Kedu ihe bụ viscosity nke mmiri mmiri hydroxypropyl methylcellulose?

Hydroxypropyl methylcellulose (HPMC)bụ ihe polymer na-agbaze mmiri nke a na-ejikarị eme ihe n'ọgwụ, ihe owuwu, nri, ihe ịchọ mma na mpaghara ndị ọzọ. Njirimara viscosity ya bụ paramita dị mkpa iji tụọ àgwà rheological ya n'okpuru gburugburu dị iche iche. Ịghọta njirimara viscosity nke ngwọta mmiri HPMC na-enyere anyị aka ịghọta nke ọma omume na ọrụ ya n'ọtụtụ ngwa.

1. Nhazi kemịkalụ na ihe onwunwe nke HPMC

A na-enweta HPMC site na mgbanwe kemịkalụ nke cellulose eke, nke a na-emepụtakarị site na hydroxypropylation na methylation nke molecule cellulose. N'ime usoro kemịkalụ nke HPMC, ntinye nke otu methyl (-OCH₃) na hydroxypropyl (-OCH₂CHOHCH₃) na-eme ka ọ bụrụ mmiri na-agbaze ma nwee ikike mgbanwe viscosity dị mma. Ọtụtụ ihe na-emetụta arụmọrụ viscosity nke ihe ngwọta mmiri ya na njupụta na okpomọkụ dị iche iche dịka ibu molekul, ogo nnọchi, njupụta ngwọta, wdg.

2. Mmekọrịta dị n'etiti viscosity na ntinye uche

Ọbara mmiri nke mmiri AnxinCel®HPMC na-abawanye ka ọ na-abawanye. Nke a bụ n'ihi na na oke ibu, mmekọrịta dị n'etiti molekul na-eme ka ọ dịkwuo mma, na-ebute mmụba nke iguzogide mmiri. Agbanyeghị, oke ibu nke molekul na-emetụtakwa àgwà ịgbaze na viscosity nke HPMC n'ime mmiri. HPMC nwere oke ibu nke molekul na-egosipụtakarị viscosity dị elu, ebe obere ibu nke molekul dị obere.

N'ebe dị ala: Mmiri HPMC na-egosi obere viscosity na obere resolution (dịka ihe na-erughị 0.5%). N'oge a, mmekọrịta dị n'etiti molekul adịghị ike ma mmiri mmiri dị mma. A na-ejikarị ya eme ihe dịka mkpuchi na mwepụta ọgwụ na-adịgide adịgide.

N'ọkwa dị elu: N'ọkwa dị elu (dịka 2% ma ọ bụ karịa), ọwa mmiri HPMC na-abawanye nke ukwuu, na-egosi ihe ndị yiri nke mmiri colloidal. N'oge a, ọwa mmiri nke mmiri ahụ na-eguzogide nke ukwuu.

3. Mmekọrịta dị n'etiti viscosity na okpomọkụ

Ọbara mmiri nke mmiri HPMC na-enwe mmetụta dị ukwuu na okpomọkụ. Ka okpomọkụ na-arị elu, mmegharị dị n'etiti mkpụrụ ndụ mmiri na-abawanye, mmekọrịta dị n'etiti mkpụrụ ndụ HPMC na-adịkwa njọ, na-ebute mbelata na viscosity. Àgwà a na-eme ka itinye HPMC n'ọrụ n'ọnọdụ okpomọkụ dị iche iche na-egosi ike mgbanwe siri ike. Dịka ọmụmaatụ, n'ọnọdụ okpomọkụ dị elu, viscosity nke HPMC na-ebelatakarị, nke dị mkpa karịsịa na usoro ọgwụ, karịsịa n'ụdị ọgwụ na-adịgide adịgide, ebe mgbanwe okpomọkụ nwere ike imetụta nkwụsi ike na mmetụta nke ngwọta ahụ.

