I-HEC (Hydroxyethyl Cellulose)iyi-polymer evamile encibilika emanzini esetshenziswa kabanzi ekulungiseleleni imithi. Iphuma ku-cellulose, etholakala ngokuphendula i-ethanolamine (i-ethylene oxide) ne-cellulose. Ngenxa yokuncibilika kwayo okuhle, ukuzinza, ikhono lokulungiswa kwe-viscosity kanye ne-biocompatibility, i-HEC inohlu olubanzi lwezinhlelo zokusebenza emkhakheni wezokwelapha, ikakhulukazi ekuthuthukisweni kokwakhiwa, ukuklama kwefomu lomthamo kanye nokulawulwa kokukhululwa kwezidakamizwa.
1. Izakhiwo eziyisisekelo ze-HEC
I-HEC, njenge-cellulose eguquliwe, inezindawo ezilandelayo eziyisisekelo:
Ukunyibilika kwamanzi: I-AnxinCel®HEC ingakha isixazululo se-viscous emanzini, futhi ukuncibilika kwayo kuhlobene nezinga lokushisa ne-pH. Lesi sakhiwo sikwenza kusetshenziswe amafomu ahlukahlukene womthamo njengomlomo kanye ne-topical.
I-Biocompatibility: I-HEC ayinabo ubuthi futhi ayicasuli emzimbeni womuntu futhi iyahambisana nezidakamizwa eziningi. Ngakho-ke, isetshenziswa kakhulu kumafomu omthamo wokukhishwa okuqhubekayo kanye nezinhlobo zomthamo wokuphatha wendawo wezidakamizwa.
I-viscosity eguquguqukayo: I-viscosity ye-HEC ingalungiswa ngokushintsha isisindo sayo samangqamuzana noma ukugxila, okubalulekile ekulawuleni izinga lokukhishwa kwezidakamizwa noma ukuthuthukisa ukuzinza kwezidakamizwa.
2. Ukusetshenziswa kwe-HEC emalungiselelweni emithi
Njengomsizi obalulekile emalungiselelweni emithi, i-HEC inemisebenzi eminingi. Okulandelayo yizindawo zayo eziyinhloko zokufaka isicelo emalungiselelweni emithi.
2.1 Isicelo emalungiselelweni omlomo
Emafomu omthamo womlomo, i-HEC ivame ukusetshenziswa ekukhiqizeni amaphilisi, amaphilisi kanye namalungiselelo oketshezi. Imisebenzi yayo eyinhloko ihlanganisa:
I-Binder: Kumaphilisi nama-granules, i-HEC ingasetshenziswa njengesibophezelo ukuze ibophe kangcono izinhlayiya zezidakamizwa noma izimpushana ndawonye ukuze kuqinisekiswe ubulukhuni nokuzinza kwamaphilisi.
Ukulawulwa kokukhululwa okusimeme: I-HEC ingafinyelela umphumela wokukhululwa oqhubekayo ngokulawula izinga lokukhululwa lomuthi. Uma i-HEC isetshenziswa kanye nezinye izithako (njenge-polyvinyl pyrrolidone, i-carboxymethyl cellulose, njll.), ingandisa ngempumelelo isikhathi sokukhululwa kwesidakamizwa emzimbeni, inciphise imvamisa yemithi, futhi ithuthukise ukuthobela isiguli.
I-Thickener: Emalungiselelweni omlomo awuketshezi, i-AnxinCel®HEC njenge-thickener ingathuthukisa ukunambitheka komuthi nokuzinza kwefomu lomthamo.
2.2 Ukufaka isicelo ekulungiseleleni izihloko
I-HEC isetshenziswa kabanzi kuma-topical ointments, okhilimu, ama-gel, ama-lotions namanye amalungiselelo, idlala izindima eziningi:
I-Gel matrix: I-HEC ivame ukusetshenziswa njenge-matrix yamajeli, ikakhulukazi ezinhlelweni zokulethwa kwezidakamizwa ezishintshashintshayo. Inganikeza ukuvumelana okufanele futhi yandise isikhathi sokuhlala somuthi esikhumbeni, ngaleyo ndlela ithuthukise ukusebenza kahle.
I-Viscosity nokuzinza: I-viscosity ye-HEC ingathuthukisa ukunamathela kwamalungiselelo e-topical esikhumbeni futhi ivimbele umuthi ukuthi ungawi ngaphambi kwesikhathi ngenxa yezinto zangaphandle ezifana nokungqubuzana noma ukugeza. Ngaphezu kwalokho, i-HEC ingathuthukisa ukuzinza kwama-creams namafutha okugcoba futhi ivimbele ukuhlukaniswa noma i-crystallization.
