IHydroxypropyl Methylcellulose (HPMC)yipolymer enyibilikayo emanzini esetyenziswa kakhulu kumashishini amayeza, ukutya, izinto zokuthambisa, kunye nokwakha. Umxholo wokufuma we-HPMC udlala indima ebalulekileyo ekucutshungulweni nasekuzinzeni kwayo. Ichaphazela iipropati ze-rheological, ukunyibilika, kunye nobomi beshelufu bezinto. Ukuqonda umxholo wokufuma kubalulekile ekubunjweni kwayo, ekugcinweni kwayo, nasekusetyenzisweni kwayo ekugqibeleni.
Ubungakanani bokufuma be-HPMC
Umthamo wokufuma we-AnxinCel®HPMC uqhele ukugqitywa ziimeko zenkqubo kunye nomgangatho othile wepolymer esetyenzisiweyo. Umthamo wokufuma unokwahluka ngokuxhomekeke kwizinto eziluhlaza, iimeko zokugcina, kunye nenkqubo yokomisa. Ihlala ibonakaliswa njengepesenti yobunzima besampulu ngaphambi nasemva kokomisa. Kwizicelo zoshishino, umxholo wokufuma ubaluleke kakhulu, njengoko ukufuma okugqithisileyo kunokukhokelela ekuwohlokeni, ekuqhekekeni, okanye ekusebenzeni okunciphileyo kwe-HPMC.
Umthamo wokufuma we-HPMC ungasukela kwi-5% ukuya kwi-12%, nangona uluhlu oluqhelekileyo luphakathi kwe-7% kunye ne-10%. Umthamo wokufuma ungamiselwa ngokomisa isampuli kubushushu obuthile (umz., i-105°C) ide ifikelele kubunzima obungaguqukiyo. Umahluko kubunzima ngaphambi nasemva kokomisa umele umxholo wokufuma.
Izinto Ezichaphazela Umxholo Wokufuma kwi-HPMC
Ziliqela izinto ezinokuchaphazela umxholo wokufuma kwe-HPMC:
Iimeko zokufuma kunye nokugcinwa:
Ukufuma okuphezulu okanye iimeko zokugcina ezingafanelekanga zinokunyusa ukufuma kwe-HPMC.
I-HPMC i-hygroscopic, oko kuthetha ukuba ithambekele ekufunxeni umswakama emoyeni ojikelezileyo.
Ukupakishwa kunye nokutywinwa kwemveliso kunokunciphisa ukufunxwa komswakama.
Iimeko Zokucubungula:
Ubushushu bokomisa kunye nexesha ngexesha lokwenziwa kwemveliso kunokuchaphazela umxholo wokugqibela wokufuma.
Ukomisa ngokukhawuleza kunokubangela ukufuma okushiyekileyo, ngelixa ukomisa kancinci kunokubangela ukuba kufuma okuninzi.
Ibanga le-HPMC:
Iindidi ezahlukeneyo ze-HPMC (umz., i-viscosity ephantsi, i-viscosity ephakathi, okanye i-viscosity ephezulu) zinokuba nomxholo wokufuma owahluka kancinci ngenxa yokwahluka kwisakhiwo se-molecular kunye nokucutshungulwa kwayo.
Iinkcukacha zoMthengisi:
Ababoneleli banokubonelela nge-HPMC ngomthamo othile wokufuma ohambelana nemigangatho yemizi-mveliso.
Ubungakanani bokufuma obuqhelekileyo be-HPMC ngokwezinga
Ubungakanani bokufuma be-HPMC buyahluka ngokuxhomekeke kudidi kunye nokusetyenziswa okucetywayo. Nantsi itheyibhile ebonisa amanqanaba aqhelekileyo obungakanani bokufuma kwiindidi ezahlukeneyo ze-HPMC.
| Ibanga le-HPMC | Ukuqina (cP) | Umxholo wobumanzi (%) | Izicelo |
| Ukuxinana okuphantsi kwe-HPMC | 5 – 50 | 7 – 10 | Amayeza (iipilisi, iikhaphu), izinto zokuthambisa |
| Ukuxinana okuPhakathi kweHPMC | 100 – 400 | 8 – 10 | Amayeza (ukukhululwa okulawulwayo), ukutya, izinto zokuncamathelisa |
| I-HPMC enobungqindilili obuphezulu | 500 – 2000 | 8 – 12 | Ulwakhiwo (olusekwe kwisamente), ukutya (iarhente yokutyebisa) |
| I-HPMC yamayeza | 100 – 4000 | 7 – 9 | Iipilisi, iikhaphukhaphu, iifomyula zejeli |
| I-HPMC yodidi lokutya | 50 – 500 | 7 – 10 | Ukuqina kokutya, ukuxuba, ukugquma |
| Ibanga loKwakha i-HPMC | 400 – 10000 | 8 – 12 | I-mortar, izinto zokuncamathelisa, iiplasta, imixube eyomileyo |
Uvavanyo kunye nokuQinisekiswa koMxholo woBumanzi
Kukho iindlela ezahlukeneyo zokufumanisa umxholo wokufuma we-HPMC. Ezona ndlela zimbini zixhaphakileyo zezi:
Indlela yeGravimetric (Ukulahlekelwa xa womisa, iLOD):
Le yeyona ndlela isetyenziswa kakhulu ekufumaneni umxholo womswakama. Ubunzima obaziwayo be-HPMC bubekwa kwi-oven eyomileyo ebekwe kwi-105°C. Emva kwexesha elithile (ngesiqhelo iiyure ezi-2-4), isampuli iyalinganiswa kwakhona. Umahluko kubunzima unika umxholo womswakama, ochazwa njengepesenti yobunzima bokuqala besampuli.
