HEC (Hydroxyethyl Cellulose)ndiyo yakajairika inonyungudika mumvura polymer inoshandiswa zvakanyanya mukugadzirira kwemishonga. Inobva kune cellulose, inowanikwa nekuita ethanolamine (ethylene oxide) ne cellulose. Nekuda kwekunaka kwayo kunyungudika, kugadzikana, viscosity kugadzirisa kugona uye biocompatibility, HEC ine huwandu hwakawanda hwemashandisirwo mumunda wemishonga, kunyanya mukugadzirwa kwekugadzira, dhizaini dhizaini dhizaini uye dhizaini kuburitswa kwezvinodhaka.
1. Zvinhu zvinokosha zveHEC
HEC, seyakagadziridzwa cellulose, ine zvinotevera zvakakosha zvivakwa:
Kunyungudika kwemvura: AnxinCel®HEC inogona kugadzira viscous solution mumvura, uye kunyungudika kwayo kunoenderana nekupisa uye pH. Ichi chivakwa chinoita kuti chishandiswe mumhando dzakasiyana dzeyero seyemuromo uye topical.
Biocompatibility: HEC haina-chepfu uye isingatsamwire mumuviri wemunhu uye inowirirana nemishonga yakawanda. Naizvozvo, inoshandiswa zvakanyanya mukusimudzira-kuburitsa dosage mafomu uye yemuno manejimendi dosage mafomu emishonga.
Adjustable viscosity: Iyo viscosity yeHEC inogona kugadziridzwa nekushandura iyo molecular uremu kana kutarisisa, izvo zvakakosha pakudzora kuburitswa kwezvinodhaka kana kuvandudza kugadzikana kwezvinodhaka.
2. Kushandiswa kweHEC mukugadzirira kwemishonga
Sechinhu chakakosha mukugadzirira kwemishonga, HEC ine mabasa akawanda. Izvi zvinotevera nzvimbo dzayo huru dzekushandisa mukugadzirira kwemishonga.
2.1 Kushandiswa mukugadzirira kwemuromo
Mune oral dosage mafomu, HEC inowanzoshandiswa mukugadzirwa kwemapiritsi, capsules uye gadziriro yemvura. Mabasa ayo makuru anosanganisira:
Binder: Mumapiritsi nemagranules, HEC inogona kushandiswa sebhainda kuti zvisunge zvirinani zvimedu zvemishonga kana poda pamwe chete kuti ive nechokwadi chekuoma uye kugadzikana kwemapiritsi.
Sustained kusunungurwa kutonga: HEC inogona kuwana yakasimbiswa yekuburitsa mhedzisiro nekudzora kuburitswa kwemushonga. Apo HEC inoshandiswa pamwe chete nezvimwe zvinhu (zvakadai se polyvinyl pyrrolidone, carboxymethyl cellulose, nezvimwewo), inogona kunyatsowedzera nguva yekubudiswa kwechirwere mumuviri, kuderedza kuwanda kwemishonga, nekuvandudza kutevedza kwevarwere.
Thickener: Mumvura inogadziriswa yemuromo, AnxinCel®HEC seyakakora inogona kuvandudza kuravira kwemushonga uye kugadzikana kweiyo dosage fomu.
2.2 Kushandisa mugadziriro dzemusoro
HEC inoshandiswa zvakanyanya mumafuta ekuzora, makirimu, gels, lotions uye mamwe magadzirirwo, achitamba akawanda mabasa:
Gel matrix: HEC inowanzoshandiswa sematrix yejeri, kunyanya mu transdermal drug delivery systems. Inogona kupa kuwirirana kwakakodzera uye kuwedzera nguva yekugara kwemushonga paganda, nokudaro nekuvandudza kushanda.
Viscosity uye kugadzikana: The viscosity yeHEC inogona kuwedzera kunamatira kwezvinyorwa zvekugadzirira paganda uye kudzivirira kuti mushonga urege kudonha nguva isati yakwana nekuda kwekunze kwezvinhu zvakadai sekukwenya kana kugeza. Mukuwedzera, HEC inogona kuvandudza kugadzikana kwemafuta nemafuta uye kudzivirira stratification kana crystallization.