I-Lubricant ne-moisturizer: I-HEC inezinto ezinhle zokuthambisa futhi ingasiza ukugcina isikhumba simanzi futhi ivimbele ukoma, ngakho-ke isetshenziselwa izinto zokuthambisa kanye neminye imikhiqizo yokunakekelwa kwesikhumba.
2.3 Ukufaka isicelo elungiselelweni le-ophthalmic
Ukusetshenziswa kwe-HEC kumalungiselelo e-ophthalmic kubonakala ikakhulukazi endimeni yayo njenge-adhesive and lubricant:
Ama-gel ophthalmic kanye namaconsi e-eye: I-HEC ingasetshenziswa njenge-adhesive yamalungiselelo e-ophthalmic ukwandisa isikhathi sokuxhumana phakathi kwesidakamizwa neso futhi kuqinisekiswe ukusebenza okuqhubekayo komuthi. Ngesikhathi esifanayo, i-viscosity yayo ingaphinde ivimbele amaconsi esweni ukuthi alahlekelwe ngokushesha futhi andise isikhathi sokugcina somuthi.
Ukugcoba: I-HEC ine-hydration enhle futhi inganikeza ukugcoba okuqhubekayo ekwelapheni izifo zamehlo ezifana neso elomile, ukunciphisa ukungakhululeki kwamehlo.
2.4 Isicelo ekulungiseleleni umjovo
I-HEC ingasetshenziswa futhi ekulungiseni amafomu omthamo womjovo, ikakhulukazi emijovo esebenza isikhathi eside kanye namalungiselelo okukhululwa okuqhubekayo. Imisebenzi esemqoka ye-HEC kulawa malungiselelo ihlanganisa:
I-thickener ne-stabilizer: Emjovweni,I-HECingakhuphula i-viscosity yesisombululo, yehlise ijubane lomjovo lomuthi, futhi ithuthukise ukuzinza komuthi.
Ukulawula ukukhululwa kwezidakamizwa: Njengenye yezingxenye zesistimu yokukhishwa kwezidakamizwa okuqhubekayo, i-HEC ingakwazi ukulawula izinga lokukhululwa kwesidakamizwa ngokwenza ungqimba lwejeli ngemva kokujova, ukuze kuzuzwe injongo yokwelashwa kwesikhathi eside.
3. Iqhaza le-HEC ezinhlelweni zokulethwa kwezidakamizwa
Ngokuthuthukiswa kobuchwepheshe bemithi, i-HEC isetshenziswe kabanzi ezinhlelweni ezihlukahlukene zokulethwa kwezidakamizwa, ikakhulukazi emikhakheni yabathwali bezidakamizwa ze-nano-drug, ama-microspheres, kanye nabathwali abakhipha izidakamizwa. I-HEC ingahlanganiswa nezinhlobonhlobo zezinto ezithwala izidakamizwa ukuze zakhe inkimbinkimbi ezinzile ukuze kuqinisekiswe ukukhululwa okuqhubekayo nokulethwa okuphumelelayo kwezidakamizwa.
Umthwali wezidakamizwa ze-Nano: I-HEC ingasetshenziswa njengesizinzisi kubathwali bezidakamizwa ze-nano ukuvimbela ukuhlanganisa noma ukuna kwezinhlayiya ezithwala futhi kwandiswe i-bioavailability yezidakamizwa.
Ama-Microspheres kanye nezinhlayiya: I-HEC ingasetshenziswa ukulungisa ama-microspheres nabathwali bezidakamizwa ezincane ukuze kuqinisekiswe ukukhululwa kancane kwezidakamizwa emzimbeni futhi kuthuthukiswe ukusebenza kahle kwezidakamizwa.
Njengomsizi wemithi osebenza ngezinto eziningi futhi osebenza kahle, i-AnxinCel®HEC inamathuba abanzi okufaka isicelo emalungiselelweni emithi. Ngokuthuthuka okuqhubekayo kobuchwepheshe bemithi, i-HEC idlala indima ebaluleke kakhulu ekulawuleni ukukhishwa kwezidakamizwa, ukuphathwa kwendawo, amalungiselelo okukhishwa okuqhubekayo kanye nezinhlelo ezintsha zokulethwa kwezidakamizwa. I-biocompatibility yayo enhle, i-viscosity eguquguqukayo kanye nokuzinza kuyenza ingenakuthathelwa indawo emkhakheni wezokwelapha. Esikhathini esizayo, ngokucwaninga okujulile kwe-HEC, ukusetshenziswa kwayo emalungiselelweni emithi kuzoba okubanzi futhi okuhlukahlukene.
Isikhathi sokuthumela: Dec-28-2024