a lilo i mea hoʻoheheʻe ʻole i ka wai. ʻO nā aldehydes e hoʻolilo i ka hydroxypropyl methylcellulose insoluble ʻole e komo pū me formaldehyde, glyoxal, succinic aldehyde, adipaldehyde, etc. I ka wā e hoʻohana ai i ka formaldehyde, pono e uku ʻia ka nānā kūikawā i ka waiwai pH o ka hopena, ma waena o ia mea e pane wikiwiki ai ka glyoxal, no laila hoʻohana pinepine ʻia ka glyoxal ma ke ʻano he mea hoʻopili i ka hana ʻoihana. ʻO ka nui o kēia ʻano mea hoʻopili i loko o ka hopena he 0.2% ~ 10% o ka nui o ka ether, ʻoi aku ka maikaʻi o 7% ~ 10%, no ka laʻana, 3.3% ~ 6% o ka glyoxal ka mea kūpono loa. Ma keʻano laulā, ʻo ka mālama ʻana

ʻO ka mahana he 0 ~ 30 ℃, a ʻo ka manawa he 1 ~ 120min. Pono e hoʻokō ʻia ka hopena cross-linking ma lalo o nā kūlana acidic. Ma ke ʻano laulā, hoʻohui mua ʻia ka hopena me ka waikawa ikaika inorganic a i ʻole ka waikawa carboxylic organik e hoʻoponopono i ka pH o ka hopena i kahi 2 ~ 6, ʻoi aku ka maikaʻi ma waena o 4 ~ 6, a laila hoʻohui i nā aldehydes e hoʻokō i ka hopena cross-linking. Loaʻa i ka waikawa i hoʻohana ʻia ka waikawa hydrochloric, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxyacetic acid, succinic acid a i ʻole citric acid etc., kahi e kūpono ai me ka formic acid a i ʻole acetic acid, a ʻo ka formic acid ka mea kūpono. Hiki ke hoʻohui pū ʻia ka waikawa a me ka aldehyde i ka manawa like e ʻae i ka hopena e hana i kahi hopena cross-linking i loko o ka pae pH i makemake ʻia. Hoʻohana pinepine ʻia kēia hopena i ke kaʻina hana hope loa i ke kaʻina hana hoʻomākaukau o nā cellulose ethers. Ma hope o ka hiki ʻole ke hoʻoheheʻe ʻia o ka cellulose ether, he kūpono ia e hoʻohana.

20~25℃ wai no ka holoi ʻana a me ka hoʻomaʻemaʻe ʻana. Ke hoʻohana ʻia ka huahana, hiki ke hoʻohui ʻia nā mea alkaline i ka hopena o ka huahana e hoʻoponopono i ka pH o ka hopena i alkaline, a e hoʻoheheʻe koke ka huahana i loko o ka hopena. Hoʻohana pū ʻia kēia ʻano hana no ka mālama ʻana i ke kiʻiʻoniʻoni ma hope o ka hana ʻana o ka hopena cellulose ether i kiʻiʻoniʻoni e hana ai i kiʻiʻoniʻoni hiki ʻole ke hoʻoheheʻe ʻia.

(7) ʻO ke kū'ē ʻana o ka enzyme o ka hydroxypropyl methylcellulose he mau derivatives cellulose theoretically, e like me kēlā me kēia hui anhydroglucose, inā he hui substituent i hoʻopaʻa paʻa ʻia, ʻaʻole maʻalahi ka maʻi ʻia e nā microorganisms, akā ʻo ka ʻoiaʻiʻo ka huahana i hoʻopau ʻia Ke ʻoi aku ka waiwai o ka pani ʻana ma mua o 1, e hoʻohaʻahaʻa ʻia hoʻi e nā enzymes, ʻo ia hoʻi, ʻaʻole lawa ka like o ke kekelē o ka pani ʻana o kēlā me kēia hui ma ke kaulahao cellulose, a hiki i nā microorganisms ke hoʻopau i ka hui anhydroglucose i hoʻololi ʻole ʻia e hana i nā kō, e like me nā meaʻai no nā microorganisms e omo. No laila, inā piʻi ke kekelē o ka etherification substitution o ka cellulose, e piʻi pū ke kū'ē ʻana i ka enzymatic erosion o ka cellulose ether. Wahi a nā hōʻike, ma lalo o nā kūlana i kāohi ʻia, ʻo nā hopena hydrolysis o nā enzymes, ʻo ke koena o ka viscosity o ka hydroxypropyl methylcellulose (DS=1.9) he 13.2%, methylcellulose (DS=1.83) he 7.3%, methylcellulose (DS=1.66) he 3.8%, a ʻo hydroxyethyl cellulose he 1.7%. Hiki ke ʻike ʻia he ikaika ka hiki ke pale i ka enzyme o ka hydroxypropyl methylcellulose. No laila, ʻo ke kūpaʻa enzyme maikaʻi loa o ka hydroxypropyl methylcellulose, me kona ʻano hoʻolaha maikaʻi, ka mānoanoa a me nā waiwai hana kiʻiʻoniʻoni, hoʻohana ʻia i loko o nā uhi emulsion wai, a pēlā aku, a ʻaʻole pono e hoʻohui i nā mea mālama. Eia nō naʻe, no ka mālama lōʻihi ʻana o ka hopena a i ʻole ka haumia mai waho, hiki ke hoʻohui ʻia nā mea mālama ma ke ʻano he akahele, a hiki ke hoʻoholo ʻia ke koho e like me nā koi hope o ka hopena. He mau mea mālama maikaʻi ka Phenylmercuric acetate a me ka manganese fluorosilicate, akā he ʻawaʻawa ko lākou a pau, pono e nānā pono i ka hana. Ma ke ʻano laulā, hiki ke hoʻohui ʻia he 1 ~ 5mg o ka phenylmercury acetate i ka hopena no kēlā me kēia lita o ka dosage.

(8) ʻO ka hana o ka kiʻiʻoniʻoni hydroxypropyl methylcellulose He mau waiwai hoʻokumu kiʻiʻoniʻoni maikaʻi loa ka Hydroxypropyl methylcellulose. Ua uhi ʻia kona hopena wai a i ʻole ka hopena solvent organik ma luna o kahi pā aniani, a lilo ia i kala ʻole a moakaka ma hope o ka maloʻo ʻana. A me ka kiʻiʻoniʻoni paʻakikī. Loaʻa iā ia ke kūpaʻa maikaʻi i ka makū a noho paʻa i nā mahana kiʻekiʻe. Inā hoʻohui ʻia ka plasticizer hygroscopic, hiki ke hoʻonui ʻia kona elongation a me ka maʻalahi. No ka hoʻomaikaʻi ʻana i ka maʻalahi, ʻo nā plasticizers e like me ka glycerin a me ka sorbitol ka mea kūpono loa. Ma keʻano laulā, ʻo ka nui o ka hopena he 2% ~ 3%, a ʻo ka nui o ka plasticizer he 10% ~ 20% o ka cellulose ether. Inā kiʻekiʻe loa ka ʻike o ka plasticizer, e hōʻemi ʻia ka dehydration colloidal i ka haʻahaʻa kiʻekiʻe. ʻO ka ikaika tensile o ke kiʻiʻoniʻoni me

ʻOi aku ka nui o ka plasticizer i hoʻohui ʻia ma mua o ka mea me ka ʻole o ka plasticizer, a hoʻonui ia me ka hoʻonui ʻana o ka nui i hoʻohui ʻia. No ke hygroscopicity o ka ʻiliʻili, hoʻonui pū ia me ka hoʻonui ʻana o ka nui o ka plasticizer.