IHydroxypropyl methylcellulose (HPMC) sisongezo sekhemikhali esibalulekileyo, esisetyenziswa kakhulu kwiinkalo ezininzi ezifana nokwakhiwa, amayeza, ukutya, kunye nezithambiso. Inokuqina okulungileyo, i-gelling, i-emulsifying, ifilimu-ifom, kunye neempawu zokudibanisa, kwaye inozinzo oluthile kwiqondo lokushisa kunye ne-pH. I-solubility ye-HPMC yenye yezinto eziphambili ekusebenziseni kwayo. Ukuqonda indlela echanekileyo yokutshatyalaliswa kubalulekile ukuqinisekisa ukusebenza kwayo.
1. Iimpawu ezisisiseko zokuchithwa kwe-HPMC
I-Hydroxypropyl methylcellulose yi-ether ye-cellulose engancibiliki emanzini e-non-ionic enokuthi inyibilike emanzini abandayo okanye ashushu ukwenza isisombululo se-viscous esicacileyo okanye esiguquguqukayo. Ukunyibilika kwayo kuchaphazeleka ikakhulu bubushushu. Kulula ukunyibilika emanzini abandayo kwaye kulula ukwenza i-colloid emanzini ashushu. I-HPMC ine-gelation ye-thermal, oko kukuthi, i-solubility embi kumaqondo aphezulu, kodwa inokuchithwa ngokupheleleyo xa ubushushu buthotywa. I-HPMC inobunzima beemolekyuli ezahlukeneyo kunye ne-viscosities, ngoko ke ngexesha lenkqubo yokuchithwa, imodeli efanelekileyo ye-HPMC kufuneka ikhethwe ngokweemfuno zemveliso.
2. Indlela yokuchithwa kwe-HPMC
Indlela yokusasazwa kwamanzi abandayo
Indlela yokusasazwa kwamanzi abandayo yeyona ndlela ixhaphakileyo yokuchithwa kweHPMC kwaye ilungele iimeko ezininzi zokusetyenziswa. Amanyathelo athile ngala alandelayo:
Lungisa amanzi abandayo: Galela umlinganiselo ofunekayo wamanzi abandayo kwisitya sokuxuba. Ubushushu bamanzi budla ngokucetyiswa ukuba bube ngaphantsi kwama-40°C ukuthintela i-HPMC ekwenzeni amaqhuma kumaqondo obushushu aphezulu.
Yongeza ngokuthe ngcembe i-HPMC: Kancinci yongeza i-HPMC powder kwaye uqhubeke uvuselela. Ukuze ugweme i-powder agglomeration, isantya esifanelekileyo sokushukumisa kufuneka sisetyenziswe ukuqinisekisa ukuba i-HPMC inokusasazwa ngokulinganayo emanzini.
Ukuma kunye nokunyibilika: Emva kokuba i-HPMC ihlakazwe emanzini abandayo, kufuneka ime ixesha elithile ukuze inyibilike ngokupheleleyo. Ngokuqhelekileyo, ishiywe imile imizuzu engama-30 ukuya kwiiyure ezininzi, kwaye ixesha elithile liyahluka ngokuxhomekeke kwimodeli ye-HPMC kunye nobushushu bamanzi. Ngexesha lokuma, i-HPMC iya kunyibilika ngokuthe ngcembe ukwenza isisombululo se-viscous.
Amanzi ashushu pre-dissolution indlela
Indlela yokuchithwa kwamanzi ashushu yangaphambi kokuchithwa ifanelekile kwiimodeli ezithile ze-HPMC ezine-viscosity ephezulu okanye kunzima ukunyibilika ngokupheleleyo emanzini abandayo. Le ndlela kukuqala ukuxuba umgubo we-HPMC kunye nenxalenye yamanzi ashushu ukwenza intlama, uze uyixube ngamanzi abandayo ekugqibeleni ufumane isisombululo esifanayo. Amanyathelo athile ngala alandelayo:
Ukufudumeza amanzi: Fudumeza umlinganiselo othile wamanzi ukuya kuma-80°C uze uwagalele kwisitya sokuxuba.
Ukongeza i-HPMC powder: Galela umgubo we-HPMC emanzini ashushu kwaye uvuselele ngelixa ugalela ukwenza umxube we-paste. Emanzini ashushu, i-HPMC iya kunyibilika okwethutyana kwaye yenze into efana nejeli.
Ukongeza amanzi abandayo ukuhlambulula: Emva kokuba umxube we-paste upholile, ngokuthe ngcembe wongeza amanzi abandayo ukuze uhlambulule kwaye uqhubeke uvuselela de udibaniswe ngokupheleleyo kwisisombululo esicacileyo okanye esiguquguqukayo.
Indlela yokusasazwa kwesinyibilikisi se-organic
Ngamanye amaxesha, ukuze kukhawuleziswe ukuchithwa kwe-HPMC okanye ukuphucula umphumo wokutshatyalaliswa kwezicelo ezithile ezikhethekileyo, i-solvent ye-organic ingasetyenziselwa ukuxuba namanzi ukunyibilikisa i-HPMC. Ngokomzekelo, izinyibilikisi eziphilayo ezifana ne-ethanol kunye ne-acetone zingasetyenziselwa ukusasaza i-HPMC kuqala, kwaye ke amanzi anokongezwa ukunceda i-HPMC ukunyibilika ngokukhawuleza. Le ndlela isoloko isetyenziselwa ukuveliswa kweemveliso ezithile ezisekelwe kwi-solvent, ezifana neengubo kunye neepeyinti.
