Hydroxypropyl methylcellulose (HPMC)yog cov khoom siv polymer uas yaj tau hauv dej uas siv dav hauv kev lag luam tshuaj, kev tsim kho, khoom noj, tshuaj pleev ib ce thiab lwm yam. Nws cov khoom viscosity yog qhov tseem ceeb los ntsuas nws cov cwj pwm rheological hauv qab ntau qhov chaw sib txawv. Kev nkag siab txog cov khoom viscosity ntawm HPMC aqueous solution pab peb nkag siab zoo dua nws cov cwj pwm thiab kev ua haujlwm hauv ntau yam kev siv.
1. Cov qauv tshuaj lom neeg thiab cov khoom ntawm HPMC
HPMC tau los ntawm kev hloov kho tshuaj ntawm cov cellulose ntuj, feem ntau yog tsim los ntawm hydroxypropylation thiab methylation ntawm cellulose molecules. Hauv cov qauv tshuaj ntawm HPMC, kev qhia txog methyl (-OCH₃) thiab hydroxypropyl (-OCH₂CHOHCH₃) pawg ua rau nws yaj hauv dej thiab muaj peev xwm hloov kho viscosity zoo. Kev ua tau zoo viscosity ntawm nws cov kua dej ntawm ntau qhov sib txawv thiab qhov kub thiab txias cuam tshuam los ntawm ntau yam xws li qhov hnyav molecular, qib ntawm kev hloov pauv, kev daws teeb meem, thiab lwm yam.
2. Kev sib raug zoo ntawm viscosity thiab concentration
Qhov viscosity ntawm AnxinCel®HPMC aqueous solution feem ntau nce nrog rau qhov concentration nce. Qhov no yog vim tias thaum muaj concentration ntau dua, kev sib cuam tshuam ntawm cov molecules raug txhim kho, ua rau muaj kev tiv thaiv dej ntws ntau dua. Txawm li cas los xij, qhov solubility thiab viscosity ntawm HPMC hauv dej kuj raug cuam tshuam los ntawm qhov hnyav molecular. HPMC nrog qhov hnyav molecular siab feem ntau qhia txog viscosity siab dua, thaum qhov hnyav molecular qis yog qhov tsawg.
Thaum muaj cov concentration qis: Cov tshuaj HPMC qhia tau tias muaj viscosity qis dua thaum muaj cov concentration qis dua (xws li qis dua 0.5%). Lub sijhawm no, kev sib cuam tshuam ntawm cov molecule tsis muaj zog thiab qhov fluidity zoo. Nws feem ntau yog siv rau hauv cov ntawv thov xws li cov tshuaj pleev xim thiab cov tshuaj tso tawm tas mus li.
Thaum muaj cov concentration siab: Thaum muaj cov concentration siab dua (xws li 2% lossis siab dua), qhov viscosity ntawm HPMC aqueous solution nce ntxiv ntau, qhia txog cov khoom zoo ib yam li cov colloidal solutions. Lub sijhawm no, qhov fluidity ntawm cov tshuaj yuav raug kev tiv thaiv ntau dua.
3. Kev sib raug zoo ntawm viscosity thiab kub
Qhov viscosity ntawm HPMC aqueous kua yog rhiab heev rau qhov kub thiab txias. Thaum qhov kub nce ntxiv, kev txav mus los ntawm cov dej molecule nce ntxiv, thiab kev sib cuam tshuam ntawm HPMC molecule ua rau qaug zog, ua rau viscosity txo qis. Cov yam ntxwv no ua rau kev siv HPMC ntawm ntau qhov kub thiab txias qhia tau tias muaj kev hloov kho tau zoo. Piv txwv li, nyob rau hauv qhov kub siab, qhov viscosity ntawm HPMC feem ntau txo qis, uas yog qhov tseem ceeb tshwj xeeb hauv cov txheej txheem tshuaj, tshwj xeeb tshaj yog hauv cov tshuaj tso tawm cov tshuaj, qhov twg qhov kub hloov pauv yuav cuam tshuam rau qhov ruaj khov thiab cov nyhuv ntawm cov tshuaj.
