Hydroxypropyl methylcellulose (HPMC) yog cov polymer semi-synthetic uas siv dav hauv ntau lub lag luam, tshwj xeeb tshaj yog hauv kev lag luam tshuaj. HPMC tau dhau los ua ib qho khoom siv tseem ceeb hauv kev npaj tshuaj vim nws cov biocompatibility, tsis muaj tshuaj lom thiab cov khoom zoo heev ntawm lub cev thiab tshuaj lom neeg.
(1) Cov yam ntxwv tseem ceeb ntawm cov tshuaj HPMC
HPMC yog cov cellulose ether uas tsis yog ionic uas tau npaj los ntawm kev sib xyaw ntawm cellulose nrog propylene oxide thiab methyl chloride hauv qab alkaline. Nws cov qauv tshuaj lom neeg tshwj xeeb muab HPMC zoo heev solubility, thickening, zaj duab xis-tsim thiab emulsifying zog. Cov hauv qab no yog qee qhov tseem ceeb ntawm HPMC:
Kev yaj dej thiab pH nyob ntawm: HPMC yaj hauv dej txias thiab tsim cov kua nplaum pob tshab. Qhov viscosity ntawm nws cov tshuaj muaj feem cuam tshuam nrog kev sib xyaw thiab qhov hnyav molecular, thiab nws muaj kev ruaj khov rau pH thiab tuaj yeem ruaj khov hauv ob qho tib si acidic thiab alkaline ib puag ncig.
Cov khoom siv thermogel: HPMC ua rau pom cov khoom siv thermogel tshwj xeeb thaum cua sov. Nws tuaj yeem tsim cov gel thaum cua sov rau qee qhov kub thiab rov qab mus rau lub xeev kua tom qab txias. Cov khoom no yog qhov tseem ceeb tshwj xeeb hauv kev npaj tshuaj uas tso tawm tas mus li.
Kev sib haum xeeb ntawm lub cev thiab tsis muaj tshuaj lom: Vim tias HPMC yog ib qho khoom siv los ntawm cellulose thiab tsis muaj nqi thiab yuav tsis cuam tshuam nrog lwm cov khoom xyaw, nws muaj kev sib haum xeeb zoo heev thiab yuav tsis nqus tau rau hauv lub cev. Nws yog ib qho khoom siv tsis muaj tshuaj lom.
(2) Daim ntawv thov ntawm HPMC hauv cov tshuaj
HPMC siv dav hauv kev lag luam tshuaj, npog ntau yam teb xws li noj, tshuaj pleev thiab tshuaj txhaj. Nws cov lus qhia tseem ceeb rau kev siv yog raws li nram no:
1. Cov khoom siv ua zaj duab xis hauv cov ntsiav tshuaj
HPMC siv dav hauv cov txheej txheem txheej ntawm cov ntsiav tshuaj ua cov khoom siv ua zaj duab xis. Cov txheej txheem ntsiav tshuaj tsis tsuas yog tiv thaiv cov tshuaj los ntawm kev cuam tshuam ntawm ib puag ncig sab nraud, xws li dej noo thiab lub teeb, tab sis kuj tseem npog cov ntxhiab tsw phem thiab saj ntawm cov tshuaj, yog li txhim kho kev ua raws li tus neeg mob. Cov zaj duab xis tsim los ntawm HPMC muaj kev tiv thaiv dej zoo thiab lub zog, uas tuaj yeem ua kom lub sijhawm txee ntawm cov tshuaj ntev dua.
Tib lub sijhawm, HPMC kuj tseem siv tau ua cov khoom tseem ceeb ntawm cov membranes tswj-tso tawm rau kev tsim cov ntsiav tshuaj tso tawm tas mus li thiab cov ntsiav tshuaj tswj-tso tawm. Nws cov khoom thermal gel tso cai rau cov tshuaj kom raug tso tawm hauv lub cev ntawm tus nqi tso tawm ua ntej, yog li ua tiav cov txiaj ntsig ntawm kev kho mob ntev. Qhov no tseem ceeb heev rau kev kho cov kab mob ntev, xws li cov kev xav tau tshuaj mus sij hawm ntev ntawm cov neeg mob uas muaj ntshav qab zib thiab ntshav siab.
2. Ua ib tus neeg sawv cev tso tawm tas mus li
HPMC siv dav ua tus neeg sawv cev tso tawm ntev hauv kev npaj tshuaj noj. Vim tias nws tuaj yeem tsim cov gel hauv dej thiab cov txheej gel maj mam yaj thaum cov tshuaj tso tawm, nws tuaj yeem tswj tau qhov nrawm ntawm cov tshuaj tso tawm. Daim ntawv thov no tseem ceeb heev rau cov tshuaj uas xav tau kev tso tawm tshuaj ntev, xws li insulin, tshuaj antidepressants, thiab lwm yam.
