Hydroxypropyl Methylcellulose (HPMC)ndi mankhwala osinthidwa a cellulose omwe amagwiritsidwa ntchito kwambiri m'mafakitale osiyanasiyana monga mankhwala, kupanga chakudya, ndi zomangamanga. Ndiwogwiritsidwa ntchito mosiyanasiyana, nthawi zambiri amagwiritsidwa ntchito ngati thickener, binder, film-forming agent, and stabilizer. Komabe, ilibe "chiwerengero" chachindunji m'lingaliro lachikhalidwe, monga chinthu kapena nambala yagawo yomwe mungapeze muzinthu zina zopanga. M'malo mwake, HPMC imadziwika ndi kapangidwe kake kamankhwala ndi mawonekedwe angapo, monga kuchuluka kwa m'malo ndi kukhuthala.
Zambiri Zokhudza Hydroxypropyl Methylcellulose (HPMC)
Kapangidwe ka Mankhwala: HPMC imapangidwa ndi kusintha kwa cellulose kudzera m'malo mwa magulu a hydroxyl (-OH) ndi magulu a hydroxypropyl ndi methyl. Kulowetsedwa kumasintha mawonekedwe a cellulose, kuwapangitsa kusungunuka m'madzi ndikuupatsa mawonekedwe ake apadera monga luso lopanga filimu, luso lomanga, komanso kusunga chinyezi.
Zizindikiritso Zofanana ndi Kutchula mayina
Kuzindikirika kwa Hydroxypropyl Methylcellulose nthawi zambiri kumadalira mitundu yosiyanasiyana ya mayina omwe amafotokozera kapangidwe kake ka mankhwala ndi katundu wake:
Nambala ya CAS:
Chemical Abstracts Service (CAS) imapereka chizindikiritso chapadera ku mankhwala aliwonse. Nambala ya CAS ya Hydroxypropyl Methylcellulose ndi 9004-65-3. Ichi ndi nambala yokhazikika yomwe amagwiritsidwa ntchito ndi akatswiri a zamankhwala, ogulitsa katundu, ndi mabungwe olamulira kuti atchule chinthucho.
Ma Khodi a InChi ndi SMILES:
InChI (International Chemical Identifier) ndi njira ina yoimirira kapangidwe kakemidwe ka chinthu. HPMC ingakhale ndi chingwe chachitali cha InChI chomwe chimayimira mamolekyu ake mumtundu wokhazikika.
SMILES (Simplified Molecular Input Line Entry System) ndi dongosolo lina lomwe limagwiritsidwa ntchito kuimira mamolekyu m'malemba. HPMC ilinso ndi nambala ya SMILES yofananira, ngakhale ingakhale yovuta kwambiri chifukwa cha kukula kwake komanso kusinthika kwake.
Zogulitsa:
Pamsika wamalonda, HPMC nthawi zambiri imadziwika ndi manambala azinthu, omwe amatha kusiyanasiyana ndi wopanga. Mwachitsanzo, wogulitsa akhoza kukhala ndi giredi ngati HPMC K4M kapena HPMC E15. Izi zizindikiritso nthawi zambiri zimatanthawuza kukhuthala kwa polima mu yankho, komwe kumatsimikiziridwa ndi kuchuluka kwa methylation ndi hydroxypropylation komanso kulemera kwa maselo.
Magulu Odziwika a Hydroxypropyl Methylcellulose (HPMC)
Makhalidwe a Hydroxypropyl Methylcellulose amasiyana malinga ndi kuchuluka kwa m'malo mwa magulu a methyl ndi hydroxypropyl, komanso kulemera kwa maselo. Kusiyanasiyana kumeneku kumatsimikizira kukhuthala kwa HPMC ndi kusungunuka kwake m'madzi, zomwe zimakhudzanso ntchito zake m'mafakitale osiyanasiyana.
Pansipa pali tebulo lomwe limafotokoza magawo osiyanasiyana a Hydroxypropyl Methylcellulose:
| Gulu | Viscosity (cP mu 2% yankho) | Mapulogalamu | Kufotokozera |
| HPMC K4M | 4000 - 6000 cP | Pharmaceutical tablet binder, chakudya, zomangamanga (zomatira) | Sing'anga mamasukidwe akayendedwe kalasi, ambiri ntchito pakamwa mapiritsi formulations. |
| HPMC K100M | 100,000 - 150,000 cP | Zopangidwa molamuliridwa zotulutsidwa muzamankhwala, zomanga, ndi zokutira utoto | High mamasukidwe akayendedwe, abwino kwa ankalamulira kumasulidwa kwa mankhwala. |
| HPMC E4M | 3000 - 4500 cP | Zodzoladzola, zimbudzi, kukonza chakudya, zomatira, ndi zokutira | Zosungunuka m'madzi ozizira, zomwe zimagwiritsidwa ntchito pazinthu zosamalira anthu komanso zakudya. |
| Chithunzi cha HPMC E15 | 15,000 cP | Zonenepa mu utoto, zokutira, chakudya, ndi mankhwala | Kukhuthala kwakukulu, kusungunuka m'madzi ozizira, ogwiritsidwa ntchito m'mafakitale ndi mankhwala. |
| HPMC M4C | 4000 - 6000 cP | Makampani azakudya ndi zakumwa ngati chokhazikika, mankhwala ngati chomangira | Kukhuthala kwapakati, komwe nthawi zambiri kumagwiritsidwa ntchito ngati chowonjezera pazakudya zokonzedwa. |
| Chithunzi cha HPMC2910 | 3000 - 6000 cP | Zodzoladzola (zopaka, mafuta odzola), chakudya (confectionery), mankhwala (makapisozi, zokutira) | Chimodzi mwazofala kwambiri, chomwe chimagwiritsidwa ntchito ngati stabilizing ndi thickening wothandizira. |
| Mtengo wa HPMC 2208 | 5000 - 15000 cP | Amagwiritsidwa ntchito popanga simenti ndi pulasitala, nsalu, zokutira zamapepala | Zabwino kwa mapulogalamu omwe amafunikira mawonekedwe abwino kwambiri opangira mafilimu. |
Mapangidwe Atsatanetsatane ndi Katundu wa HPMC
Zomwe zimapangidwira za Hydroxypropyl Methylcellulose zimadalira kwambiri momwe angasinthire magulu a hydroxyl mu molekyulu ya cellulose. Nazi zinthu zazikulu:
Digiri ya Kusintha (DS):
Izi zikutanthauza kuti ndi magulu angati a hydroxyl mu cellulose omwe asinthidwa ndi magulu a methyl kapena hydroxypropyl. Mlingo wolowa m'malo umakhudza kusungunuka kwa HPMC m'madzi, kukhuthala kwake, komanso kuthekera kwake kupanga makanema. Ma DS wamba a HPMC amachokera ku 1.4 mpaka 2.2, kutengera giredi.
