HEC (Hydroxyethyl Cellulose)yog ib qho polymer uas yaj tau hauv dej uas siv dav hauv kev npaj tshuaj. Nws yog ib qho derivative ntawm cellulose, tau los ntawm kev sib xyaw ethanolamine (ethylene oxide) nrog cellulose. Vim nws cov solubility zoo, kev ruaj khov, viscosity adjustment peev xwm thiab biocompatibility, HEC muaj ntau yam kev siv hauv kev lag luam tshuaj, tshwj xeeb tshaj yog hauv kev tsim cov qauv, kev tsim cov tshuaj thiab kev tswj cov tshuaj tso tawm.
1. Cov khoom tseem ceeb ntawm HEC
HEC, ua ib qho cellulose hloov kho, muaj cov khoom yooj yim hauv qab no:
Kev yaj hauv dej: AnxinCel®HEC tuaj yeem tsim cov kua nplaum hauv dej, thiab nws qhov kev yaj yog cuam tshuam nrog qhov kub thiab pH. Cov yam ntxwv no ua rau nws siv rau hauv ntau hom tshuaj xws li noj thiab siv rau sab nraud.
Kev sib haum xeeb ntawm lub cev: HEC tsis muaj tshuaj lom thiab tsis ua rau khaus rau tib neeg lub cev thiab sib haum nrog ntau yam tshuaj. Yog li ntawd, nws siv dav hauv cov tshuaj uas tso tawm tas mus li thiab cov tshuaj hauv zos.
Kev hloov kho viscosity: Lub viscosity ntawm HEC tuaj yeem hloov kho los ntawm kev hloov nws qhov hnyav molecular lossis concentration, uas yog qhov tseem ceeb rau kev tswj hwm kev tso tawm ntawm cov tshuaj lossis kev txhim kho kev ruaj khov ntawm cov tshuaj.
2. Daim ntawv thov HEC hauv kev npaj tshuaj
Ua ib qho khoom siv tseem ceeb hauv kev npaj tshuaj, HEC muaj ntau yam haujlwm. Cov hauv qab no yog nws cov chaw thov tseem ceeb hauv kev npaj tshuaj.
2.1 Daim ntawv thov rau kev npaj noj
Hauv cov ntawv qhia tshuaj noj, HEC feem ntau siv rau hauv kev tsim cov ntsiav tshuaj, tshuaj ntsiav thiab cov kua ua kua. Nws cov haujlwm tseem ceeb suav nrog:
Cov Khoom Siv: Hauv cov ntsiav tshuaj thiab cov granules, HEC tuaj yeem siv los ua cov khoom siv los khi cov tshuaj lossis cov hmoov ua ke kom ntseeg tau tias qhov nyuaj thiab ruaj khov ntawm cov ntsiav tshuaj.
Kev tswj kev tso tawm tas mus li: HEC tuaj yeem ua tiav qhov kev tso tawm tas mus li los ntawm kev tswj qhov kev tso tawm ntawm cov tshuaj. Thaum HEC siv ua ke nrog lwm cov khoom xyaw (xws li polyvinyl pyrrolidone, carboxymethyl cellulose, thiab lwm yam), nws tuaj yeem ua kom lub sijhawm tso tawm ntawm cov tshuaj hauv lub cev ntev dua, txo qhov zaus ntawm cov tshuaj, thiab txhim kho kev ua raws li tus neeg mob.
Cov Khoom Ua Kom Tuab: Hauv cov tshuaj ua kua hauv qhov ncauj, AnxinCel®HEC ua cov khoom ua kom tuab tuaj yeem txhim kho qhov saj ntawm cov tshuaj thiab qhov ruaj khov ntawm daim ntawv tshuaj.
2.2 Kev siv rau hauv kev npaj tshuaj pleev
HEC yog dav siv rau hauv cov tshuaj pleev, tshuaj pleev, tshuaj pleev, tshuaj pleev thiab lwm yam kev npaj, ua si ntau lub luag haujlwm:
Gel matrix: HEC feem ntau siv ua matrix rau cov gels, tshwj xeeb tshaj yog nyob rau hauv cov txheej txheem xa tshuaj transdermal. Nws tuaj yeem muab qhov sib xws tsim nyog thiab ua kom lub sijhawm nyob ntawm cov tshuaj ntawm daim tawv nqaij, yog li txhim kho qhov ua tau zoo.
Viscosity thiab stability: Lub viscosity ntawm HEC tuaj yeem txhim kho qhov adhesion ntawm cov tshuaj pleev rau ntawm daim tawv nqaij thiab tiv thaiv cov tshuaj kom tsis txhob poob ua ntej vim muaj lwm yam xws li kev sib txhuam lossis kev ntxuav. Tsis tas li ntawd, HEC tuaj yeem txhim kho qhov ruaj khov ntawm cov tshuaj pleev thiab tshuaj pleev thiab tiv thaiv kev sib cais lossis crystallization.
