I-HPMC (Hydroxypropyl Methylcellulose)iyi-polymer engeyona i-ionic semi-synthetic esetshenziswa kakhulu kwezokwelapha, ukudla, ukwakhiwa, okokumboza nezinye izimboni. Mayelana nokuthi i-HPMC ingancibilika yini emanzini ashisayo, izici zayo zokuncibilika kanye nomthelela wezinga lokushisa ekuziphatheni kwayo kokuhlakazeka kufanele kucatshangelwe.
Uhlolojikelele lokuncibilika kwe-HPMC
I-HPMC inokuncibilika okuhle kwamanzi, kodwa ukuziphatha kwayo kokuncibilika kuhlobene eduze nezinga lokushisa lamanzi. Ngokuvamile, i-HPMC ingahlakazwa kalula futhi incibilike emanzini abandayo, kodwa ibonisa izici ezihlukahlukene emanzini ashisayo. Ukuncibilika kwe-HPMC emanzini abandayo kuthinteka kakhulu ukwakheka kwayo kwamangqamuzana kanye nohlobo oluthatha indawo. Uma i-HPMC ihlangana namanzi, amaqembu e-hydrophilic (afana ne-hydroxyl ne-hydroxypropyl) kuma-molecule ayo azokwakha amabhondi e-hydrogen nama-molecule amanzi, okwenza ukuthi avuvuke kancane futhi ancibilike. Nokho, izici zokuncibilika kwe-HPMC zihlukile emanzini emazingeni okushisa ahlukene.
Ukuncibilika kwe-HPMC emanzini ashisayo
Ukuncibilika kwe-HPMC emanzini ashisayo kuncike ebangeni lokushisa:
Izinga lokushisa eliphansi (0-40°C): I-HPMC ingakwazi ukumunca kancane amanzi futhi ikhukhumale, futhi ekugcineni yakhe isixazululo se-viscous esisobala noma esikhanyayo. Izinga lokuqedwa lihamba kancane emazingeni okushisa aphansi, kodwa i-gelation ayenzeki.
Izinga lokushisa elimaphakathi (40-60°C): I-HPMC ikhukhumala kuleli banga, kodwa ayincibiliki ngokuphelele. Esikhundleni salokho, yenza kalula ama-agglomerate angalingani noma ukumiswa, okuthinta ukufana kwesixazululo.
Izinga lokushisa eliphezulu (ngaphezulu kuka-60°C): I-HPMC izohlukaniswa ngezigaba emazingeni okushisa aphakeme, abonakale njenge-gelation noma imvula, okwenza kube nzima ukuncibilika. Ngokuvamile, lapho izinga lokushisa lamanzi lidlula u-60-70°C, ukunyakaza okushisayo kweketango lamangqamuzana e-HPMC kuyaqina, futhi ukuncibilika kwawo kuncipha, futhi kungase kugcine sekwakhe ijeli noma imvula.
Izakhiwo ze-Thermogel ze-HPMC
I-HPMC inezici ezijwayelekile ze-thermogel, okungukuthi, yakha ijeli emazingeni okushisa aphezulu futhi ingaphinde incibilike emazingeni okushisa aphansi. Lesi sakhiwo sibaluleke kakhulu ezinhlelweni eziningi, njenge:
Imboni yezokwakha: I-HPMC isetshenziswa njenge-thiener yodaka lukasimende. Ingakwazi ukugcina umswakama omuhle ngesikhathi sokwakhiwa futhi ibonise i-gelation ezindaweni zokushisa okuphezulu ukunciphisa ukulahlekelwa kwamanzi.
Amalungiselelo emithi: Uma isetshenziswa njengento yokumboza ezibhebheni, izakhiwo zayo ze-gelation ezishisayo zidinga ukucatshangelwa ukuze kuqinisekiswe ukuncibilika okuhle.
Imboni yokudla: I-HPMC isetshenziswa njenge-thickener kanye ne-emulsifier kokunye ukudla, futhi i-gelation yayo eshisayo isiza ukuzinza kokudla.
Indlela yokuhlakaza i-HPMC ngendlela efanele?
Ukuze ugweme i-HPMC ekwenzeni ijeli emanzini ashisayo futhi yehluleke ukuncibilika ngokulinganayo, izindlela ezilandelayo zivame ukusetshenziswa:
Indlela yokusabalalisa amanzi abandayo:
Okokuqala, hlakaza ngokulinganayo i-HPMC emanzini abandayo noma emanzini okushisa kwegumbi ukuze imanziswe ngokuphelele futhi ivuvuke.
Khulisa kancane izinga lokushisa ngesikhathi sokunyakazisa ukuze uqhubeke nokuncibilikisa i-HPMC.
Ngemva kokuqedwa ngokuphelele, izinga lokushisa linganyuswa ngokufanelekile ukuze kusheshiswe ukwakheka kwesixazululo.
Indlela yokupholisa yokusabalalisa amanzi ashisayo:
Okokuqala, sebenzisa amanzi ashisayo (cishe 80-90 ° C) ukuze uhlakaze ngokushesha i-HPMC ukuze ungqimba lokuvikela lwejeli olungancibiliki lwakhiwe ebusweni balo ukuze kuvinjelwe ukwakheka ngokushesha kwezigaxa ezinamathelayo.
Ngemva kokupholisa ekamelweni lokushisa noma ukwengeza amanzi abandayo, i-HPMC iyancibilika kancane kancane ukuze yakhe isisombululo esifanayo.
Indlela yokuxuba okomile:
Xuba i-HPMC nezinye izinto ezincibilikayo (njengoshukela, isitashi, i-mannitol, njll.) bese wengeza amanzi ukuze unciphise ukuhlangana futhi ukhuthaze ukuncibilika okufanayo.
I-HPMCayikwazi ukuncibilika ngokuqondile emanzini ashisayo. Kulula ukwenza ijeli noma imvula ekushiseni okuphezulu, okunciphisa ukuncibilika kwayo. Indlela engcono kakhulu yokuhlakaza iwukuhlakaza emanzini abandayo kuqala noma ngaphambi kokuhlakaza ngamanzi ashisayo bese upholisa ukuze uthole isixazululo esilinganayo nesizinzile. Ezinhlelweni ezisebenzayo, khetha indlela efanelekile yokuhlakaza ngokwezidingo zokuqinisekisa ukuthi i-HPMC isebenza kahle kakhulu.
Isikhathi sokuthumela: Mar-25-2025