Hydroxypropyl methylcellulose (HPMC) imhando yepolymer inoshandiswa zvakanyanya, inoshandiswa zvakanyanya mukuvaka, mishonga, chikafu uye mamwe maindasitiri. Sepolymer inonyungudika mumvura, HPMC ine hunhu hwakanaka hwekuchengetedza mvura, kugadzira mafirimu, kukora uye emulsifying. Kuchengetedza kwayo mvura ndeimwe yehunhu hwayo hwakakosha mumashandisirwo akawanda, kunyanya muzvinhu zvakaita sesimende, dhaka uye machira muindasitiri yekuvaka, izvo zvinogona kunonotsa kubuda kwemvura uye kuvandudza mashandiro ekuvaka uye mhando yechigadzirwa chekupedzisira. Zvisinei, kuchengetedza mvura kweHPMC kwakabatana zvakanyanya nekuchinja kwekushisa munzvimbo yekunze, uye kunzwisisa hukama uhwu kwakakosha pakushandiswa kwayo muminda yakasiyana.
1. Maumbirwo uye kuchengetwa kwemvura kweHPMC
HPMC inogadzirwa nekuchinja kwemakemikari e cellulose yechisikigo, kunyanya nekuiswa kwe hydroxypropyl (-C3H7OH) uye methyl (-CH3) mapoka mu cellulose chain, izvo zvinoita kuti inyungudike zvakanaka uye ive nehunhu hwakanaka hwekutonga. Mapoka ehydroxyl (-OH) ari mumamorekuru eHPMC anogona kuumba hydrogen bonds nemamorekuru emvura. Nokudaro, HPMC inogona kunwisa mvura uye kusangana nemvura, zvichiratidza kuchengetedza mvura.
Kuchengetwa kwemvura zvinoreva kugona kwechinhu kuchengetedza mvura. Kune HPMC, inonyanya kuratidzwa mukukwanisa kwayo kuchengetedza huwandu hwemvura muhurongwa kuburikidza nekunyorovesa, kunyanya munzvimbo dzinopisa zvakanyanya kana hunyoro hwakawanda, izvo zvinogona kudzivirira kurasikirwa nekukurumidza kwemvura uye kuchengetedza kunyorova kwechinhu ichi. Sezvo kunyorovesa mumvura mumamorekuru eHPMC kwakabatana zvakanyanya nekudyidzana kwechimiro chayo chemamorekuru, shanduko dzekupisa dzichakanganisa zvakananga kugona kwemvura uye kuchengetedza mvura kweHPMC.
2. Mhedzisiro yekupisa pakuchengetedza mvura kweHPMC
Hukama huripo pakati pekuchengetwa kwemvura kweHPMC netembiricha hunogona kukurukurwa kubva pazvinhu zviviri: chimwe ndechekuti tembiricha inokonzeresa kunyungudika kweHPMC, uye chimwe ndechekuti tembiricha inokonzeresa sei chimiro chemolekyulu uye kunyorova kwayo.
2.1 Mhedzisiro yekupisa pakunyungudika kweHPMC
Kunyungudika kweHPMC mumvura kunoenderana nekupisa. Kazhinji, kunyungudika kweHPMC kunowedzera nekupisa kuri kuwedzera. Kana tembiricha ikakwira, mamorekuru emvura anowana simba rekupisa rakawanda, zvichikonzera kushomeka kwekudyidzana pakati pemamorekuru emvura, nokudaro zvichikurudzira kunyungudika kwe HPMCKune HPMC, kuwedzera kwekupisa kunogona kuita kuti zvive nyore kugadzira colloidal solution, zvichiita kuti iwedzere kuchengetedza mvura mumvura.
Zvisinei, tembiricha yakakwira inogona kuwedzera kusimba kwemushonga weHPMC, zvichikanganisa hunhu hwawo hwe rheological uye kupararira kwawo. Kunyangwe izvi zvichibatsira pakuvandudza kunyunguduka kwemvura, tembiricha yakakwira inogona kuchinja kugadzikana kwechimiro chawo chemamorekuru uye zvichikonzera kudzikira kwekuchengetwa kwemvura.
2.2 Mhedzisiro yetembiricha pachimiro chemamorekuru eHPMC
Muchimiro chemamorekuru eHPMC, mabhondi ehydrogen anonyanya kugadzirwa nemamorekuru emvura kuburikidza nemapoka ehydroxyl, uye chisungo ichi chehydrogen chakakosha pakuchengetedza mvura kweHPMC. Sezvo tembiricha ichiwedzera, simba rechisungo chehydrogen rinogona kuchinja, zvichikonzera kushomeka kwesimba rekubatanidza pakati pemorekuru yeHPMC nemorekuru yemvura, nokudaro zvichikanganisa kuchengetedza kwayo mvura. Kunyanya, kuwedzera kwekupisa kuchaita kuti mabhondi ehydrogen ari mumorekuru yeHPMC aparadzane, nokudaro zvichideredza kugona kwayo kupinza mvura uye kuchengetedza mvura.
