Hydroxypropyl methylcellulose le hydroxyethyl cellulose ka bobeli ke cellulose

Hydroxypropyl methylcellulose (HPMC)le hydroxyethyl cellulose (HEC) ke di-derivatives tse pedi tsa bohlokwa tsa cellulose tse sebediswang haholo diindastering tse fapaneng ka lebaka la thepa ya tsona e ikgethang. Le hoja ka bobedi di nkwa ho cellulose, di na le dibopeho tse fapaneng tsa dikhemikhale mme di bontsha dibopeho le ditshebediso tse fapaneng.

1. Selelekela ho Dintho tse tswang ho Cellulose:
Cellulose ke polysaccharide ea tlhaho e fumanoang maboteng a sele ea limela, e nang le liketane tse otlolohileng tsa li-unit tsa glucose tse hokahantsoeng ke litlamo tsa glycosidic tsa β(1→4). Li-derivative tsa cellulose li fumanoa ka ho fetola cellulose ka lik'hemik'hale ho ntlafatsa thepa e itseng kapa ho hlahisa mesebetsi e mecha. HPMC le HEC ke li-derivative tse peli tse joalo tse sebelisoang haholo liindastering ho tloha meriana ho ea kahong.

2. Ts'ebetso:
HPMC e hlahisoa ka ho kopanya cellulose le propylene oxide ho hlahisa lihlopha tsa hydroxypropyl ebe ka mor'a moo methyl chloride ho hlahisa lihlopha tsa methyl. Sena se fella ka ho nkeloa sebaka ha lihlopha tsa hydroxyl ketaneng ea cellulose, e leng se hlahisang sehlahisoa se nang le thepa e ntlafetseng ea ho qhibiliha le ho etsa filimi.

Ka lehlakoreng le leng, HEC e hlahisoa ka ho kopanya cellulose le ethylene oxide ho kenyelletsa lihlopha tsa hydroxyethyl. Tekanyo ea phetolo (DS) ho HPMC le HEC e ka laoloa ka ho fetola maemo a karabelo, e amang thepa ea tsona joalo ka viscosity, ho qhibiliha le boitšoaro ba gelation.

3. Sebopeho sa Lik'hemik'hale:
HPMC le HEC li fapana ka mefuta ea lihlopha tse nkelang sebaka tse khomaretsoeng mokokotlong oa cellulose. HPMC e na le lihlopha tsa hydroxypropyl le methyl, ha HEC e na le lihlopha tsa hydroxyethyl. Lintho tsena tse nkelang sebaka li fana ka litšobotsi tse ikhethang ho derivative e 'ngoe le e 'ngoe, li susumetsa boitšoaro ba tsona lits'ebetsong tse fapaneng.

4. Thepa ea 'Mele:
HPMC le HEC ka bobeli ke li-polymer tse qhibilihang ka metsing tse nang le thepa e ntle ea ho tenya. Leha ho le joalo, li bontša phapang ho viscosity, bokhoni ba ho nosetsa le bokhoni ba ho etsa filimi. HPMC hangata e na le viscosity e phahameng ha e bapisoa le HEC ka maemo a lekanang, e leng se etsang hore e lokele lits'ebetso tse hlokang ho tenya ho hoholo.

Ho phaella moo, HPMC e etsa lifilimi tse hlakileng le tse kopaneng haholoanyane ka lebaka la metsoako ea eona ea methyl, athe HEC e etsa lifilimi tse bonolo le tse tenyetsehang haholoanyane. Phapang ena ea thepa ea filimi e etsa hore sehlahisoa se seng le se seng se lokele lits'ebetso tse itseng meriana, lihlahisoa tsa tlhokomelo ea botho le liindasteri tsa lijo.

5. Likopo:
5.1 Indasteri ea Meriana:
HPMC le HEC ka bobeli li sebelisoa haholo mefuteng ea meriana e le li-binder, li-thickeners, le li-agent tse koahelang filimi. Li ntlafatsa botšepehi ba matlapa, li laola ho lokolloa ha meriana, 'me li ntlafatsa maikutlo a molomo mefuteng ea metsi. HPMC e khethoa bakeng sa mefuteng ea ho lokolloa e tsoelang pele ka lebaka la sekhahla sa eona sa ho nosetsa butle, ha HEC e sebelisoa hangata litharollong tsa mahlo le litlolong tsa letlalo ka lebaka la ho hlaka ha eona le ho lumellana ha eona le maro a baeloji.

5.2 Indasteri ea Kaho:
Indastering ea kaho,HPMCleHECLi sebelisoa e le lintho tse eketsang linthong tse thehiloeng samenteng, tse kang li-mortar, grouts le li-render. Li ntlafatsa ho sebetsa hantle, ho boloka metsi le ho khomarela, e leng se fellang ka ts'ebetso e ntlafetseng le ho tšoarella ha sehlahisoa sa ho qetela. Hangata HPMC e ratoa ka lebaka la bokhoni ba eona bo phahameng ba ho boloka metsi, e leng se fokotsang ho petsoha le ho ntlafatsa nako ea ho beha.

5.3 Lihlahisoa tsa Tlhokomelo ea Motho ka Mong:
Di-derivatives tsena ka bobedi di sebediswa dihlahisweng tsa tlhokomelo ya motho ka mong tse kang di-shampoo, di-lotion le di-cream e le di-agent tse teteanang, di-emulsifier le di-stabilizer. HEC e fana ka sebopeho se boreledi le se benyang mefuteng, e leng se etsang hore e lokele dihlahiswa tsa tlhokomelo ya moriri le di-cream tsa letlalo. HPMC, ka thepa ya yona e ntle ya ho etsa filimi, e sebediswa mefuteng ya di-sunscreen le mefuteng ya ditlolo e hlokang ho hanela metsi le ho kgathala nako e telele.

5.4 Indasteri ea Lijo:
Indastering ea lijo, HPMC le HEC li sebetsa e le metsoako e tenyang, e tsitsitseng, le e kopanyang lintho tse fapaneng lihlahisoa tse fapaneng ho kenyeletsoa le lisoso, litlolo le lijo tse tsoekere. Li ntlafatsa maikutlo a molomo, li thibela ho kopana ha metsoako, 'me li ntlafatsa litšobotsi tsa kutlo tsa metsoako ea lijo. HPMC hangata e khethoa ka lebaka la ho hlaka ha eona le botsitso ba mocheso, e leng se etsang hore e lokele lits'ebetso tse hlokang li-gel tse bonaletsang le li-emulsion tse tsitsitseng.

6. Qetello:
hydroxypropyl methylcellulose (HPMC) le hydroxyethyl cellulose (HEC) ke di-derivative tsa cellulose tse nang le dibopeho tse fapaneng tsa dikhemikhale, thepa le ditshebediso. Le hoja ka bobedi di fana ka thepa e ntle ya ho tenya le ho etsa filimi, di bontsha dipharologanyo tsa viscosity, ho hlaka ha filimi le boitshwaro ba ho metsa metsi. Ho utlwisisa dipharologanyo tsena ho bohlokwa bakeng sa ho kgetha derivative e nepahetseng bakeng sa ditshebediso tse itseng diindastering tse kang meriana, kaho, tlhokomelo ya motho ka mong le dijo. Ha dipatlisiso di ntse di tswela pele, ho lebelletswe diphetoho tse ding le ditshebediso tsa di-derivative tsa cellulose, tse tlatsetsang bohlokwa ba tsona bo tswelang pele makaleng a fapaneng a diindasteri.