UKarl Fischer Isikhundla:
Le ndlela ichaneke ngakumbi kune-LOD kwaye ibandakanya impendulo yamakhemikhali elinganisa ubungakanani bamanzi. Le ndlela idla ngokusetyenziswa xa kufuneka ukuqinisekiswa komswakama ngokuchanekileyo.
Impembelelo yoMxholo woBumanzi kwiipropati zeHPMC
Umthamo wokufuma we-AnxinCel®HPMC unefuthe ekusebenzeni kwayo kwiindlela ezahlukeneyo zokusebenza:
Ukuxinana:Umthamo womswakama ungachaphazela ukuqina kwezisombululo ze-HPMC. Umthamo womswakama ophezulu unokunyusa ukuqina kwezinye iindlela, ngelixa ubuninzi bomswakama bunokubangela ukuqina okuphantsi.
Ukunyibilika:Ukufuma okugqithisileyo kunokukhokelela ekuhlanganiseni okanye ekunciphiseni ukunyibilika kwe-HPMC emanzini, nto leyo eyenza ukuba ingasebenzi kakuhle kwiindlela ezithile, ezifana neefomyula zokukhululwa ezilawulwayo kwishishini lamayeza.
Uzinzo:I-HPMC iqhele ukuba izinzile kwiimeko ezomileyo, kodwa ukufuma okuphezulu kunokubangela ukukhula kweentsholongwane okanye ukonakala kweekhemikhali. Ngenxa yesi sizathu, i-HPMC idla ngokugcinwa kwizikhongozeli ezivaliweyo kwiindawo ezinomswakama omncinci.
Ubungakanani bokufuma kunye nokupakishwa kwe-HPMC
Ngenxa yokuba i-HPMC ithambile, ipakisha kakuhle kubalulekile ukuthintela ukufunxwa komswakama emoyeni. I-HPMC idla ngokupakishwa kwiingxowa okanye kwiikhonteyina ezenziwe ngezinto ezifana ne-polyethylene okanye ii-laminates ezininzi ukuze ikhuseleke kumswakama. Le paki iqinisekisa ukuba umxholo womswakama uhlala ngaphakathi koluhlu olufunekayo ngexesha lokugcina nokuthutha.
Ulawulo loMxholo woBumanzi kwiMveliso
Ngexesha lokwenziwa kwe-HPMC, kubalulekile ukujonga nokulawula umxholo wokufuma ukuze kugcinwe umgangatho wemveliso. Oku kunokufezekiswa ngokuthi:
Iindlela Zokomisa:I-HPMC ingomiswa kusetyenziswa umoya oshushu, ukomisa nge-vacuum, okanye ii-rotary dryers. Ubushushu kunye nobude bokomisa kufuneka kuphuculwe ukuze kuthintelwe ukomisa okungaphelelanga (umthamo ophezulu wokufuma) kunye nokomisa kakhulu (okunokukhokelela ekuwohlokeni kobushushu).
Ulawulo lweNdalo:Ukugcina imeko-bume elawulwayo enomswakama omncinci kwindawo yemveliso kubalulekile. Oku kunokubandakanya izixhobo zokususa umswakama, umoya opholileyo, kunye nokusetyenziswa kwezinzwa zomswakama ukujonga imeko yomoya ngexesha lokucubungula.
Ubungakanani bokufuma I-HPMCNgokwesiqhelo iphakathi kwe-7% ukuya kwi-10%, nangona inokwahluka ngokuxhomekeke kudidi, ukusetyenziswa, kunye neemeko zokugcina. Umxholo womswakama yiparameter ebalulekileyo echaphazela iipropati ze-rheological, ukunyibilika, kunye nozinzo lwe-AnxinCel®HPMC. Abavelisi kunye nabaqulunqi kufuneka balawule ngononophelo kwaye bajonge umxholo womswakama ukuqinisekisa ukusebenza kakuhle kwizicelo zabo ezithile.
Ixesha leposi: Jan-20-2025