Pamusoro pezvo, kunzwa kwekupisa kweHPMC kunoratidzwawo mukuita kwechikamu chemushonga wayo. HPMC ine huremu hwakasiyana hwemamorekuru uye mapoka akasiyana-siyana ane kunzwa kwakasiyana kwekupisa. Kazhinji, HPMC ine huremu hwakaderera hwemamorekuru inonyanya kunzwa kupisa, nepo HPMC ine huremu hwakanyanya hwemamorekuru ichiratidza kushanda kwakasimba. Saka, mukushanda kwakakodzera, zvakakosha kusarudza mhando yakakodzera yeHPMC zvichienderana nehuwandu hwekupisa hwakatarwa kuti ive nechokwadi chekuti mvura inochengetwa pakupisa kuri kushanda.
2.3 Mhedzisiro yekupisa pamvura inobuda
Munzvimbo dzine tembiricha yakakwira, kuchengetwa kwemvura kweHPMC kuchakanganiswa nekukwira kwemvura kunokonzerwa nekuwedzera kwetembiricha. Kana tembiricha yekunze yakakwira zvakanyanya, mvura iri muHPMC system inogona kupwanyika. Kunyangwe HPMC ichigona kuchengetedza mvura kusvika pamwero wakati kuburikidza nechimiro chayo chemamorekuru, kupisa kwakakwira zvakanyanya kunogona kukonzera kuti system irasikirwe nemvura nekukurumidza kupfuura kugona kweHPMC kuchengetedza mvura. Muchiitiko ichi, kuchengetwa kwemvura kweHPMC kunodziviswa, kunyanya munzvimbo dzine tembiricha yakakwira uye yakaoma.
Kuti dambudziko iri ripere, zvimwe zvidzidzo zvakaratidza kuti kuwedzera humectants yakakodzera kana kugadzirisa zvimwe zvikamu mufomura kunogona kuvandudza mhedzisiro yekuchengetedza mvura yeHPMC munzvimbo inodziya zvakanyanya. Semuenzaniso, nekugadzirisa viscosity modifier mufomura kana kusarudza solvent isinganyungudike zvakanyanya, kuchengetedza mvura kweHPMC kunogona kuvandudzwa kusvika pamwero wakati, zvichideredza mhedzisiro yekuwedzera kwekushisa pakubuda kwemvura.
3. Zvinhu zvinopesvedzera
Mhedzisiro yekupisa pakuchengetwa kwemvura kweHPMC haingotsamiri chete pakupisa kwemhepo pachayo, asiwo pahuremu hwemamorekuru, mwero wekutsiva, huwandu hwemvura inogadziriswa uye zvimwe zvinhu zveHPMC. Semuenzaniso:
Kurema kwemamorekuru:HPMC Kana paine huremu hwakawanda hwemamorekuru, kazhinji kacho mvura inochengetwa zvakanyanya, nekuti chimiro che network chinoumbwa nemaketani ane huremu hwakawanda hwemamorekuru mumushonga chinogona kunwisa nekuchengetedza mvura zvinobudirira.
Dhigirii rekutsiva: Dhigirii remethylation nehydroxypropylation yeHPMC zvinokanganisa kudyidzana kwayo nemamorekuru emvura, nokudaro zvichikanganisa kuchengetwa kwemvura. Kazhinji, dhigirii repamusoro rekutsiva rinogona kuwedzera kushanduka kwemvura kweHPMC, nokudaro zvichivandudza kuchengetwa kwayo kwemvura.
Kuwanda kwemvura mu HPMC: Kuwanda kwemvura mu HPMC kunokanganisawo kuchengetwa kwemvura mu HPMC. Kuwanda kwemvura mu HPMC kunowanzoita kuti mvura irambe ichichengetwa zvakanaka, nekuti kuwanda kwemvura mu HPMC kunogona kuchengetedza mvura kuburikidza nekubatana kwakasimba pakati pemasero.
Pane hukama hwakaoma pakati pekuchengetwa kwemvura yeHPMCuye tembiricha. Kupisa kwakanyanya kunowanzo kurudzira kunyungudika kweHPMC uye kunogona kutungamira mukuvandudzwa kwekuchengetwa kwemvura, asi tembiricha yakakwira zvakanyanya inoparadza chimiro chemamorekuru eHPMC, inoderedza kugona kwayo kubatana nemvura, uye nokudaro ichikanganisa mashandiro ayo ekuchengetedza mvura. Kuti uwane kushanda kwakanakisa kwekuchengetedza mvura pasi pemamiriro akasiyana ekupisa, zvakakosha kusarudza mhando yakakodzera yeHPMC zvichienderana nezvinodiwa zvekushandisa uye kugadzirisa zvine musoro mamiriro ayo ekushandisa. Pamusoro pezvo, zvimwe zvikamu zviri mufomura uye nzira dzekudzora tembiricha zvinogona zvakare kuvandudza kuchengetwa kwemvura kweHPMC munzvimbo dzinopisa zvakanyanya kusvika pamwero wakati.
Nguva yekutumira: Mbudzi-11-2024