Lubricant uye moisturizer: HEC ine hunhu hwakanaka hwekunyorovesa uye inogona kubatsira kuchengetedza ganda rakanyorova uye kudzivirira kuoma, saka rinoshandiswawo mune moisturizers uye zvimwe zvigadzirwa zvekuchengetedza ganda.
2.3 Kushandiswa mukugadzirira kwemaziso
Kushandiswa kweHEC mukugadzirira kwemaziso kunonyanya kuratidzwa mubasa rayo sekunamatira uye mafuta:
Ophthalmic gels uye madonhwe eziso: HEC inogona kushandiswa seanonamatira kune ophthalmic kugadzirira kuwedzera nguva yekubatana pakati pemishonga uye ziso uye kuve nechokwadi chekuenderera mberi kwechirwere. Panguva imwecheteyo, viscosity yayo inogonawo kudzivirira madonhwe eziso kubva pakurasikirwa nekukurumidza uye kuwedzera nguva yekuchengetedza yemishonga.
Lubrication: HEC ine hydration yakanaka uye inogona kupa rubrication inoenderera mukurapa kwezvirwere zvemaziso senge ziso rakaoma, kuderedza kusagadzikana kweziso.
2.4 Kushandiswa mukugadzirira jekiseni
HEC inogona zvakare kushandiswa mukugadzirira kwemajekiseni majekiseni mafomu, kunyanya mumajekiseni akareba-anoita uye gadziriro-yekuburitsa. Iwo makuru mabasa eHEC mugadziriro idzi anosanganisira:
Thickener uye stabilizer: mujekiseni,HECinogona kuwedzera viscosity yemushonga, inonoke kumhanyisa jekiseni remushonga, uye kuwedzera kugadzikana kwemushonga.
Kudzora kusunungurwa kwezvinodhaka: Seimwe yezvikamu zvemishonga inogadziriswa-yakasunungurwa, HEC inogona kudzora kusunungurwa kwemishonga kuburikidza nekugadzira gel layer mushure mejojo, kuitira kuti iwane chinangwa chekurapa kwenguva refu.
3. Basa reHEC muhurongwa hwekupa zvinodhaka
Nekuvandudzwa kwehunyanzvi hwekugadzira mishonga, HEC yakashandiswa zvakanyanya mumhando dzakasiyana dzekutakura zvinodhaka, kunyanya muminda ye nano-zvinodhaka vatakuri, microspheres, uye zvinodhaka zvinosimudzira-kuburitswa vatakuri. HEC inogona kusanganiswa nemhando dzakasiyana-siyana dzekutakura zvinodhaka kuti dziumbe yakagadzikana yakaoma kuti ive nechokwadi chekusunungurwa kwakasimba uye kuendesa kwakanaka kwezvinodhaka.
Nano drug carrier: HEC inogona kushandiswa seyakagadzikana kune nano zvinodhaka vatakuri kudzivirira kuunganidzwa kana kunaya kwezvimedu zvinotakura uye kuwedzera bioavailability yezvinodhaka.
Microspheres uye zvidimbu: HEC inogona kushandiswa kugadzirira microspheres uye microparticle drug carriers kuti ive nechokwadi chekusunungurwa kwezvinodhaka mumuviri uye kugadzirisa kushanda kwemishonga.
Semubatsiri wemishonga wakawanda uye unoshanda, AnxinCel®HEC ine tarisiro yakakura yekushandisa mukugadzirira kwemishonga. Nekuenderera mberi kwekuvandudza tekinoroji yemishonga, HEC inoita basa rinowedzera rakakosha mukudzora kuburitswa kwezvinodhaka, kutungamira kwenzvimbo, kugadzirira-kuburitswa kwakasimba uye maitiro matsva ekupa zvinodhaka. Yayo yakanaka biocompatibility, inogadziriswa viscosity uye kugadzikana kunoita kuti isadzorereke mumunda wemishonga. Mune ramangwana, nekudzidza kwakadzama kweHEC, kushandiswa kwayo mukugadzirira kwemishonga kuchave kwakanyanya uye kwakasiyana.
Nguva yekutumira: Zvita-28-2024