Hydroxypropyl Methylcellulose (HPMC) yog ib qho polymer uas siv tau ntau yam hauv ntau yam lag luam xws li tshuaj, kev tsim kho, khoom noj, thiab tshuaj pleev ib ce. Nws yog los ntawm cellulose, ib qho polymer ntuj uas pom muaj nyob rau hauv cov nroj tsuag. HPMC tau txais kev qhuas dav rau nws cov khoom ua zaj duab xis, ua kom tuab, ruaj khov, thiab khaws dej. Hauv kev lag luam tshuaj, nws feem ntau siv ua cov tshuaj ntxiv hauv cov ntawv noj tshuaj, cov tshuaj pleev qhov muag, cov tshuaj pleev, thiab cov txheej txheem xa tshuaj tswj hwm.
HPMC tuaj yeem raug faib ua pawg raws li ntau yam kev ntsuas suav nrog nws qhov hnyav molecular, qib kev hloov pauv, thiab qhov loj ntawm cov khoom me me. Nov yog cov lus piav qhia ntawm ntau hom HPMC raws li cov kev ntsuas no:
Raws li Qhov Hnyav Molecular:
HPMC Qhov Hnyav Molecular Siab: Hom HPMC no muaj qhov hnyav molecular siab dua, ua rau muaj viscosity thiab cov khoom tsim zaj duab xis zoo dua. Nws feem ntau nyiam siv rau hauv cov ntawv thov uas xav tau viscosity siab dua, xws li hauv cov qauv tswj kev tso tawm.
Qhov Hnyav Molecular Qis HPMC: Ntawm qhov tod tes, qhov hnyav molecular qis HPMC muaj viscosity qis dua thiab siv rau hauv cov ntawv thov uas xav tau viscosity qis dua thiab kev yaj sai dua.
Raws li Qib Kev Hloov Chaw (DS):
HPMC Hloov Chaw Siab (HPMC-HS): HPMC nrog qib siab ntawm kev hloov chaw feem ntau qhia tau tias muaj kev yaj zoo dua hauv dej thiab tuaj yeem siv rau hauv cov qauv uas xav tau kev yaj sai.
HPMC Hloov Chaw Nruab Nrab (HPMC-MS): Hom HPMC no muab kev sib npaug ntawm kev yaj thiab viscosity. Nws feem ntau siv rau hauv ntau hom tshuaj.
HPMC Hloov Chaw Qis (HPMC-LS): HPMC nrog qib hloov chaw qis dua muab cov nqi yaj qeeb dua thiab viscosity siab dua. Nws feem ntau siv rau hauv cov ntawv tso tawm tshuaj.
Raws li Qhov Loj ntawm Cov Khoom Me Me:
Qhov Loj Me HPMC: HPMC nrog cov khoom me me muaj cov yam ntxwv ntws zoo dua thiab feem ntau nyiam siv rau hauv cov ntawv khoj xws li cov ntsiav tshuaj thiab cov tshuaj ntsiav.
Qhov Loj ntawm Cov Khoom Me Me HPMC: Cov khoom me me dua yog qhov tsim nyog rau cov ntawv thov uas xav tau kev tswj hwm kev tso tawm lossis kev tso tawm ntev. Lawv feem ntau siv rau hauv cov ntsiav tshuaj matrix thiab pellets.
Cov Qib Tshwj Xeeb:
Enteric HPMC: Hom HPMC no yog tsim tshwj xeeb los tiv thaiv cov kua dej hauv plab, ua rau nws hla dhau lub plab kom zoo thiab tso cov tshuaj tawm hauv plab. Nws feem ntau siv rau cov tshuaj uas rhiab rau pH hauv plab lossis rau kev xa khoom raws li lub hom phiaj.
Kev Tso Tawm HPMC Ntev: Cov qauv no yog tsim los tso cov khoom xyaw nquag maj mam dhau lub sijhawm ntev, ua rau cov tshuaj ua haujlwm ntev thiab txo qhov zaus noj tshuaj. Lawv feem ntau siv rau hauv cov mob ntev uas tswj cov tshuaj kom ruaj khov hauv cov ntshav yog qhov tseem ceeb.
Cov Qib Sib Xyaws:
HPMC-Acetate Succinate (HPMC-AS): Hom HPMC no muab cov khoom ntawm HPMC thiab acetyl pawg sib xyaw ua ke, ua rau nws tsim nyog rau cov txheej txheem enteric thiab cov txheej txheem xa tshuaj pH-sensitive.
HPMC-Phthalate (HPMC-P): HPMC-P yog ib qho polymer uas nyob ntawm pH uas feem ntau siv rau hauv cov txheej txheem enteric los tiv thaiv cov tshuaj los ntawm cov mob acidic hauv plab.
Kev Sib Xyaws Tshwj Xeeb:
Cov chaw tsim khoom tuaj yeem tsim cov khoom sib xyaw ua ke ntawm HPMC nrog lwm cov polymers lossis cov khoom siv kom ua tiav cov kev cai tshwj xeeb xws li cov qauv tso tawm tshuaj zoo dua, kev ruaj khov zoo dua, lossis cov yam ntxwv zoo dua.
Cov khoom sib txawv ntawm HPMC tso cai rau nws siv rau hauv ntau yam tshuaj tsim, txhua tus tsim los ua kom tau raws li cov kev xav tau tshwj xeeb xws li solubility, viscosity, tso tawm kinetics, thiab ruaj khov. Kev nkag siab txog ntau hom HPMC thiab lawv cov yam ntxwv yog qhov tseem ceeb rau cov neeg tsim qauv los tsim cov txheej txheem xa tshuaj zoo thiab zoo tshaj plaws.
Lub sijhawm tshaj tawm: Lub Peb Hlis-19-2024