Hydroxypropyl methylcellulose (HPMC)bụ ihe a na-ejikarị cellulose eme ihe nke nwere ngwa dị iche iche, karịsịa na mpaghara ọgwụ, ihe ịchọ mma, nri, na ihe ụlọ. Ọ bụghị ihe mgbaze, ma mmiri na-agbaze mmiri nke nwere ike igbari na mmiri ma mepụta ngwọta colloidal transperent. Solubility nke AnxinCel®HPMC dabere na ọnụọgụ na ọnọdụ methyl na hydroxypropyl nọchiri anya n'ụdị molekụla ya.
1. Njirimara ndị bụ isi nke hydroxypropyl methylcellulose
A na-enweta Hydroxypropyl methylcellulose site na methylation na hydroxypropylation nke cellulose. Cellulose n'onwe ya bụ polysaccharide dị elu dị elu nke dị na mgbidi cell osisi. Nhazi kemịkalụ nke HPMC bụ nke kachasị nke glucose nkeji, bụ ụmụ irighiri akwara ogologo jikọtara site na njikọ β-1,4 glycosidic. N'ime usoro ihe omimi a, a na-eji methyl (-OCH₃) na hydroxypropyl (-C₃H₇OH) dochie ụfọdụ otu hydroxyl, na-enye ya ezigbo solubility na ihe ndị ọzọ anụ ahụ na kemịkal.
Usoro ihe omimi na-emetụta solubility nke HPMC ma na-enwekarị àgwà ndị a:
Mmiri solubility: HPMC nwere ike ịmepụta ngwọta viscous na mmiri ma gbazee ngwa ngwa. Ya solubility nwere njikọ chiri anya na okpomọkụ nke mmiri na molekụla arọ nke HPMC.
Nnukwu viscosity: N'otu ntinye uche, ihe ngwọta nke HPMC na-egosi viscosity dị elu, karịsịa na ịdị arọ dị elu na ịdị elu.
Nkwụsi ike nke okpomọkụ: HPMC nwere ezigbo nkwụsi ike na ọnọdụ okpomọkụ dị iche iche na ọ dịghị mfe ire ere, ya mere ọ nwere uru ụfọdụ na nhazi nhazi okpomọkụ.
2. Solubility nke HPMC
HPMC bụ ihe na-agbaze mmiri, mana ihe mgbaze niile anaghị agbaze ya. Omume mgbasa ya metụtara polarity nke ihe mgbaze na mmekọrịta dị n'etiti ihe mgbaze na ụmụ irighiri ihe HPMC.
Mmiri: HPMC nwere ike igbari na mmiri. Mmiri bụ ihe mgbaze ya na-ejikarị, na n'oge usoro mgbasa, ụmụ irighiri ihe AnxinCel®HPMC ga-eme njikọ hydrogen na ụmụ irighiri mmiri iji nweta mgbasa. Ọkwa nke mgbasa na-emetụta ihe ndị dị ka molekụla arọ nke HPMC, ogo methylation na hydroxypropylation, okpomọkụ, na pH uru mmiri. Ọtụtụ mgbe, solubility nke HPMC bụ ihe kacha mma na gburugburu pH na-anọpụ iche.
Ihe mgbaze Organic: HPMC fọrọ nke nta ka ọ ghara ịsacha n'ọtụtụ ihe mgbaze organic, dị ka alcohols, ethers, na hydrocarbons. Nke a bụ n'ihi na usoro ihe omimi ya nwere otu hydrophilic hydroxyl na lipophilic methyl na hydroxypropyl otu. Ọ bụ ezie na ọ nwere njikọ siri ike maka mmiri, ọ nwere ndakọrịta adịghị mma na ọtụtụ ihe mgbaze organic.
Mmiri ọkụ na-ekpo ọkụ: Na mmiri ọkụ (na-emekarị 40 ° C ruo 70 ° C), HPMC na-agbaze ngwa ngwa na ngwọta gbazere na-egosipụta nnukwu viscosity. Ka okpomọkụ na-abawanye, ọnụọgụ mgbasa na solubility ga-abawanye, ma na oke okpomọkụ, viscosity nke ngwọta nwere ike imetụta.
3. Ngwa nke HPMC
N'ihi ezigbo mmiri solubility ya, obere nsí dị ala, na viscosity na-agbanwe agbanwe, a na-eji HPMC eme ihe n'ọtụtụ ebe na ụlọ ọrụ dị iche iche.
Ụlọ ọrụ na-emepụta ọgwụ: N'ime ụlọ ọrụ na-emepụta ọgwụ, a na-eji HPMC eme ihe n'ọtụtụ ebe na nkwadebe mwepụta nke ọgwụ, ịkpụzi mbadamba nkume, gels na ndị na-ebu ọgwụ. Ọ nwere ike inyere ọgwụ aka ịgbaze n'ime mmiri ma mezie ọnụego mwepụta ọgwụ.
Ụlọ ọrụ nri: HPMC, dị ka ihe mgbakwunye nri, bụ nke a na-ejikarị eme emulsification, thickening, and moisturizes. N'ime ihe ndị e ghere eghe, ọ nwere ike melite ductility na nkwụsi ike nke mgwakota agwa. A na-ejikwa HPMC na ice cream, ihe ọṅụṅụ na nri ndị nwere obere abụba.
Ụlọ ọrụ ihe owuwu: N'ime ụlọ ọrụ ihe owuwu, a na-ejikarị HPMC eme ihe dị ka ihe na-esi ísì ụtọ maka ịmepụta ngwa agha, nke nwere ike imeziwanye arụmọrụ ihe owuwu, njigide mmiri na ike njikọ nke ngwa agha.
Ihe ịchọ mma: N'ihe ịchọ mma, AnxinCel®HPMC bụ nke a na-ejikarị dị ka ihe na-agba agba, onye na-akwụsịtụ ya na stabilizer, a na-ejikwa ya na ngwaahịa ndị dị ka ude ihu, ncha ntutu, na mmiri ịsa ahụ.
HPMCbụ ihe mgbaze cellulose na-agbaze mmiri na nnukwu viscous nke nwere ike ịmepụta ngwọta colloidal transperent na mmiri. Ọ bụghị ihe mgbaze, ma ihe dị elu nke nwere ike igbari na mmiri. Ya solubility bụ tumadi pụtara na ezi solubility na mmiri, ma insoluble na ọtụtụ organic solvents. Njirimara HPMC ndị a na-eme ka a na-ejikarị ya n'ọtụtụ ụlọ ọrụ, gụnyere ọgwụ, nri, ihe owuwu, na ihe ịchọ mma.
Oge nzipu: Feb-17-2025