HEC (Hydroxyethyl Cellulose)ke polima e tloaelehileng e qhibilihang ka metsing e sebelisoang haholo litokisong tsa meriana. Ke ntho e tsoang ho selulose, e fumanoang ka ho arabela ethanolamine (ethylene oxide) ka selulose. Ka lebaka la ho qhibiliha ha eona hantle, botsitso, bokhoni ba ho fetola li-viscosity le biocompatibility, HEC e na le mefuta e mengata ea likopo lefapheng la meriana, haholo-holo ho nts'etsopele ea tlhahiso, moralo oa foromo ea litekanyetso le taolo ea ho lokolloa ha lithethefatsi.
1. Lintho tsa motheo tsa HEC
HEC, joalo ka selulose e fetotsoeng, e na le thepa ea mantlha e latelang:
Ho qhibiliha ha metsi: AnxinCel®HEC e ka etsa tharollo ea viscous ka metsing, 'me ho qhibiliha ha eona ho amana le mocheso le pH. Thepa ena e etsa hore e sebelisoe ka mefuta e fapaneng ea litekanyetso tse kang molomo le lihlooho.
Biocompatibility: HEC ha e na chefo ebile ha e halefise 'meleng oa motho' me e lumellana le lithethefatsi tse ngata. Ka hona, e sebelisoa haholo mefuteng ea litekanyetso tsa tokollo e tsitsitseng le mefuta ea litekanyetso tsa tsamaiso ea lehae ea lithethefatsi.
Viscosity e feto-fetohang: The viscosity ea HEC e ka fetoloa ka ho fetola boima ba molek'hule kapa mahloriso, e leng ntho ea bohlokoa bakeng sa ho laola sekhahla sa ho lokolloa ha lithethefatsi kapa ho ntlafatsa botsitso ba lithethefatsi.
2. Kopo ea HEC litokisetsong tsa meriana
E le mothusi oa bohlokoa litokisetsong tsa meriana, HEC e na le mesebetsi e mengata. Lintlha tse latelang ke libaka tsa eona tse ka sehloohong tsa kopo litokisetsong tsa meriana.
2.1 Tšebeliso ea litokisetso tsa molomo
Ka mefuta ea litekanyetso tsa molomo, HEC e atisa ho sebelisoa ha ho etsoa matlapa, li-capsules le litokisetso tsa metsi. Mesebetsi ea eona ea mantlha e kenyelletsa:
Binder: Ka matlapa le li-granules, HEC e ka sebelisoa e le tlamahano ho molemo ho tlama likaroloana tsa lithethefatsi kapa li-powders hammoho ho netefatsa ho thatafala le botsitso ba matlapa.
Taolo e tsitsitseng ea ho lokolloa: HEC e ka finyella phello e tsitsitseng ea ho lokolloa ka ho laola tekanyo ea ho lokolloa ha lithethefatsi. Ha HEC e sebelisoa hammoho le lisebelisoa tse ling (tse kang polyvinyl pyrrolidone, carboxymethyl cellulose, joalo-joalo), e ka atleha ho lelefatsa nako ea ho lokolloa ha lithethefatsi 'meleng, ho fokotsa makhetlo a meriana, le ho ntlafatsa ho latela mokuli.
Thickener: Litokisetsong tsa molomo oa metsi, AnxinCel®HEC e le motenya e ka ntlafatsa tatso ea lithethefatsi le botsitso ba foromo ea litekanyetso.
2.2 Kopo ka litokisetso tsa lihlooho
HEC e sebelisoa haholo ho litlolo tsa lihlooho, litlolo, li-gel, li-lotions le litokisetso tse ling, li bapala likarolo tse ngata:
Gel matrix: HEC e atisa ho sebelisoa e le matrix bakeng sa li-gel, haholo-holo tsamaisong ea phepelo ea lithethefatsi ea transdermal. E ka fana ka botsitso bo loketseng le ho eketsa nako ea ho lula ha moriana letlalong, ka hona ho ntlafatsa katleho.
Viscosity le botsitso: The viscosity ea HEC e ka ntlafatsa ho khomarela ha litokisetso tsa lihlooho letlalong le ho thibela lithethefatsi hore li se ke tsa oela pele ho nako ka lebaka la lintho tse ka ntle tse kang ho ferekana kapa ho hlatsoa. Ho phaella moo, HEC e ka ntlafatsa botsitso ba litlolo le mafura le ho thibela stratification kapa crystallization.