Indlela yokuxuba eyomileyo
Indlela yokuxuba eyomileyo ifanelekile kwimveliso yemveliso enkulu. I-HPMC iqhele ukuba yomiswe kwangaphambili ixutywe nezinye izinto zomgubo (ezifana nesamente, igypsum, njl.), emva koko amanzi agalelwe ukuxuba xa esetyenziswa. Le ndlela yenza lula amanyathelo okusebenza kwaye inqanda ingxaki ye-agglomeration xa i-HPMC ichithwa iyodwa, kodwa ifuna ukuvuselela okwaneleyo emva kokudibanisa amanzi ukuqinisekisa ukuba i-HPMC inokunyibilika ngokulinganayo kwaye idlale indima yokuqina.
3. Izinto ezichaphazela ukuchithwa kwe-HPMC
Ubushushu: Ukunyibilika kwe-HPMC kubuthathaka kakhulu kubushushu. Ubushushu obuphantsi buvumela ukusasazwa kunye nokuchithwa kwayo emanzini, ngelixa ubushushu obuphezulu bubangela ukuba i-HPMC yenze i-colloids, ithintela ukuchithwa kwayo ngokupheleleyo. Ngoko ke, ngokuqhelekileyo kuyacetyiswa ukuba kusetyenziswe amanzi abandayo okanye ukulawula ubushushu bamanzi ngaphantsi kwe-40 ° C xa uchitha i-HPMC.
Isantya esishukumisayo: Ukuvuselela okufanelekileyo kunokunqanda ngokufanelekileyo i-HPMC agglomeration, ngaloo ndlela inyusa isantya sokunyibilika. Nangona kunjalo, isantya esishukumisayo esikhawulezayo sinokuzisa inani elikhulu lamaqamza kwaye sichaphazele ukufana kwesisombululo. Ke ngoko, ekusebenzeni kokwenyani, isantya esifanelekileyo sokushukumisa kunye nesixhobo kufuneka sikhethwe.
Umgangatho wamanzi: Ukungcola, ukuqina, ixabiso le-pH, njl. emanzini kuya kuchaphazela ukunyibilika kwe-HPMC. Ngokukodwa, i-calcium kunye ne-magnesium ion emanzini anzima inokusabela nge-HPMC kwaye ichaphazele ukunyibilika kwayo. Ke ngoko, ukusebenzisa amanzi acocekileyo okanye amanzi athambileyo kunceda ukuphucula ukusebenza kakuhle kokupheliswa kweHPMC.
Imodeli ye-HPMC kunye nobunzima bemolekyuli: Iimodeli ezahlukeneyo ze-HPMC ziyahluka kwisantya sokunyibilika, i-viscosity kunye nobushushu bokupheliswa. I-HPMC enobunzima obuphezulu bemolekyuli inyibilika ngokucothayo, ine-viscosity yesisombululo esiphezulu, kwaye ithatha ixesha elide ukunyibilika ngokupheleleyo. Ukukhetha imodeli eyiyo ye-HPMC kunokuphucula ukusebenza kakuhle konyiso kunye nokuhlangabezana neemfuno ezahlukeneyo zesicelo.
4. Iingxaki eziqhelekileyo kunye nezisombululo kwi-HPMC yokuchithwa
Ingxaki ye-Agglomeration: Xa i-HPMC inyibilika emanzini, i-agglomerations inokwenza ukuba umgubo awusasazwanga ngokulinganayo. Ukuze ugweme le ngxaki, i-HPMC kufuneka yongezwe ngokuthe ngcembe ngexesha lokuchithwa kwaye igcinwe kwisantya esifanelekileyo esishukumisayo, ngelixa ugwema ukongeza i-HPMC powder kumaqondo aphezulu.
Isisombululo esingalinganiyo: Ukuba ukuvuselela akwanelanga okanye ixesha lokuma alanelanga, i-HPMC ayinakuchithwa ngokupheleleyo, kubangele isisombululo esingalinganiyo. Ngeli xesha, ixesha lokuvuselela kufuneka landiswe okanye ixesha lokuma kufuneka linyuswe ukuqinisekisa ukuchithwa ngokupheleleyo.
Ingxaki yeBubble: Ukukhawuleza ngokukhawuleza okanye ukungcola emanzini kunokwazisa inani elikhulu lamaqamza, okuchaphazela umgangatho wesisombululo. Ngenxa yesi sizathu, kuyacetyiswa ukuba ulawule isantya eshukumisayo xa ukunyibilika HPMC ukuphepha amaqamza kakhulu, kwaye wongeze defoamer ukuba kuyimfuneko.
Ukupheliswa kwe-HPMC likhonkco eliphambili kwisicelo sayo. Ukuqonda indlela echanekileyo yokutshatyalaliswa kunceda ukuphucula umgangatho wemveliso kunye nokusebenza kakuhle kwemveliso. Ngokutsho kweentlobo ezahlukeneyo ze-HPMC kunye neemfuno zesicelo, ukuchithwa kwamanzi abandayo, ukuchithwa kwamanzi ashushu kwangaphambili, ukuchithwa kwe-solvent ye-organic okanye ukuxuba okomileyo kunokukhethwa. Ngelo xesha, ingqalelo kufuneka ihlawulwe kwizinto zokulawula ezifana neqondo lokushisa, isantya esishukumisayo kunye nomgangatho wamanzi ngexesha lenkqubo yokuchithwa ukuphepha iingxaki ezifana ne-agglomeration, i-bubbles kunye nokuchithwa okungagqibekanga. Ngokulungisa iimeko zokuchithwa, kunokuqinisekiswa ukuba i-HPMC inokunika umdlalo ogcweleyo kwiipropati zayo ezityebileyo kunye zokwenza ifilimu, ibonelela ngezisombululo ezikumgangatho ophezulu kwiinkqubo ezahlukeneyo zemizi-mveliso kunye nemihla ngemihla.
Ixesha lokuposa: Sep-30-2024