IHydroxypropyl Methylcellulose (HPMC)luhlobo lweselulosi eguqulwe ngokwekhemikhali esetyenziswa kakhulu kumashishini ahlukeneyo afana namayeza, imveliso yokutya, kunye nokwakha. Yikhompawundi eguquguqukayo, ehlala isetyenziswa njenge-thickener, binder, iarhente yokwenza ifilim, kunye nokuzinzisa. Nangona kunjalo, ayinayo "inombolo yochungechunge" ethile ngokwengqiqo yemveli, njengemveliso okanye inxalenye yenombolo onokuthi uyifumane kwezinye iimeko zokuvelisa. Endaweni yoko, i-HPMC ichongiwe ngesakhiwo sayo sekhemikhali kunye nenani leempawu, ezifana nenqanaba lokuthatha indawo kunye ne-viscosity.
Ulwazi oluphangaleleyo malunga neHydroxypropyl Methylcellulose (HPMC)
Ubume beMichiza: I-HPMC yenziwe ngokuguqula iikhemikhali zeselulosi ngokufaka endaweni yamaqela e-hydroxyl (-OH) nge-hydroxypropyl kunye namaqela e-methyl. Ukutshintshwa kuguqula iipropati zeselulosi, iyenze inyibilike ngakumbi emanzini kwaye inike iimpawu zayo ezizodwa ezifana nokuphuculwa kwesakhono sokwenza ifilimu, ukukwazi ukubopha, kunye nokukwazi ukugcina ukufuma.
Izichongi eziqhelekileyo kunye nokubizwa kwamagama
Ukuchongwa kweHydroxypropyl Methylcellulose ngokwesiqhelo kuxhomekeke kwiindlela ezahlukeneyo zokuthiywa kwamagama ezichaza ubume bayo bekhemikhali kunye neempawu:
Inombolo yeCAS:
INkonzo yeMichiza yeeNgcaciso zeMichiza (i-CAS) inika into eyodwa yokufanisa kuyo yonke imichiza. Inombolo ye-CAS ye-Hydroxypropyl Methylcellulose yi-9004-65-3. Eli linani elisemgangathweni elisetyenziswa ngamachiza, ababoneleli kunye namaqumrhu alawulayo ukubhekisa kwinto leyo.
Iikhowudi ze-InchI kunye ne-SMILES:
I-InChI (Isichongi seMichiza saMazwe ngaMazwe) yenye indlela yokumela ubume bekhemikhali bento. I-HPMC inokuba nomtya omde we-InChI omele ubume bayo bemolekyuli ngendlela esemgangathweni.
I-SMILES (ISimplified Molecular Input Line Entry System) yenye inkqubo esetyenziselwa ukumela iimolekyuli kwifomu yombhalo. I-HPMC nayo inekhowudi ye-SMILES ehambelanayo, nangona iya kuba nzima kakhulu ngenxa yendalo enkulu kunye nokutshintsha kwesakhiwo sayo.
Iinkcukacha zeMveliso:
Kwimarike yorhwebo, i-HPMC idla ngokuchongwa ngamanani emveliso, anokwahluka ngumenzi. Umzekelo, umthengisi unokuba nebakala elifana ne-HPMC K4M okanye i-HPMC E15. Ezi zichongi zihlala zibhekisa kwi-viscosity ye-polymer kwisisombululo, esinqunywe yinqanaba le-methylation kunye ne-hydroxypropylation kunye ne-molecular weight.
Amabanga aqhelekileyo eHydroxypropyl Methylcellulose (HPMC)
Iimpawu zeHydroxypropyl Methylcellulose ziyahlukahluka ngokusekelwe kwinqanaba lokutshintshwa kwamaqela e-methyl kunye ne-hydroxypropyl, kunye nesisindo se-molecular. Olu tshintsho lumisela i-viscosity ye-HPMC kunye nokunyibilika emanzini, nto leyo echaphazela ukusetyenziswa kwayo kumashishini ahlukeneyo.