Cov roj nplua nyeem thiab cov tshuaj pleev kom noo noo: HEC muaj cov khoom ua kom noo noo zoo thiab tuaj yeem pab ua kom daim tawv nqaij noo thiab tiv thaiv kom qhuav, yog li nws kuj siv rau hauv cov tshuaj pleev kom noo noo thiab lwm yam khoom tu tawv nqaij.
2.3 Daim ntawv thov rau kev npaj kho qhov muag
Daim ntawv thov ntawm HEC hauv kev npaj kho qhov muag yog qhov pom tseeb hauv nws lub luag haujlwm ua cov nplaum thiab lubricant:
Cov tshuaj pleev qhov muag thiab cov tshuaj zawv qhov muag: HEC siv tau ua cov nplaum rau kev npaj qhov muag kom ntev lub sijhawm sib cuag ntawm cov tshuaj thiab lub qhov muag thiab xyuas kom meej tias cov tshuaj ua haujlwm tau zoo. Tib lub sijhawm, nws qhov viscosity kuj tseem tuaj yeem tiv thaiv cov tshuaj zawv qhov muag kom tsis txhob poob sai dhau thiab ua rau lub sijhawm khaws cia ntawm cov tshuaj ntev dua.
Kev Siv Lubrication: HEC muaj cov dej noo zoo thiab tuaj yeem muab kev siv lubrication tas mus li hauv kev kho mob ntawm cov kab mob qhov muag xws li qhov muag qhuav, txo qhov muag tsis xis nyob.
2.4 Daim ntawv thov rau kev npaj txhaj tshuaj
HEC kuj tseem siv tau rau hauv kev npaj cov tshuaj txhaj tshuaj, tshwj xeeb tshaj yog rau kev txhaj tshuaj ntev thiab kev npaj tso tawm mus tas li. Lub luag haujlwm tseem ceeb ntawm HEC hauv cov kev npaj no suav nrog:
Cov khoom ua kom tuab thiab ruaj khov: Hauv kev txhaj tshuaj,HECtuaj yeem ua rau kom cov viscosity ntawm cov tshuaj, qeeb qeeb qhov kev txhaj tshuaj ntawm cov tshuaj, thiab txhim kho qhov ruaj khov ntawm cov tshuaj.
Tswj kev tso tshuaj: Ua ib qho ntawm cov khoom ntawm cov tshuaj uas tso tawm tas mus li, HEC tuaj yeem tswj tau qhov kev tso tawm ntawm cov tshuaj los ntawm kev tsim cov txheej gel tom qab txhaj tshuaj, kom ua tiav lub hom phiaj ntawm kev kho mob mus sij hawm ntev.
3. Lub luag haujlwm ntawm HEC hauv cov txheej txheem xa tshuaj
Nrog rau kev txhim kho cov thev naus laus zis tshuaj, HEC tau siv dav hauv ntau yam kev xa tshuaj, tshwj xeeb tshaj yog nyob rau hauv cov teb ntawm nano-tshuaj nqa khoom, microspheres, thiab tshuaj nqa khoom tso tawm. HEC tuaj yeem ua ke nrog ntau yam khoom siv nqa tshuaj los tsim kom muaj kev ruaj khov kom ntseeg tau tias kev tso tawm mus tas li thiab kev xa tshuaj zoo.
Nano tshuaj nqa khoom: HEC tuaj yeem siv ua lub stabilizer rau nano tshuaj nqa khoom kom tiv thaiv kev sib sau ua ke lossis nag lossis daus ntawm cov khoom thauj khoom thiab ua kom muaj kev nyab xeeb ntawm cov tshuaj.
Cov microspheres thiab cov khoom me me: HEC tuaj yeem siv los npaj cov microspheres thiab cov khoom siv tshuaj microparticle kom ntseeg tau tias cov tshuaj tso tawm qeeb hauv lub cev thiab txhim kho cov tshuaj ua haujlwm tau zoo.
Ua ib yam khoom siv tshuaj uas siv tau ntau yam thiab ua tau zoo, AnxinCel®HEC muaj ntau yam kev siv rau hauv kev npaj tshuaj. Nrog rau kev txhim kho tas mus li ntawm cov thev naus laus zis tshuaj, HEC ua lub luag haujlwm tseem ceeb hauv kev tswj kev tso tshuaj, kev tswj hwm hauv zos, kev npaj tso tshuaj mus tas li thiab cov txheej txheem xa tshuaj tshiab. Nws cov biocompatibility zoo, viscosity hloov kho tau thiab ruaj khov ua rau nws tsis muaj qhov hloov pauv tau hauv kev kho mob. Yav tom ntej, nrog rau kev kawm tob txog HEC, nws daim ntawv thov hauv kev npaj tshuaj yuav dav dua thiab ntau yam.
Lub sijhawm tshaj tawm: Lub Kaum Ob Hlis-28-2024