Hydroxypropyl Methylcellulose (HPMC)bụ cellulose ether nke na-abụghị ionic a na-ejikarị eme ihe, nke a na-ejikarị eme ihe n'ihe owuwu ụlọ, ọgwụ, nri, ihe mkpuchi, na ubi ndị ọzọ. Nkwụsi ike na ịdị mma arụmọrụ ya na-emetụta mmetụta ngwaahịa ikpeazụ ozugbo; ya mere, nnwale usoro nke HPMC n'oge mmepụta na itinye ya n'ọrụ dị oke mkpa.
1. Ọdịdị na Nnwale Ihe Onwunwe Ndị Dị Mkpa
Tupu a nwalee ya, a ga-ebu ụzọ hụ ihe nlele ahụ anya. HPMC dị elu kwesịrị ịbụ ntụ ntụ ọcha ma ọ bụ nke na-acha ọcha nke nwere ike ịgbapụ nke ọma, na-enweghị ntụpọ, isi ọjọọ, ma ọ bụ ihe na-adịghị mma. Mmiri mmiri ya kwesịrị ịpụta ìhè ma ọ bụ dị ntakịrị gbara ọchịchịrị, na-enweghị ihe doro anya a kpọchiri akpọchi. Mgbe nke ahụ gasịrị, a na-achọpụta ọdịnaya mmiri ya, a na-ejikarị ihe nyocha mmiri infrared ma ọ bụ usoro nkụcha (usoro ịdị arọ 105℃ na-adịgide adịgide). Ngwaahịa ndị ruru eru na-enwekarị mmiri dị n'okpuru 5%.
Nchọpụta nke ihe dị n'ime ntụ na-egosi ihe dị n'ime ya na-adịghị ọcha. A na-agba ihe nlele ahụ ọkụ n'ime ọkụ muffle na okpomọkụ 550℃ ruo mgbe ọ ga-adị arọ. A na-achọkarị ka ihe dị n'ime ntụ ahụ ghara ịgafe 1.5%. Oke ntụ ga-emetụta nghọta na ịdịgide nke ihe ngwọta ahụ.
2. Nnwale Viscosity
Viscosity bụ otu n'ime ihe ngosi arụmọrụ kachasị mkpa nke HPMC, na-ekpebi kpọmkwem otú o si sie ike, otú mmiri si ejide ya, na otú o si etolite ihe nkiri. A na-ejikarị viscometer na-agbagharị agbagharị (dị ka viscometer Brookfield) ma ọ bụ viscometer Ubbelohde capillary eme nnwale.
N'oge nnwale, a na-anwale oke ntinye (na-abụkarị 2%) nke mmiri mmiri HPMC na okpomọkụ akọwapụtara (n'ozuzu 20 ± 0.1℃). Ụdị HPMC dị iche iche nwere oke viscosity dị iche iche, dịka 400, 15000, na 100000 mPa·s. viscosity a tụrụ kwesịrị ikwekọ na oke ọkọlọtọ ngwaahịa; ma ọ bụghị ya, ọ na-egosi na ogo polymerization ma ọ bụ nnọchi ya adịghị agbanwe agbanwe.
3. Ọkwa nke Nnwale Mgbanwe (Ọdịnaya Methoxy na Hydroxypropoxy)
A na-ekpebi arụmọrụ nke HPMC site na ọdịnaya nke ihe ndị na-anọchi ya.
Ọdịnaya nke methoxy (–OCH₃) na-emetụta ike ịgbaze, okpomọkụ jel, na ọrụ elu;
Ihe dị na hydroxypropoxy (–OCH₂CHOHCH₃) na-emetụta mgbanwe na idobe mmiri.
Usoro nchọpụta na-ejikarị titration kemịkalụ ma ọ bụ gas chromatography eme ihe. Dịka ọmụmaatụ, mgbe acid hydrolysis gasịrị, ihe nlele ahụ na-emepụta mmanya ndị kwekọrọ na ya, nke a na-enyocha site na titration ma ọ bụ chromatography n'ọtụtụ. Ngwaahịa HPMC ruru eru na-enwekarị ọdịnaya methoxyl 19%–24% na ọdịnaya hydroxypropoxyl 4%–12%.
