Hydroxypropylmethylcellulose (HPMC), sepolymer inowanzoshandiswa muindasitiri yemishonga, inoshandiswa zvakanyanya mukuisa mapiritsi, maforomamu ekuburitsa mishonga anodzorwa uye mamwe masisitimu ekupa mishonga. Chimwe chezvinhu zvakakosha zveHPMC kugona kwayo kuchengetedza mvura, izvo zvinokanganisa mashandiro ayo semubatsiri wemishonga. Muchinyorwa chino, tichaongorora zvinhu zvikuru zvinokanganisa kuchengetwa kwemvura kweHPMC, kusanganisira huremu hwemamorekuru, rudzi rwekuchinjana, huwandu, uye pH.
huremu hwemorekuru
Huremu hwemamorekuru hweHPMC hune basa rakakosha pakuona kugona kwayo kuchengetedza mvura. Kazhinji, huremu hwakawanda hweHPMC hunopfava kupfuura HPMC ine huremu hwakaderera uye hunogona kunyudza mvura yakawanda. Izvi zvinodaro nekuti maHPMC ane huremu hwakawanda ane cheni refu dzinogona kupindirana nekugadzira network yakakura, zvichiwedzera huwandu hwemvura inogona kunyudzwa. Zvisinei, zvinofanira kucherechedzwa kuti huremu hwakawanda hweHPMC hunokonzera matambudziko akadai sekusviba uye kuoma kwekugadzirisa.
imwe nzira
Chimwe chinhu chinokanganisa kugona kweHPMC kuchengetedza mvura imhando yechinhu chinotsiva. HPMC inowanzo kuve nenzira mbiri: hydroxypropyl-substituted uye methoxy-substituted. Mhando yehydroxypropyl-substituted ine kugona kwakanyanya kwekunwa mvura kupfuura mhando yemethoxy-substituted. Izvi zvinodaro nekuti boka rehydroxypropyl riri muHPMC molecule rinofema mumvura uye rinowedzera hukama hweHPMC nemvura. Kusiyana neizvi, mhando yemethoxy-substituted haina hydrophilic yakawanda uye nekudaro ine kugona kwakaderera kwekuchengetedza mvura. Saka, dzimwe mhando dzeHPMC dzinofanira kusarudzwa nokungwarira zvichienderana nezvinodiwa zvechigadzirwa chekupedzisira.
nyatsotarisa pa
Kuwanda kweHPMC kunokanganisawo kugona kwayo kuchengetedza mvura. Kana iri shoma, HPMC haiumbi chimiro chakaita sejeli, saka kugona kwayo kuchengetedza mvura kwakaderera. Sezvo kuwanda kweHPMC kwakawedzera, mamorekuru epolymer akatanga kupindirana, zvichigadzira chimiro chakaita sejeli. Iyi network yejeli inonwisa uye inochengetedza mvura, uye kugona kweHPMC kuchengetedza mvura kunowedzera nekuwanda. Zvisinei, zvinofanira kucherechedzwa kuti kuwanda kwakanyanya kweHPMC kunotungamira kumatambudziko ekugadzira akadai sekuoma uye kuoma kwekugadzirisa. Nokudaro, kuwanda kweHPMC inoshandiswa kunofanirwa kugadziriswa kuti kusvike pakukwanisa kwekuchengetedza mvura kwaunoda uku uchidzivirira matambudziko ataurwa pamusoro apa.
Kukosha kwePH
Kuwanda kwepH yenzvimbo inoshandiswa HPMC kuchakanganisawo kugona kwayo kuchengetedza mvura. Maumbirwo eHPMC ane mapoka eanionic (-COO-) uye mapoka ehydrophilic ethylcellulose (-OH). Kuiswa kwe-ionization kwemapoka e-COO- kunoenderana nepH, uye mwero weionization yavo unowedzera nepH. Nokudaro, HPMC ine kugona kwakanyanya kuchengetedza mvura papH yakakwira. PapH yakaderera, boka re-COO- rinoonekwa seprotonated uye hydrophilicity yaro inoderera, zvichikonzera kugona kwakaderera kwekuchengetedza mvura. Nokudaro, pH yenharaunda inofanira kugadziriswa kuti iwane kugona kwainodiwa kwekuchengetedza mvura kweHPMC.
mukupedzisa
Mukupedzisa, kugona kweHPMC kuchengetedza mvura chinhu chikuru chinokanganisa mashandiro ayo semushonga unobatsira pakurapa. Zvinhu zvikuru zvinokanganisa kugona kweHPMC kuchengetedza mvura zvinosanganisira huremu hwemamorekuru, rudzi rwekutsiva, huwandu uye pH. Nekugadzirisa zvinhu izvi nokungwarira, kugona kweHPMC kuchengetedza mvura kunogona kugadziriswa kuti kusvike pahunhu hwaunoda hwechigadzirwa chekupedzisira. Vaongorori vemishonga nevagadziri vanofanirwa kunyatsoteerera zvinhu izvi kuti vave nechokwadi chekuti mishonga yeHPMC ine mhando yepamusoro uye inoshanda.
Nguva yekutumira: Nyamavhuvhu-05-2023