Hydroxypropyl methylcellulose (HPMC) ipolymer yakagadzirwa semi-synthetic inoshandiswa zvakanyanya mumaindasitiri mazhinji, kunyanya mumunda wemishonga. HPMC yave chinhu chakakosha mukugadzirwa kwemishonga nekuda kwekushanda kwayo zvakanaka, kusakuvadza uye hunhu hwayo hwakanaka hwemuviri nemakemikari.
(1) Hunhu hwepakutanga hweHPMC yemhando yemishonga
HPMC imhando ye cellulose ether isingashandisi ionic yakagadzirwa nekuita kwe cellulose ne propylene oxide ne methyl chloride pasi pemamiriro e alkaline. Maumbirwo ayo akasiyana emakemikari anopa HPMC hunhu hwakanaka hwekunyunguduka, kukora, kugadzira firimu uye emulsifying. Izvi zvinotevera zvimwe zvezvinhu zvakakosha zveHPMC:
Kunyungudika kwemvura uye kuvimba ne pH: HPMC inonyungudika mumvura inotonhora uye inoumba mhinduro yakajeka ine viscous. Kunyungudika kwemhinduro yayo kwakabatana nekuwanda kwayo uye huremu hwemamorekuru, uye ine kugadzikana kwakasimba kune pH uye inogona kuramba yakagadzikana munzvimbo dzine acidic nealkaline.
Hunhu hweThermogel: HPMC ine hunhu hwakasiyana hwethermogel kana yapiswa. Inogona kugadzira gel kana yapiswa kusvika patembiricha yakati uye yodzokera pamamiriro ayo emvura mushure mekutonhora. Hunhu uhwu hunonyanya kukosha mukugadzirira mishonga inoburitswa kwenguva refu.
Kuenderana kwemuviri uye kusave nehupfu: Sezvo HPMC iri chinhu chinobva mu cellulose uye chisina chaji uye chisingazosangani nezvimwe zvinhu, ine hukama hwakanaka uye haizonyungudike mumuviri. Ichinhu chinobatsira muviri.
(2) Kushandiswa kweHPMC mumishonga
HPMC inoshandiswa zvakanyanya muindasitiri yemishonga, ichisanganisira mishonga yakawanda yakadai seyekunwa, yemushonga wepamusoro uye yekubaiwa jekiseni. Mirayiridzo yekushandisa kwayo huru ndeiyi inotevera:
1. Zvinhu zvinogadzira firimu mumapiritsi
HPMC inoshandiswa zvakanyanya mukuita kwekuputira mapiritsi sechinhu chinoumba firimu. Kuputira mapiritsi hakungogoni chete kudzivirira mishonga kubva mukukanganiswa nemamiriro ekunze, akadai sehunyoro nechiedza, asiwo kufukidza kunhuhwirira kwakashata uye kuravira kwemishonga, nokudaro zvichivandudza kutevedzera kwemurwere. Firimu rakagadzirwa neHPMC rine simba rakanaka uye rinodzivirira mvura, izvo zvinogona kuwedzera hupenyu hwemishonga.
Panguva imwe chete, HPMC inogonawo kushandiswa sechinhu chikuru che membranes dzinodzorwa kuti dzigadzirwe mapiritsi anosunungurwa kwenguva refu uye anodzorwa. Hunhu hwayo hwe thermal gel hunoita kuti mishonga iburitswe mumuviri nekukurumidza kwakatemwa, nokudaro zvichiita kuti pave nemigumisiro yekurapwa kwenguva refu. Izvi zvakakosha zvikuru mukurapa zvirwere zvisingaperi, zvakaita sezvinodiwa nemishonga kwenguva refu kune varwere vane chirwere cheshuga neBP.
2. Semumiririri anosunungura nguva dzose
HPMC inoshandiswa zvakanyanya sechinhu chinoburitsa mushonga kwenguva refu mukugadzirira mishonga inonwiwa. Nekuti inogona kugadzira gel mumvura uye gel layer inonyunguduka zvishoma nezvishoma sezvo mushonga unoburitswa, inogona kudzora zvinobudirira mwero wekuburitswa kwemushonga. Kushandiswa uku kwakakosha zvikuru mumishonga inoda kuburitswa kwemushonga kwenguva refu, senge insulin, mishonga inorwisa kushushikana, nezvimwewo.
