Hydroxypropyl Methylcellulose (HPMC) ipolymer inoshandiswa zvakasiyana-siyana mumaindasitiri akasiyana-siyana anosanganisira mishonga, kuvaka, chikafu, uye zvizoro. Inotorwa kubva ku cellulose, polymer yechisikigo inowanikwa mumiti. HPMC inokosheswa zvikuru nekuda kwehunhu hwayo hwekuumba firimu, kukora, kugadzikana, uye kuchengetedza mvura. Muindasitiri yemishonga, inowanzo shandiswa semushonga unobatsira mumishonga mumhando dzemushonga unonwiwa, zvigadzirwa zvemaziso, mafomura emushonga, uye masisitimu ekutumira mishonga anodzorwa.
HPMC inogona kuiswa muzvikamu zvichienderana nezvimiro zvakasiyana-siyana zvinosanganisira huremu hwayo hwemamorekuru, mwero wekutsiva, uye saizi yezvikamu. Heino tarisiro yemhando dzakasiyana dzeHPMC zvichibva pane izvi:
Zvichibva paMolecular Weight:
HPMC ine huremu hwakanyanya hwemamorekuru: Rudzi urwu rweHPMC rune huremu hwakanyanya hwemamorekuru, zvichikonzera kuwedzera kwekusimba uye hunhu hwekugadzira firimu. Inowanzo shandiswa mukushandiswa uko kusimba kwakawanda kunodiwa, senge mumafomula anodzorwa.
Huremu Hwakaderera hweMorekuru HPMC: Kusiyana neizvi, huremu hushoma hwemamorekuru HPMC ine huremu hushoma uye inoshandiswa mukushandiswa uko huremu hushoma uye kunyungudika nekukurumidza kunodiwa.
Zvichibva padanho rekutsiva (DS):
High Substitution HPMC (HPMC-HS): HPMC ine mwero wepamusoro wekutsiva inowanzo nyungudika zviri nani mumvura uye inogona kushandiswa mumafomura anoda kunyungudika nekukurumidza.
Chinzvimbo Chepakati CheHPMC (HPMC-MS): Rudzi urwu rweHPMC runopa chiyero pakati pekunyungudika uye kusimba. Inowanzoshandiswa mumhando dzakasiyana dzemishonga.
Kutsiva Kwakaderera HPMC (HPMC-LS): HPMC ine mwero wakaderera wekutsiva inopa mwero wekunyungudika unononoka uye kusimba kwakanyanya. Inowanzo shandiswa mumhando dzemushonga unoburitswa kwenguva refu.
Zvichibva paSaizi yeChidimbu:
Saizi yezvikamu zvidiki HPMC: HPMC ine saizi diki inopa hunhu huri nani hwekuyerera kwemvura uye inowanzo shandiswa mumhando dzakasimba dzakadai semapiritsi nemakapisi.
Saizi yezvikamu zvakakora HPMC: Zvikamu zvakakora zvakakodzera kushandiswa kana paine zvinhu zvinodzora kuburitswa kana kuti zvinowedzerwa kuburitswa. Zvinowanzoshandiswa mumapiritsi nemapellets.
Magiredhi Akakosha:
HPMC yemudumbu: Rudzi urwu rweHPMC rwakagadzirwa kuti rurambe mvura yemudumbu, zvichiita kuti ipfuure nemudumbu isina chinhu uye ibudise mushonga mudumbu. Inoshandiswa zvakanyanya pamishonga inonzwa pH yemudumbu kana kuti pakupa mushonga zvakananga.
HPMC Inosunungurwa Zvisingaperi: Mishonga iyi yakagadzirirwa kuburitsa mushonga unoshanda zvishoma nezvishoma kwenguva yakareba, zvichiita kuti mushonga ushande kwenguva refu uye kuderedza kuwanda kwemishonga. Inowanzo shandiswa muzvirwere zvisingaperi apo kuchengetedza huwandu hwemishonga muropa kwakakosha.
Magiredhi Akasanganiswa:
HPMC-Acetate Succinate (HPMC-AS): Rudzi urwu rweHPMC runosanganisa hunhu hweHPMC nemapoka eacetyl, zvichiita kuti ive yakakodzera kuputira mukati medumbu uye masisitimu ekutumira mishonga anonzwa pH.
HPMC-Phthalate (HPMC-P): HPMC-P ipolymer inoenderana nepH inowanzoshandiswa mu enteric coating kudzivirira mushonga kubva kumamiriro eacidic mudumbu.
Misanganiswa Yakagadzirwa Nemunhu:
Vagadziri vanogona kugadzira musanganiswa weHPMC nemamwe mapolymer kana zvimwe zvinoshandiswa kuti vawane zvinodiwa zvakaita sekuvandudzwa kwehuwandu hwemishonga inoburitswa, kugadzikana kwakawedzerwa, kana kuti hunhu huri nani hwekuvhara kuravira.
Hunhu hwakasiyana-siyana hweHPMC hunobvumira kushandiswa kwayo mumhando dzakasiyana-siyana dzemishonga, imwe neimwe yakagadzirirwa kusangana nezvinodiwa zvakaita sekunyunguduka, viscosity, release kinetics, uye kugadzikana. Kunzwisisa mhando dzakasiyana dzeHPMC nehunhu hwadzo kwakakosha kuti vagadziri vagadzire masisitimu ekutumira mishonga anoshanda uye akagadziridzwa.
Nguva yekutumira: Kurume-19-2024