HEC (Iselulosi yeHydroxyethyl)yipolymer eqhelekileyo enyibilikayo emanzini esetyenziswa kakhulu kumalungiselelo amayeza. I-derivative ye-cellulose, efunyenwe ngokuphendula i-ethanolamine (i-ethylene oxide) kunye ne-cellulose. Ngenxa yokunyibilika kwayo okulungileyo, ukuzinza, amandla okulungelelaniswa kwe-viscosity kunye ne-biocompatibility, i-HEC inoluhlu olubanzi lwezicelo kwintsimi yamachiza, ngokukodwa kuphuhliso lokuqulunqa, ukuyila ifom yedosi kunye nokulawulwa kokukhululwa kweziyobisi.
1. Iipropati ezisisiseko ze-HEC
I-HEC, njengeselulosi elungisiweyo, inezi mpawu zilandelayo:
Ukunyibilika kwamanzi: I-AnxinCel®HEC inokwenza isisombululo se-viscous emanzini, kwaye ukunyibilika kwayo kuhambelana nokushisa kunye ne-pH. Le propati yenza ukuba isetyenziswe kwiifom ezahlukeneyo zedosi ezifana nomlomo kunye ne-topical.
I-Biocompatibility: I-HEC ayinayo ityhefu kwaye ayicaphukisi emzimbeni womntu kwaye iyahambelana namachiza amaninzi. Ke ngoko, isetyenziswa ngokubanzi kwiifom zedosi yokukhutshwa okuzinzileyo kunye neendlela zolawulo lwasekhaya lwamachiza.
I-viscosity ehlengahlengiswayo: I-viscosity ye-HEC inokulungelelaniswa ngokutshintsha ubunzima bayo be-molecular okanye ukugxila, okubalulekileyo ekulawuleni izinga lokukhululwa kweziyobisi okanye ukuphucula ukuzinza kwamachiza.
2. Ukusetyenziswa kwe-HEC kumalungiselelo amayeza
Njengomxhasi obalulekileyo kumalungiselelo amayeza, i-HEC inemisebenzi emininzi. Ezi zilandelayo ziindawo zayo eziphambili zesicelo kumalungiselelo amayeza.
2.1 Ukusetyenziswa kumalungiselelo omlomo
Kwiifom zedosi yomlomo, i-HEC isoloko isetyenziselwa ukuveliswa kweepilisi, iipilisi kunye namalungiselelo olwelo. Imisebenzi yayo ephambili ibandakanya:
I-Binder: Kwiipilisi kunye ne-granules, i-HEC ingasetyenziselwa njenge-binder ukubopha kangcono iincinci zeziyobisi okanye iipowders kunye nokuqinisekisa ubulukhuni kunye nokuzinza kweepilisi.
Ukulawulwa kokukhululwa okuzinzileyo: I-HEC inokufezekisa umphumo wokukhululwa ngokuqhubekayo ngokulawula izinga lokukhululwa kweyeza. Xa i-HEC isetyenziswe kunye nezinye izithako (ezifana ne-polyvinyl pyrrolidone, i-carboxymethyl cellulose, njl.), inokwandisa ngokufanelekileyo ixesha lokukhululwa kweyeza emzimbeni, ukunciphisa ukuphindaphinda kwamayeza, kunye nokuphucula ukuthotyelwa kwesigulane.
I-Thickener: Kumalungiselelo omlomo olwelo, i-AnxinCel®HEC njenge-thickener inokuphucula incasa yeyeza kunye nokuzinza kwefom yedosi.
2.2 Ukusetyenziswa kumalungiselelo ezihloko
I-HEC isetyenziswa ngokubanzi kwi-ointments ye-topical, i-creams, i-gels, i-lotions kunye namanye amalungiselelo, idlala iindima ezininzi:
I-matrix ye-Gel: I-HEC isoloko isetyenziswa njenge-matrix yeegels, ngakumbi kwiinkqubo zokuhanjiswa kweziyobisi ze-transdermal. Inokubonelela ngokuhambelana okufanelekileyo kunye nokwandisa ixesha lokuhlala kweziyobisi esikhumbeni, ngaloo ndlela kuphuculwe ukusebenza kakuhle.
I-Viscosity kunye nokuzinza: I-viscosity ye-HEC inokunyusa ukunamathela kwamalungiselelo e-topical esikhumbeni kwaye ithintele iyeza ukuba liwele ngaphambi kwexesha ngenxa yezinto zangaphandle ezifana nokukhuhlana okanye ukuhlamba. Ukongezelela, i-HEC inokuphucula ukuzinza kwama-creams kunye namafutha kunye nokukhusela i-stratification okanye i-crystallization.
