Ziziphi iimpawu ze-hydroxypropyl methylcellulose?

1. Ukubonakala kunye nokunyibilika

I-HPMC idla ngokuba ngumgubo omhlophe okanye ongekho-mhlophe, ongenavumba, ongenancasa kwaye awunayo ityhefu. Inokunyibilika kumanzi abandayo kunye nezinyibilikisi ezithile eziphilayo (ezifana nezinyibilikisi ezixubeneyo ezifana ne-ethanol/amanzi kunye ne-acetone/amanzi), kodwa ayinyibiliki kwi-ethanol ecocekileyo, i-ether kunye ne-chloroform. Ngenxa yobume bayo obungeyiyo i-ionic, ayiyi kusabela kwi-electrolytic reaction in aqueous solution kwaye ayiyi kuchaphazeleka kakhulu ngexabiso le-pH.

2. I-Viscosity kunye ne-rheology

Isisombululo samanzi se-HPMC sinokutyeba okulungileyo kunye ne-thixotropy. Iindidi ezahlukeneyo ze-AnxinCel®HPMC zine-viscosities ezahlukeneyo, kwaye uluhlu oluqhelekileyo luyi-5 ukuya kwi-100000 mPa·s (2% isisombululo se-aqueous, 20 ° C). Isisombululo sayo sibonisa i-pseudoplasticity, oko kukuthi, i-shear thinning phenomenon, kwaye ifanelekile kwiimeko zesicelo ezifana neengubo, i-slurries, i-adhesives, njl. ezifuna i-rheology efanelekileyo.

3. I-Gelation ye-Thermal

Xa i-HPMC ishushu emanzini, ukucaca kwesisombululo kuyancipha kwaye ijeli yenziwe kwiqondo lokushisa elithile. Emva kokupholisa, i-gel state iya kubuyela kwisimo sesisombululo. Iindidi ezahlukeneyo ze-HPMC zinamaqondo obushushu ejeli ahlukeneyo, ngokubanzi phakathi kwama-50 nama-75°C. Le propati ibaluleke kakhulu kwizicelo ezifana nokwakha udaka kunye nekhepsuli zamachiza.

4. Umsebenzi womphezulu

Ngenxa yokuba iimolekyuli ze-HPMC ziqulethe amaqela e-hydrophilic kunye ne-hydrophobic, zibonisa umsebenzi othile ongaphezulu kwaye zinokudlala indima emulsifying, yokusabalalisa kunye nokuzinzisa. Ngokomzekelo, kwiingubo kunye ne-emulsions, i-HPMC inokuphucula ukuzinza kwe-emulsion kunye nokukhusela ukuchithwa kweengqungquthela ze-pigment.

5. Hygroscopicity

I-HPMC ine-hygroscopicity ethile kwaye inokufunxa ukufuma kwindawo efumileyo. Ke ngoko, kwezinye izicelo, kufuneka kuqwalaselwe ingqalelo kwipakethe yokutywina ukuthintela ukufunxwa komswakama kunye ne-agglomeration.

6. Ipropati yokwenza ifilimu

I-HPMC inokwenza ifilimu eqinile kwaye ecacileyo, esetyenziswa ngokubanzi ekutyeni, amayeza (afana nee-agent zokugquma) kunye neengubo. Ngokomzekelo, kwishishini lamachiza, ifilimu ye-HPMC ingasetyenziselwa ukugquma ithebhulethi ukuphucula ukuzinza kweziyobisi kunye nokukhululwa kokulawula.

7. Biocompatibility kunye nokhuseleko

I-HPMC ayinayo ityhefu kwaye ayinabungozi, kwaye inokutshizwa ngokukhuselekileyo ngumzimba womntu, ngoko ke isetyenziswa kakhulu kwiinkalo zamayeza nokutya. Njengomxhasi wamayeza, ngokuqhelekileyo isetyenziselwa ukuvelisa iipilisi ezizinzileyo, iigobolondo ze-capsule, njl.

8. Ukuzinza kwe-pH yesisombululo

I-HPMC izinzile kuluhlu lwe-pH lwe-3 ukuya kwi-11, kwaye ayilulanga okanye iyancipha nge-asidi kunye ne-alkali, ngoko ingasetyenziselwa kwiinkqubo ezahlukeneyo zeekhemikhali, ezifana nezixhobo zokwakha, iimveliso zemichiza yemihla ngemihla kunye nokwakhiwa kwamachiza.