IHydroxypropyl Methylcellulose (HPMC)iwuhlobo lwe-cellulose oluguqulwe ngamakhemikhali olusetshenziswa kakhulu ezimbonini ezihlukahlukene ezifana nemithi, ukukhiqiza ukudla, kanye nezokwakha. Kuyinhlanganisela ehlukahlukene, evame ukusetshenziswa njenge-thickener, binder, i-ejenti yokwakha ifilimu, kanye ne-stabilizer. Nokho, ayinayo “inombolo yomkhiqizo” ethile ngomqondo ovamile, njengomkhiqizo noma ingxenye yenombolo ongayithola kwezinye izimo zokukhiqiza. Esikhundleni salokho, i-HPMC ikhonjwa ngesakhiwo sayo samakhemikhali kanye nenani lezimpawu, njengezinga lokushintshwa kanye ne-viscosity.
Ulwazi Olujwayelekile Mayelana ne-Hydroxypropyl Methylcellulose (HPMC)
Isakhiwo Sekhemikhali: I-HPMC yenziwa ngokushintsha i-cellulose amakhemikhali ngokufaka amaqembu e-hydroxyl (-OH) esikhundleni samaqembu e-hydroxypropyl namaqembu e-methyl. Ukushintshanisa kushintsha izici ze-cellulose, kuyenze incibilike kakhulu emanzini futhi inikeze izici zayo ezihlukile njengekhono elithuthukisiwe lokwenza ifilimu, amandla okubopha, kanye nekhono lokugcina umswakama.
Izihlonzi Ezivamile kanye Nokuqanjwa Kwegama
Ukuhlonzwa kwe-Hydroxypropyl Methylcellulose ngokuvamile kuncike ezinhlobonhlobo zezivumelwano zokuqamba ezichaza ukwakheka kwamakhemikhali kanye nezakhiwo zayo:
Inombolo ye-CAS:
I-Chemical Abstracts Service (CAS) inika isihlonzi esiyingqayizivele kuyo yonke into yamakhemikhali. Inombolo ye-CAS ye-Hydroxypropyl Methylcellulose ithi 9004-65-3. Lena inombolo emisiwe esetshenziswa osokhemisi, abahlinzeki, nezindikimba ezilawulayo ukubhekisela kunto.
Amakhodi e-InchI kanye ne-SMILES:
I-InChI (Isihlonzi Samakhemikhali Samazwe Ngamazwe) ingenye indlela yokumela ukwakheka kwamakhemikhali ento. I-HPMC izoba neyunithi yezinhlamvu ende ye-InChI emele ukwakheka kwayo kwamangqamuzana ngefomethi esezingeni.
I-SMILES (Uhlelo Olulula Lokufaka Lokungena Kwe-Molecular) olunye uhlelo olusetshenziselwa ukumela ama-molecule efomini lombhalo. I-HPMC futhi inekhodi ehambisanayo ethi SMILES, nakuba izoba yinkimbinkimbi kakhulu ngenxa yemvelo enkulu neguquguqukayo yesakhiwo sayo.
Imininingwane Yomkhiqizo:
Emakethe yezohwebo, i-HPMC ivamise ukukhonjwa ngezinombolo zomkhiqizo, ezingahluka ngomkhiqizi. Isibonelo, umphakeli angase abe nebanga elifana ne-HPMC K4M noma i-HPMC E15. Lezi zihlonzi zivame ukubhekisela ku-viscosity ye-polymer esixazululweni, enqunywa izinga le-methylation ne-hydroxypropylation kanye nesisindo samangqamuzana.
Amabanga Ajwayelekile we-Hydroxypropyl Methylcellulose (HPMC)
Izici ze-Hydroxypropyl Methylcellulose ziyahlukahluka ngokuya ngezinga lokushintshwa kwamaqembu e-methyl kanye ne-hydroxypropyl, kanye nesisindo samangqamuzana. Lokhu kuhlukahluka kunquma i-viscosity ye-HPMC kanye nokuncibilika emanzini, okubuye kube nomthelela ekusebenzeni kwayo ezimbonini ezahlukene.