Hauv ib puag ncig ntawm txoj hnyuv, cov txheej gel ntawm HPMC tuaj yeem tswj hwm qhov kev tso tawm ntawm cov tshuaj, zam kev tso tawm sai ntawm cov tshuaj hauv lub sijhawm luv luv, yog li txo cov kev mob tshwm sim thiab ua kom ntev lub sijhawm ua haujlwm. Cov khoom tso tawm ntev no yog qhov tshwj xeeb tshaj yog rau kev kho cov tshuaj uas xav tau cov tshuaj ntshav ruaj khov, xws li tshuaj tua kab mob, tshuaj tiv thaiv kab mob qaug dab peg, thiab lwm yam.
3. Ua ib daim ntawv khi
HPMC feem ntau siv ua cov khoom sib txuas hauv cov txheej txheem tsim cov ntsiav tshuaj. Los ntawm kev ntxiv HPMC rau cov tshuaj me me lossis hmoov, nws cov kua thiab kev nplaum tuaj yeem txhim kho, yog li txhim kho cov nyhuv nias thiab lub zog ntawm cov ntsiav tshuaj. Qhov tsis muaj tshuaj lom thiab kev ruaj khov ntawm HPMC ua rau nws yog cov khoom sib txuas zoo tshaj plaws hauv cov ntsiav tshuaj, granules thiab capsules.
4. Ua ib qho thickener thiab stabilizer
Hauv kev npaj kua, HPMC yog siv dav ua cov khoom ua kom tuab thiab ruaj khov hauv ntau yam kua dej hauv qhov ncauj, tshuaj qhov muag thiab tshuaj pleev rau sab nraud. Nws cov khoom ua kom tuab tuaj yeem ua rau cov tshuaj kua viscosity nce ntxiv, zam kev faib tshuaj lossis nag, thiab xyuas kom meej tias cov khoom xyaw tshuaj sib npaug. Tib lub sijhawm, cov khoom ua kom lubricity thiab noo noo ntawm HPMC ua rau nws txo qhov tsis xis nyob ntawm cov tshuaj qhov muag thiab tiv thaiv qhov muag los ntawm kev khaus sab nraud.
5. Siv rau hauv cov tshuaj ntsiav
Ua ib qho cellulose los ntawm cov nroj tsuag, HPMC muaj kev sib raug zoo zoo, ua rau nws yog ib qho khoom siv tseem ceeb rau kev ua cov tshuaj ntsiav cog. Piv nrog rau cov tshuaj ntsiav gelatin tsiaj ib txwm muaj, HPMC capsules muaj kev ruaj khov zoo dua, tshwj xeeb tshaj yog nyob rau hauv qhov kub thiab txias thiab noo noo, thiab tsis yooj yim rau deform lossis yaj. Tsis tas li ntawd, HPMC capsules yog qhov tsim nyog rau cov neeg tsis noj nqaij thiab cov neeg mob uas ua xua rau gelatin, nthuav dav qhov ntau thiab tsawg ntawm kev siv cov tshuaj ntsiav.
(3) Lwm cov ntawv thov tshuaj ntawm HPMC
Ntxiv rau cov tshuaj siv dav dav saum toj no, HPMC kuj tseem siv tau rau hauv qee qhov chaw muag tshuaj tshwj xeeb. Piv txwv li, tom qab phais qhov muag, HPMC siv rau hauv cov tshuaj qhov muag ua cov roj nplua nyeem kom txo qhov sib txhuam ntawm qhov muag thiab txhawb kev rov zoo. Tsis tas li ntawd, HPMC kuj tseem siv tau rau hauv cov tshuaj pleev thiab cov gels los txhawb kev nqus tshuaj thiab txhim kho kev ua haujlwm ntawm cov tshuaj hauv zos.
Qib tshuaj HPMC ua lub luag haujlwm tseem ceeb hauv kev npaj tshuaj vim nws cov khoom siv lub cev thiab tshuaj zoo heev. Ua ib qho tshuaj ntxiv rau ntau yam tshuaj, HPMC tsis yog tsuas yog txhim kho kev ruaj khov ntawm cov tshuaj thiab tswj kev tso tawm cov tshuaj, tab sis kuj txhim kho kev paub txog kev noj tshuaj thiab ua rau cov neeg mob ua raws li txoj cai. Nrog rau kev nce qib tas mus li ntawm cov thev naus laus zis tshuaj, daim ntawv thov ntawm HPMC yuav dav dua thiab ua lub luag haujlwm tseem ceeb hauv kev tsim tshuaj yav tom ntej.
Lub sijhawm tshaj tawm: Cuaj hlis-19-2024