HEC (Hydroxyethyl Cellulose)ndi polima wamba wosungunuka m'madzi omwe amagwiritsidwa ntchito kwambiri popanga mankhwala. Ndiwochokera ku cellulose, yomwe imapezeka pochita ethanolamine (ethylene oxide) ndi cellulose. Chifukwa cha kusungunuka kwake kwabwino, kukhazikika, kusinthika kwa viscosity kusintha ndi biocompatibility, HEC ili ndi ntchito zambiri m'munda wa mankhwala, makamaka pakupanga mapangidwe, mapangidwe a mawonekedwe a mlingo ndi kulamulira kumasulidwa kwa mankhwala.
1. Zinthu zoyambira za HEC
HEC, monga cellulose yosinthidwa, ili ndi zotsatirazi:
Kusungunuka kwa madzi: AnxinCel®HEC ikhoza kupanga yankho la viscous m'madzi, ndipo kusungunuka kwake kumagwirizana ndi kutentha ndi pH. Katunduyu amamupangitsa kuti azigwiritsidwa ntchito m'njira zosiyanasiyana monga pakamwa komanso pamutu.
Biocompatibility: HEC ndi yopanda poizoni komanso yosakwiya m'thupi la munthu ndipo imagwirizana ndi mankhwala ambiri. Chifukwa chake, amagwiritsidwa ntchito kwambiri pamawonekedwe amtundu wanthawi zonse komanso makonzedwe amtundu wamankhwala.
Ma viscosity osinthika: Kukhuthala kwa HEC kumatha kusinthidwa posintha kulemera kwake kwa maselo kapena kukhazikika kwake, komwe ndikofunikira kwambiri pakuwongolera kuchuluka kwa mankhwala kapena kuwongolera kukhazikika kwamankhwala.
2. Kugwiritsa ntchito HEC pakukonzekera mankhwala
Monga chothandizira chofunikira pakukonzekera mankhwala, HEC ili ndi ntchito zambiri. Zotsatirazi ndizomwe zimagwiritsidwa ntchito kwambiri pokonzekera mankhwala.
2.1 Kugwiritsa ntchito pokonzekera pakamwa
Mu mawonekedwe a mlingo wapakamwa, HEC imagwiritsidwa ntchito popanga mapiritsi, makapisozi ndi kukonzekera kwamadzimadzi. Ntchito zake zazikulu ndi izi:
Binder: M'mapiritsi ndi ma granules, HEC ikhoza kugwiritsidwa ntchito ngati binder kuti imangirire bwino tinthu tating'onoting'ono ta mankhwala kapena ufa pamodzi kuti zitsimikizire kuuma ndi kukhazikika kwa mapiritsi.
Kuwongolera kumasulidwa kokhazikika: HEC ikhoza kukwaniritsa kumasulidwa kosalekeza poyang'anira kuchuluka kwa mankhwala. HEC ikagwiritsidwa ntchito limodzi ndi zinthu zina (monga polyvinyl pyrrolidone, carboxymethyl cellulose, etc.), imatha kukulitsa nthawi yotulutsa mankhwala m'thupi, kuchepetsa kuchuluka kwa mankhwala, ndikuwongolera kutsatira kwa odwala.
Thickener: Pokonzekera pakamwa pamadzi, AnxinCel®HEC ngati thickener akhoza kusintha kukoma kwa mankhwala ndi kukhazikika kwa mawonekedwe a mlingo.
2.2 Kugwiritsa ntchito pokonzekera mitu
HEC chimagwiritsidwa ntchito mafuta apakhungu, zonona, gel osakaniza, mafuta odzola ndi zina kukonzekera, kusewera maudindo angapo:
Gel matrix: HEC imagwiritsidwa ntchito nthawi zambiri ngati matrix a gels, makamaka m'machitidwe operekera mankhwala a transdermal. Ikhoza kupereka kugwirizana koyenera ndikuwonjezera nthawi yokhala ndi mankhwala pakhungu, potero kuwongolera mphamvu.
Kukhuthala ndi kukhazikika: Kukhuthala kwa HEC kumatha kupititsa patsogolo kumamatira kwa zokonzekera zam'mutu pakhungu ndikuletsa mankhwalawa kuti asagwe msanga chifukwa cha zinthu zakunja monga kukangana kapena kutsuka. Kuphatikiza apo, HEC imatha kuwongolera kukhazikika kwamafuta ndi mafuta odzola ndikuletsa kusanja kapena crystallization.