Lubricant le moisturizer: HEC e na le mekhoa e metle ea ho kolobisa 'me e ka thusa ho boloka letlalo le le mongobo le ho thibela ho omella, kahoo e boetse e sebelisoa ho litlolo le lihlahisoa tse ling tsa tlhokomelo ea letlalo.
2.3 Kopo ka litokisetso tsa mahlo
Tšebeliso ea HEC litokisetsong tsa mahlo e bonahala haholo-holo karolong ea eona e le sekhomaretsi le setlolo:
Li-gels tsa mahlo le marotholi a mahlo: HEC e ka sebelisoa e le sekhomaretsi bakeng sa litokisetso tsa ophthalmic ho lelefatsa nako ea ho kopana pakeng tsa lithethefatsi le leihlo le ho tiisa hore ho tsoela pele ho sebetsa hantle ha moriana. Ka nako e ts'oanang, viscosity ea eona e ka boela ea thibela marotholi a mahlo ho lahleheloa ke kapele le ho eketsa nako ea ho boloka lithethefatsi.
Lubrication: HEC e na le hydration e ntle 'me e ka fana ka lubrication e tsoelang pele kalafo ea mafu a mahlo a kang mahlo a omileng, ho fokotsa ho se utloise bohloko ha mahlo.
2.4 Kopo ka litokisetso tsa ente
HEC e ka boela ea sebelisoa ha ho etsoa liforomo tsa litekanyetso tsa ente, haholo-holo liente tse nkang nako e telele le litokisetso tsa tokollo e tsitsitseng. Mesebetsi ea mantlha ea HEC litokisetsong tsena e kenyelletsa:
Thickener le stabilizer: ka ente,HECe ka eketsa viscosity ea tharollo, ea fokotsa lebelo la ente ea moriana, 'me ea matlafatsa botsitso ba moriana.
Ho laola ho lokolloa ha lithethefatsi: E le e 'ngoe ea likarolo tsa mokhoa o tsitsitseng oa ho lokolloa ha lithethefatsi, HEC e ka laola tekanyo ea ho lokolloa ha lithethefatsi ka ho etsa lesela la gel ka mor'a ente, e le ho finyella morero oa phekolo ea nako e telele.
3. Karolo ea HEC mekhoeng ea ho fana ka lithethefatsi
Ka nts'etsopele ea thekenoloji ea meriana, HEC e 'nile ea sebelisoa haholo mekhoeng e sa tšoaneng ea ho fana ka lithethefatsi, haholo-holo masimong a li-nano-drug carriers, microspheres, le bajari ba ts'ebeliso e tsitsitseng ea lithethefatsi. HEC e ka kopanngoa le mefuta e sa tšoaneng ea lisebelisoa tse tsamaisang lithethefatsi ho theha motsoako o tsitsitseng ho etsa bonnete ba ho lokolloa ho tsitsitseng le ho fana ka meriana ka katleho.
Nano drug carrier: HEC e ka sebelisoa e le stabilizer bakeng sa bajari ba lithethefatsi ba nano ho thibela ho bokellana kapa ho theoha ha likaroloana tsa thepa le ho eketsa bioavailability ea lithethefatsi.
Li-microspheres le likaroloana: HEC e ka sebelisoa ho lokisetsa li-microspheres le li-microparticle drug carriers ho etsa bonnete ba ho lokolloa butle-butle ha lithethefatsi 'meleng le ho ntlafatsa katleho ea lithethefatsi.
Joalo ka mothusi oa meriana ea sebetsang ka bongata le e sebetsang hantle, AnxinCel®HEC e na le menyetla e pharaletseng ea ts'ebeliso ea litokisetso tsa meriana. Ka nts'etsopele e tsoelang pele ea thekenoloji ea meriana, HEC e phetha karolo e ntseng e eketseha ea bohlokoa ho laola ho lokolloa ha lithethefatsi, tsamaiso ea libaka, litokisetso tsa ho lokolloa ka mokhoa o tsitsitseng le mekhoa e mecha ea ho fana ka lithethefatsi. Biocompatibility ea eona e ntle, viscosity e feto-fetohang le botsitso li etsa hore e se ke ea nkeloa sebaka lefapheng la bongaka. Nakong e tlang, ka thuto e tebileng ea HEC, ts'ebeliso ea eona ho litokisetso tsa meriana e tla ba e pharaletseng le e fapaneng.
Nako ea poso: Dec-28-2024