Mumamiriro emudumbu, gel layer yeHPMC inogona kudzora mwero wekuburitswa kwemushonga, ichidzivirira kuburitswa kwemushonga nekukurumidza munguva pfupi, nokudaro ichideredza migumisiro yakaipa uye kuwedzera kushanda kwayo. Hunhu uhwu hwekuburitswa kwenguva refu hwakakodzera zvakanyanya kurapwa kwemishonga inoda huwandu hwakagadzikana hwemishonga muropa, senge mishonga inorwisa mabhakitiriya, mishonga inorwisa epileptic, nezvimwewo.
3. Sechinhu chinosunga
HPMC inowanzoshandiswa sechinobatanidza mushonga mukugadzirwa kwepiritsi. Nekuwedzera HPMC muzvikamu zvemushonga kana hupfu, kuyerera kwayo nekunamatira kwayo zvinogona kuvandudzwa, nokudaro zvichivandudza kudzvanywa uye simba repiritsi. Kusava nehupfu uye kugadzikana kweHPMC kunoita kuti ive chinobatanidza chakakodzera mumapiritsi, magranules nemakapisi.
4. Sechinhu chinosimbisa uye chinosimbisa
Mukugadzirwa kwemvura, HPMC inoshandiswa zvakanyanya semushonga wekuomesa uye wekusimbisa muviri muzvinwiwa zvakasiyana-siyana zvinonwiwa, madonhwe emaziso uye mafuta emushonga. Hunhu hwayo hwekuomesa hunogona kuwedzera kusimba kwemishonga yemvura, kudzivirira kupatsanurwa kwemishonga kana kunaya kwemvura, uye kuona kuti zvinhu zvinoshandiswa mumishonga zvinopararira zvakaenzana. Panguva imwe chete, mafuta uye hunhu hwekunyorovesa hweHPMC zvinoita kuti ikwanise kuderedza kusagadzikana kwemaziso mumadonhwe emaziso uye kudzivirira maziso kubva pakutsamwa kwekunze.
5. Inoshandiswa mumakapisi
Se cellulose inobva mumiti, HPMC ine hutano hwakanaka, zvichiita kuti ive chinhu chakakosha pakugadzira makapisi emiti. Kana ichienzaniswa nemakapisi egelatin emhuka echinyakare, makapisi eHPMC ane kugadzikana kuri nani, kunyanya munzvimbo dzinopisa zvakanyanya uye dzine hunyoro hwakawanda, uye hazvisi nyore kuchinjika kana kunyunguduka. Pamusoro pezvo, makapisi eHPMC akakodzera vanhu vanodya miriwo chete nevarwere vane allergy kugelatin, zvichiwedzera mukana wekushandisa mishonga yemakapupisi.
(3) Mamwe mashandisirwo emishonga eHPMC
Pamusoro pekushandiswa kwemishonga yataurwa pamusoro apa, HPMC inogona kushandiswawo mune mamwe madhiragi chaiwo. Semuenzaniso, mushure mekuvhiyiwa kwemaziso, HPMC inoshandiswa mumadonhwe emaziso semafuta ekuderedza kukweshana pamusoro peziso uye kukurudzira kupora. Pamusoro pezvo, HPMC inogona kushandiswawo mumafuta ekuzora uye majeli ekukurudzira kunyudzwa kwemishonga uye kuvandudza kushanda kwemishonga yemuno.
HPMC yemhando yemishonga ine basa rakakosha mukugadzirira mishonga nekuda kwehunhu hwayo hwakanaka hwemuviri nemakemikari. Semubatsiri wemishonga unoshanda mabasa akawanda, HPMC haingogone chete kuvandudza kugadzikana kwemishonga nekudzora kuburitswa kwemishonga, asiwo inovandudza ruzivo rwekutora mishonga uye kuwedzera kutevedzera mitemo yemurwere. Nekufambira mberi kuri kuitwa tekinoroji yemishonga, nzvimbo yekushandisa HPMC ichave yakakura uye ichaita basa rakakosha mukugadzirwa kwemishonga mune ramangwana.
Nguva yekutumira: Gunyana-19-2024