Lubricant ndi moisturizer: HEC ili ndi zinthu zabwino zowonongeka ndipo ingathandize kuti khungu likhale lonyowa komanso kuteteza kuuma, choncho imagwiritsidwanso ntchito muzosakaniza ndi zinthu zina zosamalira khungu.
2.3 Kugwiritsa ntchito mankhwala ophthalmic
Kugwiritsiridwa ntchito kwa HEC pokonzekera maso kumawonekera makamaka mu ntchito yake monga zomatira ndi mafuta:
Ophthalmic gels ndi madontho a diso: HEC ingagwiritsidwe ntchito ngati zomatira pokonzekera maso kuti atalikitse nthawi yolumikizana pakati pa mankhwala ndi diso ndikuonetsetsa kuti mankhwalawa akupitirizabe kugwira ntchito. Panthawi imodzimodziyo, kukhuthala kwake kungathenso kuteteza madontho a maso kuti asawonongeke mofulumira ndikuwonjezera nthawi yosungira mankhwala.
Kupaka mafuta: HEC ili ndi hydration yabwino ndipo imatha kupereka mafuta ochulukirapo pochiza matenda a maso monga diso louma, kuchepetsa kusokonezeka kwa maso.
2.4 Kugwiritsa ntchito pokonzekera jekeseni
HEC itha kugwiritsidwanso ntchito pokonza mafomu a jakisoni, makamaka mu jakisoni wanthawi yayitali komanso kukonzekera kumasulidwa kosalekeza. Ntchito zazikulu za HEC pokonzekera izi ndi izi:
Thickener ndi stabilizer: mu jakisoni,HECkuonjezera mamasukidwe akayendedwe a yankho, kuchepetsa jekeseni liwiro la mankhwala, ndi kumapangitsanso bata la mankhwala.
Kulamulira kutulutsidwa kwa mankhwala: Monga chimodzi mwa zigawo za mankhwala omasulidwa okhazikika, HEC ikhoza kulamulira mlingo wa kutulutsidwa kwa mankhwala mwa kupanga gel wosanjikiza pambuyo pa jekeseni, kuti akwaniritse cholinga cha chithandizo cha nthawi yaitali.
3. Udindo wa HEC mu machitidwe operekera mankhwala
Ndi chitukuko cha teknoloji ya mankhwala, HEC yakhala ikugwiritsidwa ntchito kwambiri m'machitidwe osiyanasiyana operekera mankhwala osokoneza bongo, makamaka m'magulu a nano-drug carriers, microspheres, ndi zonyamula mankhwala osatha. HEC ikhoza kuphatikizidwa ndi zida zosiyanasiyana zonyamulira mankhwala kuti apange zovuta zokhazikika kuti zitsimikizire kumasulidwa kosalekeza komanso kupereka bwino kwa mankhwala.
Nano mankhwala chonyamulira: HEC angagwiritsidwe ntchito ngati stabilizer kwa nano mankhwala onyamula kupewa aggregation kapena mpweya wa particles chonyamulira ndi kuonjezera bioavailability wa mankhwala.
Microspheres ndi particles: HEC ikhoza kugwiritsidwa ntchito pokonzekera ma microspheres ndi microparticle drug carriers kuti atsimikizire kutulutsidwa kwapang'onopang'ono kwa mankhwala m'thupi ndikuwongolera mphamvu ya mankhwala.
Monga mankhwala ambiri komanso ogwira ntchito, AnxinCel®HEC ili ndi mwayi wogwiritsa ntchito pokonzekera mankhwala. Ndi chitukuko chokhazikika chaukadaulo wamankhwala, HEC imagwira ntchito yofunika kwambiri pakuwongolera kutulutsa mankhwala, kayendetsedwe ka malo, kukonzekera kosalekeza komanso njira zatsopano zoperekera mankhwala. Biocompatibility yake yabwino, kukhuthala kosinthika komanso kukhazikika kumapangitsa kuti zisalowe m'malo mwazamankhwala. M'tsogolomu, ndi kafukufuku wozama wa HEC, kugwiritsidwa ntchito kwake pakukonzekera mankhwala kudzakhala kwakukulu komanso kosiyana.
Nthawi yotumiza: Dec-28-2024