4. Cov nyhuv ntawm pH rau Viscosity
Qhov viscosity ntawm HPMC aqueous kua kuj tseem yuav raug cuam tshuam los ntawm tus nqi pH ntawm cov kua. Txawm hais tias HPMC yog ib yam khoom tsis-ionic, nws cov hydrophilicity thiab viscosity cov khoom feem ntau cuam tshuam los ntawm cov qauv molecular thiab ib puag ncig ntawm cov kua. Txawm li cas los xij, nyob rau hauv cov xwm txheej acidic lossis alkaline heev, qhov solubility thiab cov qauv molecular ntawm HPMC yuav hloov pauv, yog li cuam tshuam rau viscosity. Piv txwv li, nyob rau hauv cov xwm txheej acidic, qhov solubility ntawm HPMC yuav me ntsis qaug zog, ua rau muaj viscosity ntau ntxiv; thaum nyob rau hauv cov xwm txheej alkaline, qhov hydrolysis ntawm qee qhov HPMC yuav ua rau nws qhov hnyav molecular txo qis, yog li txo nws cov viscosity.
5. Qhov Hnyav Molecular thiab Viscosity
Qhov hnyav molecular yog ib qho ntawm cov yam tseem ceeb uas cuam tshuam rau qhov viscosity ntawm HPMC aqueous solution. Qhov hnyav molecular siab dua ua rau muaj kev sib txuas thiab kev sib txuas ntawm cov molecules, ua rau muaj viscosity ntau dua. Qhov hnyav molecular qis AnxinCel®HPMC muaj solubility zoo dua hauv dej thiab viscosity qis dua. Cov kev cai thov sib txawv feem ntau xav tau kev xaiv HPMC nrog cov qhov hnyav molecular sib txawv. Piv txwv li, hauv cov txheej thiab cov nplaum, qhov hnyav molecular siab HPMC feem ntau raug xaiv rau kev nplaum zoo dua thiab fluidity; thaum nyob rau hauv kev npaj tshuaj, qhov hnyav molecular qis HPMC yuav siv tau los tswj qhov kev tso tawm ntawm cov tshuaj.
6. Kev sib raug zoo ntawm qhov nrawm thiab viscosity
Qhov viscosity ntawm HPMC aqueous kua feem ntau hloov pauv nrog rau qhov shear rate, qhia txog tus cwj pwm rheological pseudoplastic. Pseudoplastic kua yog cov kua uas nws viscosity maj mam txo qis nrog rau qhov nce ntawm shear rate. Cov yam ntxwv no ua rau HPMC kua kom tswj tau qhov viscosity siab ntawm qhov shear rate qis thaum siv, thiab txhim kho fluidity ntawm qhov shear rate siab dua. Piv txwv li, hauv kev lag luam txheej, HPMC kua feem ntau yuav tsum qhia qhov viscosity siab dua ntawm qhov shear rate qis dua thaum siv kom ntseeg tau tias qhov adhesion thiab leveling ntawm cov txheej, thaum lub sijhawm tsim kho, nws yog qhov tsim nyog los nce qhov shear rate kom ua rau nws muaj kua ntau dua.
7. Daim ntawv thov thiab viscosity yam ntxwv ntawm HPMC
Cov yam ntxwv ntawm viscosityHPMCua rau nws siv dav hauv ntau qhov chaw. Piv txwv li, hauv kev lag luam tshuaj, HPMC feem ntau siv ua tus neeg sawv cev tso tshuaj, thiab nws cov kev tswj hwm viscosity siv los tswj qhov kev tso tawm ntawm cov tshuaj; hauv kev lag luam kev tsim kho, HPMC siv ua cov khoom siv tuab kom txhim kho kev ua haujlwm thiab kev ua haujlwm ntawm cov tshuaj mortar thiab cov nplaum; hauv kev lag luam zaub mov, HPMC tuaj yeem siv ua cov khoom siv tuab, emulsifier thiab stabilizer los txhim kho qhov saj thiab tsos ntawm cov zaub mov.
Cov yam ntxwv ntawm viscosity ntawm AnxinCel®HPMC aqueous solution yog qhov tseem ceeb rau nws siv rau hauv ntau qhov chaw sib txawv. Kev nkag siab txog nws txoj kev sib raug zoo nrog cov yam xws li concentration, kub, pH, molecular weight thiab shear rate yog qhov tseem ceeb heev rau kev ua kom zoo dua cov khoom ua tau zoo thiab txhim kho cov txiaj ntsig ntawm kev siv.
Lub sijhawm tshaj tawm: Lub Ib Hlis-27-2025