I-Hydroxypropyl methylcellulose (HPMC)i-non-ionic cellulose ether esetshenziswa kabanzi ezintweni zokwakha, imithi, ukudla, izimonyo kanye neminye imikhakha yezimboni. Inezici eziningi ezinhle kakhulu zomzimba, eziyenza isebenze kahle ezinhlelweni ezahlukahlukene.
1. Ukubukeka nokuncibilika
I-HPMC ngokuvamile iyimpushana emhlophe noma emhlophe, engenaphunga, ayinambitheki futhi engenabuthi. Ingancibilika emanzini abandayo nakwezinye izincibilikisi zemvelo (njengezincibilikisi ezixubile njenge-ethanol/amanzi kanye ne-acetone/amanzi), kodwa ayincibiliki ku-ethanol emsulwa, i-ether ne-chloroform. Ngenxa yemvelo yayo engeyona i-ionic, ngeke ibhekane ne-electrolytic reaction in aqueous solution futhi ngeke ithintwe kakhulu ngevelu ye-pH.
2. I-Viscosity kanye ne-rheology
Isixazululo samanzi se-HPMC sinokuqina okuhle kanye ne-thixotropy. Izinhlobo ezahlukene ze-AnxinCel®HPMC zinama-viscosity ahlukene, futhi ububanzi obujwayelekile bungu-5 kuya ku-100000 mPa·s (2% isixazululo esinamanzi, 20°C). Isixazululo saso sibonisa i-pseudoplasticity, okungukuthi, i-shear thinning phenomenon, futhi ifanele izimo zokufaka isicelo ezifana nezingubo, ama-slurries, ama-adhesives, njll. ezidinga i-rheology enhle.
3. I-Gelation eshisayo
Uma i-HPMC ishiswa emanzini, ukukhanya kwesisombululo kuncipha futhi ijeli yakheka ekushiseni okuthile. Ngemuva kokupholisa, isimo se-gel sizobuyela esimweni sesixazululo. Izinhlobo ezahlukene ze-HPMC zinamazinga okushisa ejeli ahlukene, ngokuvamile aphakathi kuka-50 no-75°C. Lesi sakhiwo sibaluleke kakhulu ekusetshenzisweni okufana nokwakha udaka namaphilisi ekhemisi.
4. Umsebenzi ongaphezulu
Ngenxa yokuthi ama-molecule e-HPMC aqukethe amaqembu e-hydrophilic kanye ne-hydrophobic, abonisa umsebenzi othile ongaphezulu futhi angadlala indima yokuhlanganisa, yokuhlakaza kanye nokuzinzisa. Isibonelo, ekugqokeni nase-emulsion, i-HPMC ingathuthukisa ukuzinza kwe-emulsion futhi ivimbele ukuchithwa kwezinhlayiya ze-pigment.
5. Hygroscopicity
I-HPMC ine-hygroscopicity ethile futhi ingakwazi ukumunca umswakama endaweni enomswakama. Ngakho-ke, kwezinye izinhlelo zokusebenza, ukunakwa kufanele kukhokhwe ekufakweni uphawu ukuze kuvinjelwe ukumuncwa komswakama kanye nokuhlangana.
6. Indawo yokwenza ifilimu
I-HPMC ingakha ifilimu eqinile futhi esobala, esetshenziswa kakhulu ekudleni, emithini (njengama-ejenti okugcoba) kanye nama-coatings. Isibonelo, embonini yezemithi, ifilimu ye-HPMC ingasetshenziswa njengendwangu yethebhulethi ukuze kuthuthukiswe ukuzinza kwezidakamizwa nokukhululwa kokulawula.
7. I-Biocompatibility nokuphepha
I-HPMC ayinabo ubuthi futhi ayinabungozi, futhi ingashintshwa ngokuphepha ngumzimba womuntu, ngakho isetshenziswa kabanzi emkhakheni wezokwelapha nokudla. Njengomsizi wemithi, imvamisa isetshenziselwa ukukhiqiza amaphilisi akhishwa isikhathi eside, amagobolondo e-capsule, njll.
8. Ukuzinza kwe-pH yesisombululo
I-HPMC izinzile ebangeni le-pH lika-3 kuya ku-11, futhi ayonakaliswa kalula noma incishwe i-asidi ne-alkali, ngakho ingasetshenziswa ezinhlelweni zamakhemikhali ezihlukahlukene, njengezinto zokwakha, imikhiqizo yamakhemikhali yansuku zonke kanye nokwakheka kwemithi.
9. Ukumelana nosawoti
Isixazululo se-HPMC azinzile uma kuqhathaniswa nosawoti wezinto ezingaphili futhi awenzi kalula noma angasebenzi ngenxa yezinguquko ekugxilweni kwe-ion, okusivumela ukuthi sigcine ukusebenza kahle kwezinye izinhlelo eziqukethe usawoti (njengodaka lukasimende).
10. Ukuzinza okushisayo
I-AnxinCel®HPMC inokusimama okuhle ezindaweni zokushisa okuphezulu, kodwa ingehlisa noma ishintshe umbala lapho ichayeke emazingeni okushisa aphakeme isikhathi eside. Isengakwazi ukugcina ukusebenza okuhle phakathi kwebanga elithile lokushisa (imvamisa ibe ngaphansi kuka-200°C), ngakho ilungele izinhlelo zokusebenza zokucubungula izinga lokushisa eliphezulu.
11. Ukuzinza kwamakhemikhali
I-HPMCizinzile ekukhanyeni, ama-oxidants namakhemikhali avamile, futhi ayithinteki kalula izici zamakhemikhali zangaphandle. Ngakho-ke, ingasetshenziswa emikhiqizweni edinga ukugcinwa isikhathi eside, njengezinto zokwakha kanye nemithi.
IHydroxypropyl methylcellulose isetshenziswa kabanzi ezimbonini eziningi ngenxa yokuncibilika kwayo okuhle kakhulu, ukuqina, i-gelation eshisayo, izakhiwo zokwakha ifilimu nokuzinza kwamakhemikhali. Embonini yezokwakha, ingasetshenziswa njengendlela yokuqinisa udaka lukasimende; embonini yezemithi, ingasetshenziswa njenge-excipient yezemithi; embonini yokudla, kuyisithasiselo esivamile sokudla. Yilezi zakhiwo zomzimba eziyingqayizivele ezenza i-HPMC ibe yinto ebalulekile esebenzayo ye-polymer.
Isikhathi sokuthumela: Feb-10-2025