Apha ngezantsi kukho itheyibhile echaza amabanga ahlukeneyo eHydroxypropyl Methylcellulose:
| IBanga | Viscosity (cP kwisisombululo se-2%) | Usetyenziso | Inkcazo |
| HPMC K4M | 4000 - 6000 cP | Isibophelelo sethebhulethi yamayeza, ishishini lokutya, ulwakhiwo (izinto zokuncamathelisa) | Ibanga le-viscosity eliphakathi, elisetyenziswa ngokuqhelekileyo kwiifom zepilisi zomlomo. |
| HPMC K100M | 100,000 - 150,000 cP | Ukwenziwa kokukhutshwa okulawulwayo kumayeza, ulwakhiwo, kunye neepeyinti zokwaleka | I-viscosity ephezulu, ebalaseleyo ekukhululweni okulawulwayo kwamachiza. |
| HPMC E4M | 3000 - 4500 cP | Izithambiso, izinto zangasese, ukulungiswa kokutya, izinto zokuncamathelisa, kunye neengubo | Inyibilika kumanzi abandayo, asetyenziswa kwiimveliso zokhathalelo lomntu kunye nezinto zokutya. |
| HPMC E15 | 15,000 cP | I-arhente yokutyebisa kwiipeyinti, iingubo, ukutya, kunye namayeza | I-viscosity ephezulu, i-soluble emanzini abandayo, esetyenziswa kwiimveliso zoshishino kunye namayeza. |
| HPMC M4C | 4000 - 6000 cP | Ishishini lokutya kunye nesiselo njenge-stabilizer, i-pharmacy njenge-binder | I-viscosity ephakathi, edla ngokusetyenziswa njenge-thickener ekutyeni okucutshungulweyo. |
| HPMC 2910 | 3000 - 6000 cP | Izithambiso (iikhrimu, izinto zokuthambisa), ukutya (i-confectionery), amayeza (iicapsules, iingubo) | Elinye lawona mabanga aqhelekileyo, asetyenziswa njenge-arhente yokuzinzisa kunye nokuqina. |
| HPMC 2208 | 5000 - 15000 cP | Isetyenziswe kwi-samente kunye ne-plaster formulations, i-textiles, i-coatings yamaphepha | Ilungele usetyenziso olufuna iimpawu ezibalaseleyo zokwenza ifilim. |
Ubume obuneenkcukacha kunye neePropati zeHPMC
Iimpawu ezibonakalayo zeHydroxypropyl Methylcellulose zixhomekeke kakhulu kubungakanani bokutshintshwa kwamaqela e-hydroxyl kwi-molecule ye-cellulose. Nazi iimpawu eziphambili:
Isidanga soTshintsho (DS):
Oku kubhekiselele ekubeni mangaphi amaqela e-hydroxyl kwi-cellulose afakwe endaweni yawo ngamaqela e-methyl okanye e-hydroxypropyl. Iqondo lokutshintsha lichaphazela ukunyibilika kwe-HPMC emanzini, i-viscosity yayo, kunye nokukwazi kwayo ukwenza iifilimu. I-DS eqhelekileyo ye-HPMC isuka ku-1.4 ukuya ku-2.2, kuxhomekeke kwibakala.
Viscosity:
Amabanga e-HPMC ahlelwa ngokusekwe kwi-viscosity yawo xa inyibilikiswa emanzini. Ukuphakama kobunzima be-molecular kunye neqondo lokutshintshwa, ukuphakama kwe-viscosity. Umzekelo, i-HPMC K100M (enoluhlu oluphezulu lwe-viscosity) isoloko isetyenziswa ekuxutyweni kweziyobisi ezilawulwayo, ngelixa amabanga asezantsi e-viscosity afana ne-HPMC K4M eqhele ukusetyenziselwa izibophelelo zethebhulethi kunye nezicelo zokutya.
