Hydroxypropyl Methylcellulose (HPMC)ikemikari yakagadziridzwa fomu ye cellulose inoshandiswa zvakanyanya mumaindasitiri akasiyana semishonga, kugadzira chikafu, uye kuvaka. Mushonga unosiyana-siyana, unowanzo shandiswa semukobvu, bhainda, mugadziri wemufirimu, uye anodzikamisa. Nekudaro, iyo haina chaiyo "serial nhamba" mupfungwa yechinyakare, sechigadzirwa kana chikamu chikamu chaungawana mune mamwe mamiriro ekugadzira. Pane kudaro, HPMC inotaridzwa nechimiro chayo chemakemikari uye huwandu hwehunhu, hwakadai sedhigirii rekutsiva uye viscosity.
Ruzivo Rwose Pamusoro peHydroxypropyl Methylcellulose (HPMC)
Chemical Structure: HPMC inogadzirwa nekemikari inoshandura cellulose kuburikidza nekutsiva hydroxyl (-OH) mapoka ane hydroxypropyl uye methyl mapoka. Iyo inotsiva inoshandura zvimiro zve cellulose, zvichiita kuti inyungudika mumvura uye ichipa iyo yakasarudzika midziyo senge yakagadziridzwa firimu-kugadzira kugona, kugona kusunga, uye kugona kuchengetedza unyoro.
Common Identifiers uye Kupa Mazita
Kuzivikanwa kweHydroxypropyl Methylcellulose kazhinji kunotsamira pane akasiyana siyana emazita magungano anotsanangura chimiro chayo chemakemikari uye zvimiro:
Nhamba yeCAS:
Iyo Chemical Abstracts Service (CAS) inopa yakasarudzika identifier kune yega makemikari zvinhu. Nhamba yeCAS yeHydroxypropyl Methylcellulose ndeye 9004-65-3. Iyi inhamba yakamisikidzwa inoshandiswa nemachemist, vatengesi, uye masangano anodzora kureva chinhu.
InChI uye SMILES Makodhi:
InChI (International Chemical Identifier) ndiyo imwe nzira yekumiririra chimiro chemakemikari chechinhu. HPMC yaizove neyakareba InChI tambo inomiririra chimiro chayo chemorekuru mune yakamisikidzwa fomati.
SMILES (Simplified Molecular Input Line Entry System) imwe sisitimu inoshandiswa kumiririra mamorekuru muchimiro chemavara. HPMC zvakare ine inoenderana SMILES kodhi, kunyangwe ingave yakaoma zvakanyanya nekuda kwehukuru uye hwakasiyana hunhu hwechimiro chayo.
Zvinodiwa neChigadzirwa:
Mumusika wekutengesa, HPMC inowanzozivikanwa nenhamba dzechigadzirwa, dzinogona kusiyana nemugadziri. Semuenzaniso, mutengesi anogona kunge aine giredhi rakaita seHPMC K4M kana HPMC E15. Aya maziviro anowanzo tarisa kune viscosity yepolymer mune mhinduro, iyo inotarwa nechiyero chemethylation uye hydroxypropylation pamwe nehuremu hwemamorekuru.
Yakajairika Magiredhi eHydroxypropyl Methylcellulose (HPMC)
Hunhu hweHydroxypropyl Methylcellulose hunosiyana zvichienderana nehuwandu hwekutsiviwa kwemapoka emethyl uye hydroxypropyl, pamwe nehuremu hwemamorekuru. Iyi misiyano inosarudza viscosity yeHPMC uye kunyungudika mumvura, izvo zvinozokanganisa mashandisirwo ayo mumaindasitiri akasiyana.
Pazasi pane tafura inotsanangura mamakisi akasiyana eHydroxypropyl Methylcellulose:
| Giredhi | Viscosity (cP mu2% mhinduro) | Applications | Tsanangudzo |
| HPMC K4M | 4000 - 6000 cP | Pharmaceutical tablet binder, indasitiri yechikafu, kuvaka (zvinonamira) | Medium viscosity giredhi, inowanzoshandiswa mumuromo piritsi maumbirwo. |
| HPMC K100M | 100,000 - 150,000 cP | Kudzorwa-kuburitsa maumbirwo mumishonga, kuvaka, uye pendi coatings | High viscosity, yakanakira kuburitswa kwezvinodhaka. |
| HPMC E4M | 3000 - 4500 cP | Zvizoro, zvekugezesa, kugadzira chikafu, zvinonamira, uye machira | Soluble mumvura inotonhora, inoshandiswa muzvigadzirwa zvekuchengetedza munhu uye zvinhu zvekudya. |
| HPMC E15 | 15,000 cP | Iyo yekukora mumiriri mupendi, machira, chikafu, uye mishonga | High viscosity, soluble mumvura inotonhora, inoshandiswa mumaindasitiri uye mishonga yemishonga. |
| HPMC M4C | 4000 - 6000 cP | Indasitiri yechikafu nechinwiwa seyakagadzikana, yemishonga sebhainda | Moderate viscosity, inowanzoshandiswa seyakakora muchikafu chakagadzirwa. |
| HPMC 2910 | 3000 - 6000 cP | Zvizoro (mafuta, lotions), chikafu (confectionery), mishonga (capsules, coatings) | Imwe yemagiredhi akajairika, anoshandiswa seanodzikamisa uye thickening agent. |
| HPMC 2208 | 5000 - 15000 cP | Inoshandiswa mukugadzira simende uye plaster, machira, mapepa ekuputira | Yakanakira maapplication anoda yakanakisa firimu-kugadzira zvivakwa. |
Yakadzama Kuumbwa uye Zvivakwa zveHPMC
Hunhu hwemuviri hweHydroxypropyl Methylcellulose hunoenderana zvakanyanya nehupamhi hwekutsiviwa kwemapoka ehydroxyl mune cellulose molecule. Heano maitiro makuru:
Dhigirii reKutsiva (DS):
Izvi zvinoreva kuti mangani emapoka ehydroxyl mu cellulose akatsiviwa ne methyl kana hydroxypropyl mapoka. Iyo dhigirii yekutsiva inokanganisa kunyungudika kweHPMC mumvura, viscosity yayo, uye kugona kwayo kugadzira mafirimu. Iyo yakajairika DS yeHPMC inotangira pa1.4 kusvika 2.2, zvichienderana negiredhi.