Ngezansi kunethebula elichaza amabanga ahlukene e-Hydroxypropyl Methylcellulose:
| Ibanga | I-Viscosity (cP kusixazululo esingu-2%) | Izinhlelo zokusebenza | Incazelo |
| I-HPMC K4M | 4000 - 6000 cP | Isibophezelo sethebhulethi yezemithi, imboni yokudla, ezokwakha (izinamatheliso) | Ibanga le-viscosity elimaphakathi, elivame ukusetshenziswa ekwakhiweni kwethebhulethi yomlomo. |
| I-HPMC K100M | 100,000 - 150,000 cP | Ukwakhiwa okukhishwayo okulawulwayo kwezemithi, ukwakhiwa, nama-coating opende | I-viscosity ephezulu, enhle kakhulu ekukhululweni okulawulwayo kwezidakamizwa. |
| I-HPMC E4M | 3000 - 4500 cP | Izimonyo, izinto zokugeza, ukucubungula ukudla, izinto zokunamathisela, nezingubo zokugqoka | Incibilika emanzini abandayo, isetshenziswa emikhiqizweni yokunakekelwa komuntu siqu nasezintweni zokudla. |
| I-HPMC E15 | 15,000 cP | I-ejenti yokujiya kumapende, ama-coatings, ukudla, nemithi | I-viscosity ephezulu, encibilikayo emanzini abandayo, esetshenziswa emikhiqizweni yezimboni neyemithi. |
| I-HPMC M4C | 4000 - 6000 cP | Imboni yokudla nesiphuzo njengesizinzisi, ikhemisi njengesibophezelo | I-viscosity emaphakathi, evame ukusetshenziswa njenge-thickener ekudleni okugayiwe. |
| I-HPMC 2910 | 3000 - 6000 cP | Izimonyo (okhilimu, okokugcoba), ukudla (i-confectionery), imithi (amaphilisi, okokugcoba) | Elinye lamabanga ajwayelekile, asetshenziswa njenge-ejenti yokusimamisa nokujiya. |
| I-HPMC 2208 | 5000 - 15000 cP | Isetshenziswa ekwenziweni kukasimende kanye ne-plaster, izindwangu, ukufakwa kwamaphepha | Ilungele izinhlelo zokusebenza ezidinga izakhiwo ezinhle kakhulu zokwenza ifilimu. |
Ukubunjwa Okuningiliziwe kanye Nezakhiwo ze-HPMC
Izici ezibonakalayo ze-Hydroxypropyl Methylcellulose zincike kakhulu ezingeni lokushintshana kwamaqembu e-hydroxyl ku-molecule ye-cellulose. Nazi izakhiwo ezinkulu:
I-Degree of Substitution (DS):
Lokhu kusho ukuthi mangaki amaqembu e-hydroxyl ku-cellulose athathelwe indawo ngamaqembu e-methyl noma e-hydroxypropyl. Izinga lokushintsha linomthelela ekuncibilikeni kwe-HPMC emanzini, i-viscosity yayo, kanye nekhono layo lokwenza amafilimu. I-DS ejwayelekile ye-HPMC isukela ku-1.4 kuye ku-2.2, kuye ngebanga.
I-Viscosity:
Amabanga e-HPMC ahlukaniswa ngokusekelwe ku-viscosity yawo lapho encibilika emanzini. Ukuphakama kwesisindo samangqamuzana kanye nezinga lokushintshwa, ukuphakama kwe-viscosity. Isibonelo, i-HPMC K100M (enebanga eliphakeme le-viscosity) ivamise ukusetshenziswa ekwakhiweni kwezidakamizwa ezikhishwa okulawulwayo, kuyilapho amamaki e-viscosity aphansi njenge-HPMC K4M evamise ukusetshenziselwa izibophezelo zamathebulethi nezinhlelo zokudla.