Viscosity:
HPMC makalasi ndi m'gulu kutengera mamasukidwe akayendedwe awo pamene kusungunuka m'madzi. Kulemera kwa maselo ndi kuchuluka kwa kulowetsa m'malo, kumapangitsanso kukhuthala kwamphamvu. Mwachitsanzo, HPMC K100M (yokhala ndi kukhuthala kwapamwamba) imagwiritsidwa ntchito nthawi zambiri popanga mankhwala opangidwa ndi olamulidwa, pomwe magiredi otsika ngati HPMC K4M amagwiritsidwa ntchito kwambiri pophatikiza mapiritsi ndi zakudya.
Kusungunuka kwamadzi:
HPMC imasungunuka m'madzi ndipo imapanga chinthu chofanana ndi gel ikasungunuka, koma kutentha ndi pH zimatha kukhudza kusungunuka kwake. Mwachitsanzo, m'madzi ozizira, amasungunuka msanga, koma kusungunuka kwake kumatha kuchepetsedwa m'madzi otentha, makamaka pamlingo wapamwamba.
Luso Lopanga Mafilimu:
Chimodzi mwazinthu zazikulu za Hydroxypropyl Methylcellulose ndi kuthekera kwake kupanga filimu yosinthika. Katunduyu amapangitsa kuti ikhale yoyenera kugwiritsidwa ntchito pazovala zamapiritsi, pomwe imapereka malo osalala, oyendetsedwa bwino. Ndiwothandizanso m'makampani azakudya kuti apititse patsogolo mawonekedwe komanso moyo wa alumali.
Gelation:
Pazinthu zina ndi kutentha, HPMC imatha kupanga ma gels. Katunduyu ndi wopindulitsa pakupanga mankhwala, komwe amagwiritsidwa ntchito popanga machitidwe owongolera otulutsidwa.
Kugwiritsa ntchito Hydroxypropyl Methylcellulose
Makampani Azamankhwala:
HPMC imagwiritsidwa ntchito ngati chomangira pamipangidwe yamapiritsi, makamaka pamakina otulutsa-otalikirapo komanso otulutsa mowongolera. Zimagwiranso ntchito ngati ❖ kuyanika kwa mapiritsi ndi makapisozi kuti athetse kutulutsidwa kwa chinthu chogwira ntchito. Kukhoza kwake kupanga mafilimu okhazikika ndi ma gels ndi abwino kwa machitidwe operekera mankhwala.
Makampani a Chakudya
M'makampani azakudya, HPMC imagwiritsidwa ntchito ngati thickening agent, emulsifier, ndi stabilizer muzinthu zosiyanasiyana, kuphatikiza ma sauces, mavalidwe, ndi zinthu zophika. Zimathandizira kukonza kapangidwe kake ndikukulitsa moyo wa alumali pochepetsa kutaya chinyezi.
Zodzoladzola ndi Zosamalira Munthu:
HPMC chimagwiritsidwa ntchito zodzoladzola, kumene amachita monga thickener ndi stabilizer mu creams, mafuta odzola, shampu, ndi mankhwala ena munthu chisamaliro. Kuthekera kwake kupanga mawonekedwe a gel ndikofunikira kwambiri pazogwiritsa ntchito izi.
Makampani Omanga:
M'makampani omanga, makamaka popanga simenti ndi pulasitala, HPMC imagwiritsidwa ntchito ngati chosungira madzi. Zimathandizira kukonza magwiridwe antchito ndikuwonjezera kulumikizidwa kwa zinthu.
Mapulogalamu Ena:
HPMC imagwiritsidwanso ntchito m'makampani opanga nsalu, zokutira mapepala, komanso ngakhale kupanga mafilimu osawonongeka.
Hydroxypropyl Methylcellulose (HPMC)ndi gulu losinthika kwambiri lomwe limagwiritsidwa ntchito m'mafakitale angapo chifukwa cha mawonekedwe ake apadera monga luso lopanga mafilimu, kukhuthala, komanso kusunga madzi. Ngakhale ilibe “chiwerengero” mwanjira wamba, imadziwika ndi zozindikiritsa mankhwala monga nambala yake ya CAS (9004-65-3) ndi magiredi okhudzana ndi malonda (mwachitsanzo, HPMC K100M, HPMC E4M). Mitundu yosiyanasiyana ya HPMC yomwe ilipo imatsimikizira kuti ikugwira ntchito m'magawo osiyanasiyana, kuyambira pazamankhwala kupita ku chakudya, zodzoladzola, ndi zomangamanga.
Nthawi yotumiza: Mar-21-2025