I-HPMC (Hydroxypropyl Methylcellulose)yipolymer engeyiyo ionic semi-synthetic esetyenziswa kakhulu kumayeza, ukutya, ulwakhiwo, iingubo kunye namanye amashishini. Ngokumalunga nokuba i-HPMC inokunyibilika na emanzini ashushu, iimpawu zayo zokunyibilika kunye nefuthe lobushushu ekuziphatheni kwayo konyibiliko kufuneka ziqwalaselwe.
Isishwankathelo sokunyibilika kweHPMC
I-HPMC inonyibiliko olulungileyo lwamanzi, kodwa indlela yokuziphatha kwayo yonyibiliko inxulumene ngokusondeleyo nobushushu bamanzi. Ngokubanzi, i-HPMC inokusasazwa ngokulula kwaye inyibilikiswe kumanzi abandayo, kodwa ibonisa iimpawu ezahlukeneyo emanzini ashushu. I-solubility ye-HPMC emanzini abandayo ichatshazelwa kakhulu yi-molecular structure kunye nohlobo oluthatha indawo. Xa i-HPMC idibana namanzi, amaqela e-hydrophilic (afana ne-hydroxyl kunye ne-hydroxypropyl) kwiimolekyuli zayo ziya kwenza iibhondi ze-hydrogen kunye neemolekyuli zamanzi, ezibangela ukuba zidumbe kwaye zinyibilike. Nangona kunjalo, iimpawu zokunyibilika kwe-HPMC zahlukile emanzini kumaqondo obushushu ahlukeneyo.
Ukunyibilika kwe-HPMC emanzini ashushu
Ukunyibilika kwe-HPMC emanzini ashushu kuxhomekeke kuluhlu lobushushu:
Ubushushu obuphantsi (0-40 ° C): I-HPMC inokufunxa kancinci amanzi kwaye idumbe, kwaye ekugqibeleni yenze isisombululo se-viscous esicacileyo okanye esiguquguqukayo. Izinga lokuchithwa lihamba kancinci kumaqondo aphantsi, kodwa i-gelation ayenzeki.
Ubushushu obuphakathi (40-60 ° C): I-HPMC idumba kolu luhlu lobushushu, kodwa ayinyibiliki ngokupheleleyo. Endaweni yoko, yenza ngokulula ii-agglomerates ezingalinganiyo okanye ukumiswa, okuchaphazela ukufana kwesisombululo.
Ubushushu obuphezulu (ngaphezu kwe-60 ° C): I-HPMC iya kuhlukana kwisigaba kumaqondo aphezulu aphezulu, abonakaliswe njenge-gelation okanye imvula, eyenza kube nzima ukunyibilika. Ngokuqhelekileyo, xa ubushushu bamanzi budlula i-60-70 ° C, intshukumo ye-thermal ye-HPMC ye-molecular chain iqinisa, kwaye ukunyibilika kwayo kuyancipha, kwaye ekugqibeleni kunokwenza i-gel okanye i-precipitate.
Iipropati ze-Thermogel ze-HPMC
I-HPMC ineempawu ze-thermogel eziqhelekileyo, oko kukuthi, yenza ijeli kumaqondo obushushu aphezulu kwaye inokuphinda inyibilike kumaqondo aphantsi. Le propati ibaluleke kakhulu kwizicelo ezininzi, ezifana:
Umzi-mveliso wokwakha: I-HPMC isetyenziswa njengesityebi sodaka lwesamente. Iyakwazi ukugcina umswakama omhle ngexesha lokwakhiwa kwaye ibonise i-gelation kwiindawo eziphezulu zokushisa ukunciphisa ukulahleka kwamanzi.
Amalungiselelo amayeza: Xa isetyenziswe njengento yokugqoka kwiipilisi, iimpawu zayo ze-thermal gelation kufuneka ziqwalaselwe ukuqinisekisa ukunyibilika okulungileyo.
Ishishini lokutya: I-HPMC isetyenziswa njenge-thickener kunye ne-emulsifier kwezinye ukutya, kwaye i-gelation yayo ye-thermal inceda ukuzinza kokutya.
Indlela yokunyibilikisa i-HPMC ngokuchanekileyo?
Ukuze uthintele i-HPMC ekwenzeni ijeli emanzini ashushu kwaye isilele ukunyibilika ngokulinganayo, ezi ndlela zilandelayo zidla ngokusetyenziswa:
Indlela yokusasazwa kwamanzi abandayo:
Okokuqala, ukusasaza ngokulinganayo i-HPMC emanzini abandayo okanye ubushushu begumbi amanzi ukuze imanziswe ngokupheleleyo kwaye idumbe.
Yandisa kancinci iqondo lobushushu ngexesha lokuxhokonxa ukunyibilika ngakumbi i-HPMC.
Emva kokuba ichithwe ngokupheleleyo, ukushisa kunokunyuswa ngokufanelekileyo ukukhawulezisa ukubunjwa kwesisombululo.
Indlela yokupholisa yokusasazwa kwamanzi ashushu:
Okokuqala, sebenzisa amanzi ashushu (malunga ne-80-90 ° C) ukusasaza ngokukhawuleza i-HPMC ukwenzela ukuba ijeli yokukhusela i-insoluble isekwe kumphezulu wayo ukukhusela ukubunjwa kwangoku kweengqungquthela ezincangathi.
Emva kokupholisa kwiqondo lobushushu begumbi okanye ukongeza amanzi abandayo, i-HPMC iyanyibilika ngokuthe ngcembe ukwenza isisombululo esifanayo.
Indlela yokuxuba okomileyo:
Xuba HPMC kunye nezinye izinto ezinyibilikayo (ezifana iswekile, istatshi, mannitol, njl.) uze wongeze amanzi ukunciphisa agglomeration nokukhuthaza ukunyibilika efanayo.
HPMCayinakunyibilika ngokuthe ngqo emanzini ashushu. Kulula ukwenza i-gel okanye i-precipitate kwiqondo lokushisa eliphezulu, elinciphisa ukunyibilika kwayo. Eyona ndlela ingcono yokutshatyalaliswa kukusasaza emanzini abandayo kuqala okanye ukusasazwa kwangaphambili ngamanzi ashushu kwaye emva koko upholise ukufumana isisombululo esifanayo kunye nesizinzileyo. Kwizicelo ezisebenzayo, khetha indlela efanelekileyo yokuphelisa ngokweemfuno zokuqinisekisa ukuba i-HPMC isebenza kangangoko.
Ixesha lokuposa: Mar-25-2025