Ukunyibilika kwamanzi:
I-HPMC iyanyibilika emanzini kwaye yenza into efana nejeli xa inyibilikiswa, kodwa ubushushu kunye ne-pH inokuchaphazela ukunyibilika kwayo. Ngokomzekelo, emanzini abandayo, inyibilika ngokukhawuleza, kodwa ukunyibilika kwayo kunokuncitshiswa emanzini ashushu, ngakumbi kwiindawo eziphezulu.
Isakhono sokwenza ifilim:
Enye yezinto eziphambili zeHydroxypropyl Methylcellulose kukukwazi ukwenza ifilimu eguquguqukayo. Le propati yenza ukuba ilungele ukusetyenziswa kwiingubo zethebhulethi, apho inika indawo epholileyo, elawulwayo yokukhutshwa. Kwakhona luncedo kwishishini lokutya ukuphucula ukuthungwa kunye nobomi beshelufu.
IGelation:
Kwiindawo ezithile kunye namaqondo obushushu, i-HPMC inokwenza iijeli. Le propati inenzuzo ekuqulunqweni kwamachiza, apho isetyenziselwa ukudala iinkqubo ezilawulwayo zokukhutshwa.
Ukusetyenziswa kweHydroxypropyl Methylcellulose
Umzi mveliso wamachiza:
I-HPMC isetyenziswa njengesibophelelo kwiinkqubo zethebhulethi, ngakumbi kwiinkqubo zokukhutshwa okwandisiweyo kunye nokulawulwa kokukhutshwa. Ikwasebenza njenge-agent yokugqoka iipilisi kunye neepilisi zokulawula ukukhutshwa kwesithako esisebenzayo. Ikhono layo lokwenza iifilimu ezizinzileyo kunye neegels zilungele iinkqubo zokuhanjiswa kweziyobisi.
Ishishini lokutya
Kushishino lokutya, i-HPMC isetyenziswa njenge-ajenti yokujiya, i-emulsifier, kunye ne-stabilizer kwiimveliso ezahlukeneyo, kubandakanya iisosi, izinxibo, kunye neempahla ezibhakiweyo. Inceda ukuphucula ukuthungwa kunye nokwandisa ubomi beshelufu ngokunciphisa ilahleko yokufuma.
Izithambiso kunye noNonophelo lomntu:
I-HPMC isetyenziswa ngokubanzi kwizinto zokuthambisa, apho isebenza njenge-thickener kunye nokuzinzisa kwiikhrimu, izinto zokuthambisa, iishampu, kunye nezinye iimveliso zokhathalelo lobuqu. Ikhono layo lokwenza i-gel isakhiwo luncedo kakhulu kwezi zicelo.
Ushishino loKwakha:
Kushishino lolwakhiwo, ingakumbi kwisamente kunye nokwakhiwa kodaka, iHPMC isetyenziswa njengearhente yokugcina amanzi. Inceda ukuphucula ukusebenza kunye nokwandisa iimpawu zokudibanisa izinto.
Ezinye izicelo:
I-HPMC ikwaqeshwa kushishino lwempahla olulukiweyo, ukugquma kwamaphepha, nakwimveliso yeefilimu ezinokonakala.
IHydroxypropyl Methylcellulose (HPMC)Yikhompawundi esebenza ngeendlela ezininzi esetyenziswa kumashishini amaninzi ngenxa yeempawu zayo ezizodwa ezifana nesakhono sokwenza ifilim, ukuba nako ukujiya, kunye nokugcinwa kwamanzi. Ngelixa ingenayo “inombolo yesiriyali” ngokwendlela eqhelekileyo, ichongwa ngezichongi zemichiza njengenombolo yayo yeCAS (9004-65-3) kunye namabakala angqamene nemveliso (umz., HPMC K100M, HPMC E4M). Uluhlu olwahlukeneyo lwamabanga akhoyo e-HPMC luqinisekisa ukusebenza kwawo kwiinkalo ezahlukeneyo, ukusuka kumayeza ukuya ekutyeni, kwizinto zokuthambisa, kunye nolwakhiwo.
Ixesha lokuposa: Mar-21-2025