I-ethyl cellulose(I-ethyl cellulose ether), eyaziwa nangokuthi i-cellulose ether, ebizwa ngokuthi i-EC.
Ukwakheka kwama-molecule kanye nefomula yesakhiwo: [C6H7O2(OC2H5)3] n.
1. Ukusebenzisa
Lo mkhiqizo unemisebenzi yokubopha, ukugcwalisa, ukwakha ifilimu, njll. Usetshenziselwa amapulasitiki okwenziwa nge-resin, izembozo, izinto ezithatha indawo yerabha, uyinki, izinto zokuvikela, futhi usetshenziswa njengezinamathelisi, izinto zokuqeda izindwangu, njll., futhi ungasetshenziswa njengesilwane kwezolimo nasekufuyeni. Isengezo sokudla, esisetshenziswa njengenamathelisi emikhiqizweni kagesi kanye nemishini yokuvikela yezempi.
2. Izidingo zobuchwepheshe
Ngokwezindlela ezahlukene zokusebenzisa, i-EC ethengiswayo ingahlukaniswa ngezigaba ezimbili: ibanga lezimboni kanye nebanga lemithi, futhi ngokuvamile iyancibilika ezinyibilikisweni eziphilayo. Kwi-EC yezinga lemithi, izinga layo lekhwalithi kufanele lihlangabezane nezindinganiso ze-Chinese Pharmacopoeia 2000 edition (noma i-USP XXIV/NF19 edition kanye ne-Japanese Pharmacopoeia JP standard).
3. Izakhiwo zomzimba nezamakhemikhali
1. Ukubukeka: I-EC iyimpuphu yoketshezi olumhlophe noma olumpunga okhanyayo, ayinaphunga.
2. Izakhiwo: I-EC ethengiswayo ngokuvamile ayincibiliki emanzini, kodwa incibilika ezinyibilikisweni ezahlukene zezinto eziphilayo. Inokuzinza okuhle kokushisa, okuqukethwe komlotha okuphansi kakhulu uma kushiswa, futhi ayivami ukunamathela noma ukuzizwa inamandla okubamba. Ingakha ifilimu eqinile. Isengalondoloza ukuguquguquka. Lo mkhiqizo awunabo ubuthi, unezakhiwo eziqinile zokulwa nezinto eziphilayo, futhi awusebenzi kahle emzimbeni, kodwa uthambekele ekuwohlokeni kwe-oxidative ngaphansi kwelanga noma ekukhanyeni kwe-ultraviolet. Nge-EC yenhloso ekhethekile, kunezinhlobo ezincibilika ku-lye nasemanzini ahlanzekile. Nge-EC enezinga lokushintshaniswa elingaphezu kuka-1.5, iyi-thermoplastic, enephuzu lokuthambisa elingu-135 ~ 155 °C, iphuzu lokuncibilika elingu-165 ~ 185 °C, amandla adonsela phansi angama-0.3 ~ 0.4 g/cm3, kanye nobuningi obungama-1.07 ~ 1.18 g/cm3. Izinga lokushintshashintsha kwe-EC lithinta ukuncibilika, ukumuncwa kwamanzi, izakhiwo zemishini kanye nezakhiwo zokushisa. Njengoba izinga lokushintshashintsha kwe-ether likhula, ukuncibilika kwe-lye kuyancipha, kuyilapho ukuncibilika kwe-organic solvent kuyanda. Kuncibilika kwe-organic solvents eziningi. I-solvent evame ukusetshenziswa yi-toluene/ethanol njenge-solvent exubile engu-4/1 (isisindo). Izinga lokushintshashintsha kwe-ether liyanda, iphuzu lokuthambisa kanye ne-hygroscopicity kuyancipha, kanti izinga lokushisa lokusebenzisa lingu--60°C~85°C. Amandla okudonsa angu-13.7~54.9Mpa, ukumelana kwevolumu 10*e12~10*e14 ω.cm
I-ethyl cellulose (DS: 2.3-2.6) iyi-non-ionic cellulose ether engancibiliki emanzini kodwa encibilikayo ezinyibilikisini eziphilayo.
1.Akulula ukusha.
2. Ukuqina okuhle kokushisa kanye ne-thermos-plasticity enhle kakhulu.
3.Ayishintshi umbala ube ukukhanya kwelanga.
4. Ukuguquguquka okuhle.
5. Izakhiwo ezinhle ze-dielectric.
6.Inokumelana okuhle kakhulu kwe-alkali kanye nokumelana ne-asidi ebuthakathaka.
7. Ukusebenza okuhle kokulwa nokuguga.
8. Ukumelana okuhle nosawoti, ukumelana nokubanda kanye nokumelana nokumuncwa komswakama.
9. Ihlala iqinile kumakhemikhali futhi ngeke yonakale lapho igcinwa isikhathi eside.
10. Ingahambisana nama-resin amaningi futhi ihambisana kahle nawo wonke ama-plasticizer.
11. Kulula ukushintsha umbala ngaphansi kwendawo enamandla ye-alkaline kanye nokushisa.
4. Indlela yokuncibilikisa
Izithako ezixubile ezisetshenziswa kakhulu ze-ethyl cellulose (DS: 2.3 ~ 2.6) ama-aromatic hydrocarbons nama-alcohols. Ama-aromatic angaba yi-benzene, i-toluene, i-ethylbenzene, i-xylene, njll., ngenani elingu-60-80%; ama-alcohols angaba yi-methanol, i-ethanol, njll., ngenani elingu-20-40%. Faka kancane i-EC esitsheni esiqukethe isithako esingaphansi kokuxubha kuze kube yilapho simanzi ngokuphelele futhi sincibilika.
Inombolo ye-CAS: 9004-57-3
5. Isicelo
Ngenxa yokungancibiliki kwamanzi,i-ethyl celluloseisetshenziswa kakhulu njenge-tablet binder kanye nezinto zokumboza ifilimu, njll., futhi ingasetshenziswa njenge-matrix material blocker ukulungiselela izinhlobo ezahlukene zama-matrix-sustained release tablets;
Kusetshenziswa njengento exubile ukulungiselela amalungiselelo okukhululwa okuqhubekayo ambozwe ngendwangu kanye nama-pellets okukhululwa okuqhubekayo;
Isetshenziswa njengento eyisizayo yokuhlanganisa ama-microcapsule ukulungiselela ama-microcapsule akhishwa njalo, ukuze umphumela wesidakamizwa ukhishwe njalo futhi kuvinjelwe eminye imithi encibilika emanzini ukuthi ingasebenzi ngaphambi kwesikhathi;
Ingasetshenziswa futhi njengesihlanzisi, isiqinisi, kanye nesigcina amanzi ngezindlela ezahlukene zomthamo wemithi ukuvimbela umswakama kanye nokuwohloka kwemithi nokuthuthukisa ukugcinwa okuphephile kwamaphilisi.
Isikhathi sokuthunyelwe: Ephreli-28-2024