4. Nha Okpomọkụ Gel
Àgwà thermogelation nke HPMC bụ ihe dị mkpa na-eme ka ọ dị iche na cellulose ethers ndị ọzọ. N'oge nnwale, a na-ekpo ọkụ ma na-akpali mmiri HPMC nwayọ nwayọ, a na-edekwa okpomọkụ nke mmiri ahụ na-agbanwe site na doro anya gaa na turbid dị ka okpomọkụ gel ya.
N'ozuzu, HPMC nwere oke methoxyl nwere okpomọkụ jel dị ala, ebe oke hydroxypropoxyl nwere okpomọkụ jel dị elu. Ihe ngosi a metụtara nkwụsi ike nke ngwaahịa ahụ na ngwa dịka ihe owuwu ụlọ na mkpuchi mbadamba.
5. Nnwale Uru pH na Ngụkọta Mmiri
Mgbe emechara nkwadebe HPMC nke 2%, a na-eji mita pH tụọ pH ya. Oke nkịtị bụ 5.0–8.0. N'ime oke a, HPMC kwụsiri ike ma agaghị emeghachi omume ọjọọ na ọtụtụ ihe ma ọ bụ ihe mgbakwunye na-adịghị mma.
Nnwale ịgbaze na-enyocha ọsọ mgbasa na mgbaze ya n'ime mmiri oyi. HPMC dị elu kwesịrị ịgbasa ngwa ngwa mgbe a na-akpali ya, na-emepụta ngwọta yiri nke ahụ ma doo anya n'ime nkeji iri atọ.
6. Nchọpụta Ịdị Ọcha na Ịdị Ọcha
Nchọpụta ịdị ọcha gụnyere ule maka ọla dị arọ, chlorides, sulfates, na oke nje bacteria.
Ọkwa ígwè dị arọ (dịka Pb) ekwesịghị ịgafe 20 ppm; chloride ≤ 0.2%, sulfate ≤ 0.5%;
Maka ọgwụ ma ọ bụ nri, a ga-anwale ọnụọgụ nje bacteria zuru oke, nje bacteria coliform, na ọnụọgụ ebu/yist iji hụ na nchekwa dị.
7. Nnyocha Thermogravimetric na Fourier Transform Infrared Spectroscopy
Iji nyochaa nhazi na nkwụsi ike okpomọkụ nke HPMC, enwere ike iji nyocha thermogravimetric (TGA) na Fourier transform infrared spectroscopy (FTIR).
TGA nwere ike ịchọpụta mgbanwe oke nke HPMC na okpomọkụ dị iche iche, si otú a chọpụta okpomọkụ nke mmebi okpomọkụ ya na oke nkwụsi ike ya;
FTIR na-enyocha nhazi otu ọrụ site na oke mmịpụta, na-egosi ọnụnọ nke eriri mmịpụta -OH, -OCH₃, na -OCH₂CHOHCH₃ njirimara iji kwado izi ezi nke nhazi molekul.
Nnwale usoro e kwuru n'elu na-enye ohere maka nyocha zuru oke nke njirimara physicochemical na ịdị mma nke HPMC. Viscosity, ogo nke nnọchi, na ọdịnaya mmiri bụ isi ihe na-egosi njikwa mma; ebe pH, ọdịnaya ntụ, na okpomọkụ gelation na-egosipụta ọkwa nhazi na ịdị ọcha ya. Nrubeisi siri ike na usoro nnwale ndị a abụghị naanị na-eme ka ngwaahịa kwụsie ike na ịdịgide arụmọrụ kamakwa ọ na-enye nkwado data a pụrụ ịdabere na ya maka nchekwa nangwa ngwa nke HPMCn'ime ụlọ ọrụ dịka owuwu ụlọ, ọgwụ, na nri.
Oge ozi: Ọktoba-31-2025