HPMC (hydroxypropyl methylcellulose) bụ ihe polymer na-agbaze mmiri nke a na-ejikarị eme ihe n'ihe gbasara owuwu ụlọ, ọgwụ, nri na kemịkalụ kwa ụbọchị. O nwere ezigbo ọkpụrụkpụ, emulsification, nhazi ihe nkiri, nchekwa colloid na ihe ndị ọzọ. Na sistemụ emulsion, HPMC nwere ike ijikwa viscosity nke emulsion n'ọtụtụ ụzọ.
1. Nhazi molekul nke HPMC
Oke ibu nke HPMC na oke mgbanwe ya na-emetụta oke viscosity nke HPMC. Ka ibu nke molekul buru ibu, otú ahụ ka viscosity nke ngwọta ahụ dị elu; na oke mgbanwe (ya bụ, oke mgbanwe nke hydroxypropyl na otu methoxy) na-emetụta ike ịgbaze na viscosity nke HPMC. N'ụzọ doro anya, ka oke mgbanwe ahụ dị elu, otú ahụ ka ike ịgbaze mmiri nke HPMC ka mma, viscosity na-abawanyekwa otú ahụ. Ndị nrụpụta na-enye ngwaahịa HPMC dị iche iche ibu na ogo mgbanwe iji gboo mkpa nke ngwa dị iche iche.
2. Jiri njupụta mee ihe
Njupụta nke HPMC na mmiri mmiri bụ otu n'ime ihe ndị dị mkpa na-emetụta viscosity. N'ikwu ya n'ozuzu, ka ntinye nke HPMC dị elu, otú ahụ ka viscosity nke ngwọta ahụ si ka mma. Agbanyeghị, viscosity nke ụdị HPMC dị iche iche n'otu ntinye nwere ike ịdị iche nke ukwuu. Ya mere, n'ọrụ bara uru, ọ dị mkpa ịhọrọ ntinye kwesịrị ekwesị nke ngwọta HPMC dịka ihe achọrọ maka viscosity si dị. Dịka ọmụmaatụ, n'ọrụ owuwu, a na-achịkwa ntinye nke HPMC n'etiti 0.1% na 1% iji nye viscosity ọrụ kwesịrị ekwesị na arụmọrụ owuwu.
3. Usoro mgbaze
Usoro ịgbasa nke HPMC nwekwara mmetụta dị mkpa na viscosity ikpeazụ. HPMC dị mfe ịgbasa na mmiri oyi, mana ọnụego ịgbasa na-adị nwayọ; ọ na-agbaze ngwa ngwa na mmiri ọkụ, mana ọ dị mfe ịgbasa. Iji zere ịgbasa, enwere ike iji usoro mgbakwunye nwayọ nwayọ, ya bụ, buru ụzọ tinye HPMC nwayọ nwayọ na mmiri oyi ka ọ gbasaa, wee kpoo ọkụ ma kpalie ruo mgbe ọ ga-agbaze kpamkpam. Na mgbakwunye, enwere ike ịgwakọta HPMC na ntụ ndị ọzọ kpọrọ nkụ wee tinye ya na mmiri iji gbazee iji melite arụmọrụ ịgbasa na nkwụsi ike.
4. Okpomọkụ
Okpomọkụ nwere mmetụta dị ukwuu na viscosity nke ngwọta HPMC. N'ozuzu, viscosity nke ngwọta HPMC na-ebelata ka okpomọkụ na-arị elu. Nke a bụ n'ihi na ịrị elu okpomọkụ ga-eme ka njikọ hydrogen dị n'etiti molekul ghara ịdị ike, na-eme ka agbụ molekul HPMC na-amị amị ngwa ngwa, si otú a na-ebelata viscosity nke ngwọta ahụ. Ya mere, n'ime ngwa ndị chọrọ viscosity dị elu, a na-ejikarị ngwọta HPMC eme ihe na obere okpomọkụ. Dịka ọmụmaatụ, na ngwa ọgwụ, a na-ejikarị ngwọta HPMC eme ihe na okpomọkụ ụlọ iji hụ na ọgwụ ahụ kwụsiri ike ma dị irè.
5. uru pH
Ọnụọgụ pH na-emetụtakwa oke mmiri mmiri nke ngwọta HPMC. HPMC nwere oke mmiri mmiri kachasị elu n'okpuru ọnọdụ acidic na-anọpụ iche na nke na-adịghị ike, ebe oke mmiri mmiri ga-ebelata nke ukwuu n'okpuru ọnọdụ acidic ma ọ bụ alkaline siri ike. Nke a bụ n'ihi na oke mmiri ...
6. Ihe mgbakwunye ndị ọzọ
N'ime sistemụ emulsion, enwere ike ịgbanwe viscosity nke HPMC site na ịgbakwunye ihe ndị ọzọ na-eme ka ihe sie ike ma ọ bụ ihe mgbaze. Dịka ọmụmaatụ, itinye nnu ndị na-adịghị mma (dịka sodium chloride) kwesịrị ekwesị nwere ike ime ka viscosity nke ngwọta HPMC dịkwuo elu; ebe itinye ihe mgbaze organic dị ka ethanol nwere ike ibelata viscosity ya. Na mgbakwunye, mgbe ejiri ya na ihe ndị ọzọ na-eme ka ihe sie ike (dịka xanthan gum, carbomer, wdg), viscosity na nkwụsi ike nke emulsion nwekwara ike ime ka ọ ka mma nke ukwuu. Ya mere, na nhazi usoro n'ezie, enwere ike ịhọrọ ihe mgbakwunye kwesịrị ekwesị dịka ọ dị mkpa iji melite viscosity na arụmọrụ nke emulsion.
HPMC nwere ike nweta njikwa ziri ezi nke viscosity emulsion site na nhazi molekul ya, ntinye ojiji ya, usoro mgbasa ya, okpomọkụ, uru pH na ihe mgbakwunye ya. N'ọrụ bara uru, a ga-atụle ihe ndị a nke ọma iji họrọ ụdị HPMC na ọnọdụ ojiji kwesịrị ekwesị iji nweta mmetụta siri ike kachasị mma. Site na nhazi usoro sayensị na njikwa usoro, HPMC nwere ike ịrụ ọrụ dị mkpa n'ọhịa nke owuwu, ọgwụ, nri na kemịkalụ kwa ụbọchị, na-enye arụmọrụ dị mma na ahụmịhe onye ọrụ.
Oge ozi: Julaị-17-2024