Viscosity:
HPMC mamakisi akaiswa muzvikamu zvichibva pane yavo viscosity kana yakanyungudika mumvura. Iyo yakakwirira iyo molecular uremu uye dhigirii yekutsiva, iyo inokwirisa viscosity. Semuyenzaniso, HPMC K100M (ine yakakwira viscosity range) inowanzoshandiswa mukugadzirwa kwezvinodhaka zvinodzorwa, nepo magiredhi ekuona akaderera seHPMC K4M achinyanya kushandiswa pakusunga mahwendefa uye maapplication echikafu.
Kunyungudika kwemvura:
HPMC inonyungudika mumvura uye inoumba gel-sechinhu kana yanyungudutswa, asi tembiricha uye pH zvinogona kukanganisa kunyungudika kwayo. Semuenzaniso, mumvura inotonhora, inonyungudika nekukurumidza, asi kunyungudika kwayo kunogona kudzikiswa mumvura inopisa, kunyanya pakakwirira.
Kukwanisa Kugadzira Mafirimu:
Chimwe chezvinhu zvakakosha zveHydroxypropyl Methylcellulose kugona kwayo kugadzira firimu rinoshanduka. Iyi pfuma inoita kuti ive yakakodzera kushandiswa mumucheka wepiritsi, uko inopa yakatsetseka, inodzorwa-inoburitswa nzvimbo. Izvo zvinobatsirawo muindasitiri yezvekudya kuvandudza magadzirirwo uye hupenyu hwesherufu.
Gelation:
Pane kumwe kutariswa uye tembiricha, HPMC inogona kugadzira gels. Ichi chivakwa chinobatsira mukugadzirwa kwemishonga, uko inoshandiswa kugadzira inodzorwa-kuburitsa masisitimu.
Kushandiswa kweHydroxypropyl Methylcellulose
Indasitiri yemishonga:
HPMC inoshandiswa sebhainda mukuumbwa kwehwendefa, kunyanya mukurebesa-kuburitsa uye nekudzora-kuburitsa masisitimu. Inoshandawo sechinhu chinoputira mahwendefa uye capsules kudzora kusunungurwa kwechinhu chinoshanda. Kugona kwayo kugadzira mafirimu akagadzikana uye gels kwakanakira zvirongwa zvekuendesa zvinodhaka.
Indasitiri Yezvokudya
Muindasitiri yechikafu, HPMC inoshandiswa seyakakora mumiriri, emulsifier, uye inodzikamisa mumhando dzakasiyana dzezvigadzirwa, zvinosanganisira sosi, mapfekero, uye zvinhu zvakabikwa. Inobatsira kuvandudza kuumbwa uye kuwedzera hupenyu hwesherufu nekuderedza kurasikirwa kwehunyoro.
Zvekuzora uye Kuchengeta Pamunhu:
HPMC inoshandiswa zvakanyanya muzvizoro, uko inoshanda seyakakora uye inodzikamisa mumakirimu, lotions, shampoos, uye zvimwe zvigadzirwa zvekuchengeta munhu. Kukwanisa kwayo kugadzira gel chimiro kunonyanya kukosha mune izvi zvinoshandiswa.
Indasitiri yekuvaka:
Muindasitiri yekuvaka, kunyanya mune simende uye plaster magadzirirwo, HPMC inoshandiswa sechinhu chinochengeta mvura. Inobatsira kuvandudza kushanda uye inowedzera kusungirirwa kwezvinhu zvezvinhu.
Zvimwe Zvishandiso:
HPMC inoshandiswawo muindasitiri yemachira, mapeji ekuputira, uye kunyangwe mukugadzirwa kwemafirimu anoodza.
Hydroxypropyl Methylcellulose (HPMC)musanganiswa unoshandiswa zvakasiyana-siyana unoshandiswa mumaindasitiri akawanda nekuda kwezvimiro zvawo zvakasiyana sekugona kugadzira firimu, kugona kukora, uye kuchengetedza mvura. Nepo isina “serial number” mupfungwa yakajairika, inotaridzwa nezviziviso zvemakemikari senge nhamba yayo yeCAS (9004-65-3) uye magiredhi akanangana nechigadzirwa (semuenzaniso, HPMC K100M, HPMC E4M). Iwo akasiyana siyana emagiredhi eHPMC anowanikwa anovimbisa kushanda kwayo muminda dzakasiyana, kubva kumishonga kusvika kuchikafu, zvekuzora, uye kuvaka.
Nguva yekutumira: Mar-21-2025