Zombini i-hydroxypropyl methylcellulose kunye ne-hydroxyethyl cellulose ziselulosi

IHydroxypropyl methylcellulose (HPMC)kunye ne-hydroxyethyl cellulose (HEC) zimbini ezibalulekileyo ze-cellulose derivatives ezisetyenziswa ngokubanzi kumashishini ahlukeneyo ngenxa yeempawu zabo ezizodwa. Ngelixa zombini ziphuma kwiselulosi, zinezakhiwo zeekhemikhali ezahlukeneyo kwaye zibonisa iimpawu ezahlukeneyo kunye nokusetyenziswa.

1. Intshayelelo yeCellulose Derivatives:
I-Cellulose yi-polysaccharide yendalo efumaneka kwiindonga zeeseli zezityalo, eziqulethwe ngamatyathanga ahlukeneyo eeyunithi ze-glucose ezidityaniswe yi-β (1→ 4) iibhondi ze-glycosidic. I-cellulose ephuma kwi-cellulose ifunyanwa ngokuguqula iikhemikhali zeselulosi ukuphucula iimpawu ezithile okanye ukwazisa imisebenzi emitsha. I-HPMC kunye ne-HEC zizinto ezimbini ezifana nezi zisetyenziswa kakhulu kumashishini ukusuka kumayeza ukuya kulwakhiwo.

2. Ukudibanisa:
I-HPMC idityaniswe ngokusabela i-cellulose nge-propylene oxide ukwazisa amaqela e-hydroxypropyl kwaye emva koko i-methyl chloride ukwazisa amaqela e-methyl. Oku kubangela ukutshintshwa kwamaqela e-hydroxyl kwikhonkco le-cellulose, ukuvelisa imveliso ene-solubility ephuculweyo kunye neempawu zokwenza ifilimu.

I-HEC, ngakolunye uhlangothi, iveliswa ngokuphendula i-cellulose nge-ethylene oxide ukubandakanya amaqela e-hydroxyethyl. I-degree of substitution (DS) kuzo zombini i-HPMC kunye ne-HEC inokulawulwa ngokulungelelanisa iimeko zokusabela, ezichaphazela iipropati zabo ezifana ne-viscosity, i-solubility, kunye nokuziphatha kwe-gelation.

3. Ulwakhiwo lweMichiza:
I-HPMC kunye ne-HEC ziyahluka kwiindidi zamaqela abambeleyo aqhotyoshelwe kwi-cellulose backbone. I-HPMC iqulethe omabini amaqela e-hydroxypropyl kunye ne-methyl, ngelixa i-HEC iqulethe amaqela e-hydroxyethyl. Ezi zinto zithatha indawo zinika iimpawu ezizodwa kwisisusa ngasinye, ziphembelela ukuziphatha kwazo kwizicelo ezahlukeneyo.

4. IiPropati zoMzi:
Zombini i-HPMC kunye ne-HEC zipolima ezinyibilikayo emanzini ezineempawu ezigqwesileyo zokujiya. Nangona kunjalo, babonisa umahluko kwi-viscosity, umthamo we-hydration, kunye nokukwazi ukwenza ifilimu. I-HPMC idla ngokuba ne-viscosity ephezulu xa kuthelekiswa ne-HEC kugxininiso olulinganayo, iyenza ilungele usetyenziso olufuna ukujiya okukhulu.

Ukongeza, i-HPMC yenza iifilimu ezicacileyo nezidibeneyo ngenxa ye-methyl substituents, ngelixa i-HEC yenza iifilimu ezithambileyo nezibhetyebhetye ngakumbi. Ezi zintlukwano kwiipropati zefilimu zenza i-derivative nganye ifaneleke kwizicelo ezithile kumachiza, iimveliso zokunakekelwa komntu, kunye namashishini okutya.

5. Usetyenziso:
5.1 Ishishini loShishino:
Zombini i-HPMC kunye ne-HEC zisetyenziswa ngokubanzi kuqulunqo lwamayeza njengezibophelelo, ii-thickeners, kunye nee-agent zokugquma ifilimu. Baphucula ingqibelelo yethebhulethi, balawule ukukhutshwa kweziyobisi, kwaye baphucule i-mouthfeel kwimixube yolwelo. I-HPMC ikhethwa kwimixube yokukhutshwa okuzinzileyo ngenxa yokucotha kwesantya sokugalela amanzi, ngelixa i-HEC isetyenziswa ngokuqhelekileyo kwizisombululo zamehlo kunye neekhrim zamehlo ngenxa yokucaca kunye nokuhambelana nolwelo lwebhayoloji.

5.2 Ushishino loKwakha:
Kushishino lokwakha,HPMCkwayeI-HECzisetyenziswa njengezongezo kwizinto ezisekwe kwisamente, ezinje ngodaka, iigrouts, kunye neerenders. Baphucula ukusebenza, ukugcinwa kwamanzi, kunye nokubambelela, okukhokelela ekusebenzeni okuphuculweyo kunye nokuqina kwemveliso yokugqibela. I-HPMC isoloko ikhethwa kumthamo wayo ophezulu wokugcinwa kwamanzi, okunciphisa ukuqhekeka kunye nokuphucula ixesha lokumisela.

5.3 Iimveliso zokuKhathalela umntu:
Zombini izinto eziphuma kuzo zifumana usetyenziso kwiimveliso zokhathalelo lomntu ezinje ngeeshampu, iiloshini, kunye neekhrimu njengeearhente zokujiya, iziminyinyili kunye nezizinzisi. I-HEC inika i-texture egudileyo kunye ne-glossy kwi-formulation, iyenza ifaneleke kwiimveliso zokunakekelwa kweenwele kunye neekhrimu zesikhumba. I-HPMC, kunye neempawu zayo eziphezulu zokwenza ifilimu, isetyenziswe kwi-sunscreens kunye ne-cosmetic formulations efuna ukuxhathisa kwamanzi kunye nokunxiba okuhlala ixesha elide.

5.4 Ishishini lokutya:
Kushishino lokutya, i-HPMC kunye ne-HEC zisebenza njengee-arhente ezityebisayo, izizinzisi, kunye neetekisi kwiimveliso ezahlukeneyo ezibandakanya iisosi, iilokhwe, kunye nezimuncumuncu. Baphucula umlomo, banqande i-syneresis, kwaye baphucula iimpawu zoluvo lokuqulunqwa kokutya. I-HPMC idla ngokukhethwa ukucaca kwayo kunye nokuzinza kobushushu, iyenza ifaneleke kwizicelo ezifuna iijeli ezibonakalayo kunye ne-emulsions ezinzileyo.

6. Isiphelo:
I-hydroxypropyl methylcellulose (HPMC) kunye ne-hydroxyethyl cellulose (HEC) ziphuma kwi-cellulose ezinezakhiwo zeekhemikhali ezicacileyo, iipropati kunye nokusetyenziswa. Ngelixa zombini zibonelela ngokuqina okugqwesileyo kunye neempawu zokwenza ifilimu, zibonisa umahluko kwi-viscosity, ukucaca kwefilimu, kunye nokuziphatha kwe-hydration. Ukuqonda lo mahluko kubalulekile ekukhetheni i-derivative efanelekileyo kwizicelo ezithile kuwo wonke amashishini afana namayeza, ulwakhiwo, ukhathalelo lomntu, kunye nokutya. Njengoko uphando luqhubela phambili, uhlengahlengiso olongezelelekileyo kunye nokusetyenziswa kwezinto eziphuma kwi-cellulose kulindeleke, kube negalelo ekuqhubekeni kokubaluleka kwazo kumacandelo ahlukeneyo oshishino.