I-Lubricant kunye ne-moisturizer: I-HEC ineempawu ezintle zokuthambisa kwaye inokunceda ukugcina ulusu lufumile kwaye luthintele ukoma, ngoko ke isetyenziselwa ukuthambisa kunye nezinye iimveliso zokunakekelwa kwesikhumba.
2.3 Ukusetyenziswa kumalungiselelo e-ophthalmic
Ukusetyenziswa kwe-HEC kumalungiselelo e-ophthalmic kubonakala ikakhulu kwindima yayo njengento yokubambelela kunye ne-lubricant:
Iigels ze-Ophthalmic kunye ne-eye drops: I-HEC ingasetyenziselwa njengento yokubambelela kumalungiselelo e-ophthalmic ukwandisa ixesha lokudibanisa phakathi kweyeza kunye neliso kunye nokuqinisekisa ukusebenza okuqhubekayo kweyeza. Kwangaxeshanye, i-viscosity yayo inokuthintela ukuhla kwamehlo ukuba ingalahleki ngokukhawuleza kwaye yandise ixesha lokugcinwa kwechiza.
I-Lubrication: I-HEC ine-hydration efanelekileyo kwaye inokubonelela nge-lubrication eqhubekayo kunyango lwezifo ze-ophthalmic ezifana neso elomileyo, ukunciphisa ukungathandeki kwamehlo.
2.4 Ukusetyenziswa kumalungiselelo esitofu
I-HEC inokusetyenziswa ekulungiseleleni iifom zedosi yesitofu, ngakumbi kwiinaliti ezisebenza ixesha elide kunye namalungiselelo okukhutshwa okuzinzileyo. Imisebenzi ephambili ye-HEC kula malungiselelo ibandakanya:
I-Thickener kunye ne-stabilizer: kwinaliti,I-HECinokunyusa i-viscosity yesisombululo, icothe isantya sokutofa kwechiza, kwaye yandise uzinzo lwechiza.
Ukulawula ukukhutshwa kweziyobisi: Njengenye yamacandelo enkqubo yokukhululwa kweziyobisi, i-HEC inokulawula izinga lokukhululwa kweyeza ngokwenza i-gel layer emva kwenaliti, ukuze kufezekiswe injongo yonyango lwexesha elide.
3. Indima ye-HEC kwiinkqubo zokuhanjiswa kweziyobisi
Ngokuphuhliswa kwetheknoloji yezobisi, i-HEC isetyenziswe ngokubanzi kwiinkqubo ezahlukeneyo zokuhanjiswa kweziyobisi, ngokukodwa kwiinkalo ze-nano-drug carriers, i-microspheres, kunye nabathwali beziyobisi ezizinzileyo. I-HEC inokudibaniswa kunye neentlobo zezixhobo zokuthwala iziyobisi ukwenza i-complex ezinzile ukuqinisekisa ukukhululwa okuqhubekayo kunye nokuhanjiswa ngokufanelekileyo kwamachiza.
I-Nano i-carrier carrier: I-HEC ingasetyenziselwa njenge-stabilizer ye-nano abathwali beziyobisi ukukhusela ukudibanisa okanye ukugqithiswa kweengqungquthela ze-carrier kunye nokwandisa i-bioavailability yamachiza.
I-Microspheres kunye neengqungquthela: I-HEC ingasetyenziselwa ukulungiselela i-microspheres kunye ne-microparticle drug carriers ukuqinisekisa ukukhutshwa okucothayo kweziyobisi emzimbeni kunye nokuphucula ukusebenza kweziyobisi.
Njengomxhasi osebenzayo kunye osebenzayo wamachiza, i-AnxinCel®HEC inamathuba okusetyenziswa okubanzi kumalungiselelo amayeza. Ngophuhliso oluqhubekayo lwetheknoloji yamayeza, i-HEC idlala indima ebalulekileyo ekulawuleni ukukhutshwa kweziyobisi, ulawulo lwendawo, amalungiselelo okukhutshwa okuzinzileyo kunye neenkqubo ezintsha zokuhanjiswa kweziyobisi. I-biocompatibility yayo elungileyo, i-viscosity ehlengahlengiswayo kunye nokuzinza kwenza ukuba ingabinandawo kwindawo yeyeza. Kwixesha elizayo, ngophando olunzulu lwe-HEC, ukusetyenziswa kwayo kumalungiselelo amayeza kuya kuba kuninzi kwaye kuhluke.
Ixesha lokuposa: Dec-28-2024