Ukunyibilika kwamanzi:
I-HPMC iyancibilika emanzini futhi yenza into efana nejeli lapho incibilika, kodwa izinga lokushisa ne-pH kungaba nomthelela ekuncibilikeni kwayo. Isibonelo, emanzini abandayo, incibilika ngokushesha, kodwa ukuncibilika kwayo kungase kuncishiswe emanzini ashisayo, ikakhulukazi ezindaweni eziphakeme.
Ikhono Lokwenza Ifilimu:
Esinye sezici ezibalulekile zeHydroxypropyl Methylcellulose yikhono layo lokwenza ifilimu eguquguqukayo. Lesi sakhiwo siyenza ifanelekele ukusetshenziswa ezimbotsheni zethebhulethi, lapho ihlinzeka ngobushelelezi, indawo ekhishwayo elawulwayo. Kuyasiza futhi embonini yokudla ukwenza ngcono ukuthungwa nempilo yeshelufu.
I-Gelation:
Ezimweni ezithile namazinga okushisa, i-HPMC ingakha amajeli. Lesi sakhiwo sinenzuzo ekwenziweni kwemithi, lapho sisetshenziselwa khona ukudala amasistimu okukhishwa okulawulwayo.
Izicelo zeHydroxypropyl Methylcellulose
Imboni Yezemithi:
I-HPMC isetshenziswa njengesihlanganisi ekwakhiweni kwethebhulethi, ikakhulukazi kumasistimu okukhishwa okunwetshiwe kanye nokukhishwa okulawulwayo. Iphinde isebenze njenge-ejenti yokugcoba amaphilisi nama-capsules ukulawula ukukhululwa kwesithako esisebenzayo. Ikhono layo lokwenza amafilimu azinzile nama-gel lilungele izinhlelo zokulethwa kwezidakamizwa.
Imboni Yokudla
Embonini yokudla, i-HPMC isetshenziswa njenge-ejenti ejiyayo, i-emulsifier, kanye ne-stabilizer emikhiqizweni eyahlukene, okuhlanganisa amasoso, okokugqoka, nezimpahla ezibhakiwe. Isiza ukuthuthukisa ukuthungwa nokwelula impilo yeshalofu ngokunciphisa ukulahlekelwa umswakama.
Izimonyo Nokunakekela Umuntu:
I-HPMC isetshenziswa kakhulu kuzimonyo, lapho isebenza njenge-thickener kanye ne-stabilizer kuma-creams, ama-lotions, ama-shampoos, neminye imikhiqizo yokunakekelwa komuntu siqu. Ikhono layo lokwenza isakhiwo sejeli liwusizo ikakhulukazi kulezi zicelo.
Imboni yezokwakha:
Embonini yezokwakha, ikakhulukazi ekwenziweni kukasimende nokhonkolo, i-HPMC isetshenziswa njenge-ejenti egcina amanzi. Kuyasiza ukuthuthukisa ukusebenza kahle futhi kuthuthukise izakhiwo zokubopha zezinto.
Ezinye izinhlelo zokusebenza:
I-HPMC iphinde iqashwe embonini yendwangu, ukumbozwa kwamaphepha, ngisho nasekukhiqizeni amafilimu abolayo.
IHydroxypropyl Methylcellulose (HPMC)iyinhlanganisela eguquguqukayo kakhulu esetshenziswa kuzo zonke izimboni eziningi ngenxa yezakhiwo zayo ezihlukile ezifana nekhono lokwenza ifilimu, amandla okuqina, nokugcinwa kwamanzi. Yize ingenayo “inombolo yomkhiqizo” ngomqondo ojwayelekile, ikhonjwa ngezihlonzi zamakhemikhali njengenombolo yayo ye-CAS (9004-65-3) kanye namamaki aqondene nomkhiqizo (isb., HPMC K100M, HPMC E4M). Uhlu oluhlukene lwamabanga e-HPMC atholakalayo luqinisekisa ukusebenza kwawo emikhakheni ehlukene, kusukela kwezokwelapha kuya ekudleni, kwezimonyo, kanye nokwakhiwa.
Isikhathi sokuthumela: Mar-21-2025