4. Mmetụta nke pH na Viscosity

Ọkwa pH nke ngwọta ahụ nwekwara ike imetụta oke mmiri nke ngwọta mmiri HPMC. Ọ bụ ezie na HPMC abụghị ihe na-abụghị ionic, ihe ndị dị na hydrophilicity na viscosity ya na-emetụtakarị site na nhazi molekul na gburugburu ebe ngwọta ahụ. Agbanyeghị, n'okpuru ọnọdụ acidic ma ọ bụ alkaline dị oke njọ, ike ịgbaze na nhazi molekul nke HPMC nwere ike ịgbanwe, si otú a na-emetụta viscosity ahụ. Dịka ọmụmaatụ, n'okpuru ọnọdụ acidic, ike ịgbaze nke HPMC nwere ike ịda ntakịrị, na-ebute mmụba viscosity; ebe n'okpuru ọnọdụ alkaline, hydrolysis nke ụfọdụ HPMC nwere ike ime ka ibu molekul ya belata, si otú a belata viscosity ya.

5. Ibu na Viscositi nke molekụla

Ibu molekul bụ otu n'ime ihe ndị dị mkpa na-emetụta viscosity nke mmiri mmiri HPMC. Ibu molekul dị elu na-eme ka njikọ dị n'etiti molekul dịkwuo elu, na-ebute mmụba viscosity. Ibu molekul dị ala AnxinCel®HPMC nwere ike ịgbaze nke ọma na mmiri yana obere viscosity. Ihe dị iche iche achọrọ maka ojiji na-achọkarị nhọrọ nke HPMC nwere ibu molekul dị iche iche. Dịka ọmụmaatụ, na mkpuchi na ihe nrapado, a na-ahọrọ HPMC dị arọ molekul dị elu maka nrapado na mmiri mmiri ka mma; ebe na nkwadebe ọgwụ, enwere ike iji obere molekul dị arọ HPMC iji chịkwaa ọnụego mwepụta nke ọgwụ.

6. Mmekọrịta dị n'etiti ọnụego shear na viscosity

Ọbara mmiri nke ngwọta mmiri HPMC na-agbanwekarị ka ọ na-agbanwe, na-egosi omume rheological pseudoplastic nkịtị. Mmiri Pseudoplastic bụ mmiri nke viscosity ya na-ebelata nwayọ nwayọ ka mmụba nke speed rate na-abawanye. Njirimara a na-eme ka ngwọta HPMC nwee ike ịnọgide na-enwe viscosity dị elu na obere speed rate mgbe etinyere ya, ma mee ka fluidity dịkwuo elu na speed rate dị elu. Dịka ọmụmaatụ, n'ụlọ ọrụ mkpuchi, ngwọta HPMC na-achọkarị igosi viscosity dị elu na obere speed rate mgbe etinyere ya iji hụ na a na-ejikọ na ọkwa nke mkpuchi ahụ, ebe n'oge usoro owuwu, ọ dị mkpa ịbawanye speed rate ka ọ bụrụ mmiri mmiri karịa.

7. Njirimara ngwa na viscosity nke HPMC

Mmetụta nke viscosity nke eriri afọHPMCmee ka e jiri ya mee ihe nke ọma n'ọtụtụ ebe. Dịka ọmụmaatụ, n'ụlọ ọrụ ọgwụ, a na-ejikarị HPMC eme ihe dị ka ihe na-eme ka ọgwụ na-adịgide adịgide, a na-ejikwa njikwa viscosity ya achịkwa ọnụego mwepụta nke ọgwụ ahụ; n'ụlọ ọrụ owuwu, a na-eji HPMC eme ihe dị ka ihe na-eme ka ọ dị arọ iji melite ike na mmiri nke ngwa agha na ihe na-arapara; na ụlọ ọrụ nri, enwere ike iji HPMC mee ihe dị ka ihe na-eme ka ọ dị arọ, ihe na-eme ka ọ dị nro na ihe na-eme ka nri dị mma.

Àgwà viscosity nke mmiri AnxinCel®HPMC bụ isi ihe dị mkpa maka ojiji ya n'ọhịa dị iche iche. Ịghọta mmekọrịta ya na ihe ndị dị ka ntinye uche, okpomọkụ, pH, ibu molekul na ọnụego shea dị oke mkpa maka ime ka arụmọrụ ngwaahịa ka mma na imeziwanye mmetụta ojiji.